Human resistin in cardiovascular disease

Journal of Smooth Muscle Research

Volumn 48, Issue 1, 2012, Pages 27-35

  Lee, Sang Eun ^a,b,c   Kim, Hyo Soo ^a,b,c,d  

^a National Research Laboratory for Cardiovascular Stem Cell Niche   (South Korea)

^b Innovative Research Institute for Cell Therapy   (South Korea)

^c Seoul National University Hospital   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Adipokine; Atherosclerosis; Cardiovascular disease; Heart failure; Inflammation; Resistin

Indexed keywords

BIOLOGICAL MARKER; RESISTIN;

ARTICLE; CARDIOVASCULAR DISEASE; HUMAN; METABOLISM; PHYSIOLOGY;

BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; HUMANS; RESISTIN;

EID: 84864739259     PISSN: 09168737     EISSN: 18848796     Source Type: Journal    
DOI: 10.1540/jsmr.48.27     Document Type: Article

References (62)

1. Arner, P. (2005). Resistin: yet another adipokine tells us that men are not mice. Diabetologia 48: 2203-2205.
2. Bokarewa, M., Nagaev, I., Dahlberg, L., Smith, U. and Tarkowski, A. (2005). Resistin, an adipokine with potent proinflammatory properties. J. Immunol. 174: 5789-5795.
3. Butler, J., Kalogeropoulos, A., Georgiopoulou, V., de Rekeneire, N., Rodondi, N., Smith, A.L., Hoffmann, U., Kanaya, A., Newman, A.B., Kritchevsky, S.B., Vasan, R.S., Wilson, P.W., Harris, T.B.; Health ABC Study. (2009). Serum resistin concentrations and risk of new onset heart failure in older persons: the health, aging, and body composition (Health ABC) study. Arterioscler. Thromb. Vasc. Biol. 29: 1144-1149.
4. Calabro, P., Samudio, I., Willerson, J.T. and Yeh, E.T. (2004). Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways. Circulation 110: 3335-3340.
5. Chen, B.H., Song, Y., Ding, E.L., Roberts, C.K., Manson, J.E., Rifai, N., Buring, J.E., Gaziano, J.M. and Liu, S. (2009). Circulating levels of resistin and risk of type 2 diabetes in men and women: results from two prospective cohorts. Diabetes Care 32: 329-334.
6. Cho, Y., Lee, S.E., Lee, H.C., Hur, J., Lee, S., Youn, S.W., Lee, J., Lee, H.J., Lee, T.K., Park, J., Hwang, S.J., Kwon, Y.W., Cho, H.J., Oh, B.H., Park, Y.B. and Kim, H.S. (2011). Adipokine resistin is a key player to modulate monocytes, endothelial cells, and smooth muscle cells, leading to progression of atherosclerosis in rabbit carotid artery. J. Am. Coll. Cardiol. 57: 99-109.
7. Chu, S., Ding, W., Li, K., Pang, Y. and Tang, C. (2008). Plasma resistin associated with myocardium injury in patients with acute coronary syndrome. Circ. J. 72: 1249-1253.
8. Cook, K.S., Min, H.Y., Johnson, D., Chaplinsky, R.J., Flier, J.S., Hunt, C.R. and Spiegelman, B.M. (1987). Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve. Science 237: 402-405.
9. Efstathiou, S.P., Tsiakou, A.G., Tsioulos, D.I., Panagiotou, T.N., Pefanis, A.V., Achimastos, A.D. and Mountokalakis, T.D. (2007). Prognostic significance of plasma resistin levels in patients with atherothrombotic ischemic stroke. Clin. Chim. Acta. 378: 78-85.
10. Fain, J.N., Cheema, P.S., Bahouth, S.W. and Lloyd Hiler, M. (2003). Resistin release by human adipose tissue explants in primary culture. Biochem. Biophys. Res. Commun. 300: 674-678.
11. Frankel, D.S., Vasan, R.S., D'Agostino, R.B.Sr., Benjamin, E.J., Levy, D., Wang, T.J. and Meigs, J.B. (2009). Resistin, adiponectin, and risk of heart failure the Framingham offspring study. J. Am. Coll. Cardiol. 53: 754-762.
12. Ghosh, S., Singh, A.K., Aruna, B., Mukhopadhyay, S. and Ehtesham, N.Z. (2003). The genomic organization of mouse resistin reveals major differences from the human resistin: functional implications. Gene 305: 27-34.
