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Volumn 4, Issue 3, 2012, Pages 139-147

Improving survival and limiting toxicity: Latest advances in treating human epidermal growth factor receptor 2 overexpressing breast cancer

Author keywords

breast cancer; HER2 overexpressing; human epidermal growth factor receptor 2; lapatinib; pertuzumab; trastuzumab; trastuzumab emtansine

Indexed keywords

ANTHRACYCLINE; CAPECITABINE; CYCLOPHOSPHAMIDE; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; ESTROGEN RECEPTOR; EVEROLIMUS; FLUOROURACIL; LAPATINIB; LETROZOLE; NAVELBINE; PACLITAXEL; PERTUZUMAB; PROGESTERONE RECEPTOR; TAXANE DERIVATIVE; TRASTUZUMAB; TRASTUZUMAB EMTANSINE;

EID: 84864490937     PISSN: 17588340     EISSN: 17588359     Source Type: Journal    
DOI: 10.1177/1758834012440834     Document Type: Review
Times cited : (3)

References (31)
  • 1
    • 0035125614 scopus 로고    scopus 로고
    • Clinical trials of Herceptin(R) (trastuzumab)
    • Baselga J. (2001) Clinical trials of Herceptin(R) (trastuzumab). Eur J Cancer 37(Suppl. 1): 18–24.
    • (2001) Eur J Cancer , vol.37 , pp. 18-24
    • Baselga, J.1
  • 2
    • 79952258750 scopus 로고    scopus 로고
    • First results of the NeoALTTO trial (BIG 01-06 / EGF 106903): a phase III, randomized, open label, neoadjuvant study of lapatinib, trastuzumab, and their combination plus paclitaxel in women with HER2-positive primary breast cancer
    • abstract S3–3
    • Baselga J. Bradbury I. Eidtmann H. Di Cosimo S. Aura C. de Azambuja E. et al. (2010 a) First results of the NeoALTTO trial (BIG 01-06 / EGF 106903): a phase III, randomized, open label, neoadjuvant study of lapatinib, trastuzumab, and their combination plus paclitaxel in women with HER2-positive primary breast cancer. Cancer Res 70(Suppl. 2): 82s, abstract S3–3.
    • (2010) Cancer Res , vol.70 , pp. 82s
    • Baselga, J.1    Bradbury, I.2    Eidtmann, H.3    Di Cosimo, S.4    Aura, C.5    de Azambuja, E.6
  • 3
    • 77949903478 scopus 로고    scopus 로고
    • Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
    • Baselga J. Gelmon K.A. Verma S. Wardley A. Conte P. Miles D. et al. (2010 b) Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol 28: 1138–1144.
    • (2010) J Clin Oncol , vol.28 , pp. 1138-1144
    • Baselga, J.1    Gelmon, K.A.2    Verma, S.3    Wardley, A.4    Conte, P.5    Miles, D.6
  • 4
    • 84862914692 scopus 로고    scopus 로고
    • Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer
    • Baselga J. Cortes J. Kim S. Im S. Hegg R. Im Y. et al. (2011) Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer. NEJM 366: 109–119.
    • (2011) NEJM , vol.366 , pp. 109-119
    • Baselga, J.1    Cortes, J.2    Kim, S.3    Im, S.4    Hegg, R.5    Im, Y.6
  • 5
    • 77949884661 scopus 로고    scopus 로고
    • Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
    • Blackwell K.L. Burstein H.J. Storniolo A.M. Rugo H. Sledge G. Koehler M. et al. (2010) Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol 28: 1124–1130.
    • (2010) J Clin Oncol , vol.28 , pp. 1124-1130
    • Blackwell, K.L.1    Burstein, H.J.2    Storniolo, A.M.3    Rugo, H.4    Sledge, G.5    Koehler, M.6
  • 6
    • 0035873822 scopus 로고    scopus 로고
    • Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer
    • Burstein H.J. Kuter I. Campos S.M. Gelman R.S. Tribou L. Parker L.M. et al. (2001) Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer. J Clin Oncol 19: 2722–2730.
