Could cadmium be responsible for some of the neurological signs and symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Medical Hypotheses

Volumn 79, Issue 3, 2012, Pages 403-407

  Pacini, Stefania ^a   Fiore, Maria G ^a   Magherini, Stefano ^a   Morucci, Gabriele ^a   Branca, Jacopo J V ^a   Gulisano, Massimo ^a   Ruggiero, Marco ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CADMIUM; MAGNESIUM; ZINC;

AMNESIA; ANGIOGENESIS; ARTICLE; ATTENTION DISTURBANCE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN DYSFUNCTION; BRAIN SIZE; CENTRAL NERVOUS SYSTEM; CHRONIC FATIGUE SYNDROME; COGNITION; CONTROLLED STUDY; DIET SUPPLEMENTATION; EARLY DIAGNOSIS; ECHOGRAPHY; EXPOSURE; FOLLOW UP; GRAY MATTER; HUMAN; IN VIVO STUDY; LIPID PEROXIDATION; MENINX; NERVE CELL NECROSIS; NEUROIMAGING; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL ACTIVITY; PROPHYLAXIS; SOCIAL BEHAVIOR; SYMPTOM; TEMPORAL CORTEX; TEMPORAL LOBE; WORKING MEMORY;

CADMIUM; FATIGUE SYNDROME, CHRONIC; HUMANS; MODELS, THEORETICAL;

RATTUS;

EID: 84864628710     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.06.007     Document Type: Article

References (34)

