Heightened DNA damage response impairs hematopoiesis in fanconi anemia

Haematologica

Volumn 97, Issue 8, 2012, Pages 1117-

  Dokal, Inderjeet ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BUTADIENE DIEPOXIDE; FANCONI ANEMIA GROUP D2 PROTEIN; MITOMYCIN C; PROTEIN P21; PROTEIN P53;

ARTICLE; BONE MARROW DEPRESSION; CANCER SUSCEPTIBILITY; CELL CYCLE ARREST; CHROMOSOME BREAKAGE; DISORDERS OF DNA SYNTHESIS AND REPAIR; DNA DAMAGE; FANCONI ANEMIA; GENOMIC INSTABILITY; HEMATOPOIESIS; HUMAN; NONHUMAN;

ANIMALS; BONE MARROW; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; FANCONI ANEMIA; HEMATOPOIETIC STEM CELLS; HUMANS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84864752056     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2012.073643     Document Type: Article

References (6)

1. Fanconi G. Familiare infantile pernziosaartige anaemie (pernizioses Blutbild und Konstitution). Jahrb Kinderheilkd. 1927;117: 257-80.
2. Auerbach AD, Buchwald M, Joenje H. Fanconi anemia. In: The Metabolic and Molecular Basis of Inherited Disease (Eds CR Scriver et al) 2001, pp 753-768. McGraw-Hill, New York.
3. Bagby GC, Alter BP. Fanconi anemia. Semin Hematol. 2006;43(3):147-56.
4. Sasaki MS, Tonomra A. A high susceptibility of Fanconi anemia to chromosomal breakage by DNA cross-linking agents. Cancer Res. 1973;33(8):1829-36.
5. Crossan GP, Patel KJ. The Fanconi anemia pathway orchestrates incisions at sites of crosslinked DNA. J Pathol. 2012;226(2):326-37.
6. Ceccaldi R, Parmar K, Mouly E, Delord M, Kim JM, Regairaz M, et al. Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. Cell Stem Cell. 2012;11(1):36-49.