Hepatocellular MR contrast agents: Enhancement characteristics of liver parenchyma and portal vein after administration of gadoxetic acid in comparison to gadobenate dimeglumine

European Journal of Radiology

Volumn 81, Issue 9, 2012, Pages 2037-2041

  Feuerlein, Sebastian ^a   Gupta, Rajan T ^a   Boll, Daniel T ^a   Merkle, Elmar M ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Dose dynamics; Hepatobiliary MR contrast agents; MR imaging; Pharmacokinetics

Indexed keywords

GADOBENATE DIMEGLUMINE; GADOXETIC ACID;

ADULT; AGED; ARTICLE; CALCULATION; CONTRAST ENHANCEMENT; FEMALE; HUMAN; INTERMETHOD COMPARISON; LIVER PARENCHYMA; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PORTAL VEIN; PRIORITY JOURNAL; RADIATION DOSE; RETROSPECTIVE STUDY; SIGNAL NOISE RATIO; STATISTICAL SIGNIFICANCE;

ADULT; AGED; CONTRAST MEDIA; FEMALE; GADOLINIUM DTPA; HUMANS; LIVER; LIVER DISEASES; MAGNETIC RESONANCE IMAGING; MALE; MEGLUMINE; MIDDLE AGED; ORGANOMETALLIC COMPOUNDS; PORTAL VEIN; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84864708187     PISSN: 0720048X     EISSN: 18727727     Source Type: Journal    
DOI: 10.1016/j.ejrad.2011.06.014     Document Type: Article

References (20)

1. T.J. Vogl, S. Kummel, and R. Hammerstingl Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA Radiology 200 1 1996 59 67
2. P. Reimer, E.J. Rummeny, and K. Shamsi Phase II clinical evaluation of Gd-EOB-DTPA: dose, safety aspects, and pulse sequence Radiology 199 1 1996 177 183
3. R.C. Brasch New directions in the development of MR imaging contrast media Radiology 183 1 1992 1 11
4. G. Morana, E. Salviato, and A. Guarise Contrast agents for hepatic MRI Cancer Imaging 7 Spec No A 2007 S24 S27
5. R. Manfredi, G. Maresca, and R.L. Baron Gadobenate dimeglumine (BOPTA) enhanced MR imaging: patterns of enhancement in normal liver and cirrhosis J Magn Reson Imaging 8 4 1998 862 867
6. J.E. van Montfoort, B. Stieger, D.K. Meijer, H.J. Weinmann, P.J. Meier, and K.E. Fattinger Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1 J Pharmacol Exp Ther 290 1 1999 153 157
7. K.I. Ringe, D.B. Husarik, C.B. Sirlin, and E.M. Merkle Gadoxetate disodium-enhanced MRI of the liver: part 1, protocol optimization and lesion appearance in the noncirrhotic liver AJR Am J Roentgenol 195 1 2010 13 28
8. M. Rohrer, H. Bauer, J. Mintorovitch, M. Requardt, and H.J. Weinmann Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths Invest Radiol 40 11 2005 715 724
9. J.G. McNulty, and F. Khosa Absence of bifurcation of the portal vein Radiology 211 2 1999 589 590
10. Y. Maetani, K. Itoh, and N. Kojima Portal vein anomaly associated with deviation of the ligamentum teres to the right and malposition of the gallbladder Radiology 207 3 1998 723 728
11. C. Gallego, M. Velasco, P. Marcuello, D. Tejedor, L. De Campo, and A. Friera Congenital and acquired anomalies of the portal venous system Radiographics 22 1 2002 141 159
12. A. Filippone, A. Blakeborough, and J. Breuer Enhancement of liver parenchyma after injection of hepatocyte-specific MRI contrast media: a comparison of gadoxetic acid and gadobenate dimeglumine J Magn Reson Imaging 31 2 2010 356 364
13. G. Morana, L. Grazioli, and G. Schneider Hypervascular hepatic lesions: dynamic and late enhancement pattern with Gd-BOPTA Acad Radiol 9 Suppl. 2 2002 S476 S479
14. B. Hamm, T. Staks, and A. Muhler Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging Radiology 195 3 1995 785 792
15. P. Reimer, G. Schneider, and W. Schima Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications Eur Radiol 14 4 2004 559 578
16. G. Schuhmann-Giampieri, H. Schmitt-Willich, W.R. Press, C. Negishi, H.J. Weinmann, and U. Speck Preclinical evaluation of Gd-EOB-DTPA as a contrast agent in MR imaging of the hepatobiliary system Radiology 183 1 1992 59 64
17. D.A. Bluemke, D. Sahani, and M. Amendola Efficacy and safety of MR imaging with liver-specific contrast agent: U.S. multicenter phase III study Radiology 237 1 2005 89 98
18. A. Huppertz, T. Balzer, and A. Blakeborough Improved detection of focal liver lesions at MR imaging: multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings Radiology 230 1 2004 266 275
19. S. Feuerlein, D.T. Boll, R.T. Gupta, K.I. Ringe, D. Marin, and E.M. Merkle Gadoxetate disodium-enhanced hepatic MRI: dose-dependent contrast dynamics of hepatic parenchyma and portal vein AJR Am J Roentgenol 196 1 2011 W18 W24
20. B.J. Soher, B.M. Dale, and E.M. Merkle A review of MR physics: 3 T versus 1.5 T Magn Reson Imaging Clin N Am 15 3 2007 277-90, v