    • (2001) J Clin Oncol , vol.19 , pp. 2722-2730
    • Burstein, H.J.1    Kuter, I.2    Campos, S.M.3    Gelman, R.S.4    Tribou, L.5    Parker, L.M.6
  • 7
    • 80051508992 scopus 로고    scopus 로고
    • TBCRC 006: a multicenter phase II study of neoadjuvant lapatinib and trastuzumab in patients with HER2-overexpressing breast cancer
    • abstract 505
    • Chang J.C.N. Mayer I.A. Forero-Torres A. Nanda R. Goetz M.P. Rodriguez A.A. et al. (2011) TBCRC 006: a multicenter phase II study of neoadjuvant lapatinib and trastuzumab in patients with HER2-overexpressing breast cancer. J Clin Oncol 29(Suppl.): abstract 505.
    • (2011) J Clin Oncol , vol.29
    • Chang, J.C.N.1    Mayer, I.A.2    Forero-Torres, A.3    Nanda, R.4    Goetz, M.P.5    Rodriguez, A.A.6
  • 8
    • 37049033440 scopus 로고    scopus 로고
    • Lapatinib (L) with paclitaxel compared to paclitaxel as first-line treatment for patients with metastatic breast cancer: a phase III randomized, double-blind study of 580 patients
    • Di Leo A. Gomez H. Aziz Z. Zvirbule Z. Arbushites M. Oliva C.R. et al. (2007) Lapatinib (L) with paclitaxel compared to paclitaxel as first-line treatment for patients with metastatic breast cancer: a phase III randomized, double-blind study of 580 patients. Proc Am Soc Clin Oncol 25(18 Suppl.): 34s.
    • (2007) Proc Am Soc Clin Oncol , vol.25 , Issue.18 Suppl. , pp. 34s
    • Di Leo, A.1    Gomez, H.2    Aziz, Z.3    Zvirbule, Z.4    Arbushites, M.5    Oliva, C.R.6
  • 9
    • 20244374413 scopus 로고    scopus 로고
    • Biomarker changes during neoadjuvant anastrozole, tamoxifen, or the combination: influence of hormonal status and HER-2 in breast cancer – a study from the IMPACT trialists
    • Dowsett M. Ebbs S.R. Dixon J.M. Skene A. Griffith C. Boeddinghaus I. et al. (2005) Biomarker changes during neoadjuvant anastrozole, tamoxifen, or the combination: influence of hormonal status and HER-2 in breast cancer – a study from the IMPACT trialists. J Clin Oncol 23: 2477–2492.
    • (2005) J Clin Oncol , vol.23 , pp. 2477-2492
    • Dowsett, M.1    Ebbs, S.R.2    Dixon, J.M.3    Skene, A.4    Griffith, C.5    Boeddinghaus, I.6
  • 10
    • 1842863554 scopus 로고    scopus 로고
    • Greater Ki 67 response after 2 weeks neoadjuvant treatment with anastrozole (A) than with tamoxifen (T) or anastrozole plus tamoxifen (C) in the IMPACT trial: a potential predictor of relapse-free survival
    • Dowsett M. Smith I.E. Ebbs S.R. Dixon J.M. Skene A. Griffith C. et al. (2003) Greater Ki 67 response after 2 weeks neoadjuvant treatment with anastrozole (A) than with tamoxifen (T) or anastrozole plus tamoxifen (C) in the IMPACT trial: a potential predictor of relapse-free survival. Breast Cancer Res Treat 82(Suppl. 1): S6.
    • (2003) Breast Cancer Res Treat , vol.82 , pp. S6
    • Dowsett, M.1    Smith, I.E.2    Ebbs, S.R.3    Dixon, J.M.4    Skene, A.5    Griffith, C.6
  • 11
    • 84867842898 scopus 로고    scopus 로고
    • MARIANNE: a phase III, randomized study of trastuzumab-DM1 (T-DM1) with or without pertuzumab (P) compared with trastuzumab (H) plus taxane for first-line treatmetn of HER2-positive, progressive, or recurrent locally advanced or metastatic breast cancer (MBC)
    • abstract TPS 102
