Randomised controlled trial for emphysema with a selective agonist of the γ-type retinoic acid receptor

European Respiratory Journal

Volumn 40, Issue 2, 2012, Pages 306-312

  Stolk, Jan ^a   Stockley, Robert A ^b   Stoel, Berend C ^a   Cooper, Brendan G ^b   Piitulainen, Eeva ^c   Seersholm, Niels ^d   Chapman, Kenneth R ^e   Burdon, Jonathan G W ^f   Decramer, Marc ^g   Abboud, Raja T ^h   Mannes, Gregorius P M ⁱ   Wouters, Emiel F ^j   Garrett, Jeffrey E ^k   Barros Tizon, Juan C ^l   Russi, Erich W ^m   Lomas, David A ⁿ   MacNee, William A ^o   Rames, Alexis ^p  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^e TORONTO WESTERN HOSPITAL   (Canada)

^f ST VINCENT S HOSPITAL   (Australia)

^g UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^h UNIVERSITY OF BRITISH COLUMBIA   (Canada)

ⁱ Twenteborgziekenhuis ^*  (Netherlands)

^j MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^k MIDDLEMORE HOSPITAL   (New Zealand)

^l HOSPITAL XERAL CÍES   (Spain)

^m UNIVERSITY HOSPITAL ZURICH   (Switzerland)

ⁿ UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^o UNIVERSITY OF EDINBURGH   (United Kingdom)

^p F HOFFMANN LA ROCHE LTD   (Switzerland)

more..

Author keywords

1 antitrypsin; Chronic obstructive pulmonary disease treatment; Clinical trials; Densitometry; Emphysema; Retinoids

Indexed keywords

PALOVAROTENE; PLACEBO;

ADULT; ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG TREATMENT FAILURE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LUNG DIFFUSION; LUNG EMPHYSEMA; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TOTAL LUNG CAPACITY;

ADULT; AGED; ANIMALS; DOUBLE-BLIND METHOD; EMPHYSEMA; FEMALE; FORCED EXPIRATORY VOLUME; GASES; GENOTYPE; HUMANS; INFLAMMATION; LEAST-SQUARES ANALYSIS; MALE; MIDDLE AGED; PLACEBOS; PYRAZOLES; RECEPTORS, RETINOIC ACID; SMOKING; STILBENES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84864770563     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00161911     Document Type: Article

References (19)

1. McDonough JE, Yuan R, Suzuki M, et al. Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. N Engl J Med 2011; 365: 1567-1575.
2. Damiano VV, Tsang A, Kucich U, et al. Immunolocalization of elastase in human emphysematous lungs. J Clin Invest 1986; 78: 482-493. (Pubitemid 16074086)
3. Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for diagnosis and prevention of chronic obstructive pulmonary disease. NHLBI/WHO workshop report. Bethesda, National Heart, Lung and Blood Institute, 2001; NIH Publication No. 2701.
4. Stockley RA, Parr DG, Piitulainen E, et al. Therapeutic efficacy of α1-antitrypsin augmentation therapy on the loss of lung tissue: an integrated analysis of 2 randomised clinical trials using computed tomography densitometry. Respir Res 2010; 11: 136.
5. Belloni PN, Garvin L, Mao CP, et al. Effects of all-trans-retinoic acid in promoting alveolar repair. Chest 2000; 117: 235S-241S. (Pubitemid 30326965)
6. Massaro GD, Massaro D. Retinoid acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nat Med 1997; 3: 675-677. (Pubitemid 27264979)
7. Roth MD, Connett JE, D'Armiento JM, et al. Feasibility of retinoids for the treatment of emphysema study. Chest 2006; 130: 1334-1345. (Pubitemid 44786724)
8. Massaro D, Massaro GD. Lung development, lung function, and retinoids. N Engl J Med 2010; 362: 1829-1831.
9. Stockley RA, Luisetti M, Miravitlles M, et al. Ongoing research in Europe: Alpha One International Registry (AIR) objectives and development. Eur Respir J 2007; 29: 582-586. (Pubitemid 46379103)
10. Stoel BC, Putter H, Bakker ME, et al. Volume correction in computed tomography densitometry for follow-up studies on pulmonary emphysema. Proc Am Thorac Soc 2008; 5: 919-924.
11. Gould GA, MacNee W, McLean A, et al. CT measurements of lung density in life can quantitate distal airspace enlargement - an essential defining feature of human emphysema. Am Rev Respir Dis 1988; 37: 380-392. (Pubitemid 18050189)
12. Stolk J, Cooper BG, Stoel B, et al. Retinoid treatment of Emphysema in Patients on the Alpha-1 International Registry. The REPAIR study: study design, methodology and quality control of study assessments. Ther Adv Respir Dis 2010; 4: 319-332.
13. European Respiratory Society. Standardized lung function testing. Lung volumes and forced ventilatory flows. 1993 update. Eur Respir J 1993; 6: 5-40.
14. Cotes JE, Chinn DJ, Quanjer PH, et al. Standardization of the measurement of transfer factor (diffusing capacity). Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J 1993; 6: Suppl. 16, 41-52.
15. Rodríguez-Roisin R. COPD exacerbations. 5: Management. Thorax 2006; 61: 535-544.
16. Dirksen A, Dijkman JH, Madsen F, et al. A randomized clinical trial of α1-antitrypsin augmentation therapy. Am J Respir Crit Care Med 1999; 160: 1468-1472.
17. Parr DG, Sevenoaks M, Deng C, et al. Detection of emphysema progression in α1-antitrypsin deficiency using CT densitometry; methodological advances. Respir Res 2008; 9: 21.
18. Tanabe N, Muro S, Hirai T, et al. Impact of exacerbations on emphysema progression in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2011; 183: 1653-9.
19. Bakker ME, Putter H, Stolk J, et al. Assessment of regional progression of pulmonary emphysema with CT densitometry. Chest 2008; 134: 931-937.