Vitamin D supplementation as an adjuvant therapy for patients with T2DM: An 18-month prospective interventional study

Cardiovascular Diabetology

Volumn 11, Issue , 2012, Pages

  Al Daghri, Nasser M ^a,b   Alkharfy, Khalid M ^a,b,c   Al Othman, Abdulaziz ^d   El Kholie, Emad ^a   Moharram, Osama ^e   Alokail, Majed S ^a,b   Al Saleh, Yousef ^b   Sabico, Shaun ^a,b   Kumar, Sudhesh ^f   Chrousos, George P ^a,g  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

^e KING ABDUL AZIZ UNIVERSITY HOSPITAL   (Saudi Arabia)

^f Clinical Sciences Research Institute   (United Kingdom)

^g UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Diabetes mellitus; Saudi; Supplementation; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; CHOLESTEROL; COLECALCIFEROL; UNCLASSIFIED DRUG; VIGANTOLETTEN;

ADULT; AGED; ANTHROPOMETRY; ARTICLE; CALCIUM BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INTERVENTION STUDY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PROSPECTIVE STUDY; VITAMIN SUPPLEMENTATION;

ADULT; AGED; CALCIUM; CHOLECALCIFEROL; CHOLESTEROL, LDL; DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENTS; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SEX CHARACTERISTICS; SEX FACTORS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84864751461     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/1475-2840-11-85     Document Type: Article

References (36)

