miR-122 regulates hepatic lipid metabolism and tumor suppression

Journal of Clinical Investigation

Volumn 122, Issue 8, 2012, Pages 2773-2776

  Wen, Jessica ^a   Friedman, Joshua R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA 122;

CANCER INCIDENCE; CANCER INHIBITION; CHOLESTEROL METABOLISM; GENE DELETION; GENE LOSS; HEPATITIS; HUMAN; LIPID METABOLISM; LIVER CELL; LIVER CELL CARCINOMA; LIVER FIBROSIS; LIVER METABOLISM; MICRORNA 122A ONCOGENE; NONHUMAN; NOTE; ONCOGENE; PRIORITY JOURNAL;

EID: 84864770242     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI63966     Document Type: Note

References (23)

1. Hand NJ, Master ZR, Le Lay J, Friedman JR. Hepatic function is preserved in the absence of mature microRNAs. Hepatology. 2009;49(2):618-626.
2. Sekine S, et al. Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis. Gastroenterology. 2009;136(7):2304-2315.e4.
3. Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T. Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002;12(9):735-739. (Pubitemid 34455427)
4. Esau C, et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab. 2006;3(2):87-98.
5. Krutzfeldt J, et al. Silencing of microRNAs in vivo with 'antagomirs'. Nature. 2005;438(7068):685-689.
6. Saito Y, et al. MicroRNAs in hepatobiliary and pancreatic cancers. Front Genet. 2011;2:66.
7. Hsu S-H, et al. Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. J Clin Invest. 2012;122(8):2871-2883.
8. Tsai W-C, et al. MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. J Clin Invest. 2012;122(8):2884-2897.
9. Kim YJ, Cho SY, Yun CH, Moon YS, Lee TR, Kim SH. Transcriptional activation of Cidec by PPAR-gamma2 in adipocyte. Biochem Biophys Res Commun. 2008;377(1):297-302.
10. Hussain MM, Shi J, Dreizen P. Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly. J Lipid Res. 2003;44(1):22-32. (Pubitemid 36114766)
11. Karlmark KR, et al. Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology. 2009;50(1):261-274.
12. Miele L, et al. The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease. Gastroenterology 2008;135(1):282-291.e1.
13. Wu X, et al. miR-122 affects the viability and apoptosis of hepatocellular carcinoma cells. Scand J Gastroenterol. 2009;44(11):1332-1339.
14. Coulouarn C, Factor VM, Andersen JB, Durkin ME, Thorgeirsson SS. Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. Oncogene. 2009;28(40):3526-3536.
15. Bai S, et al. MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib. J Biol Chem. 2009;284(46):32015-32027.
16. McGlynn KA, London WT. Epidemiology and natural history of hepatocellular carcinoma. Best PractRes Clin Gastroenterol. 2005;19(1):3-23. (Pubitemid 40331495)
17. Laudadio I, et al. A feedback loop between the liver-enriched transcription factor network and miR- 122 controls hepatocyte differentiation. Gastroenterology. 2012;142(1):119-129.
18. Machlin ES, Sarnow P, Sagan SM. Masking the 5′ terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex. Proc Natl Acad Sci U S A. 2011;108(8):3193-3198.
19. Nunnari G, Schnell MJ. MicroRNA-122: a therapeutic target for hepatitis C virus (HCV) infection. Front Biosci (Schol Ed). 2011;3:1032-1037.
20. Jopling CL. Regulation of hepatitis C virus by microRNA-122. Biochem Soc Trans. 2008;36(Pt 6):1220-1223.
21. Shimakami T, et al. Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex. Proc Natl Acad Sci U S A. 2012;109(3):941-946.
22. Sarasin-Filipowicz M, Krol J, Markiewicz I, Heim MH, Filipowicz W. Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy. Nat Med. 2009;15(1):31-33.
23. Lanford RE, et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science. 2010;327(5962):198-201.