Methodological limitations may prevent the observation of non-Hodgkin's lymphoma in bioassays of polychlorinated biphenyls

Toxicologic Pathology

Volumn 40, Issue 7, 2012, Pages 995-1003

  Strauss, Harlee S ^a   Heiger Bernays, Wendy ^b  

^a H Strauss Associates Inc   (United States)

^b BOSTON UNIVERSITY   (United States)

Author keywords

animal models; bioassays; carcinogenesis; immune dysregulation; immunosuppression; mode of action; non Hodgkin's lymphoma; polychlorinated biphenyls.

Indexed keywords

2,2',4,4',5,5' HEXACHLOROBIPHENYL; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3,3',4,4',5 PENTACHLOROBIPHENYL; ANTIINFECTIVE AGENT; AROCLOR; DIOXIN; POLYCHLORINATED BIPHENYL;

BILE DUCT TUMOR; BIOASSAY; CANCER RISK; CARCINOGENESIS; CARCINOGENICITY; CHRONIC LYMPHATIC LEUKEMIA; DISEASE ASSOCIATION; EPSTEIN BARR VIRUS; HELICOBACTER INFECTION; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE DEFICIENCY; IMMUNE DYSREGULATION; INFLAMMATION; INFLAMMATORY DISEASE; KUPFFER CELL; LEUKEMIA; LONG TERM EXPOSURE; LUNG CONGESTION; LYMPHOMA; METHODOLOGY; NEPHRITIS; NONHODGKIN LYMPHOMA; NONHUMAN; OVARY INFLAMMATION; PNEUMONIA; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; REVIEW; RHEUMATOID ARTHRITIS; RISK FACTOR; SJOEGREN SYNDROME; SKIN INFECTION;

ANIMALS; CARCINOGENS; HUMANS; IMMUNITY, INNATE; IMMUNOSUPPRESSION; LYMPHOMA, NON-HODGKIN; MICE; POLYCHLORINATED BIPHENYLS; RATS; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SPECIES SPECIFICITY; TOXICITY TESTS;

ANIMALIA; RODENTIA;

EID: 84864541867     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623312443320     Document Type: Review

References (63)

