Targeted folate receptor β fluorescence imaging as a measure of inflammation to estimate vulnerability within human atherosclerotic carotid plaque

Journal of Nuclear Medicine

Volumn 53, Issue 8, 2012, Pages 1222-1229

  Jager, Nynke A ^a   Westra, Johanna ^a   Van Dam, Gooitzen M ^a   Teteloshvili, Nato ^a   Tio, René A ^a   Breek, Jan Cees ^b   Slart, Riemer H J A ^a   Boersma, Hendrikus ^a   Low, Phillip S ^c   Bijl, Marc ^a   Zeebregts, Clark J ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b MARTINI HOSPITAL   (Netherlands)

^c PURDUE UNIVERSITY   (United States)

Author keywords

Atherosclerotic plaque; Carotid artery; Fluorescence imaging; Folate receptor ; Vulnerability

Indexed keywords

CD68 ANTIGEN; FLUORESCEIN ISOTHIOCYANATE; FOLATE RECEPTOR 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA;

AGED; ARTICLE; CAROTID ATHEROSCLEROSIS; CLINICAL ARTICLE; FEMALE; FLUORESCENCE IMAGING; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYPOXIA; IMAGE ANALYSIS; IMAGE DISPLAY; INFLAMMATION; MACROPHAGE; MALE; PRIORITY JOURNAL; RISK ASSESSMENT;

AGED; BIOLOGICAL TRANSPORT; CAROTID ARTERY DISEASES; CELL HYPOXIA; FEMALE; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; FOLATE RECEPTOR 2; FOLIC ACID; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION; MACROPHAGES; MALE; MOLECULAR IMAGING; PILOT PROJECTS; PLAQUE, ATHEROSCLEROTIC; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; SPECTROMETRY, FLUORESCENCE;

EID: 84864751124     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.111.099671     Document Type: Article

References (27)

1. Lindholm LH, Mendis S. Prevention of cardiovascular disease in developing countries. Lancet. 2007;370:720-722. (Pubitemid 47320784)
2. Antohe F. Endothelial cells and macrophages, partners in atherosclerotic plaque progression. Arch Physiol Biochem. 2006;112:245-253. (Pubitemid 46018366)
3. Ringleb PA, Chatellier G, Hacke W, et al. Safety of endovascular treatment of carotid artery stenosis compared with surgical treatment: a meta-analysis. J Vasc Surg. 2008;47:350-355. (Pubitemid 351172672)
4. Zeebregts CJ, Meerwaldt R, Geelkerken RH. Carotid artery stenting: a 2009 update. Curr Opin Cardiol. 2009;24:528-531.
5. Wallis de Vries BM, van Dam GM, Tio RA, Hillebrands JL, Slart RH, Zeebregts CJ. Current imaging modalities to visualize vulnerability within the atherosclerotic carotid plaque. J Vasc Surg. 2008;48:1620-1629.
6. Nighoghossian N, Derex L, Douek P. The vulnerable carotid artery plaque: current imaging methods and new perspectives. Stroke. 2005;36:2764-2772.
7. Fuster V, Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology. Circulation. 1994;90:2126-2146. (Pubitemid 24979909)
8. Tiwari RL, Singh V, Barthwal MK. Macrophages: an elusive yet emerging therapeutic target of atherosclerosis. Med Res Rev. 2008;28:483-544. (Pubitemid 351842141)
9. Choudhury RP, Lee JM, Greaves DR. Mechanisms of disease: macrophagederived foam cells emerging as therapeutic targets in atherosclerosis. Nat Clin Pract Cardiovasc Med. 2005;2:309-315. (Pubitemid 40852635)
10. Xia W, Hilgenbrink AR, Matteson EL, Lockwood MB, Cheng JX, Low PS. A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages. Blood. 2009;113:438-446.
11. Ayala-López W, Xia W, Varghese B, Low PS. Imaging of atherosclerosis in apoliprotein e knockout mice: targeting of a folate-conjugated radiopharmaceutical to activated macrophages. J Nucl Med. 2010;51:768-774.
12. Paulos CM, Turk MJ, Breur GJ, Low PS. Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Adv Drug Deliv Rev. 2004;56:1205-1217. (Pubitemid 38496516)
13. van Dam GM, Themelis G, Crane LM, et al. Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-alpha targeting: first inhuman results. Nat Med. 2011;17:1315-1319.
14. Luque A, Turu M, Juan-Babot O, et al. Overexpression of hypoxia/inflammatory markers in atherosclerotic carotid plaques. Front Biosci. 2008;13:6483-6490.
15. Vink A, Schoneveld AH, Lamers D, et al. HIF-1 alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophages. Atherosclerosis. 2007;195:e69-e75. (Pubitemid 350087978)
16. Westra J, Molema G, Kallenberg CG. Hypoxia-inducible factor-1 as regulator of angiogenesis in rheumatoid arthritis: therapeutic implications. Curr Med Chem. 2010;17:254-263.
17. Brevetti G, Silvestro A, Schiano V, Chiariello M. Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease: additive value of flow-mediated dilation to ankle-brachial pressure index. Circulation. 2003;108:2093-2098. (Pubitemid 37337585)
18. Wallis de Vries BM, Hillebrands JL, van Dam GM, et al. Images in cardiovascular medicine: multispectral near-infrared fluorescence molecular imaging of matrix metalloproteinases in a human carotid plaque using a matrix-degrading metalloproteinase-sensitive activatable fluorescent probe. Circulation. 2009;119:e534-e536.
19. Kinne RW, Brauer R, Stuhlmuller B, Palombo-Kinne E, Burmester GR. Macrophages in rheumatoid arthritis. Arthritis Res. 2000;2:189-202. (Pubitemid 32223726)
20. Brouwer E, Gouw AS, Posthumus MD, et al. Hypoxia inducible factor-1-alpha (HIF-1alpha) is related to both angiogenesis and inflammation in rheumatoid arthritis. Clin Exp Rheumatol. 2009;27:945-951.
21. Sluimer JC, Gasc JM, van Wanroij JL, et al. Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis. J Am Coll Cardiol. 2008;51:1258-1265. (Pubitemid 351400903)
22. Müller C, Forrer F, Schibli R, Krenning EP, de Jong M. SPECT study of folate receptor-positive malignant and normal tissues in mice using a novel 99mTc-radiofolate. J Nucl Med. 2008;49:310-317. (Pubitemid 351225671)
23. Newby AC, George SJ, Ismail Y, Johnson JL, Sala-Newby GB, Thomas AC. Vulnerable atherosclerotic plaque metalloproteinases and foam cell phenotypes. Thromb Haemost. 2009;101:1006-1011.
24. Alvarez B, Ruiz C, Chacon P, Alvarez-Sabin J, Matas M. Serum values of metalloproteinase- 2 and metalloproteinase-9 as related to unstable plaque and inflammatory cells in patients with greater than 70% carotid artery stenosis. J Vasc Surg. 2004;40:469-475. (Pubitemid 39165021)
25. Post S, Peeters W, Busser E, et al. Balance between angiopoietin-1 and angiopoietin- 2 is in favor of angiopoietin-2 in atherosclerotic plaques with high microvessel density. J Vasc Res. 2008;45:244-250. (Pubitemid 351543148)
26. Razansky D, Harlaar NJ, Hillebrands JL, et al. Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques. Mol Imaging Biol. 2012;14:277-285.
27. Ntziachristos V, Razansky D. Molecular imaging by means of multispectral optoacoustic tomography (MSOT). Chem Rev. 2010;110:2783-2794.