Actin cross-linking domain of Aeromonas hydrophila repeat in toxin A (RtxA) induces host cell rounding and apoptosis

Gene

Volumn 506, Issue 2, 2012, Pages 369-376

  Suarez, Giovanni ^a   Khajanchi, Bijay K ^a   Sierra, Johanna C ^a   Erova, Tatiana E ^a   Sha, Jian ^a   Chopra, Ashok K ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

A. hydrophila; Actin cross linking domain (ACD); Apoptosis; Cell rounding; HeLa Tet Off system; Rtx

Indexed keywords

ACTIN; ENHANCED GREEN FLUORESCENT PROTEIN;

ACTIN FILAMENT; AEROMONAS HYDROPHILA; APOPTOSIS; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; CELL CONTACT; CELL LINE; CELL STRUCTURE; CONTROLLED STUDY; CROSS LINKING; GENE EXPRESSION; MIXED INFECTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RTXA GENE; TOXIN ANALYSIS; WESTERN BLOTTING;

ACTINS; AEROMONAS HYDROPHILA; ANIMALS; APOPTOSIS; BACTERIAL TOXINS; BASE SEQUENCE; CROSS-LINKING REAGENTS; ESCHERICHIA COLI; FEMALE; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; MICE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; OPERON; RECOMBINANT PROTEINS;

AEROMONAS HYDROPHILA; VIBRIO; VIBRIO CHOLERAE;

EID: 84864557136     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2012.07.012     Document Type: Article

References (38)

