Self-assembled glycol chitosan nanogels containing palmityl-acylated exendin-4 peptide as a long-acting anti-diabetic inhalation system

Journal of Controlled Release

Volumn 161, Issue 3, 2012, Pages 728-734

  Lee, Juho ^a   Lee, Changkyu ^b   Kim, Tae Hyung ^b   Lee, Eun Seong ^c   Shin, Beom Soo ^d   Chi, Sang Cheol ^b   Park, Eun Seok ^b   Lee, Kang Choon ^b   Youn, Yu Seok ^b  

^a Pusan National University   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c The Catholic University of Korea   (South Korea)

^d Catholic University of Daegu   (South Korea)

Author keywords

Exendin 4; Fatty acylation; Inhalation; Nanogels; Type 2 diabetes

Indexed keywords

DB/DB MOUSE; DELIVERY SYSTEMS; EXENDIN-4; GLYCOL CHITOSAN; HUMAN LUNG; INHALATION; MOUSE LUNG; NANOGELS; SELF-ASSEMBLED; TYPE-2 DIABETES;

ACYLATION; BIOLOGICAL ORGANS; CHITOSAN; GLYCOLS; HISTOLOGY; INFRARED IMAGING; MAMMALS; TISSUE;

NANOSTRUCTURED MATERIALS;

CHITOSAN; EXENDIN 4; GLYCOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; GEL; HISTOPATHOLOGY; LUNG ALVEOLUS EPITHELIUM; MALE; MOUSE; NANOPHARMACEUTICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

ACYLATION; ADMINISTRATION, INHALATION; ANIMALS; CHITOSAN; DESOXYCORTICOSTERONE; DIABETES MELLITUS; DRUG CARRIERS; GELS; HYPOGLYCEMIC AGENTS; LUNG; MALE; MICE; MICE, INBRED ICR; NANOSTRUCTURES; PALMITIC ACID; PEPTIDES; VENOMS;

EID: 84864583569     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.05.029     Document Type: Article

References (32)