13. Graveleau, C., Zaha, V.G., Mohajer, A., Banerjee, R.R., Dudley-Rucker, N., Steppan, C.M., Rajala, M.W., Scherer, P.E., Ahima, R.S., Lazar, M.A. and Abel, E.D. (2005). Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action. J. Biol. Chem. 280: 31679-31685.
14. Heidemann, C., Sun, Q., van Dam, R.M., Meigs, J.B., Zhang, C., Tworoger, S.S., Mantzoros, C.S. and Hu, F.B. (2008). Total and high-molecular-weight adiponectin and resistin in relation to the risk for type 2 diabetes in women. Ann. Intern. Med. 149: 307-316.
15. Hoefle, G., Saely, C.H., Risch, L., Koch, L., Schmid, F., Rein, P., Aczel, S., Langer, P. and Drexel, H. (2007). Relationship between the adipose-tissue hormone resistin and coronary artery disease. Clin. Chim. Acta 386: 1-6.
16. Hotamisligil, G.S., Shargill, N.S. and Spiegelman, B.M. (1993). Adipose expression of tumor necrosis factoralpha: direct role in obesity-linked insulin resistance. Science 259: 87-91.
17. Hsu, W.Y., Chao, Y.W., Tsai, Y.L., Lien, C.C., Chang, C.F., Deng, M.C., Ho, L.T., Kwok, C.F. and Juan, C.C. (2011). Resistin induces monocyte-endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38MAPK-dependent pathway. J. Cell Physiol. 226: 2181-2188.
18. Hu, E., Liang, P. and Spiegelman, B.M. (1996). AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 271: 10697-10703.
19. Hung, H.F., Wang, B.W., Chang, H. and Shyu, K.G. (2008). The molecular regulation of resistin expression in cultured vascular smooth muscle cells under hypoxia. J. Hypertens. 26: 2349-2360.
20. Jiang, C., Zhang, H., Zhang, W., Kong, W., Zhu, Y., Xu, Q., Xu, Q., Li, Y. and Wang, X. (2009). Homocysteine promotes vascular smooth muscle cell migration by induction of the adipokine resistin. Am. J. Physiol. 297: C1466-C1476.
21. Jung, H.S., Park, K.H., Cho, Y.M., Chung, S.S., Cho, H.J., Cho, S.Y., Kim, S.J., Kim, S.Y., Lee, H.K. and Park, K.S. (2006). Resistin is secreted from macrophages in atheromas and promotes atherosclerosis. Cardiovasc. Res. 69: 76-85.
22. Kahn, B.B. and Flier, J.S. (2000). Obesity and insulin resistance. J. Clin. Invest. 106: 473-481.
23. Kaser, S., Kaser, A., Sandhofer, A., Ebenbichler, C.F., Tilg, H. and Patsch, J.R. (2003). Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. Biochem. Biophys. Res. Commun. 309: 286-290.
24. Kawanami, D., Maemura, K., Takeda, N., Harada, T., Nojiri, T., Imai, Y., Manabe, I., Utsunomiya, K. and Nagai, R. (2004). Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. Biochem. Biophys. Res. Commun. 314: 415-419.
25. Kim, K.H., Lee, K., Moon, Y.S. and Sul, H.S. (2001). A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J. Biol. Chem. 276: 11252-11256.
26. Kim, M., Oh, J.K., Sakata, S., Liang, I., Park, W., Hajjar, R.J. and Lebeche, D. (2008). Role of resistin in cardiac contractility and hypertrophy. J. Mol. Cell. Cardiol. 45: 270-280.
27. Krecki, R., Krzeminska-Pakula, M., Peruga, J.Z., Szczesniak, P., Lipiec, P., Wierzbowska-Drabik, K., Orszulak-Michalak, D. and Kasprzak, J.D. (2011). Elevated resistin opposed to adiponectin or angiogenin plasma levels as a strong, independent predictive factor for the occurrence of major adverse cardiac and cerebrovascular events in patients with stable multivessel coronary artery disease over 1-year follow-up. Med. Sci. Monit. 17: CR26-CR32.
28. Lazar, M.A. (2007). Resistin- and Obesity-associated metabolic diseases. Horm. Metab. Res. 39: 710-716.
