Protective value of prophylactic antibiotic treatment of tick bite for Lyme disease prevention: An animal model

Ticks and Tick-borne Diseases

Volumn 3, Issue 3, 2012, Pages 193-196

  Piesman, Joseph ^a   Hojgaard, Andrias ^a  

^a NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

Author keywords

Antibiotic; Borrelia; Ixodes scapularis; Lyme disease; Prophylaxis; Ticks

Indexed keywords

ANTIBIOTIC AGENT; DOXYCYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC PROPHYLAXIS; ARTICLE; BACTERIAL TRANSMISSION; BORRELIA BURGDORFERI; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; IXODES SCAPULARIS; LYME DISEASE; MOUSE; NONHUMAN; NYMPH; PRIORITY JOURNAL; SINGLE DRUG DOSE; THERAPY DELAY; TICK BITE;

ADMINISTRATION, ORAL; ANIMALS; ANTI-BACTERIAL AGENTS; BORRELIA BURGDORFERI GROUP; DISEASE MODELS, ANIMAL; DOXYCYCLINE; HUMANS; IXODES; LYME DISEASE; MICE; NYMPH; SPECIFIC PATHOGEN-FREE ORGANISMS; TICK BITES; TIME FACTORS;

ANIMALIA; BORRELIA; BORRELIA BURGDORFERI; FALCO; IXODES SCAPULARIS; IXODIDA; MUS;

EID: 84864754547     PISSN: 1877959X     EISSN: 18779603     Source Type: Journal    
DOI: 10.1016/j.ttbdis.2012.01.001     Document Type: Article

References (35)