1. Abrahamson L. J., Allen R. J.. The biological response of infant nonhuman primates to a polychlorinated biphenyl. Environ Health Perspect. 1973 ; 4: 81-6
2. Ansell S. M., Armitage J.. Non-Hodgkin lymphoma: Diagnosis and treatment. Mayo Clin Proc. 2005 ; 80: 1087-97
3. Arena S. M., Greeley E. H., Halbrook R. S., Hansen L. G., Segre M.. Biological effects of gestational and lactational PCB exposure in neonatal and juvenile C57BL/6 mice. Arch Environ Contam Toxicol. 2003 ; 44: 272-80
4. Baan R., Grosse Y., Straif K., Secretan B., El Ghissassi F., Bouvard V., Benbrahim-Talla L., Guha N., Freeman C., Galichet L., Coglian V. A review of human carcinogens-Part F: Chemical agents and related occupations. Lancet Oncol. 2009 ; 10: 1143-44
5. Bevins C. L., Salzman N. H.. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol. 2011 ; 9: 356-68
6. Brunner M. J., Sullivan T. M., Singer A.W., Ryan M. J., Toft J. D., Menton R. S., Graves S. W., Peters A. C 1997 :
7. Chen F., Wang D. Novel technologies for the prevention and treatment of dental caries: A patent survey. Expert Opin Ther Pat. 2010 ; 20: 681-94
8. Dallaire F., Dewailly E., Muckle G., Vezina C., Jacobson S. W., Jacobson J. L., Ayotte P. Acute infections and environmental exposure to organochlorines in Inuit infants from Nunavik. Environ Health Perspect. 2004 ; 112: 1359-64
9. Dallaire F., Dewailly E., Vezina C., Muckle G., Weber J.-P., Bruneau S., Ayotte P. Effect of prenatal exposure to polychlorinated biphenyls on incidence of acute respirtory infections in preschool Inuit children. Environ Health Perspect. 2006 ; 114: 1301-5
10. Davis D., Safe S.. Immunosuppressive activities of polychlorinated biphenyls in C57BL/6N mice: Structure-activity relationships as Ah receptor agonists and partial antagonists. Toxicology. 1990 ; 63: 97-111
11. Davis D., Safe S.. Dose-response immunotoxicities of commercial polychlorinated biphenyls (PCBs) and their interaction with 2,3,7,8- tetrachlorodibenzo-p-dioxin. Toxicol Lett. 1989 ; 48: 35-43
12. Davis D., Safe S.. Immunosuppressive activiites of polychlorinated dibenzofuran congeners: Quantitative structure-activity relationships and interactive effects. Toxicol Appl Pharmacol. 1988 ; 94: 141-49
13. Germolec D. R.. Sensitivity and predictivity in immunotoxicity testing: Immune endpoints and disease resistance. Toxicol Lett. 2004 ; 149: 109-14
14. Gersemann M., Stange E. F., Wehkamp J.. From intestinal stem cells to inflammatory bowel diseases. World Gastroenterol. 2011 ; 17: 3198-203
15. Grulich A. E., Vajdic C. M., Cozen W.. Altered immunity as a risk factor for non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev. 2007 ; 16: 405-8
16. Hara I.. Health status and PCBs in blood of workers exposed to PCBs and of their children. Environ Health Perspect. 1985 ; 59: 85-90
17. Hardell K., Carlberg M., Hardell L., Bjornfoth H., Jogsten I., Eriksson M., Van Bavel B., Lindstrom G.. Concentrations of organohalogen compounds and titres of antibodies to Epstein-Barr virus antigens and the risk for non-Hodgkin's lymphoma. Oncol Rep. 2009 ; 21: 1567-76
18. Hartge R., Wang S., Bracci P. M., Devesa S. S., Holly E. A. Cancer Epidemiology and Prevention. 2006 ). Non-Hodgkin's Lymphoma. In Cancer Epidemiology and Prevention, 3rd ed. (SchottenfeldD.FraumeniJ. F., eds.), pp.898-918. Oxford University Press, New York, NY. Schottenfeld D. Fraumeni J. F., ed. New York, NY: Oxford University Press ; 2006: 898-918.
19. Heilmann C., Budtz-Jorgensen E., Nielsen F., Heinzow B., Weihe P., Grandjean P.. Serum concentrations of antibodies against vaccine toxoids in children exosed perinatally to immunotoxicants. Environ Health Perspect. 2010 ; 118: 1434-38
20. Hogaboam J. P., Moore A. J., Lawrence B. P.. The aryl hydrocarbon receptor affects distinct tissue compartments during ontogeny of the immune system. Toxicol Sci. 2008 ; 102: 160-70
