Controlled exposure study of air pollution and T-Wave alternans in volunteers without cardiovascular disease

Environmental Health Perspectives

Volumn 120, Issue 8, 2012, Pages 1157-1161

  Kusha, Marjan ^a   Masse, Stephane ^a   Farid, Talha ^a   Urch, Bruce ^b,c   Silverman, Frances ^b,c   Brook, Robert D ^d   Gold, Diane R ^e   Mangat, Iqwal ^f   Speck, Mary ^b   Nair, Krishnakumar ^a   Poku, Kwaku ^a   Meyer, Chris ^a   Mittleman, Murray A ^g   Wellenius, Gregory A ^h   Nanthakumar, Kumaraswamy ^a  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f ST MICHAEL'S HOSPITAL   (Canada)

^g BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^h BROWN UNIVERSITY   (United States)

Author keywords

Air pollution; Arrhythmia; Controlled exposure; Ozone; Particulate matter; T wave alternans

Indexed keywords

OZONE;

ADULT; AIR POLLUTION; ARTICLE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; ENVIRONMENTAL EXPOSURE; FEMALE; HEART RATE; HEART REPOLARIZATION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PARTICULATE MATTER; PRIORITY JOURNAL; QRS COMPLEX; QT DISPERSION; T WAVE;

ADOLESCENT; ADULT; AIR POLLUTION; CARDIOVASCULAR DISEASES; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; MALE; REFERENCE VALUES; YOUNG ADULT;

EID: 84864764965     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1104171     Document Type: Article

References (48)

