Bupivacaine inhibits large conductance, voltage- and Ca2+- activated K+ channels in human umbilical artery smooth muscle cells

Channels

Volumn 6, Issue 3, 2012, Pages 174-180

  Martín, Pedro ^a   Enrique, Nicolás ^a   Palomo, Ana R Roldán ^a   Rebolledo, Alejandro ^a   Milesi, Verónica ^a  

^a FACULTAD DE CIENCIAS EXACTAS   (Argentina)

Author keywords

Bupivacaine; Human umbilical artery; Native vascular smooth muscle; Patch clamp

Indexed keywords

BUPIVACAINE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

ARTERY MUSCLE; ARTICLE; CELL FUNCTION; CELL ISOLATION; CONTROLLED STUDY; DELIVERY; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; LABOR; PATCH CLAMP; PHYSIOLOGY; POTASSIUM CURRENT; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; UMBILICAL ARTERY; WHOLE CELL;

EID: 84864491281     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.20362     Document Type: Article

References (28)

1. Hille B. Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol 1977; 69:497-515; PMID:300786; http://dx.doi.org/10.1085/jgp.69.4.497.
2. Hondeghem LM, Katzung BG. Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim Biophys Acta 1977; 472:373-98; PMID:334262.
3. Sintra Grilo L, Carrupt PA, Abriel H, Daina A. Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization. Eur J Med Chem 2011; 46:3486-98; PMID:21624711; http://dx.doi.org/10.1016/j.ejmech.2011.05.015.
4. Olschewski A, Olschewski H, Bräu ME, Hempelmann G, Vogel W, Safronov BV. Effect of bupivacaine on ATP-dependent potassium channels in rat cardiomyocytes. Br J Anaesth 1999; 82:435-8; PMID:10434831; http://dx.doi.org/ 10.1093/bja/82.3.435.
5. Kindler CH, Yost CS, Gray AT. Local anesthetic inhibition of baseline potassium channels with two pore domains in tandem. Anesthesiology 1999; 90:1092-102; PMID:10201682; http://dx.doi.org/10.1097/00000542-199904000-00024.
6. Nilsson J, Madeja M, Elinder F, Arhem P. Bupivacaine blocks N-type inactivating Kv channels in the open state: no allosteric effect on inactivation kinetics. Biophys J 2008; 95:5138-52; PMID:18790854; http://dx.doi.org/10.1529/ biophysj.108.130518.
7. Johns RA, Seyde WC, DiFazio CA, Longnecker DE. Dose-dependent effects of bupivacaine on rat muscle arterioles. Anesthesiology 1986; 65:186-91; PMID:3740507; http://dx.doi.org/10.1097/00000542-198608000-00010.
8. Monuszko E, Halevy S, Freese K, Liu-Barnett M, Altura B. Vasoactive actions of local anaesthetics on human isolated umbilical veins and arteries. Br J Pharmacol 1989; 97:319-28; PMID:2758218.
9. Tuvemo T, Willdeck-Lund G. Smooth muscle effects of lidocaine, prilocaine, bupivacaine and etiodocaine on the human umbilical artery. Acta Anaesthesiol Scand 1982; 26:104-7; PMID:7102231; http://dx.doi.org/10.1111/j. 1399-6576.1982.tb01734.x.
10. Rossner KL, Natke E, Liu-Barnett M, Freese KJ. A proposed mechanism of bupivacaine-induced contraction of human umbilical artery smooth muscle cells. Int J Obstet Anesth 1999; 8:24-9; PMID:15321172; http://dx.doi.org/10.1016/ S0959-289X(99)80148-4.
11. Milesi V, Raingo J, Rebolledo A, Grassi de Gende AO. Potassium channels in human umbilical artery cells. J Soc Gynecol Investig 2003; 10:339-46; PMID:12969776; http://dx.doi.org/10.1016/S1071-5576(03)00117-5.
12. Woodhull AM. Ionic blockage of sodium channels in nerve. J Gen Physiol 1973; 61:687-708; PMID:4541078; http://dx.doi.org/10.1085/jgp.61.6.687.
