MHC-resident variation affects risks after unrelated donor hematopoietic cell transplantation

Science Translational Medicine

Volumn 4, Issue 144, 2012, Pages

  Petersdorf, Effie W ^a,b   Malkki, Mari ^a   Gooley, Theodore A ^a   Spellman, Stephen R ^c   Haagenson, Michael D ^c   Horowitz, Mary M ^d,e   Wang, Tao ^e  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH   (United States)

^d CENTER FOR INTERNATIONAL BLOOD AND MARROW TRANSPLANT RESEARCH   (United States)

^e MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA A ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; HLA DPB1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DRB1 ANTIGEN;

ACUTE GRAFT VERSUS HOST DISEASE; ADULT; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; GENE; GENE FREQUENCY; GENE IDENTIFICATION; GENE NUMBER; GENETIC MARKER; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA A GENE; HLA B GENE; HLA DPB1 GENE; HLA DQB1 GENE; HLA DRB1 GENE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SHORT SURVEY; SINGLE NUCLEOTIDE POLYMORPHISM; UNRELATED DONORS; VALIDATION STUDY;

ADOLESCENT; ADULT; ALLELES; CHILD; CHILD, PRESCHOOL; FEMALE; GENOTYPE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA-A ANTIGENS; HLA-B ANTIGENS; HLA-DQ BETA-CHAINS; HLA-DRB1 CHAINS; HUMANS; INFANT; INFANT, NEWBORN; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; UNRELATED DONORS; YOUNG ADULT;

EID: 84864509466     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3003974     Document Type: Short Survey

References (33)

1. J. Trowsdale, The MHC, disease and selection. Immunol. Lett. 137, 1-8 (2011).
2. P. J. Norman, P. Parham, Complex interactions: The immunogenetics of human leukocyte antigen and killer cell immunoglobulin-like receptors. Semin. Hematol. 42, 65-75 (2005).
3. A. V. Hill, The immunogenetics of human infectious diseases. Annu. Rev. Immunol. 16, 593-617 (1998).
4. M. Carrington, G. W. Nelson, M. P. Martin, T. Kissner, D. Vlahov, J. J. Goedert, R. Kaslow, S. Buchbinder, K. Hoots, S. J. O'Brien, HLA and HIV-1: Heterozygote advantage and B*35-Cw*04 disadvantage. Science 283, 1748-1752 (1999).
5. J. Dausset, Leuco-agglutinins. IV. Leuco-agglutinins and blood transfusion. Vox Sang. 4, 190-198 (1954).
6. E. W. Petersdorf, J. A. Hansen, P. J. Martin, A. Woolfrey, M. Malkki, T. Gooley, B. Storer, E. Mickelson, A. Smith, C. Anasetti, Major- histocompatibility-complex class I alleles and antigens in hematopoieticcell transplantation. N. Engl. J. Med. 345, 1794-1800 (2001).
7. S. J. Lee, J. Klein, M. Haagenson, L. A. Baxter-Lowe, D. L. Confer, M. Eapen, M. Fernandez-Vina, N. Flomenberg, M. Horowitz, C. K. Hurley, H. Noreen, M. Oudshoorn, E. Petersdorf, M. Setterholm, S. Spellman, D. Weisdorf, T. M. Williams, C. Anasetti, High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood 110, 4576-4583 (2007).
8. E. W. Petersdorf, M. Malkki, T. A. Gooley, P. J. Martin, Z. Guo, MHC haplotype matching for unrelated hematopoietic cell transplantation. PLoS Med. 4, e8 (2007).
9. The International HapMap 3 Consortium, Integrating common and rare genetic variation in diverse human populations. Nature 467, 52-58 (2010).
10. R. Horton, L. Wilming, V. Rand, R. C. Lovering, E. A. Bruford, V. K. Khodiyar, M. J. Lush, S. Povey, C. C. Talbot Jr., M. W. Wright, H. M. Wain, J. Trowsdale, A. Ziegler, S. Beck, Gene map of the extended human MHC. Nat. Rev. Genet. 5, 889-899 (2004).
11. B. E. Shaw, T. A. Gooley, M. Malkki, J. A. Madrigal, A. B. Begovich, M. M. Horowitz, A. Gratwohl, O. Ringdén, S. G. Marsh, E. W. Petersdorf, The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation. Blood 110, 4560-4566 (2007).
12. S. Morishima, S. Ogawa, A. Matsubara, T. Kawase, Y. Nannya, K. Kashiwase, M. Satake, H. Saji, H. Inoko, S. Kato, Y. Kodera, T. Sasazuki, Y. Morishima; Japan Marrow Donor Program, Impact of highly conserved HLA haplotype on acute graft-versus-host disease. Blood 115, 4664-4670 (2010).
13. L. J. Palmer, L. R. Cardon, Shaking the tree: Mapping complex disease genes with linkage disequilibrium. Lancet 366, 1223-1234 (2005).
14. E. J. Yunis, C. E. Larsen, M. Fernandez-Viña, Z. L. Awdeh, T. Romero, J. A. Hansen, C. A. Alper, Inheritable variable sizes of DNA stretches in the human MHC: Conserved extended haplotypes and their fragments or blocks. Tissue Antigens 62, 1-20 (2003).
15. M. M. Miretti, E. C. Walsh, X. Ke, M. Delgado, M. Griffiths, S. Hunt, J. Morrison, P. Whittaker, E. S. Lander, L. R. Cardon, D. R. Bentley, J. D. Rioux, S. Beck, P. Deloukas, A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms. Am. J. Hum. Genet. 76, 634- 646 (2005).
16. Wellcome Trust Case Control Consortium, Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678 (2007).
17. SCAN. SNP and CNV Annotation Database, http://www.scandb.org/ newinterface/about. html [accessed 2 February 2011].
18. M. Sirota, M. A. Schaub, S. Batzoglou, W. H. Robinson, A. J. Butte, Autoimmune disease classification by inverse association with SNP alleles. PLoS Genet. 5, e1000792 (2009).
19. E. Noguchi, H. Sakamoto, T. Hirota, K. Ochiai, Y. Imoto, M. Sakashita, F. Kurosaka, A. Akasawa, S. Yoshihara, N. Kanno, Y. Yamada, N. Shimojo, Y. Kohno, Y. Suzuki, M. J. Kang, J. W. Kwon, S. J. Hong, K. Inoue, Y. Goto, F. Yamashita, T. Asada, H. Hirose, I. Saito, S. Fujieda, N. Hizawa, T. Sakamoto, H. Masuko, Y. Nakamura, I. Nomura, M. Tamari, T. Arinami, T. Yoshida, H. Saito, K. Matsumoto, Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. PLoS Genet. 7, e1002170 (2011).
20. R. M. Plenge, C. Cotsapas, L. Davies, A. L. Price, P. I. de Bakker, J. Maller, I. Pe'er, N. P. Burtt, B. Blumenstiel, M. DeFelice, M. Parkin, R. Barry, W. Winslow, C. Healy, R. R. Graham, B. M. Neale, E. Izmailova, R. Roubenoff, A. N. Parker, R. Glass, E.W. Karlson, N. Maher, D. A. Hafler, D. M. Lee, M. F. Seldin, E. F. Remmers, A. T. Lee, L. Padyukov, L. Alfredsson, J. Coblyn, M. E. Weinblatt, S. B. Gabriel, S. Purcell, L. Klareskog, P. K. Gregersen, N. A. Shadick, M. J. Daly, D. Altshuler, Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat. Genet. 39, 1477-1482 (2007).
21. L. Moutsianas, V. Enciso-Mora, Y. P.Ma, S. Leslie, A. Dilthey, P. Broderick, A. Sherborne, R. Cooke, A. Ashworth, A. J. Swerdlow, G.McVean, R. S. Houlston, Multiple Hodgkin lymphoma-associated loci within the HLA region at chromosome 6p21.3. Blood 118, 670-674 (2011).
22. TargetScan Human Database Release 6.0, http://www.targetscan.org [accessed 15 November 2011].
23. J. L. Ferrara, J. E. Levine, P. Reddy, E. Holler, Graft-versus-host disease. Lancet 373, 1550-1561 (2009).
24. L. Kruglyak, The road to genome-wide association studies. Nat. Rev. Genet. 9, 314-318 (2008). Downloaded from stm.sciencemag.org on July 26, 2012
25. L.M. Foeken, A. Green, C. K.Hurley, E.Marry, T.Wiegand,M.Oudshoorn;Donor RegistriesWorking Group of the World Marrow Donor Association (WMDA), Monitoring the international use of unrelated donors for transplantation: The WMDA annual reports. Bone Marrow Transplant. 45, 811-818 (2010).
26. J. B. Fan, K. L. Gunderson, M. Bibikova, J. M. Yeakley, J. Chen, E. Wickham Garcia, L. L. Lebruska, M. Laurent, R. Shen,D. Barker, Illumina universal bead arrays. Methods Enzymol. 410, 57-73 (2006).
27. Illumina MHC exon centric panel, http://www.illumina.com/products/mhc- exon-centric-panel. ilmn [accessed 1 December 2005].
28. K. J. Livak, J. Marmaro, J. A. Todd, Towards fully automated genome-wide polymorphism screening. Nat. Genet. 9, 341-342 (1995).
29. J. C. Barrett, B. Fry, J. Maller, M. J. Daly, Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265 (2005).
30. S. Purcell, B. Neale, K. Todd-Brown, L. Thomas, M. A. Ferreira, D. Bender, J. Maller, P. Sklar, P. I. de Bakker, M. J. Daly, P. C. Sham, PLINK: A tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007).
31. Genetics" 1.3.4, http://cran.r-project. org/web/packages/ genetics/ [accessed 20 August 2008].
32. K. S. Baker, S. M. Davies, N. S. Majhail, A. Hassebroek, J. P. Klein, K. K. Ballen, C. L. Bigelow, H. A. Frangoul, C. L. Hardy, C. Bredeson, J. Dehn, D. Friedman, T. Hahn, G. Hale, H. M. Lazarus, C. F. LeMaistre, F. Loberiza, D. Maharaj, P. McCarthy, M. Setterholm, S. Spellman, M. Trigg, R. T. Maziarz, G. Switzer, S. J. Lee, J. D. Rizzo, Race and socioeconomic status influence outcomes of unrelated donor hematopoietic cell transplantation. Biol. Blood Marrow Transplant. 15, 1543-1554 (2009).
33. National Library of Medicine, National Center for Biotechnology Information, http://www.ncbi. nlm.nih.gov/projects/mapview/maps.cgi?taxid= 9606&chr=6 [accessed 15 July 15 2011].