1. Beran J., De Clercq N., Dieussaert I., Van Hoecke C. Reactogenicity and immunogenicity of a Lyme disease vaccine in children 2-5 years old. Clin. Infect. Dis. 2000, 31:1504-1507.
2. Bharadwaj A., Stafford K.C. Evaluation of Metarhizium anisopiae strain F52 (Hypocreales: Clavicipitacea) for control of Ixodes scapularis (Acari: Ixodidae). J. Med. Entomol. 2010, 47:862-867.
3. Bhattscharya D., Bensaci M., Luker K.E., Wisdom S., Telford S.R., Hu L.T. Development of a baited oral vaccine for use in reservoir-targeted strategies against Lyme disease. Vaccine 2011, 29:7818-7825.
4. Daniels T.J., Fish D. Effect of deer exclusion on the abundance of immature Ixodes scapularis (Acari: Ixodidae) parasitizing small and medium-sized mammals. J. Med. Entomol. 1995, 32:5-11.
5. Dolan M.C., Schulze T.L., Jordan R.A., Dietrich G., Schulze C.J., Hojgaard A., Ullmann A.J., Sackal C., Zeidner N.S., Piesman J. Elimination of Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and Ixodes scapularis ticks using a doxycycline hyclate-laden bait. Am. J. Trop. Med. Hyg. 2011, 85:1114-1120.
6. Dolan M.C., Zeidner N.S., Gabitzsch E., Dietrich G., Borchert J.N., Poché R.M., Piesman J. A doxycycline hyclate rodent bait formulation for prophylaxis and treatment of tick-transmitted Borrelia burgdorferi. Am. J. Trop. Med. Hyg. 2008, 78:803-805.
7. Houck J.A., Hojgaard A., Piesman J., Kuchta R.D. Low-density microarrays for the detection of Borrelia burgdorferi s.s. (the Lyme disease spirochete) in nymphal Ixodes scapularis. Ticks Tick-Borne Dis. 2010, 2:27-36.
8. Jordan R.A., Dolan M.C., Piesman J., Schulze T.L. Suppression of host-seeking Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) nymphs after dual applications of plant-derived acaricides in New Jersey. J. Econ. Entomol. 2011, 104:659-664.
9. Knauer J., Krupka I., Fueldner C., Lehmann J., Straubinger R.K. Evaluation of the preventive capacities of a topically applied azithromycin formulation against Lyme borreliosis in a murine model. J. Antimicrob. Chemother. 2011, 66:2814-2822.
10. Lathrop S.L., Ball R., Haber P., Mootrey G.T., Braun M.M., Shadomy S.V., Ellenberg S.S., Chen R.T., Hayes E.B. Adverse event reports following vaccination for Lyme disease: December 1998-July 2000. Vaccine 2002, 20:1603-1608.
11. Lee J., Wormser G.P. Pharmacodynamics of doxycycline for chemoprophylaxis of Lyme disease: preliminary findings and possible implications for other antimicrobials. Int. J. Antimicrob. Agents 2008, 31:235-239.
12. Lima C.M.R., Zeidner N.S., Beard C.B., Soares C.A.G., Dolan M.C., Dietrich G., Piesman J. Differential infectivity of the Lyme disease spirochete Borrelia burgdorferi derived from Ixodes scapularis salivary glands and midgut. J. Med. Entomol. 2005, 42:506-510.
13. Magid D., Schwartz B., Craft J., Schwartz J.S. Prevention of Lyme disease after tick bites. A cost-effectiveness analysis. N. Engl. J. Med. 1992, 327:534-541.
14. Meirelles Richer L., Aroso M., Contente-Cuomo T., Ivanova L., Gomes-Solecki M. Reservoir targeted vaccine for Lyme borreliosis induces a year long, neutralizing antibody response to OspA in white-footed mice. Clin. Vaccine Immunol. 2011, 18:1809-1816.
15. Nadelman R.B., Nowakowski J., Fish D., Falco R.C., Freeman K., McKenna D., Welch P., Marcus R., Agúero-Rosenfeld M.E., Dennis D.T., Wormser G.P. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. N. Engl. J. Med. 2001, 345:79-84.
16. Patrican L.A., Allan S.A. Application of desiccant and insecticidal soap treatments to control Ixodes scapularis (Acari: Ixodidae) nymphs and adults in a hyperendemic woodland site. J. Med. Entomol. 1995, 32:859-863.
17. Piesman J. Standard system for infecting ticks (Acari: Ixodidae) with the Lyme disease spirochete Borrelia burgdorferi. J. Med. Entomol. 1993, 30:199-203.
18. Piesman J., Eisen L. Prevention of tick-borne diseases. Annu. Rev. Entomol. 2008, 53:323-343.
19. Poland G.A. Vaccines against Lyme disease: what happened and what lessons can we learn?. Clin. Infect. Dis. 2011, 52:s253-s258.
20. Rand P.W., Lubelczyk C., Holman M.S., Lacombe E.H., Smith R.P. Abundance of Ixodes scapularis (Acari: Ixodidae) after the complete removal of deer from an isolated offshore island, endemic for Lyme disease. J. Med. Entomol. 2004, 41:779-784.
21. Schulze T.L., Jordan R.A., Hung R.W. Suppression of subadult Ixodes scapularis (Acari: Ixodidae) following removal of leaf litter. J. Med. Entomol. 1995, 32:730-733.
22. Shih C.M., Pollack R.J., Telford S.R., Spielman A. Delayed dissemination of Lyme disease spirochetes from the site of deposition in the skin of mice. J. Infect. Dis. 1992, 166:827-831.
23. Shih C.M., Spielman A. Topical prophylaxis for Lyme disease after tick bite in a rodent model. J. Infect. Dis. 1993, 168:1042-1045.
24. Sigal L.H., Zahradnik J.M., Lavin P., Patella S.J., Bryant G., Haselby R., Hilton E., Kunkel M., Adler-Klein D., Doherty T., Evans J., Molloy P.J., Seidner A.L., Sabetta J.R., Simon H.J., Klempner M.S., Mays J., Marks D., Malawista S.E. A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. Recombinant outer-surface-protein A Lyme disease vaccine study consortium. N. Engl. J. Med. 1998, 339:216-222.
25. Sinsky R.J., Piesman J. Ear punch biopsy method for detection and isolation of Borrelia burgdorferi from rodents. J. Clin. Microbiol. 1989, 27:1723-1727.
26. Steere A.C., Malawista S.E., Snydman D.R., Shope R.E., Andiman W.A., Ross M.R., Steele F.M. Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three Connecticut communities. Arthritis Rheum. 1977, 20:7-17.
27. Steere A.C., Sikand V.K., Meurice F., Parenti D., Fikrig E., Schoen R.T., Nowakowski J., Schmid C.H., Laukamp S., Buscarino C., Krause D.S. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer surface lipoprotein A with adjuvant. Lyme disease vaccine study group. N. Engl. J. Med. 1998, 339:209-215.
28. Tsao J.I., Wootton J.T., Bunikis J., Luna M.G., Fish D., Barbour A.G. An ecological approach to preventing human infection: vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:18159-18164.
29. Warshafsky S., Lee D.H., Francois L.K., Nowakowski J., Nadelman R.B., Wormser G.P. Efficacy of antibiotic prophylaxis for the prevention of Lyme disease: an update systemic review and meta-analysis. J. Antimicrob. Chemother. 2010, 65:1137-1144.
30. Wilson M.L. Reduced abundance of adult Ixodes dammini (Acari: Ixodidae) following destruction of vegetation. J. Econ. Entomol. 1986, 3:693-696.
31. Wormser G.P., Daniels T.J., Bittker S., Cooper D., Wang G., Pavia C.S. Failure of topical antibiotics to prevent disseminated Borrelia burgdorferi infection following a tick bite in C3H/HeJ mice. J. Infect. Dis. 2012, 205:991-994.
32. Wormser G.P., Dattwyler R.J., Shapiro E.D., Halperin J.J., Steere A.C., Klempner M.S., Krause P.J., Bakken J.S., Strle F., Stanek G., Bockenstedt L., Fish D., Dumler J.S., Nadelman R.B. The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin. Infect. Dis. 2006, 43:1089-1134.
33. Zeidner N.S., Brandt K.S., Dadey E., Dolan M.C., Happ C., Piesman J. Sustained-release of doxycycline hyclate for prophylaxis of tick bite infection in a murine model of Lyme borreliosis. Antimicrob. Agents Chemother. 2004, 48:2697-2699.
34. Zeidner N.S., Schneider B.S., Dolan M.C., Piesman J. An analysis of spirochete load, strain, and pathology in a model of tick-transmitted Lyme borreliosis. Vector Borne Zoonotic Dis. 2001, 1:35-44.
35. 2 activity. Exp. Parasitol. 2008, 121:370-375.