1. Forouhi NG, Luan J, Cooper A, Boucher BJ, Wareham NJ. Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the medical research council Ely prospective study 1990-2000. Diabetes 2008, 57:2619-2625. 10.2337/db08-0593, 2551670, 18591391.
2. Forouhi NG, Ye Z, Rickard AP, Khaw KT, Luben R, Langenberg C, Wareham NJ. Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies. Diabetologia 2012, 55:2173-2182. 10.1007/s00125-012-2544-y, 22526608.
3. Akin F, Ayça B, Köse N, Duran M, Sar M, Uysal OK, Karakukcu C, Arinc H, Covic A, Goldsmith D, Okçün B, Kanbay M. Serum vitamin D levels are independently associated with severity of coronary artery disease. J Investig Med 2012, [Epub ahead of print].
4. Mathieu C, Badenhoop K. Vitamin D and type 1 diabetes mellitus: state of the art. Trends Endocrinol Metab 2005, 16:261-266. 10.1016/j.tem.2005.06.004, 15996876.
5. Mattila C, Knekt P, Männistö S, Rissanen H, Laaksonen MA, Montonen J, Reunanen A. Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes. Diabetes Care 2007, 30:2569-2570. 10.2337/dc07-0292, 17626891.
6. Di Cesar DJ, Ploutz-Snyder R, Weinstock RS, Moses AM. Vitamin D deficiency is more common in type 2 than in type 1 diabetes. Diabetes Care 2006, 29:174.
7. Grimnes G, Emaus N, Joakimsen RM, Figenschau Y, Jenssen T, Niolstad I, Schirmer H, Jorde R. Baseline serum 25-hydroxyvitamin D concentrations in the Tromso Study 1994-1995 and risk of developing type 2 diabetes mellitus during 11 years of follow-up. Diabet Med 2011, 27:1107-1115.
8. Deleskog A, Hilding A, Brismark K, Hamsten A, Efendic S, Ostenson CG. Low serum 25-hydroxyvitamin D levels predict progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance. Diabetologia 2012, 55:1668-1678. 10.1007/s00125-012-2529-x, 22426800.
9. Harris SS. Does vitamin D deficiency contribute to increased rates of cardiovascular disease and type 2 diabetes in African Americans. Am J Clin Nutr 2011, 93:1175S-1178S. 10.3945/ajcn.110.003491, 21367947.
10. Boucher BJ. Hypovitaminosis D and risk of type 2 diabetes in British South Asians. Diabet Med 2006, 23:336.
11. Nsiah-Kumi PA, Erickson JM, Beals JL, Ogle EA, Whiting M, Brushbreaker C, Borgeson CD, Qiu F, Yu F, Larsen JL. Vitamin D insufficiency is associated with diabetes risk in Native American children. Clin Pediatr (Phila) 2012, 51:146-153.
12. Maalouf G, Gannage-Yared MH, Ezzedine J, Larijani B, Badawi S, Rached A, Zakroui L, Masri B, Azar E, Saba E, Nammari R, Adib G, Abou Samra H, Alrawi Z, Salman S, El Muntasser K, Tarseen R, El Kharousi W, Al-Lamki M, Alothman AN, Almarzook N, El Dessouki M, Sulaimani R, Saleh J, Suhaili AR, Khan A, Delmas P, Seeman E. Middle East and North Africa consensus on osteoporosis. Journal of Muskuloskeletal and Neuronal Interaction 2007, 7:131-143.
13. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, El-Kholie E, Yousef M, Al-Othman A, Al-Saleh Y, Sabico S, Kumar S, Chrousos GP. Increased vitamin D supplementation recommended during summer season in the gulf region: a counterintuitive seasonal effect in vitamin D levels in adult, overweight and obese Middle Eastern residents. Clin Endocrinol (Oxf) 2012, 76:346-350.
14. Rouzi AA, Al-Sibiani SA, Al-Senani NS, Radaddi RM, Ardawi MS. Independent predictors of osteoporosis-related fractures among healthy Saudi postmenopausal women: the CEOR study. Bone 2012, 50:713-722. 10.1016/j.bone.2011.11.024, 22178778.
15. Ardawi MS, Sibiany MM, Bakhsh TM, Qari MH, Maimani AA. High prevalence of vitamin D deficiency among healthy Saudi Arabian men: relationship to bone mineral density, parathyroid hormone, bone turnover markers, and lifestyle factors. Osteoporos Int 2012, 23:675-686. 10.1007/s00198-011-1606-1, 21625888.
16. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Yousef M, Nadhrah HM, Al-Othman A, Al-Saleh Y, Sabico S, Chrousos GP. Hypovitaminosis D and cardiometabolic risk factors among non-obese youth. Cent Eur J Med 2010, 5:752-757.
17. Al-Daghri NM, Al-Attas OS, Al-Okail MS, Alkharfy KM, Al-Yousef MA, Nadhrah MH, Sabico SB, Chrousos GP. Severe hypovitaminosis D is widespread and more common in non-diabetics than diabetics in Saudi adults. Saudi Med J 2010, 31:775-780.
18. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Yousef M, Sabico SL, Chrousos GP. Diabetes mellitus type 2 and other chronic non-cmmunicable diseases in the central region, Saudi Arabia (Riyadh cohort 2): a decade of an epidemic. BMC Medicine 2011, 9:76. 10.1186/1741-7015-9-76, 3141541, 21689399.
