Systemic exposure to aminoglycosides following knee and hip arthroplasty with aminoglycoside-loaded bone cement implants;Exposición sistémica a antibióticos aminoglucósidos después de una artroplastía de rodilla y cadera con implantes de hueso cargados de aminoglucósidos

Annals of Pharmacotherapy

Volumn 46, Issue 7-8, 2012, Pages 929-934

  Kalil, Graziela Z ^a   Ernst, Erika J ^a   Johnson, Sarah J ^a   Johannsson, Birgir ^a   Polgreen, Philip M ^a   Andrew Bertolatus, J ^a   Clark, Charles R ^a  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Aminoglycoside; Arthroplasty; Bone cement; Drug implants; Gentamicin; Nephrotoxicity; Orthopedic surgery; Tobramycin

Indexed keywords

AMINOGLYCOSIDE; AMINOGLYCOSIDE BONE CEMENT; BONE CEMENT; CREATININE; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CREATININE BLOOD LEVEL; DEMOGRAPHY; DRUG BLOOD LEVEL; DRUG MEGADOSE; DRUG SAFETY; FEMALE; FOLLOW UP; HIP ARTHROPLASTY; HUMAN; IMPLANT; IMPLANTATION; INFECTION; INFECTION PREVENTION; KNEE ARTHROPLASTY; MALE; NEPHROTOXICITY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; ARTHROPLASTY, REPLACEMENT, KNEE; BONE CEMENTS; CREATININE; FEMALE; HUMANS; MALE; MIDDLE AGED; PROSTHESES AND IMPLANTS; PROSTHESIS-RELATED INFECTIONS;

EID: 84864759605     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1R049     Document Type: Article

References (15)

1. Congressional research service (CRS) report for Congress. The US approval process for medical devices: legislative issues and comparison with the drug model (2005 March 23). www.law.umaryland.edu/marshall/crsreports/crsdocuments/RL3282603232005.pdf (accessed 2012 Mar 8).
2. Food and Drug Administration. www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfPCD/classification.cfm (accessed 2011 Jul 15).
3. Package insert. Tobramycin (tobramycin sulfate) powder, lyophilized, for solution. Northport, NY: X-Gen Pharmaceuticals, revised December 2009.
4. Package insert. Gentamicin (gentamicin sulfate), injection, solution concentrate. Lake Forest, IL: Hospira, Inc., revised August 2005.
5. Package insert. Amikacin (amikacin sulfate) injection. Lake Forest, IL: Hospira, Inc., revised April 2004.
6. Passuti N, Gouin F. Antibiotic-loaded bone cement in orthopedic surgery. Joint Bone Spine 2003;70:169-174. doi:10.1016/S1297-319X(03)00002-2
7. Hsieh P, Huang K, Tai C. Liquid gentamicin in bone cement spacers: in vivo antibiotic release and systemic safety in two-stage revision of infected hip arthroplasty. J Trauma 2009;66:804-808. doi:10.1097/TA.0b013e31818896cc
8. DiCicco M, Duong T, Chi A, Jansen SA. Tobramycin and gentamicin elution analysis between two in situ polymerizable orthopedic composites. J Biomed Mater Res Part B: Appl Biomater 2003;65b:137-149. doi:10.1002/jbm.b.10528
9. Mutimer J, Gillespe G, Lovering AM, Porteous AJ. Measurements of in vivo intra-articular gentamicin levels from antibiotic loaded articulating spacers in revision total knee replacement. Knee 2009;16:39-41. doi:10.1016/j.knee.2008.07.009
10. Anagnostakos K, Wilmes P, Schmitt E, Kelm J. Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo. Acta Orthopaedica 2009;80:193-197. doi:10.3109/17453670902884700
11. Trippel SB. Antibiotic-impregnated cement in total joint arthroplasty. J Bone Joint Surg Am 1986;68:1297-1302.
12. Patrick BN, Rivey MP, Allington DR. Acute renal failure associated with vancomycin- and tobramycin-laden cement in total hip arthroplasty. Ann Pharmacother 2006;40:2037-2042. doi:10.1345/aph.1H173
13. Curtis JM, Sternhagen V, Batts D. Acute renal failure after placement of tobramycin- impregnated bone cement in an infected total knee arthroplasty. Pharmacotherapy 2005;25:876-880. doi:10.1592/phco.2005.25.6.876
14. Mehta R, Kellum JA, Shah SV, et al. Acute kidney injury network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007; 11:R31. doi:10.1186/cc5713
15. Springer BD, Lee G-C, Osmon D, Haidukewych GJ, Hanssen AD, Jacofsky DJ. Systemic safety of high-dose antibiotic-loaded cement spacers after resection of an infected total knee arthroplasty. Clin Orthop Relat Res 2004;427:47-51. doi:10.1097/01.blo.0000144476.43661.10