Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel

Biochemistry

Volumn 51, Issue 31, 2012, Pages 6195-6206

  Inada, Hitoshi ^a   Procko, Erik ^a,c   Sotomayor, Marcos ^a,b   Gaudet, Rachelle ^a  

^a HARVARD UNIVERSITY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN-REPEAT DOMAIN; ATP BINDING; BARRIER FORMATION; BIOCHEMICAL ANALYSIS; BONE HOMEOSTASIS; CATION CHANNELS; CHANNEL ACTIVITY; INHERITED DISEASE; LOOP REGIONS; MECHANOSENSATION; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR MECHANISM; SMALL MOLECULES; STABILITY ANALYSIS;

MOLECULAR DYNAMICS; PHYSIOLOGY; THERMODYNAMIC STABILITY;

CALMODULIN;

ADENOSINE TRIPHOSPHATE; ANKYRIN; VANILLOID RECEPTOR 4;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CHEMICAL ANALYSIS; GENE MUTATION; GENETIC DISORDER; PRIORITY JOURNAL; PROTEIN STRUCTURE; REGULATORY MECHANISM; THERMOSTABILITY;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANKYRIN REPEAT; DISEASE; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN STABILITY; TRPV CATION CHANNELS;

EID: 84864649745     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300279b     Document Type: Article

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