1. Antzelevitch C. 2005. Cardiac repolarization. The long and short of it. Europace 7(suppl 2):S3-S9.
2. Bloomfield DM, Hohnloser SH and Cohen RJ. 2002. Interpretation and classification of microvolt T-wave alternans tests. J Cardiovasc Electrophysiol 13(5):502-512.
3. Brook RD, Brook JR, Urch B, Vincent R, Rajagopalan S, Silverman F. 2002. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation 105(13):1534-1536.
4. Brook RD, Franklin B, Cascio W, Hong Y, Howard G, Lipsett M, et al. 2004. Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation 109(21):2655-2671.
5. Brook RD, Urch B, Dvonch JT, Bard RL, Speck M, Keeler G, et al. 2009. Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans. Hypertension 54(3):659-667.
6. Campbell M, Pengelly D, Perrotta K, Macfarlane R, Li-Muller A, Gingrich S, et al. 2001. Toronto Public Health: Condition Critical-Fixing our smog warning system. Available: http://www.toronto.ca/health/hphe/pdf/report_condition_critical_technical.pdf [accessed 7 May 2012].
7. Cavallari JM, Fang SC, Eisen EA, Schwartz J, Hauser R, Herrick RF, et al. 2008. Time course of heart rate variability decline following particulate matter exposures in an occupational cohort. Inhal Toxicol 20(4):415-422.
8. Cuesta-Frau D, Aboy M, McNames J, Goldstein B. 2003. Morphology analysis of intracranial pressure using pattern matching techniques. In: Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE (Vol. 3), 17-21 September 2003, Cancun, Mexico, 2917-2920; doi:10.1109/IEMBS.2003.1280529 [Online 5 April 2004].
9. Cuesta-Frau D, Biagetti M, Micó-Tormos P, Aboy M, Quinteiro R. 2007a. T-wave alternans analysis improvement by means of curve alignment prior to distance calculation. In: Engineering in Medicine and Biology Society, 2007. Proceedings of the 29th Annual International Conference of the IEEE, 22-26 August 2007, Lyon, France, 690-693; doi:10.1109/IEMBS.2007.4352384 [Online 22 October 2007].
10. Cuesta-Frau D, Biagetti MO, Quinteiro RA, Micó-Tormos P, Aboy M. 2007b. Unsupervised classification of ventricular extrasystoles using bounded clustering algorithms and morphology matching. Med Biol Eng Comput 45(3):229-239.
11. Dockery DW, Luttmann-Gibson H, Rich DQ, Link MS, Mittleman MA, Gold DR, et al. 2005. Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators. Environ Health Perspect 113:670-674.
12. Fu JS, Streets DG, Jang CJ, Hao J, He K, Wang L, et al. 2009. Modeling regional/urban ozone and particulate matter in Beijing, China. J Air Waste Manag Assoc 59(1):37-44.
13. Gehi AK, Stein RH, Metz LD and Gomes JA. 2005. Microvolt T-wave alternans for the risk stratification of ventricular tachyarrhythmic events: a meta-analysis. J Am Coll Cardiol 46(1):75-82.
14. Haarmark C, Hansen PR, Vedel-Larsen E, Pedersen SH, Graff C, Andersen MP, et al. 2009. The prognostic value of the T-peak-T-end interval in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. J Electrocardiol 42(6):555-560.
15. Hampel R, Schneider A, Bruske I, Zareba W, Cyrys J, Rückerl R, et al. 2010. Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors. Environ Health Perspect 118:1755-1761.
16. Henneberger A, Zareba W, Ibald-Mulli A, Rückerl R, Cyrys J, Couderc JP, et al. 2005. Repolarization changes induced by air pollution in ischemic heart disease patients. Environ Health Perspect 113:440-446.
17. Hoek G, Brunekreef B, Fischer P, van Wijnen J. 2001. The association between air pollution and heart failure, arrhythmia, embolism, thrombosis, and other cardiovascular causes of death in a time series study. Epidemiology 12(3):355-357.
18. Kaufman ES, Bloomfield DM, Steinman RC, Namerow PB, Costantini O, Cohen RJ, et al. 2006. "Indeterminate" microvolt T-wave alternans tests predict high risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction. J Am Coll Cardiol 48(7):1399-1404.
19. Kop WJ, Krantz DS, Nearing BD, Gottdiener JS, Quigley JF, O'Callahan M, et al. 2004. Effects of acute mental stress and exercise on T-wave alternans in patients with implantable cardioverter defibrillators and controls. Circulation 109(15):1864-1869.
20. Kovach JA, Nearing BD, Verrier RL. 2001. Angerlike behavioral state potentiates myocardial ischemia-induced T-wave alternans in canines. J Am Coll Cardiol 37(6):1719-1725.
21. Lampert R, Jain D, Burg MM, Batsford WP and McPherson CA. 2000. Destabilizing effects of mental stress on ventricular arrhythmias in patients with implantable cardioverter-defibrillators. Circulation 101(2):158-164.
22. Lampert R, Shusterman V, Burg MM, Lee FA, Earley C, Goldberg A, et al. 2005. Effects of psychologic stress on repolarization and relationship to autonomic and hemodynamic factors. J Cardiovasc Electrophysiol 16(4):372-377.
23. Liao D, Shaffer ML, Rodriguez-Colon S, He F, Li X, Wolbrette DL, et al. 2010. Acute adverse effects of fine particulate air pollution on ventricular repolarization. Environ Health Perspect 118:1010-1015.
24. Ljungman PL, Berglind N, Holmgren C, Gadler F, Edvardsson N, Pershagen G, et al. 2008. Rapid effects of air pollution on ventricular arrhythmias. Eur Heart J 29(23):2894-2901.