1. Abuhammour W., Hasan R.A., Rogers D. Necrotizing fasciitis caused by Aeromonas hydrophilia in an immunocompetent child. Pediatr. Emerg. Care 2006, 22:48-51.
2. Boardman B.K., Satchell K.J. Vibrio cholerae strains with mutations in an atypical type I secretion system accumulate RTX toxin intracellularly. J. Bacteriol. 2004, 186:8137-8143.
3. Borger van der Burg B.L., Bronkhorst M.W., Pahlplatz P.V. Aeromonas hydrophila necrotizing fasciitis. A case report. J. Bone Joint Surg. Am. 2006, 88:1357-1360.
4. Chopra A.K., Houston C.W. Enterotoxins in Aeromonas-associated gastroenteritis. Microbes Infect. 1999, 1:1129-1137.
5. Chopra A.K., Houston C.W., Peterson J.W., Jin G.F. Cloning, expression, and sequence analysis of a cytolytic enterotoxin gene from Aeromonas hydrophila. Can. J. Microbiol. 1993, 39:513-523.
6. Chopra A.K., Peterson J.W., Xu X.J., Coppenhaver D.H., Houston C.W. Molecular and biochemical characterization of a heat-labile cytotonic enterotoxin from Aeromonas hydrophila. Microb. Pathog. 1996, 21:357-377.
7. Cordero C.L., Kudryashov D.S., Reisler E., Satchell K.J. The actin cross-linking domain of the Vibrio cholerae RTX toxin directly catalyzes the covalent cross-linking of actin. J. Biol. Chem. 2006, 281:32366-32374.
8. Cordero C.L., Sozhamannan S., Satchell K.J. RTX toxin actin cross-linking activity in clinical and environmental isolates of Vibrio cholerae. J. Clin. Microbiol. 2007, 45:2289-2292.
9. Devenish J., Rosendal S., Johnson R., Hubler S. Immunoserological comparison of 104-kilodalton proteins associated with hemolysis and cytolysis in Actinobacillus pleuropneumoniae, Actinobacillus suis, Pasteurella haemolytica, and Escherichia coli. Infect. Immun. 1989, 57:3210-3213.
10. Eberspacher B., Hugo F., Pohl M., Bhakdi S. Functional similarity between the haemolysins of Escherichia coli and Morganella morganii. J. Med. Microbiol. 1990, 33:165-170.
11. Ferguson M.R., et al. Hyperproduction, purification, and mechanism of action of the cytotoxic enterotoxin produced by Aeromonas hydrophila. Infect. Immun. 1997, 65:4299-4308.
12. Figueras M.J., Horneman A.J., Martinez-Murcia A., Guarro J. Controversial data on the association of Aeromonas with diarrhoea in a recent Hong Kong study. J. Med. Microbiol. 2007, 56:996-998. (author reply 98).
13. Fullner K.J., Mekalanos J.J. In vivo covalent cross-linking of cellular actin by the Vibrio cholerae RTX toxin. EMBO J. 2000, 19:5315-5323.
14. Hiransuthikul N., Tantisiriwat W., Lertutsahakul K., Vibhagool A., Boonma P. Skin and soft-tissue infections among tsunami survivors in southern Thailand. Clin. Infect. Dis. 2005, 41:e93-e96.
15. Janda J.M., Abbott S.L. The genus Aeromonas: taxonomy, pathogenicity, and infection. Clin. Microbiol. Rev. 2010, 23:35-73.
16. Kehl-Fie T.E., St Geme J.W. Identification and characterization of an RTX toxin in the emerging pathogen Kingella kingae. J. Bacteriol. 2007, 189:430-436.
17. Kim Y.R., et al. Vibrio vulnificus RTX toxin kills host cells only after contact of the bacteria with host cells. Cell. Microbiol. 2008, 10:848-862.
18. Kraig E., Dailey T., Kolodrubetz D. Nucleotide sequence of the leukotoxin gene from Actinobacillus actinomycetemcomitans: homology to the alpha-hemolysin/leukotoxin gene family. Infect. Immun. 1990, 58:920-929.
19. Kwak J.S., Jeong H.G., Satchell K.J. Vibrio vulnificus rtxA1 gene recombination generates toxin variants with altered potency during intestinal infection. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:1645-1650.
20. Lee B.C., Choi S.H., Kim T.S. Vibrio vulnificus RTX toxin plays an important role in the apoptotic death of human intestinal epithelial cells exposed to Vibrio vulnificus. Microbes Infect. 2008, 10:1504-1513.
21. Lee B.C., et al. Vibrio vulnificus rtxE is important for virulence, and its expression is induced by exposure to host cells. Infect. Immun. 2008, 76:1509-1517.
22. Li L., Rock J.L., Nelson D.R. Identification and characterization of a repeat-in-toxin gene cluster in Vibrio anguillarum. Infect. Immun. 2008, 76:2620-2632.
23. Lin W., et al. Identification of a Vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:1071-1076.
24. Lo H.R., et al. RTX toxin enhances the survival of Vibrio vulnificus during infection by protecting the organism from phagocytosis. J. Infect. Dis. 2011, 203:1866-1874.
25. Merino S., Rubires X., Knochel S., Tomas J.M. Emerging pathogens: Aeromonas spp. Int. J. Food Microbiol. 1995, 28:157-168.
26. Merino S., Aguilar A., Nogueras M.M., Regue M., Swift S., Tomas J.M. Cloning, sequencing, and role in virulence of two phospholipases (A1 and C) from mesophilic Aeromonas sp. serogroup O:34. Infect. Immun. 1999, 67:4008-4013.
27. Monaghan S.F., Anjaria D., Mohr A., Livingston D.H. Necrotizing fasciitis and sepsis caused by Aeromonas hydrophila after crush injury of the lower extremity. Surg. Infect. (Larchmt.) 2008, 9:459-467.
28. Presley S.M., et al. Assessment of pathogens and toxicants in New Orleans, LA following Hurricane Katrina. Environ. Sci. Technol. 2006, 40:468-474.
29. Roig F.J., Gonzalez-Candelas F., Amaro C. Domain organization and evolution of multifunctional autoprocessing repeats-in-toxin (MARTX) toxin in Vibrio vulnificus. Appl. Environ. Microbiol. 2011, 77:657-668.
30. Satchell K.J. MARTX, multifunctional autoprocessing repeats-in-toxin toxins. Infect. Immun. 2007, 75:5079-5084.
31. Seshadri R., et al. Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades. J. Bacteriol. 2006, 188:8272-8282.
32. Sha J., Kozlova E.V., Chopra A.K. Role of various enterotoxins in Aeromonas hydrophila-induced gastroenteritis: generation of enterotoxin gene-deficient mutants and evaluation of their enterotoxic activity. Infect. Immun. 2002, 70:1924-1935.
33. Sheahan K.L., Satchell K.J. Inactivation of small Rho GTPases by the multifunctional RTX toxin from Vibrio cholerae. Cell. Microbiol. 2007, 9:1324-1335.
34. Sheahan K.L., Cordero C.L., Satchell K.J. Identification of a domain within the multifunctional Vibrio cholerae RTX toxin that covalently cross-links actin. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:9798-9803.
35. Sierra J.C., et al. Biological characterization of a new type III secretion system effector from a clinical isolate of Aeromonas hydrophila-part II. Microb. Pathog. 2007, 43:147-160.
36. Sierra J.C., Suarez G., Sha J., Baze W.B., Foltz S.M., Chopra A.K. Unraveling the mechanism of action of a new type III secretion system effector AexU from Aeromonas hydrophila. Microb. Pathog. 2010, 49:122-134.
37. Suarez G., Sierra J.C., Erova T.E., Sha J., Horneman A.J., Chopra A.K. A type VI secretion system effector protein, VgrG1, from Aeromonas hydrophila that induces host cell toxicity by ADP ribosylation of actin. J. Bacteriol. 2010, 192:155-168.
38. Suarez G., Sierra J.C., Kirtley M.L., Chopra A.K. Role of Hcp, a type 6 secretion system effector, of Aeromonas hydrophila in modulating activation of host immune cells. Microbiology 2010, 156:3678-3688.