Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study

Journal of the American College of Cardiology

Volumn 60, Issue 6, 2012, Pages 531-538

  Di Biase, Luigi ^a,b,c   Santangeli, Pasquale ^a,c   Anselmino, Matteo ^d   Mohanty, Prasant ^a   Salvetti, Ilaria ^d   Gili, Sebastiano ^d   Horton, Rodney ^a   Sanchez, Javier E ^a   Bai, Rong ^a   Mohanty, Sanghamitra ^a   Pump, Agnes ^a   Cereceda Brantes, Mauricio ^a   Gallinghouse, G Joseph ^a   Burkhardt, J David ^a   Cesarani, Federico ^e   Scaglione, Marco ^e   Natale, Andrea ^a,b   Gaita, Fiorenzo ^d  

^a TEXAS CARDIAC ARRHYTHMIA INSTITUTE   (United States)

^b The University of Texas at Austin   (United States)

^c UNIVERSITY OF FOGGIA   (Italy)

^d UNIVERSITY OF TURIN   (Italy)

^e Cardinal Guglielmo Massaia Hospital   (Italy)

Author keywords

CHADS 2 score; left atrial appendage; stroke; stroke prevention; TIA

Indexed keywords

ADULT; AGE; ARTICLE; CACTUS LEFT ATRIAL APPENDAGE; CARDIAC IMAGING; CARDIOVASCULAR MAGNETIC RESONANCE; CARDIOVASCULAR RISK; CATHETER ABLATION; CAULIFLOWER LEFT ATRIAL APPENDAGE; CHICKEN WING LEFT ATRIAL APPENDAGE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; HEART ATRIUM APPENDAGE; HEART ATRIUM FIBRILLATION; HUMAN; HYPERTENSION; INTRACARDIAC THROMBOSIS; LEFT ATRIAL APPENDAGE; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MORPHOLOGY; MULTIDETECTOR COMPUTED TOMOGRAPHY; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; STROKE; TRANSIENT ISCHEMIC ATTACK; WINDSOCK LEFT ATRIAL APPENDAGE;

ATRIAL APPENDAGE; ATRIAL FIBRILLATION; FEMALE; HUMANS; IMAGING, THREE-DIMENSIONAL; ISCHEMIC ATTACK, TRANSIENT; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RISK ASSESSMENT; STROKE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84864758434     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2012.04.032     Document Type: Article

References (23)

1. D.Y. Leung, I.W. Black, G.B. Cranney, A.P. Hopkins, W.F. Walsh Prognostic implications of left atrial spontaneous echo contrast in nonvalvular atrial fibrillation J Am Coll Cardiol 24 1994 755 762
2. W.J. Manning, D.I. Silverman, S.E. Katz Impaired left atrial mechanical function after cardioversion: relation to the duration of atrial fibrillation J Am Coll Cardiol 23 1994 1535 1540
3. Y. Wang, L. Di Biase, R.P. Horton, T. Nguyen, P. Morhanty, A. Natale Left atrial appendage studied by computed tomography to help planning for appendage closure device placement J Cardiovasc Electrophysiol 21 2010 973 982
4. Y.L. Douglas, M.R. Jongbloed, A.C. Gittenberger-de Groot Histology of vascular myocardial wall of left atrial body after pulmonary venous incorporation Am J Cardiol 97 2006 662 670
5. K.L. Moore, T.V.N. Persaud The Developing Human Clinically Oriented Embryology 6th edition 1998 WB Saunders Company Philadelphia, PA
6. N.M. Al-Saady, O.A. Obel, A.J. Camm Left atrial appendage: structure, function, and role in thromboembolism Heart 5 1999 547 554
7. W.J. Manning, R.M. Weintraub, C.A. Waksmonski Accuracy of transesophageal echocardiography for identifying left atrial thrombi A prospective, intraoperative study Ann Intern Med 123 1995 817 822
8. M.W. Martinez, J. Kirsch, E.E. Williamson Utility of nongated multidetector computed tomography for detection of left atrial thrombus in patients undergoing catheter ablation of atrial fibrillation J Am Coll Cardiol Img 2 2009 69 76
9. H. Sievert, M.D. Lesh, T. Trepels Percutaneous left atrial appendage transcatheter occlusion to prevent stroke in high-risk patients with atrial fibrillation: early clinical experience Circulation 105 2002 1887 1889
10. S.H. Ostermayer, M. Reisman, P.H. Kramer Percutaneous left atrial appendage transcatheter occlusion (PLAATO system) to prevent stroke in high-risk patients with non-rheumatic atrial fibrillation: results from the international multi-center feasibility trials J Am Coll Cardiol 46 2005 9 14
11. R. Fountain, D.R. Holmes Jr., P.K. Hodgson, K. Chandrasekaran, R. Van Tassel, P. Sick Potential applicability and utilization of left atrial appendage occlusion devices in patients with atrial fibrillation Am Heart J 152 2006 720 723
12. Y.Y. Kim, A.L. Klein, S.S. Halliburton Left atrial appendage filling defects identified by multidetector computed tomography in patients undergoing radiofrequency pulmonary vein antral isolation: a comparison with transesophageal echocardiography Am Heart J 154 2007 1199 1205
13. A. Patel, E. Au, K. Donegan Multidetector row computed tomography for identification of left atrial appendage filling defects in patients undergoing pulmonary vein isolation for treatment of atrial fibrillation: comparison with transesophageal echocardiography Heart Rhythm 5 2008 253 260
14. J.R. Landis, G.G. Koch The measurement of observer agreement for categorical data Biometrics 33 1977 159 174
15. W. Somerville, R.J. Chambers Systemic embolism in mitral stenosis: relation to the size of the left atrial appendix Br Med J 2 1964 1167 1169
16. G. Ernst, C. Stöllberger, F. Abzieher Morphology of the left atrial appendage Anat Rec 242 1995 553 561
17. J.P. Veinot, P.J. Harrity, F. Gentile Anatomy of the normal left atrial appendage: a quantitative study of age-related changes in 500 autopsy hearts: implications for echocardiographic examination Circulation 96 1997 3112 3115
18. European Heart Rhythm Association, Heart Rhythm Society V. Fuster, L.E. Ryden, D.S. Cannom et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation - executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation [erratum in: J Am Coll Cardiol 2007;50:562]) J Am Coll Cardiol 48 2006 854 906
19. L.S. Wann, A.B. Curtis, K.A. Ellenbogen 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (update on dabigatran): a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines J Am Coll Cardiol 57 2011 1330 1337
20. European Heart Rhythm Association; European Association for Cardio-Thoracic Surgery A.J. Camm, P. Kirchhof, G.Y. Lip, U. Schotten Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC) Europace 12 2010 1360 1420
21. S.J. Connolly, M.D. Ezekowitz, S. Yusuf RE-LY Steering Committee and Investigators Dabigatran versus warfarin in patients with atrial fibrillation N Engl J Med 361 2009 1139 1151
22. M.R. Patel, K.W. Mahaffey, J. Garg ROCKET AF Investigators Rivaroxaban versus warfarin in nonvalvular atrial fibrillation N Engl J Med 365 2011 883 891
23. S.J. Connolly, J. Eikelboom, C. Joyner AVERROES Steering Committee and Investigators Apixaban in patients with atrial fibrillation N Engl J Med 364 2011 806 817