    • Ellis P.A. Barrios C.H. Im Y. Patre M. Branle F. Perez E.A. et al. (2011) MARIANNE: a phase III, randomized study of trastuzumab-DM1 (T-DM1) with or without pertuzumab (P) compared with trastuzumab (H) plus taxane for first-line treatmetn of HER2-positive, progressive, or recurrent locally advanced or metastatic breast cancer (MBC). J Clin Oncol 29(Suppl.): abstract TPS 102.
    • (2011) J Clin Oncol , vol.29
    • Ellis, P.A.1    Barrios, C.H.2    Im, Y.3    Patre, M.4    Branle, F.5    Perez, E.A.6
  • 13
    • 75149145066 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2-negative cohort
    • Gianni L. Eiermann W. Semiglazov V. Manikhas A. Lluch A. Tjulandin S. et al. (2010 a) Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2-negative cohort. Lancet 375: 377–384.
    • (2010) Lancet , vol.375 , pp. 377-384
    • Gianni, L.1    Eiermann, W.2    Semiglazov, V.3    Manikhas, A.4    Lluch, A.5    Tjulandin, S.6
  • 14
    • 79952274439 scopus 로고    scopus 로고
    • Neoadjuvant pertuzumab (P) and trastuzumab (H): antitumor and safety analysis of a randomized phase II study (‘NeoSphere’)
    • abstract S3-2
    • Gianni L. Pienkowski T. Im Y-H. Roman L. Tseng L-M. Liu M-C. et al. (2010 b) Neoadjuvant pertuzumab (P) and trastuzumab (H): antitumor and safety analysis of a randomized phase II study (‘NeoSphere’). Cancer Res 70(Suppl. 2):82s, abstract S3-2.
    • (2010) Cancer Res , vol.70 , pp. 82s
    • Gianni, L.1    Pienkowski, T.2    Im, Y-H.3    Roman, L.4    Tseng, L-M.5    Liu, M-C.6
  • 15
    • 46449113024 scopus 로고    scopus 로고
    • Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer
    • Gomez H.L. Doval D.C. Chavez M.A. Ang P.C. Aziz Z. Nag S. et al. (2008) Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer. J Clin Oncol 26: 2999–3005.
    • (2008) J Clin Oncol , vol.26 , pp. 2999-3005
    • Gomez, H.L.1    Doval, D.C.2    Chavez, M.A.3    Ang, P.C.4    Aziz, Z.5    Nag, S.6
  • 16
    • 11444251764 scopus 로고    scopus 로고
    • Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years’ adjuvant treatment for breast cancer
    • Howell A. Cuzick J. Baum M. Buzdar A. Dowsett M. Forbes J.F. et al. (2005) Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years’ adjuvant treatment for breast cancer. Lancet 365: 60–62.
    • (2005) Lancet , vol.365 , pp. 60-62
    • Howell, A.1    Cuzick, J.2    Baum, M.3    Buzdar, A.4    Dowsett, M.5    Forbes, J.F.6
  • 17
    • 77949747074 scopus 로고    scopus 로고
    • A phase II study of trastuzumab-DM1 (T-DM1), a novel HER 2 antibody-drug conjugate, in patients previously treated with lapatinib, trastuzumab, and chemotherapy
    • abstract 5090
    • Krop I.E. LoRosso P. Miller K.D. Modi S. Yardley D. Rodriguez G. et al. (2009) A phase II study of trastuzumab-DM1 (T-DM1), a novel HER 2 antibody-drug conjugate, in patients previously treated with lapatinib, trastuzumab, and chemotherapy. Cancer Res 69(24 Suppl.): abstract 5090.
    • (2009) Cancer Res , vol.69 , Issue.24 Suppl.
    • Krop, I.E.1    LoRosso, P.2    Miller, K.D.3    Modi, S.4    Yardley, D.5    Rodriguez, G.6
  • 19
    • 42949112556 scopus 로고    scopus 로고
    • Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer
    • Lin N.U. Carey L.A. Liu M.C. Younger J. Come S.E. Ewend M. et al. (2008) Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol 26: 1993–1999.
    • (2008) J Clin Oncol , vol.26 , pp. 1993-1999