21. Ito N., Nagasaki H., Arai M., Makiura S., Sugihara S., Hirao K. Histopathologic studies on liver tumorigenesis by technical polychlorinated biphenyls and its promoting effect on liver tumors indicued by benzene hexachloride. J Natl Cancer Inst. 1973 ; 51: 1637-46
22. Ito N., Nagasaki H., Makiura S., Arai M. Histopathological studies on liver tumorigenesis in rats treated with polychlorinated biphenyls. Gann. 1974 ; 65: 545-49
23. Kerkvliet N. I.. AHR-mediated immunomodulation: The role of altered gene transcription. Biochem Pharmacol. 2009 ; 77: 746-60
24. Kimbrough R. D In Proceedings of the National Conference on Polychlorinated Biphenyls. 1975: 30-34.
25. Kimbrough R. D., Linder R. E.. Induction of adenofibrosis and hepatomas of the liver in BALB/cJ mice by polychlorinated biphenyls (Aroclor 1254). J Natl Cancer Inst. 1974 ; 53: 547-52
26. Kimbrough R. D., Linder R. E., Gaines T. B.. Morphological changes in livers of rats fed polychlorinated biphenyls: Light microscopy and ultrastructure. Arch Environ Health. 1972 ; 25: 354-64
27. Kimbrough R. D., Squire R. A., Linder R. E., Strandberg J. D., Montali R. J., Burse V. W.. Induction of liver tumor in Sherman strain female rats by polychlorinated biphenyl Aroclor 1260. J Natl Cancer Inst. 1975 ; 55: 1453-59
28. Kimura N., Baba T.. Neoplastic changes in the rat liver induced by polychlorinated biphenyl. Gann. 1973 ; 64: 105-8
29. Loose L. D., Pittman K. A., Benitz K. F., Silkworth J. B., Mueller W, Coulston F.. Environmental chemical-induced immune dysfunction. Ecotoxicol Environ Saf. 1978 ; 2: 173-98
30. Lu Y-C., Wu Y-C.. Clinical findings and immunological abnormalities in Yu-Cheng patients. Environ Health Perspect. 1985 ; 59: 17-29
31. Mayes B. A., McConnell E. E., Neal B. H., Brunner M. J., Hamilton S. B., Sullivan T. M., Peters A. C., Ryan M. J., Toft J. D., Singer A. W., Brown J. F., Menton R. G., Moore J. A.. Comparative carcinogenicity in Sprague-Dawley rats of the polychlorinated biphenyl mixtures Aroclors 1016, 1242, 1254, and 1260. Toxicol Sci. 1998 ; 41: 62-76
32. Morgan R. W., Ward J. M., Hartman P. E.. Aroclor 1254-induced intestinal metaplasia and adenocarcinoma in the glandular stomach of F344 rats. Cancer Res. 1981 ; 41: 5052-59
33. Nakanishi Y., Shigematsu N., Kurita Y., Matsuba K., Kanegae H., Ishimaru S., Kawazoe Y.. Respiatory involvement and immune status in Yusho patients. Environ Health Perspect. 1985 ; 59: 31-36
34. Bioassay of Aroclor for possible carcinogenicity. Natl Cancer Inst Carcinog Tech Rep Ser. 1978 ; 38: 1-62
35. 2006a :
36. 2006b :
37. 2006c :
38. 2006d :
39. NTP (2009). Immunomodulation testing and explanation of levels of evidence for immune system toxicity. http://ntp.niehs.nih.gov/go/9399. Accessed January 2012.
40. NTP (2010). Toxicology and carcinogenesis studies of 2,3′,4, 4′,5-pentachlorobiphenyl (PCB 118) (CAS No. 31508-00-6) in female Harlan Sprague-Dawley rats (gavage studies) NTP TR 559, NIH publication No. 11-5900. NIEHS, Research Triangle Park, NC.
41. NTP (2011). Polychlorinated biphenyls [CAS No. 1336-36-3] 349-353 in report on carcinogens, 12th ed. http://ntp.niehs.nih.gov/ntp/roc/twelfth/roc12. pdf. Accessed January, 2012.
42. Norback D. H., Weltman R. H.. Polychlorinated biphenyl induction of hepatocellular carcinoma in the Sprague-Dawley rat. Environ Health Perspect. 1985 ; 60: 97-105
43. Nordstrom M., Hardell L., Lindstrom G., Wingfors H., Hardell K., Linde A.. Concentrations of organochlorines related to titers to Epstein-Barr virus early antigen IgG as risk factors for hairy cell leukemia. Environ Health Perspect. 2000 ; 108: 441-45
44. Owens S. R., Smith L. B.. Molecular aspects of H. pylori-related MALT lymphoma. Patholog Res Int. 2011 2011 ;:
45. Park H.-Y., Hertz-Picciotto I., Petrik J., Palkovicova L., Kocan A., Trnovec T.. Prenatal PCB exposure and thymus size at birth in neonates in Eastern Slovakia. Environ Health Perspect. 2008 ; 116: 104-9
46. Rothman N., Cantor K. P., Blair A., Bush D., Brock J. W., Helzlsouer K., Zahm S. H., Needham L. L., Pearson G. R., Hoover R. N., Comstock G. W., Strickland P. T.. A nested case-control study of non-Hodgkin's lymphoma and serum organochlorine residues. Lancet. 1997 ; 350: 240-44
47. Schaeffer E., Greum H., Goessner W.. Pathology of chronic polychlorinated biphenyl (PCB) feeding in rats. Toxicol Appl Pharmacol. 1984 ; 75: 278-88
48. Selgrade M. K.. Immunotoxicity: The risk is real. Toxicol Sci. 2007 ; 100: 328-32
49. Smialowicz R. J., Riddle M. M., Williams W. C., Diliberto J. J.. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on humoral immunity and lymphocyte subpopulations: Differences between mice and rats. Toxicol Appl Pharmacol. 1994 ; 124: 248-56
50. Smialowicz R. J., Williams W. C., Riddle M. M.. Comparison of the T cell-independent antibody response of mice and rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol. 1996 ; 32: 293-97
51. Staples J. E., Murante F. G., Fiore N. C., Gasiewicz T. A., Silverstone A. E. Thymic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells. J Immunol. 1998 ; 160: 3844-54
52. Takagi Y., Aburada S., Otake T., Ikegami N.. Effect of polychlorinated biphenyls (PCBs) accumulated in the dam's body on mouse filial immunocompetence. Arch Environ Contam Toxicol. 1987 ; 16: 375-81
53. Tryphonas H.. Immunotoxicity of polychlorinated biphenyls: present status and future considerations. Exp Clin Immunogenet. 1994 ; 11: 149-62
54. Tryphonas H.. The use of non-human primates in the study of PCB immunomodulation. Hum Exp Toxicol. 1995 ; 14: 107-10
55. Washington, DC ; 2005 :
56. U.S. Environmental Protection Agency (2011). Toxicological Review of Trichloroethylene. Washington DC: EPA/635/R-09/011F. http://www.epa.gov/iris/ supdocs/0199index.html. Accessed January, 2012.
57. Wang S. S., Cerhan J. R., Hartge P., Davis S., Cozen W., Severson R. K., Chatterjee N., Yeager M., Chanock S. J., Rothman N.. Common genetic variants in proinflammatory and other immunorgulatory genes and risk for non-Hodgkin's lymphoma. Cancer Res. 2006 ; 66: 9771-80
58. Wang S., Purdue M. P., Cerhan J. R., Zheng T., Menashe I., Armstrong B. K., Lan Q., Hartge P., Kricker A., Zhang Y., Morton L. M., Vajdic C. M., Holdford T. R., Severson R. K., Grulich A., Leaderer B. P., Davis S., Cozen W., Yeager M., Chanock S. J., Chatterjee N., Rothman N.. Common gene variants in tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma risk. PLoS ONE. 2009 ; 4: e5360
59. Wang S. S., Nieters A.. Unraveling the interactions between environmental factors and genetic polymorphisms in non-Hodgkin's lymphoma risk. Expert Rev Anticancer Ther. 2010 ; 10: 403-13
60. Ward J.. Proliferative lesions of the glandular stomach and liver in F344 rats fed diets containing Aroclor 1254. Environ Health Perspect. 1985 ; 60: 89-95
61. Weisglas-Kuperus N., Patandin S., Berbers G.A., Sas T. C., Mulder P. G., Sauer P. J., Hooijkaas H.. Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environ Health Perspect. 2000 ; 108: 1203-7
62. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 2008 ). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th Ed (SwerdlowS. H.CampoE.HarrisN. L.JaffeE. S.PileriS. A.SteinH.ThieleJ. VardimanJ. W., eds.). WHO Press, Geneva, Switzerland. Swerdlow S. H. Campo E. Harris N. L. Jaffe E. S. Pileri S. A. Stein H. Thiele J. Vardiman J. W., ed. Geneva, Switzerland: WHO Press ; 2008 :
63. Wu X. C., Andrews P., Chen V. W., Groves F. D.. Incidence of extranodal non-Hodgkin's lymphomas among whites, blacks, and Asians/Pacific Islanders in the United States: Anatomic site and histology differences. Cancer Epidemiol. 2009 ; 33: 337-46