The effect of particle size on the biodistribution of low-modulus hydrogel PRINT particles

Journal of Controlled Release

Volumn 162, Issue 1, 2012, Pages 37-44

  Merkel, Timothy J ^a   Chen, Kai ^a   Jones, Stephen W ^a   Pandya, Ashish A ^a   Tian, Shaomin ^a,b   Napier, Mary E ^a   Zamboni, William E ^a,b,c   Desimone, Joseph M ^a,b,c,d,e  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c University of North Carolina   (United States)

^d North Carolina State University   (United States)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Biodistribution; Biomimetic; Deformability; Hydrogel; Long circulating

Indexed keywords

BIODISTRIBUTIONS; CIRCULATION TIME; DEFORMABLE PARTICLES; DRUG DELIVERY SYSTEM; HOLD UP; IN-VIVO; LONG CIRCULATING; LOW-MODULUS; MONODISPERSE; PARTICLE CONCENTRATIONS; RATIONAL DESIGN; RED BLOOD CELL; SIZE AND SHAPE;

BIOMIMETICS; BLOOD; CELLS; DRUG DELIVERY; ELASTIC MODULI; FORMABILITY; HISTOLOGY; HYDROGELS; TISSUE;

DEFORMATION;

1 HYDROXYCYCLOHEXYLPHENYLKETONE; 2 CARBOXYETHYL ACRYLATE; DYLIGHT MALEIMIDE; HYDROXYLPOLYETHYLENE GLYCOL ACRYLATE; MACROGOL; MACROGOL 4000; METHACRYLOXYETHYLTHIOCARBONYLRHODAMINE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CELL SHAPE; CELL SIZE; CELL STRUCTURE; DISTRIBUTION VOLUME; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; EFFECT SIZE; ERYTHROCYTE; FEMALE; FILTRATION; HYDROGEL; LUNG; MICROTECHNOLOGY; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SPLEEN;

ACRYLATES; ANIMALS; BIOMIMETIC MATERIALS; DRUG CARRIERS; ELASTIC MODULUS; ERYTHROCYTES; FEMALE; HYDROGEL; MICE; MICE, INBRED BALB C; PARTICLE SIZE; POLYETHYLENE GLYCOLS; TISSUE DISTRIBUTION;

EID: 84864678204     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.06.009     Document Type: Article

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