1. J.S. Patton, C.S. Fishburn, and J.G. Weers The lungs as a portal of entry for systemic drug delivery Proc. Am. Thorac. Soc. 1 2004 338 344
2. J.S. Patton, and P.R. Byron Inhaling medicines: delivering drugs to the body through the lungs Nat. Rev. Drug Discov. 6 2007 67 74 (Pubitemid 46020287)
3. J.S. Patton Mechanisms of macromolecular absorption by the lungs Adv. Drug Deliv. Rev. 19 1996 3 36
4. Y.S. Youn, K.C. Lee, Y.H. Bae, K. Na, and E.S. Lee Advanced pulmonary delivery of peptides or proteins using polymeric L. Jorgensen, H.M. Lielsen, Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids, and Vaccines 2009 WILEY 228 244
5. R. Singh, and J.W. Lillard Jr. Nanoparticle-based targeted drug delivery Exp. Mol. Pathol. 86 2009 215 223
6. J.D. Byrne, T. Betancourt, and L. Brannon-Peppas Active targeting schemes for nanoparticle systems in cancer therapeutics Adv. Drug Deliv. Rev. 60 2008 1615 1626
7. S. Bae, K. Ma, T.H. Kim, E.S. Lee, K.T. Oh, E.S. Park, K.C. Lee, and Y.S. Youn Doxorubicin-loaded human serum albumin nanoparticles surface-modified with TNF-related apoptosis-inducing ligand and transferrin for targeting multiple tumor types Biomaterials 33 2012 1536 1546
8. E. Miele, G.P. Spinelli, E. Miele, F. Tomao, and S. Tomao Albumin-bound formulation of paclitaxel (Abraxane ABI-007) in the treatment of breast cancer Int. J. Nanomedicine 4 2009 99 105
9. W. Yang, J.I. Peters, and R.O. Williams III Inhaled nanoparticles - a current review Int. J. Pharm. 356 2008 239 247
10. J.C. Sung, B.L. Pulliam, and D.A. Edwards Nanoparticles for drug delivery to the lungs Trends Biotechnol. 25 2007 563 570 (Pubitemid 350138179)
11. A. Makhlof, M. Werle, Y. Tozuka, and H. Takeuchi Nanoparticles of glycol chitosan and its thiolated derivative significantly improved the pulmonary delivery of calcitonin Int. J. Pharm. 397 2010 92 95
12. J.H. Park, G. Saravanakumar, K. Kim, and I.C. Kwon Targeted delivery of low molecular drugs using chitosan and its derivatives Adv. Drug Deliv. Rev. 62 2010 28 41
13. S.J. Lee, H. Koo, H. Jeong, M.S. Huh, Y. Choi, S.Y. Jeong, Y. Byun, K. Choi, K. Kim, and I.C. Kwon Comparative study of photosensitizer loaded and conjugated glycol chitosan nanoparticles for cancer therapy J. Control. Release 152 2011 21 29
14. S.J. Lee, H. Koo, D.E. Lee, S. Min, S. Lee, X. Chen, Y. Choi, J.F. Leary, K. Park, S.Y. Jeong, I.C. Kwon, K. Kim, and K. Choi Tumor-homing photosensitizer-conjugated glycol chitosan nanoparticles for synchronous photodynamic imaging and therapy based on cellular on/off system Biomaterials 32 2011 4021 4029
15. J.H. Na, H. Koo, S. Lee, K.H. Min, K. Park, H. Yoo, S.H. Lee, J.H. Park, I.C. Kwon, S.Y. Jeong, and K. Kim Real-time and non-invasive optical imaging of tumor-targeting glycol chitosan nanoparticles in various tumor models Biomaterials 32 2011 5252 5261
16. J.H. Kim, Y.S. Kim, K. Park, S. Lee, H.Y. Nam, K.H. Min, H.G. Jo, J.H. Park, K. Choi, S.Y. Jeong, R.W. Park, I.S. Kim, K. Kim, and I.C. Kwon Antitumor efficacy of cisplatin-loaded glycol chitosan nanoparticles in tumor-bearing mice J. Control. Release 127 2008 41 49
17. H. Yamamoto, Y. Kuno, S. Sugimoto, H. Takeuchi, and Y. Kawashima Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions J. Control. Release 102 2005 373 381 (Pubitemid 40093760)
18. S.Y. Chae, C.H. Jin, J.H. Shin, S. Son, T.H. Kim, S. Lee, Y.S. Youn, Y. Byun, M.S. Lee, and K.C. Lee Biochemical, pharmaceutical and therapeutic properties of long-acting lithocholic acid derivatized exendin-4 analogs J. Control. Release 142 2010 206 213
19. S. Son, S.Y. Chae, C.W. Kim, Y.G. Choi, S.Y. Jung, S. Lee, and K.C. Lee Preparation and structural, biochemical, and pharmaceutical characterizations of bile acid-modified long-acting exendin-4 derivatives J. Med. Chem. 52 2009 6889 6896
20. S.Y. Chae, Y.G. Choi, S. Son, S.Y. Jung, D.S. Lee, and K.C. Lee The fatty acid conjugated exendin-4 analogs for type 2 antidiabetic therapeutics J. Control. Release 144 2010 10 16
21. I. Kim, T.H. Kim, K. Ma, E.S. Lee, D. Kim, K.T. Oh, D.H. Lee, K.C. Lee, and Y.S. Youn Synthesis and evaluation of human serum albumin-modified exendin-4 conjugate via heterobifunctional polyethylene glycol linkage with protracted hypoglycemic efficacy Bioconjug. Chem. 21 2010 1513 1519
22. H. Kim, J. Lee, T.H. Kim, E.S. Lee, K.T. Oh, D.H. Lee, E.S. Park, Y.H. Bae, K.C. Lee, and Y.S. Youn Albumin-coated porous hollow poly(lactic-co- glycolic acid) microparticles bound with palmityl-acylated exendin-4 as a long-acting inhalation delivery system for the treatment of diabetes Pharm. Res. 28 2011 2008 2019
23. H. Kim, H. Park, J. Lee, T.H. Kim, E.S. Lee, K.T. Oh, K.C. Lee, and Y.S. Youn Highly porous large poly(lactic-co-glycolic acid) microspheres adsorbed with palmityl-acylated exendin-4 as a long-acting inhalation system for treating diabetes Biomaterials 32 2011 1685 1693
24. I. Kim, T.H. Kim, K. Ma, E.S. Park, K.T. Oh, E.S. Lee, K.C. Lee, and Y.S. Youn A 4-arm polyethylene glycol derivative conjugated with exendin-4 peptide and palmitylamine having dual-function of size-increase and albumin-binding for long hypoglycemic action Regul. Pept. 167 2011 239 245
25. A. Grenha, C.I. Grainger, L.A. Dailey, B. Seijo, G.P. Martin, C. Remuñán-López, and B. Forbes Chitosan nanoparticles are compatible with respiratory epithelial cells in vitro Eur. J. Pharm. Sci. 31 2007 73 84 (Pubitemid 46660576)
26. N. Nafee, M. Schneider, U.F. Schaefer, and C.M. Lehr Relevance of the colloidal stability of chitosan/PLGA nanoparticles on their cytotoxicity profile Int. J. Pharm. 381 2009 130 139
27. M. Choi, M. Cho, B.S. Han, J. Hong, J. Jeong, S. Park, M.H. Cho, K. Kim, and W.S. Cho Chitosan nanoparticles show rapid extrapulmonary tissue distribution and excretion with mild pulmonary inflammation to mice Toxicol. Lett. 199 2010 144 152
28. M.B. Davidson, G. Bate, and P. Kirkpatrick Exenatide Nat. Rev. Drug Discov. 4 2005 713 714
29. F. Kratz Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles J. Control. Release 132 2008 171 183
30. A. Grenha, B. Seijo, and C. Remuñán-López Microencapsulated chitosan nanoparticles for lung protein delivery Eur. J. Pharm. Sci. 25 2005 427 437 (Pubitemid 40853870)
31. R.A. Muzzarelli Human enzymatic activities related to the therapeutic administration of chitin derivatives Cell. Mol. Life Sci. 53 1997 131 140 (Pubitemid 27365884)
32. Y.C. Huang, A. Vieira, K.L. Huang, M.K. Yeh, and C.H. Chiang Pulmonary inflammation caused by chitosan microparticles J. Biomed. Mater. Res. A 75 2005 283 287 (Pubitemid 41463896)