Vagal nerve stimulation decreases blood-brain barrier disruption after traumatic brain injury

Journal of Trauma and Acute Care Surgery

Volumn 72, Issue 6, 2012, Pages 1562-1566

  Lopez, Nicole E ^a   Krzyzaniak, Michael J ^a   Costantini, Todd W ^a   Putnam, James ^a   Hageny, Ann Marie ^a   Eliceiri, Brian ^a   Coimbra, Raul ^a   Bansal, Vishal ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

AQP 4; BBB; TBI; VNS

Indexed keywords

AQUAPORIN 4; FLUORESCEIN ISOTHIOCYANATE DEXTRAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN EDEMA; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; FLUORESCENCE; MALE; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE SECTION; TRAUMATIC BRAIN INJURY; VAGUS NERVE STIMULATION;

ANALYSIS OF VARIANCE; ANIMALS; AQUAPORIN 4; BLOOD-BRAIN BARRIER; BRAIN INJURIES; DEXTRANS; DISEASE MODELS, ANIMAL; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, CONFOCAL; RANDOM ALLOCATION; REFERENCE VALUES; TREATMENT OUTCOME; UP-REGULATION; VAGUS NERVE STIMULATION;

EID: 84864549643     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e3182569875     Document Type: Article

References (24)

1. Bullock MR, Lyeth BG, Muizelaar JP. Current status of neuroprotection trials for traumatic brain injury: lessons from animal models and clinical studies. Neurosurgery. 1999;45:207-217; discussion 217-220.
2. Tracey KJ. Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest. 2007;117:289-296.
3. Bansal V, Costantini T, Ryu SY, Peterson C, Loomis W, Putnam J, Elicieri B, Baird A, Coimbra R. Stimulating the central nervous system to prevent intestinal dysfunction after traumatic brain injury. J Trauma. 2010; 68:1059-1064.
4. Bansal V, Costantini T, Kroll L, Peterson C, LoomisW, Elicieri B, Baird A, Wolf P, Coimbra R. Traumatic brain injury and intestinal dysfunction: uncovering the neuro-enteric axis. J Neurotrauma. 2009;26:1353-1359.
5. Smith DC, Modglin AA, Roosevelt RW, Neese SL, Jensen RA, Browning RA, Clough RW. Electrical stimulation of the vagus nerve enhances cognitive and motor recovery following moderate fluid percussion injury in the rat. J Neurotrauma. 2005;22:1485-1502.
6. Smith DC, Tan AA , Duke A, Neese SL, Clough RW, Browning RA, Jensen RA. Recovery of function after vagus nerve stimulation initiated 24 hours after fluid percussion brain injury. J Neurotrauma. 2006;23: 1549-1560.
7. Clough RW, Neese SL, Sherill LK, Tan AA, Duke A, Roosevelt RW, Browning RA, Smith DC. Cortical edema in moderate fluid percussion brain injury is attenuated by vagus nerve stimulation. Neuroscience. 2007;147:286-293.
8. Baskaya MK, Rao AM, Dogan A, et al. The biphasic opening of the bloodbrain barrier in the cortex and hippocampus after traumatic brain injury in rats. Neuroscience Lett. 1997;226:33-36.
9. Ivens S, Kaufer D, Flores LP, Bechmann I, Zumsteg D, Tomkins O, Seiffert E, Heinemann U, Friedman A. TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis. Brain. 2007;130:535-547.
10. Tomkins O, et al. Blood-brain barrier disruption results in delayed functional and structural alterations in the rat neocortex. Neurobiol Dis. 2007;25:367-377.
11. Sato M, Chang E, Igarashi T, et al. Neuronal injury and loss after traumatic brain injury: time course and regional variability. Brain Res. 2001; 917:45-54.
12. Carbonell WS, Grady MS. Regional and temporal characterization of neuronal, glial, and axonal response after traumatic brain injury in the mouse. Acta Neuropathol. 1999;98:396-406.
13. Cobbs CS, Fenoy A, Bredt DS, et al. Expression of nitric oxide synthase in the cerebral microvasculature after traumatic brain injury in the rat. Brain Res. 1997;751:336-338.
14. PanW, Stone KP, Hsuchou H, Manda VK, Zhang Y, Kastin AJ. Cytokine signaling modulates blood-brain barrier function. Curr Pharm Des. 2011;17:3729-3740.
15. Bansal V, Ryu SY, Lopez N, Allexan S, Krzyzaniak M, Eliceiri B, Baird A, Coimbra R. Vagal stimulation modulates inflammation through a ghrelin mediated mechanism in traumatic brain injury. Inflammation. 2012;35:214-220.
16. Li G, Bauer S, Nowak M, Norwood B, Tackenberg B, Rosenow F, Knake S, Oertel WH, Hamer HM. Cytokines and epilepsy. Seizure. 20:249-256.
17. De Herdt V, Bogaert S, Bracke KR, Raedt R, De Vos M, Vonck K, Boon P. Effects of vagus nerve stimulation on pro- and anti-inflammatory cytokine induction in patients with refractory epilepsy. J Neuroimmunol. 2009; 214:104-108.
18. Naritoku DK, Terry WJ, Helfert RH. Regional induction of fos immunoreactivity in the brain by anticonvulsant stimulation of the vagus nerve. Epilepsy Res. 1995;22:53-62.
19. Sun MC, Honey CR, Berk C, et al. Regulation of aquaporin-4 in a traumatic brain injury model in rats. J Neurosurg. 2003;98:565-569.
20. Lopez NE, Krzyzaniak MJ, Blow C, Ortiz-Pomales Y, Hageny AM, Eliceiri B, Coimbra R, Bansal V. Ghrelin prevents disruption of the blood brain barrier after traumatic brain injury. J Neurotrauma. 2012; 29:385-393.
21. Davies DC. Blood-brain barrier breakdown in septic encephalopathy and brain tumours. J Anat. 2002;200:639-646.
22. Fazzina G, Amorini AM, Marmarou CR, Fukui S, Okuno K, Dunbar JG, Glisson R, Marmarou A, Kleindienst A. The protein kinase C activator phorbol myristate acetate decreases brain edema by aquaporin 4 downregulation after middle cerebral artery occlusion in the rat. J Neurotrauma. 27:453-461.
23. Li L, Zhang H, Varrin-Doyer M, et al. Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation. FASEB J. 25:1556-1566.
24. Ersahin M, Toklu HZ, Erzik C, Cetinel S, Bangir D, Ogunc AV, Tetik S, Ozdemir ZN, Sener G, Yegen BC. The anti-inflammatory and neuroprotective effects of ghrelin in subarachnoid hemorrhage-induced oxidative brain damage in rats. J Neurotrauma. 2010;27:1143-1155.