    • Lin, N.U.1    Carey, L.A.2    Liu, M.C.3    Younger, J.4    Come, S.E.5    Ewend, M.6
  • 20
    • 79955843985 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab-DM1 versus trastuzumab plus docetaxel in HER2-positive metastatic breast cancer patients with no prior chemotherapy for metastatic disease: preliminary results of a randomized, multicenter, open-label phase 2 study
    • Oct ESMO Meeting Milan, Italy abstract LBA3
    • Perez E. Dirix L. Kocsis J. Gianni L. Lu J. Vinholes J. et al. (Oct 2010) Efficacy and safety of trastuzumab-DM1 versus trastuzumab plus docetaxel in HER2-positive metastatic breast cancer patients with no prior chemotherapy for metastatic disease: preliminary results of a randomized, multicenter, open-label phase 2 study. ESMO Meeting, Milan, Italy, abstract LBA3.
    • (2010)
    • Perez, E.1    Dirix, L.2    Kocsis, J.3    Gianni, L.4    Lu, J.5    Vinholes, J.6
  • 22
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond E.H. Perez E.A. Bryant J. Suman V.J. Geyer C.E. Jr Davidson N.E. et al. (2005) Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 353: 1673–1684.
    • (2005) N Engl J Med , vol.353 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3    Suman, V.J.4    Geyer, C.E.5    Davidson, N.E.6
  • 23
    • 0035553174 scopus 로고    scopus 로고
    • The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo
    • Rusnak D.W. Lackey K. Affleck K. Wood E.R. Alligood K.J. Rhodes N. et al. (2001) The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther 1: 85–94.
    • (2001) Mol Cancer Ther , vol.1 , pp. 85-94
    • Rusnak, D.W.1    Lackey, K.2    Affleck, K.3    Wood, E.R.4    Alligood, K.J.5    Rhodes, N.6
  • 24
    • 34247588567 scopus 로고    scopus 로고
    • Expression of p95HER2, a truncated form of the HER 2 receptor, and response to anti-HER2 therapies in breast cancer
    • Scaltriti M. Rojo F. Ocana A. Anido J. Guzman M. Cortes J. et al. (2007) Expression of p95HER2, a truncated form of the HER 2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst 99: 628–638.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 628-638
    • Scaltriti, M.1    Rojo, F.2    Ocana, A.3    Anido, J.4    Guzman, M.5    Cortes, J.6
  • 25
    • 77957300459 scopus 로고    scopus 로고
    • Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC -> T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC -> TH) with docetaxel, carboplatin and trastuzumab (TCH) in Her2neu positive early breast cancer patients: BCIRG 006 Study
    • Dec San Antonio Breast Cancer Symposium Texas, USA abstract 64
    • Slamon D.J. Eiermann W. Robert N. Pienkowski T. Martin M. Rolski J. et al. (Dec 2009) Phase III randomized trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC -> T) with doxorubicin and cyclophosphamide followed by docetaxel and trastuzumab (AC -> TH) with docetaxel, carboplatin and trastuzumab (TCH) in Her2neu positive early breast cancer patients: BCIRG 006 Study. San Antonio Breast Cancer Symposium, Texas, USA, 2009, abstract 64.
    • (2009)
    • Slamon, D.J.1    Eiermann, W.2    Robert, N.3    Pienkowski, T.4    Martin, M.5    Rolski, J.6
  • 26
    • 24644490871 scopus 로고    scopus 로고
    • Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: the Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double-blind randomized trial
    • Smith I.E. Dowsett M. Ebbs S.R. Dixon J.M. Skene A. