Electrophysiological effects of the class Ic antiarrhythmic drug pilsicainide on the guinea-pig pulmonary vein myocardium

Journal of Pharmacological Sciences

Volumn 118, Issue 4, 2012, Pages 506-511

  Takahara, Akira ^a   Takeda, Kiyoshi ^a   Tsuneoka, Yayoi ^a   Hagiwara, Mihoko ^a   Namekata, Iyuki ^a   Tanaka, Hikaru ^a  

^a TOHO UNIVERSITY   (Japan)

Author keywords

Action potential; Conduction velocity; Effective refractory period; Pilsicainide; Pulmonary vein myocardium

Indexed keywords

PILSICAINIDE;

ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; FEMALE; GUINEA PIG; HEART CONDUCTION; HEART ELECTROPHYSIOLOGY; HEART LEFT ATRIUM; HEART MUSCLE; HEART MUSCLE REFRACTORY PERIOD; HISTOLOGY; ISOLATED HEART; MALE; MEMBRANE STEADY POTENTIAL; NONHUMAN; PULMONARY VEIN; PULMONARY VEIN ISOLATION;

EID: 84864513738     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.12022FP     Document Type: Article

References (16)

1. Kaarisalo MM, Immonen-Räihä P, Marttila RJ, Salomaa V, Kaarsalo E, Salmi K, et al. Atrial fibrillation and stroke. Mortality and causes of death after the first acute ischemic stroke. Stroke. 1997;28:311-315.
2. Haïssaguerre M, Jaïs P, Shah DC, Takahashi A, Hocini M, Quiniou G, et al. Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins. N Engl J Med. 1998;339:659-666.
3. Ehrlich JR, Cha TJ, Zhang L, Chartier D, Melnyk P, Hohnloser SH, et al. Cellular electrophysiology of canine pulmonary vein cardiomyocytes: action potential and ionic current properties. J Physiol. 2003;551:801-813.
4. 2+ exchanger in the automaticity of guinea-pig pulmonary vein myocardium as revealed by SEA0400. J Pharmacol Sci. 2009;110:111-116.
5. Takahara A, Sugimoto T, Kitamura T, Takeda K, Tsuneoka Y, Namekata I, et al. Electrophysiological and pharmacological characteristics of triggered activity elicited in the guinea-pig pulmonary vein myocardium. J Pharmacol Sci. 2011;115:176-181.
6. Chen YJ, Chen SA, Chang MS, Lin CI. Arrhythmogenic activity of cardiac muscle in pulmonary veins of the dog: implication for the genesis of atrial fibrillation. Cardiovasc Res. 2000;48:265-273.
7. + channel blocker pilsicainide on the electrophysiologic properties of pulmonary veins in patients with atrial fibrillation. J Cardiovasc Electrophysiol. 2004;15:1396-1401.
8. Sakai R, Inoue D, Ishibashi K, Inoue M, Shirayama T, Yamahara Y, et al. Kinetics of frequency-dependent conduction delay by class I antiarrhythmic drugs in human atrium. J Cardiovasc Pharmacol. 1995;25:953-960.
9. Kawase A, Ikeda T, Nakazawa K, Ashihara T, Namba T, Kubota T, et al. Widening of the excitable gap and enlargement of the core of reentry during atrial fibrillation with a pure sodium channel blocker in canine atria. Circulation. 2003;107:905-910.
10. Iwasaki H, Takahara A, Nakamura Y, Satoh Y, Nagai T, Shinkai N, et al. Simultaneous assessment of pharmacokinetics of pilsicainide transdermal patch and its electropharmacological effects on atria of chronic atrioventricular block dogs. J Pharmacol Sci. 2009;110:410-414.
11. Hirose M, Ohkubo Y, Takano M, Hamazaki M, Sekido T, Yamada M. Mechanisms of the preventive effect of pilsicainide on atrial fibrillation originating from the pulmonary vein. Circ J. 2007;71:1805-1814.
12. Spach MS, Heidlage JF, Dolber PC, Barr RC. Electrophysiological effects of remodeling cardiac gap junctions and cell size: experimental and model studies of normal cardiac growth. Circ Res. 2000;86:302-311.
13. max in guinea pig myocardium. Circ Res. 1985;56:696-703.
14. Yamashita T, Murakawa Y, Sezaki K, Hayami N, Inoue M, Fukui E, et al. Uniqueness of pilsicainide in class Ic antiarrhythmics. Jpn Heart J. 1998;39:389-397.
15. Inomata N, Ishihara T, Akaike N. SUN 1165: a new antiarrhythmic Na current blocker in ventricular myocytes of guinea-pig. Comp Biochem Physiol C. 1987;87:237-243.
16. + channel blocking effects of cibenzoline on guinea-pig ventricular cells. Eur J Pharmacol. 1998;352:317-327.