Spontaneous clearance of a secondary Buruli ulcer lesion emerging ten months after completion of chemotherapy-A case report from Togo

PLoS Neglected Tropical Diseases

Volumn 6, Issue 7, 2012, Pages

  Beissner, Marcus ^a   Piten, Ebekalisai ^b   Maman, Issaka ^c   Symank, Dominik ^a   Jansson, Moritz ^a   Nitschke, Jörg ^a,d   Amekuse, Komi ^d   Kobara, Basil ^e   Wiedemann, Franz ^d   Hoffmann, Harald ^f   Diefenhardt, Adolf ^d   Badziklou, Kossi ^c   Banla Kere, Abiba ^c   Löscher, Thomas ^a   Bretzel, Gisela ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Centre Hospitalier Régional Maritime CHR Maritime   (Togo)

^c Onchocerciasis Reference Laboratory Institut National d'Hygiène   (Togo)

^d Klinikum der Ludwig Maximilians Universität München   (Togo)

^e Programme National de Lutte Contre l'Ulcère de Buruli la Lèpre et le Pian PNLUB LP   (Togo)

^f Pneumological Teaching Hospital of the University of Munich   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

RIFAMPICIN; STREPTOMYCIN; ANTIINFECTIVE AGENT; BACTERIAL DNA;

ARTICLE; BIOPSY; BURULI ULCER; CASE REPORT; CHEMOTHERAPY; CHILD; HUMAN; HUMAN TISSUE; MALE; MICROSCOPY; MYCOBACTERIUM ULCERANS; REAL TIME POLYMERASE CHAIN REACTION; RELAPSE; SCHOOL CHILD; THIGH; TOGO; WOUND CARE; GENETICS; ISOLATION AND PURIFICATION; POLYMERASE CHAIN REACTION; TRANSPOSON;

ANTI-BACTERIAL AGENTS; BURULI ULCER; CHILD; DNA TRANSPOSABLE ELEMENTS; DNA, BACTERIAL; HUMANS; MALE; MYCOBACTERIUM ULCERANS; POLYMERASE CHAIN REACTION; STREPTOMYCIN; TOGO;

EID: 84864597841     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001747     Document Type: Article

References (9)

1. Bretzel G, Huber KL, Kobara B, Beissner M, Piten E, et al. ((2011)) Laboratory confirmation of Buruli ulcer disease in Togo, 2007-2010. PLoS Negl Trop Dis 5 (7): e1228 doi:10.1371/journal.pntd.0001228.
2. Huygen K, Adjei O, Affolabi D, Bretzel G, Demangel C, et al. ((2009)) Buruli ulcer disease: prospects for a vaccine. Med Microbiol Immunol 198:: 69--77.
3. World Health Organization (2008) Buruli ulcer: progress report, 2004-2008. Wkly Epidemiol Rec 83: 145-156.
4. Herbinger KH, Brieske D, Nitschke J, Siegmund V, Thompson W, et al. ((2009)) Excision of pre-ulcerative forms of Buruli ulcer disease: a curative treatment? Infection 37 (1): 20--25.
5. Ruf M-T, Chauty A, Adeye A, Ardant M-F, Koussemou H, et al. ((2011)) Secondary Buruli ulcer skin lesions emerging several months after completion of chemotherapy: paradoxical reaction or evidence for immune protection? PLoS Negl Trop Dis 5 (8): e1252 doi:10.1371/journal.pntd.0001252.
6. O'Brien DP, Robson ME, Callan PP, McDonald AH, ((2009)) "Paradoxical" immune-mediated reactions to Mycobacterium ulcerans during antibiotic treatment: a result of treatment success, not failure. Med J 191 (10): 564--566.
7. Kibadi K, Boelaert M, Fraga AG, Kayinua M, Longatto-Filho A, et al. ((2010)) Response to treatment in a prospective cohort of patients with large ulcerated lesions suspected to be Buruli ulcer (Mycobacterium ulcerans disease). PLoS Negl Trop Dis 4 (7): e736 doi:10.1371/journal.pntd.0000736.
8. Sarfo FS, Phillips RO, Rangers B, Mahrous EA, Lee RE, et al. ((2010)) Detection of mycolactone A/B in Mycobacterium ulcerans-infected human tissue. PLoS Negl Trop Dis 4 (1): e577 doi:10.1371/journal.pntd.0000577.
9. Gordon CL, Buntine JA, Hayman JA, Lavender CJ, Fyfe JA, et al. ((2011)) Spontaneous clearance of Mycobacterium ulcerans in a case of Buruli ulcer. PLoS Negl Trop Dis 5 (10): e1290 doi:10.1371/journal.pntd.0001290.