13. Sanchez DY, Blatz AL. Block of neuronal fast chloride channels by internal tetraethylammonium ions. J Gen Physiol 1994; 104:173-90; PMID:7964594; http://dx.doi.org/10.1085/jgp.104.1.173.
14. Yellen G. Ionic permeation and blockade in Ca2+-activated K+ channels of bovine chromaffin cells. J Gen Physiol 1984; 84:157-86; PMID:6092514; http://dx.doi.org/10.1085/jgp.84.2.157.
15. Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol 1995; 268:799-822; PMID:7733230.
16. Sah P, Davies P. Calcium-activated potassium currents in mammalian neurons. Clin Exp Pharmacol Physiol 2000; 27:657-63; PMID:10972528; http://dx.doi.org/10.1046/j.1440-681.2000.03317.x.
17. Ralston DH, Shnider SM. The fetal and neonatal effects of regional anesthesia in obstetrics. Anesthesiology 1978; 48:34-64; PMID:339784; http://dx.doi.org/10.1097/00000542-197801000-00007.
18. Scanlon JW, Ostheimer GW, Lurie AO, Brown wu JR, Weiss JB, Alper MH. Neurobehavioral responses and drugs in newborns after epidural anesthesia with bupivacaine. Anesthesiology 1976; 45:400-5; PMID:973691; http://dx.doi.org/10. 1097/00000542-197610000-00008.
19. Abboud TK, Khoo SS, Miller F, Doan T, Henriksen EH. Maternal, fetal and neonatal responses after epidural anesthesia with bupivacaine, 2-chloroprocaine or lidocaine. Anesth Analg 1982; 61:638-44; PMID:7201266; http://dx.doi.org/10. 1213/00000539-198208000-00003.
20. Alahuhta S, Räsänen J, Jouppila P, Kangas-Saarela T, Jouppila R, Westerling P, et al. The effects of epidural ropivacaine and bupivacaine for cesarean section on uteroplacental and fetal circulation. Anesthesiology 1995; 83:23-32; PMID:7605013; http://dx.doi.org/10.1097/00000542-199507000-00004.
21. Morishima HO, Ishizaki A, Zhang Y, Whittington RA, Suckow RF, Cooper TB. Disposition of bupivacaine and its metabolites in the maternal, placental and fetal compartments in rats. Anesthesiology 2000; 93:1069-74; PMID:11020763; http://dx.doi.org/10.1097/00000542-200010000-00031.
22. Klöckner U. Intracellular calcium ions activate a low-conductance chloride channel in smooth-muscle cells isolated from human mesenteric artery. Pflugers Arch 1993; 424:231-7; PMID:8414911; http://dx.doi.org/10.1007/ BF00384347.
23. Raingo J, Rebolledo A, Iveli F, Grassi de Gende AO, Milesi V. Non-selective cationic channels (NSCC) in smooth muscle cells from human umbilical arteries. Placenta 2004; 25:723-9; PMID:15450390; http://dx.doi.org/ 10.1016/j.placenta.2004.01.028.
24. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981; 391:85-100; PMID:6270629; http://dx.doi.org/10.1007/BF00656997.
25. Hille B. Potassium channels in myelinated nerve. Selective permeability to small cations. J Gen Physiol 1973; 61:669-86; PMID:4541077; http://dx.doi.org/10.1085/jgp.61.6.669.
26. Goldman DE. Potential, impedance and rectification in membranes. J Gen Physiol 1943; 27:37-60; PMID:19873371; http://dx.doi.org/10.1085/jgp.27.1.37.
27. Hodgkin AL, Katz B. The effect of sodium ions on the electrical activity of giant axon of the squid. J Physiol 1949; 108:37-77; PMID:18128147.
28. Blatz AL, Magleby KL. Ion conductance and selectivity of single calcium-activated potassium channels in cultured rat muscle. J Gen Physiol 1984; 84:1-23; PMID:6086805; http://dx.doi.org/10.1085/jgp.84.1.1.