Natural and orthogonal interaction framework for modeling gene-environment interactions with application to lung cancer

Human Heredity

Volumn 73, Issue 4, 2012, Pages 185-194

  Ma, Jianzhong ^a   Xiao, Feifei ^a   Xiong, Momiao ^b   Andrew, Angeline S ^c   Brenner, Hermann ^g   Duell, Eric J ^j   Haugen, Aage ^l   Hoggart, Clive ^m   Hung, Rayjean J ⁿ   Lazarus, Philip ^d   Liu, Changlu ^a   Matsuo, Keitaro ^o   Mayordomo, Jose Ignacio ^k   Schwartz, Ann G ^e   Staratschek Jox, Andrea ^h   Wichmann, Erich ⁱ   Yang, Ping ^f   Amos, Christopher I ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

^d PENN STATE COLLEGE OF MEDICINE   (United States)

^e WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f MAYO CLINIC CANCER CENTER   (United States)

^g GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^h UNIVERSITY OF BONN   (Germany)

ⁱ INSTITUTE OF EPIDEMIOLOGY   (Germany)

^j CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^k HOSPITAL CLÍNICO UNIVERSITARIO LOZANO BLESA   (Spain)

^l NATIONAL INSTITUTE OF OCCUPATIONAL HEALTH   (Norway)

^m LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

ⁿ MOUNT SINAI HOSPITAL   (Canada)

^o AICHI CANCER CENTER HOSPITAL   (Japan)

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Author keywords

Association mapping; Case control association analysis; Environmental risk factor; Gene environment interaction; Genetic association studies; Orthogonal modeling; Statistical power

Indexed keywords

ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DATA ANALYSIS; DOMINANT GENE; ENVIRONMENTAL EXPOSURE; GENE INTERACTION; GENETIC MODEL; GENOTYPE ENVIRONMENT INTERACTION; LUNG CANCER; NATURAL AND ORTHOGONAL INTERACTION FRAMEWORK; QUANTITATIVE TRAIT; RECESSIVE GENE; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; STATISTICAL MODEL;

CASE-CONTROL STUDIES; COMPUTER SIMULATION; DATABASES, FACTUAL; EARLY DETECTION OF CANCER; GENE FREQUENCY; GENE-ENVIRONMENT INTERACTION; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LOGISTIC MODELS; LUNG NEOPLASMS; MODELS, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE; SMOKING;

EID: 84864798530     PISSN: 00015652     EISSN: 14230062     Source Type: Journal    
DOI: 10.1159/000339906     Document Type: Article

References (7)

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