29. Lee, T.S., Lin, C.Y., Tsai, J.Y., Wu, Y.L., Su, K.H., Lu, K.Y., Hsiao, S.H., Pan, C.C., Kou, Y.R., Hsu, Y.P. and Ho, L.T. (2009). Resistin increases lipid accumulation by affecting class A scavenger receptor, CD36 and ATP-binding cassette transporter-A1 in macrophages. Life Sci. 84: 97-104.
30. Lehrke, M., Reilly, M.P., Millington, S.C., Iqbal, N., Rader, D.J. and Lazar, M.A. (2004). An inflammatory cascade leading to hyperresistinemia in humans. PLoS. Med. 1: e45.
31. Lu, S.C., Shieh, W.Y., Chen, C.Y., Hsu, S.C. and Chen, H.L. (2002). Lipopolysaccharide increases resistin gene expression in vivo and in vitro. FEBS Lett. 530: 158-162.
32. Lubos, E., Messow, C.M., Schnabel, R., Rupprecht, H.J., Espinola-Klein, C., Bickel, C., Peetz, D., Post, F., Lackner, K.J., Tiret, L., Münzel, T. and Blankenberg, S. (2007). Resistin, acute coronary syndrome and prognosis results from the atherogene study. Atherosclerosis 193: 121-128.
33. Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y. and Matsubara, K. (1996). cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochem. Biophys. Res. Commun. 221: 286-289.
34. Momiyama, Y., Ohmori, R., Uto-Kondo, H., Tanaka, N., Kato, R., Taniguchi, H., Arakawa, K., Nakamura, H. and Ohsuzu, F. (2011). Serum resistin levels and cardiovascular events in patients undergoing percutaneous coronary intervention. J. Atheroscler. Thromb. 18: 108-114.
35. Ohmori, R., Momiyama, Y., Kato, R., Taniguchi, H., Ogura, M., Ayaori, M., Nakamura, H. and Ohsuzu, F. (2005). Associations between serum resistin levels and insulin resistance, inflammation, and coronary artery disease. J. Am. Coll. Cardiol. 46: 379-380.
36. On, Y.K., Park, H.K., Hyon, M.S. and Jeon, E.S. (2007). Serum resistin as a biological marker for coronary artery disease and restenosis in type 2 diabetic patients. Circ. J. 71: 868-873.
37. Ouchi, N., Parker, J.L., Lugus, J.J. and Walsh, K. (2011). Adipokines in inflammation and metabolic disease. Nat. Rev. Immunol. 11: 85-97.
38. Patel, L., Buckels, A.C., Kinghorn, I.J., Murdock, P.R., Holbrook, J.D., Plumpton, C., Macphee, C.H. and Smith, S.A. (2003). Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Biochem. Biophys. Res. Commun. 300: 472-476.
39. Patel, S.D., Rajala, M.W., Rossetti, L., Scherer, P.E. and Shapiro, L. (2004). Disulfide-dependent multimeric assembly of resistin family hormones. Science 304: 1154-1158.
40. Piestrzeniewicz, K., Luczak, K. and Goch, J.H. (2008). Value of blood adipose tissue hormones concentration- adiponectin, resistin and leptin in the prediction of major adverse cardiac events (MACE) in 1-year follow-up after primary percutaneous coronary intervention in ST-segment elevation acute myocardial infarction. Neuro. Endocrinol. Lett. 29: 581-588.
41. Pilz, S., Weihrauch, G., Seelhorst, U., Wellnitz, B., Winkelmann, B.R., Boehm, B.O. and März, W. (2007). Implications of resistin plasma levels in subjects undergoing coronary angiography. Clin. Endocrinol. (Oxf.) 66: 380-386.
42. Pischon, T., Bamberger, C.M., Kratzsch, J., Zyriax, B.C., Algenstaedt, P., Boeing, H. and Windler, E. (2005). Association of plasma resistin levels with coronary heart disease in women. Obes. Res. 13: 1764-1771.
43. Reilly, M.P., Lehrke, M., Wolfe, M.L., Rohatgi, A., Lazar, M.A. and Rader, D.J. (2005). Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 111: 932-939.
44. Sato, N., Kobayashi, K., Inoguchi, T., Sonoda, N., Imamura, M., Sekiguchi, N., Nakashima, N. and Nawata, H. (2005). Adenovirus-mediated high expression of resistin causes dyslipidemia in mice. Endocrinol. 146: 273-279.