1. Brkić S., Tomić S., Ruzić M., Marić D. Chronic fatigue syndrome. Srp Arh Celok Lek 2011, 139(3-4):256-261.
2. Carruther B.M., van de Sande M.I., De Meirleir K.L., et al. Myalgic encephalomyelitis: International Consensus Criteria. J Intern Med 2011, 270(4):327-338.
3. Dinos S., Khoshaba B., Ashby D., et al. A systematic review of chronic fatigue, its syndromes and ethnicity: prevalence, severity, co-morbidity and coping. Int J Epidemiol 2009, 38(6):1554-1570.
4. Holgate S.T., Komaroff A.L., Mangan D., Wessely S. Chronic fatigue syndrome: understanding a complex illness. Nat Rev Neurosci 2011, 12(9):539-544.
5. Lombardi V.C., Ruscetti F.W., Das Gupta J., et al. Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. Science 2009, 326(5952):585-589.
6. Groom H.C., Bishop K.N. The tale of xenotropic murine leukemia virus-related virus. J Gen Virol 2012, 93(5):915-924.
7. Hughlings Jackson J. Evolution and dissolution of the nervous system. In: Taylor J, editor. Selected Writings of John Hughlings Jackson, vol. 2, New York: Basic Books; 1884. p. 3-118.
8. Roofe PG, Matzke HA. Introduction to the study of evolution: its relationship to neuropathology In: Minkler J, editor. Pathology of the nervous system, vol. 1. New York: Blakiston; 1968, p. 14-22.
9. Sarnat H.B., Netsky M.G. Evolution of the nervous system 1981, Oxford University Press, Oxford.
10. Rapoport S.I. Brain evolution and Alzheimer's disease. Rev Neurol 1988, 144(2):79-90.
11. Rapoport S.I. Hypothesis: Alzheimer's disease is a phylogenic disease. Med Hypotheses 1989, 29(3):147-150.
12. Rapoport S.I. Integrated phylogeny of the primate brain, with special references to humans and their diseases. Brain Res Brain Res Rev 1990, 15(3):267-294.
13. Stejskal V.D., Danersund A., Lindvall A., et al. Metal-specific lymphocytes: biomarkers of sensitivity in man. Neuro Endocrinol Lett 1999, 20(5):289-298.
14. Miller R. Thimerosal, micromercurialism and chronic fatigue syndrome. Med Hypotheses 2005, 64(5):1063-1064.
15. Valentine-Thon E., Müller K., Guzzi G., Kreisel S., Ohnsorge P., Sandkamp M. LTT-MELISA is clinically relevant for detecting and monitoring metal sensitivity. Neuro Endocrinol Lett 2006, 27(1):17-24.
16. de Lange F.P., Kalkman J.S., Bleijenberg G., Hagoort P., van der Meer J.W., Toni I. Gray matter volume reduction in the chronic fatigue syndrome. Neuroimage 2005, 26(3):777-781.
17. López E., Arce C., Oset-Gasque M.J., Caňadas S., González M.P. Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture. Free Radic Biol Med 2006, 40(6):940-951.
18. Hart R.P., Rose C.S., Hamer R.M. Neuropsychological effects of occupational exposure to cadmium. J Clin Exp Neuropsychol 1989, 11(6):933-943.
19. Antonio M.T., Corredor L., Leret M.L. Study of the activity of several enzymes like markers of the neurotoxicity induced by perinatal exposure to lead and/or cadmium. Toxicol Lett 2003, 143(3):331-340.
20. Joyce E., Blumenthal S., Wessely S. Memory, attention, and executive function in chronic fatigue syndrome. J Neurol Neurosurg Psychiatry 1996, 60(5):495-503.
21. Haig-Ferguson A., Tucker P., Eaton N., Hunt L., Crawley E. Memory and attention problems in children with chronic fatigue syndrome or myalgic encephalopathy. Arch Dis Child 2009, 94(10):757-762.
22. Gulisano M., Pacini S., Punzi T., et al. Cadmium modulates proliferation and differentiation of human neuroblasts. J Neurosci Res 2009, 87(1):228-237.
23. Sarchielli E., Pacini S., Morucci G., et al. Cadmium induces alterations in the human spinal cord morphogenesis. Biometals 2012, 25(1):63-74.
24. Serdar M.A., Akin B.S., Razi C., et al. The correlation between smoking status of family members and concentrations of toxic trace elements in the hair of children. Biol Trace Elem Res 2012, 148(1):11-17.
25. Bassi N., Amital D., Amital H., Doria A., Shoenfeld Y. Chronic fatigue syndrome: characteristics and possible causes for its pathogenesis. Isr Med Assoc J 2008, 10(1):79-82.
26. von Economo C. Temporal lobe. In: Triarhou LC, editor. Cellular structure of the human cerebral cortex. Basel; 2009. p. 114-132.
27. Molnár Z. Evolution of cerebral cortical development. Brain Behav Evol 2011, 78(1):94-107.
28. Pacini S., Punzi T., Morucci G., Gulisano M., Ruggiero M. A paradox of cadmium: a carcinogen that impairs the capability of human breast cancer cells to induce angiogenesis. J Environ Pathol Toxicol Oncol 2009, 28(1):85-88.
29. Kim J., Lim W., Ko Y., et al. The effects of cadmium on VEGF-mediated angiogenesis in HUVECs. J Appl Toxicol 2012, 32(5):342-349.
30. Biswal B., Kunwar P., Natelson B.H. Cerebral blood flow is reduced in chronic fatigue syndrome as assessed by arterial spin labeling. J Neurol Sci 2011, 301(1-2):9-11.
31. Yoshiuchi K., Farkas J., Natelson B.H. Patients with chronic fayigue syndrome have reduced absolute cortical blood flow. Clin Physiol Funct Imaging 2006, 26(2):83-86.
32. Matović V., Buha A., Bulat Z., Dukić-ćosić D. Cadmium toxicity revisited: focus on oxidative stress induction and interactions with zinc and magnesium. Arh Hig Rada Toksikol 2011, 62(1):65-76.
33. Cox I.M., Campbell M.J., Dowson D. Red blood cell magnesium and chronic fatigue syndrome. Lancet 1991, 337(8744):757-760.
34. Popper K.R. The logic of scientific discovery 1959, Hutchinson, London.