25. Macfarlane R, Campbell M and Basrur SV. 2000. Toronto's Air: Let's Make it Healthy. Toronto Public Health. Available: http://www.toronto.ca/health/hphe/pdf/airquality.pdf [accessed 7 May 2012].
26. Martinez JP and Olmos S. 2005. Methodological principles of T-wave alternans analysis: a unified framework. IEEE Trans Biomed Eng 52(4):599-613.
27. Minkkinen M, Kähönen M, Viik J, Nikus K, Lehtimäki T, Lehtinen R, et al. 2009. Enhanced predictive power of quantitative TWA during routine exercise testing in the Finnish Cardiovascular Study. J Cardiovasc Electrophysiol 20(4):408-415.
28. Narayan SM. 2006. T-wave alternans and the susceptibility to ventricular arrhythmias. J Am Coll Cardiol 47(2):269-281.
29. Nearing B, Verrier R. 2002a. Progressive increases in complexity of T-wave oscillations herald ischemia-induced ventricular fibrillation. Circ Res 91(8):727-732.
30. Nearing BD, Verrier RL. 2002b. Modified moving average analysis of T-wave alternans to predict ventricular fibrillation with high accuracy. J Appl Physiol 92(2):541-549.
31. Nieminen T, Lehtimäki T, Viik J, Lehtinen R, Nikus K, Kööbi T, et al. 2007. T-wave alternans predicts mortality in a population undergoing a clinically indicated exercise test. Eur Heart J 28(19):2332-2337.
32. Pekkanen J, Peters A, Hoek G, Tiittanen P, Brunekreef B, de Hartog J, et al. 2002. Particulate air pollution and risk of ST-segment depression during repeated submaximal exercise tests among subjects with coronary heart disease: the Exposure and Risk Assessment for Fine and Ultrafine Particles in Ambient Air (ULTRA) study. Circulation 106(8):933-938.
33. Peters A, Liu E, Verrier RL, Schwartz J, Gold DR, Mittleman M, et al. 2000. Air pollution and incidence of cardiac arrhythmia. Epidemiology 11(1):11-17.
34. Rich DQ, Schwartz J, Mittleman MA, Link M, Luttmann-Gibson H, Catalano PJ, et al. 2005. Association of short-term ambient air pollution concentrations and ventricular arrhythmias. Am J Epidemiol 161(12):1123-1132.
35. Routledge HC, Ayres JG. 2005. Air pollution and the heart. Occup Med (Lond) 55(6):439-447.
36. Samet JM, Rappold A, Graff D, Cascio WE, Berntsen JH, Huang YC, et al. 2009. Concentrated ambient ultrafine particle exposure induces cardiac changes in young healthy volunteers. Am J Respir Crit Care Med 179(11):1034-1042.
37. Santos UP, Terra-Filho M, Lin CA, Pereira LA, Vieira TC, Saldiva PH, et al. 2008. Cardiac arrhythmia emergency room visits and environmental air pollution in São Paulo, Brazil. J Epidemiol Community Health 62(3):267-272.
38. Sivagangabalan G, Spears D, Masse S, Urch B, Brook RD, Silverman F, et al. 2011. The effect of air pollution on spatial dispersion of myocardial repolarization in healthy human volunteers. J Am Coll Cardiol 57(2):198-206.
39. Slawnych MP, Nieminen T, Kähönen M, Kavanagh KM, Lehtimäki T, Ramadan D, et al. 2009. Postexercise assessment of cardiac repolarization alternans in patients with coronary artery disease using the modified moving average method. J Am Coll Cardiol 53(13):1130-1137.
40. Srebot V, Gianicolo EA, Rainaldi G, Trivella MG, Sicari R. 2009. Ozone and cardiovascular injury. Cardiovasc Ultrasound 7:30; doi:10.1186/1476-7120-7-30 [Online 24 June 2009].
41. Stein PK, Sanghavi D, Domitrovich PP, Mackey RA, Deedwania P. 2008. Ambulatory ECG-based T-wave alternans predicts sudden cardiac death in high-risk post-MI patients with left ventricular dysfunction in the EPHESUS study. J Cardiovasc Electrophysiol 19(10):1037-1042.
42. Takenaka K, Ai T, Shimizu W, Kobori A, Ninomiya T, Otani H, et al. 2003. Exercise stress test amplifies genotype-phenotype correlation in the LQT1 and LQT2 forms of the long-QT syndrome. Circulation 107(6):838-844.
43. Topilski I, Rogowski O, Rosso R, Justo D, Copperman Y, Glikson M, et al. 2007. The morphology of the QT interval predicts torsade de pointes during acquired bradyarrhythmias. J Am Coll Cardiol 49(3):320-328.
44. Urch B, Silverman F, Corey P, Brook JR, Lukic KZ, Rajagopalan S, et al. 2005. Acute blood pressure responses in healthy adults during controlled air pollution exposures. Environ Health Perspect 113:1052-1055.
45. Verrier RL, Nearing BD, La Rovere MT, Pinna GD, Mittleman MA, Bigger JT, Jr., et al. 2003. Ambulatory electrocardiogram-based tracking of T-wave alternans in postmyocardial infarction patients to assess risk of cardiac arrest or arrhythmic death. J Cardiovasc Electrophysiol 14(7):705-711.
46. Wichmann HE, Mueller W, Allhoff P, Beckmann M, Bocter N, Csicsaky MJ, et al. 1989. Health effects during a smog episode in West Germany in 1985. Environ Health Perspect 79:89-99.
47. Zanobetti A, Stone PH, Speizer FE, Schwartz JD, Coull BA, Suh HH, et al. 2009. T-wave alternans, air pollution, and traffic in high-risk subjects. Am J Cardiol 104(5):665-670.
48. Zareba W and Moss AJ. 1995. Dispersion of repolarization. Relation to heart rate and repolarization duration. J Electrocardiol 28(suppl 1):S202-S206.