45. Savage, D.B., Sewter, C.P., Klenk, E.S., Segal, D.G., Vidal-Puig, A., Considine, R.V. and O'Rahilly. S. (2001). Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes 50: 2199-2202.
46. Scherer, P.E., Williams, S., Fogliano, M., Baldini, G. and Lodish, H.F. (1995). A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 270: 26746-26749.
47. Schwartz, D.R. and Lazar, M.A. (2011). Human resistin: found in translation from mouse to man. Trends Endocrinol. Metab. 22: 259-265.
48. Silswal, N., Singh, A.K., Aruna, B., Mukhopadhyay, S., Ghosh, S. and Ehtesham, N.Z. (2005). Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaBdependent pathway. Biochem. Biophys. Res. Commun. 334: 1092-1101.
49. Steppan, C.M., Bailey, S.T., Bhat, S., Brown, E.J., Banerjee, R.R., Wright, C.M., Patel, H.R., Ahima, R.S. and Lazar, M.A. (2001a). The hormone resistin links obesity to diabetes. Nature 409: 307-312.
50. Steppan, C.M., Brown, E.J., Wright, C.M., Bhat, S., Banerjee, R.R., Dai, C.Y., Enders, G.H., Silberg, D.G., Wen, X., Wu, G.D. and Lazar, M.A. (2001b). A family of tissue-specific resistin-like molecules. Proc. Natl. Acad. Sci. U.S.A. 98: 502-506.
51. Takeishi, Y., Niizeki, T., Arimoto, T., Nozaki, N., Hirono, O., Nitobe, J., Watanabe, T., Takabatake, N. and Kubota, I. (2007). Serum resistin is associated with high risk in patients with congestive heart ailure-a novel link between metabolic signals and heart failure. Circ. J. 71: 460-464.
52. Tomaru, T., Steger, D.J., Lefterova, M.I., Schupp, M. and Lazar, M.A. (2009). Adipocyte-specific expression of rodent resistin is mediated by synergism between peroxisome proliferator-activated receptor gamma and CCAAT/enhancer-binding proteins. J. Biol. Chem. 284: 6116-6125.
53. Verma, S., Li, S.H., Wang, C.H., Fedak, P.W., Li, R.K., Weisel, R.D. and Mickle, D.A. (2003). Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction. Circulation 108: 736-740.
54. Wang, B.W., Chang, H. and Shyu, K.G. (2010). Regulation of resistin by cyclic mechanical stretch in cultured rat vascular smooth muscle cells. Clin. Sci. (Lond.) 118: 221-230.
55. Wang, B.W., Hung, H.F., Chang, H., Kuan, P. and Shyu, K.G. (2007). Mechanical stretch enhances the expres sion of resistin gene in cultured cardiomyocytes via tumor necrosis factor-alpha. Am. J. Physiol. 293: H2305-H2312.
56. Wang, H., Chen, D.Y., Cao, J., He, Z.Y., Zhu, B.P. and Long, M. (2009). High serum resistin level may be an indicator of the severity of coronary disease in acute coronary syndrome. Chin. Med. Sci. J. 24: 161-166.
57. Weikert, C., Westphal, S., Berger, K., Dierkes, J., Mohlig, M., Spranger, J., Rimm, E.B., Willich, S.N., Boeing, H. and Pischon, T. (2008). Plasma resistin levels and risk of myocardial infarction and ischemic stroke. J. Clin. Endocrinol. Metab. 93: 2647-2653.
58. Xu, W., Yu, L., Zhou, W. and Luo, M. (2006). Resistin increases lipid accumulation and CD36 expression in human macrophages. Biochem. Biophys. Res. Commun. 351: 376-382.
59. Yaturu, S., Daberry, R.P., Rains, J. and Jain, S. (2006). Resistin and adiponectin levels in subjects with coronary artery disease and type 2 diabetes. Cytokine 34: 219-223.
60. Yu, Y.H. and Ginsberg, H.N. (2005). Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue. Circ. Res. 96: 1042-1052.
61. Zhang, M.H., Na, B., Schiller, N.B. and Whooley, M.A. (2011). Association of resistin with heart failure and mortality in patients with stable coronary heart disease: data from the heart and soul study. J. Card. Fail. 17: 24-30.
62. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. and Friedman, J.M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432.