19. Al-Daghri NM, Alkharfy KM, Al-Saleh Y, Al-Attas OS, Alokail MS, Al-Othman A, Moharram O, El-Kholie E, Sabico S, Kumar S, Chrousos GP. Modest reversal of metabolic syndrome manifestations with vitamin D status correction: a 12-month prospective study. Metabolism 2012, 61:661-666. 10.1016/j.metabol.2011.09.017, 22075268.
20. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modelling. Diabetes Care 2004, 27:1487-1495. 10.2337/diacare.27.6.1487, 15161807.
21. Eftekhari MH, Akbarzadeh M, Dabbaghmanesh MH, Hasanzadeh J. Impact of treatment with oral calcitriol on glucose indices in type 2 diabetes mellitus patients. Asia Pac J Clin Nutr 2011, 20:521-526.
22. Grimnes G, Figenschau Y, Almas B, Jorde R. Vitamin D, insulin secretion, sensitivity, and lipids: results from a case-control study and a randomized controlled trial using hyperglycaemic clamp technique. Diabetes 2011, 60:2748-2757. 10.2337/db11-0650, 21911741.
23. Tai K, Need AG, Horowitz M, Chapman IM. Glucose tolerance and vitamin D: effects of treating vitamin D deficiency. Nutrition 2008, 24:950-956. 10.1016/j.nut.2008.04.009, 18653316.
24. Kaviani M, Abdollahian M, Almasi V, Amini M, Yamini AA. Effects of vitamin D on insulin resistance in nursing home residents: an interventional study. Endokrynol Pol 2012, 63:191-195.
25. Mozaffari-Khosravi H, Hosseinzadeh-Shamsi-Anar M, Salami MA, Hadinedoushan H, Mozayan MR. Effects of a single post-partum injection of a high dose of vitamin D on glucose tolerance and insulin resistance in mothers with first-time gestational diabetes mellitus. Diabet Med 2012, 29:36-42.
26. Kazlauskaite R, Powell LH, Mandapakala C, Cursio JF, Avery EF, Calvin J. Vitamin D is associated with atheroprotective high density lipoprotein profile in postmenopausal women. J Clin Lipidol 2010, 4:113-119. 10.1016/j.jacl.2010.01.006, 3390416, 21122638.
27. Yavuz B, Ertugrul DT, Cil H, Ata N, Akin KO, Yalcin AA, Kucukazman M, Dal K, Hokkaomeroglu MS, Yavuz BB, Tutal E. Increased levels of 25-hydroxyvitamin D and1,25-dihydroxyvitamin D after rosuvastatin treatment: a novel pleiotropic effect of statins?. Cardiovasc Drugs Ther 2009, 23:295-299. 10.1007/s10557-009-6181-8, 19543962.
28. Vacek JL, Vanga SR, Good M, Lai SM, Lakkireddy D, Howard PA. Vitamin D deficiency nd supplementation and relation to cardiovascular health. Am J Cardiol 2012, 109:359-363. 10.1016/j.amjcard.2011.09.020, 22071212.
29. Salum E, Kampus P, Zilmer M, Eha J, Butlin M, Avolio AP, Põdramägi T, Arend A, Marina Aunapuu M, Kals J. Effect of vitamin D on aortic remodeling in streptozotocin-induced diabetes. Cardiovasc Diabetol 2012, 11:58. 10.1186/1475-2840-11-58, 3398857, 22631050.
30. Gagnon C, Lu ZX, Magliano DJ, Dunstan DW, Shaw JE, Zimmet PZ, Sikaris K, Ebeling PR, Daly RM. Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian diabetes, obesity and lifestyle study. AusDiab. J Clin Endocrinol Metab 2012, [Epub ahead of print].
31. Satin LS. Localized calcium influx in pancreatic beta-cells: its significance for Ca2+-dependent insulin secretion from the islets of Langerhans. Endocrine 2000, 13:251-262. 10.1385/ENDO:13:3:251, 11216635.
32. Mears D. Regulation of insulin secretion in islets of Langerhans by Ca(2+) channels. J Membr Biol 2004, 200:57-66. 10.1007/s00232-004-0692-9, 15520904.
33. J Jing X, Li DQ, Olofsson CS, Salehi A, Surve VV, Caballero J, Ivarsson R, Lundquist I, Pereverzev A, Schneider T, Rorsman P, Renstrom E. CaV2.3 calcium channels control second-phase insulin release. J Clin Invest 2005, 115:146-154. 539196, 15630454.
34. Bickle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab 1986, 63:954-959. 10.1210/jcem-63-4-954, 3745408.
35. Håglin L, Bäckman L, Törnkvist B. A structural equation model for assessment of links between changes in serum triglycerides, -urate, and-glucose and changes in serum calcium, -magnesium and -phosphate in type 2 diabetes and non-diabetes metabolism. Cardiovasc Diabetol 2011, 10:116. 10.1186/1475-2840-10-116, 3265426, 22192330.
36. Ogata T, Miyauchi T, Sakai S, Irukiyama-Tomobe Y, Goto K, Yamaguchi I. Stimulation of peroxisome-proliferator-activated receptor alpha (PPAR alpha) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts. Clin Sci (Lond) 2002, 103:284S-288S.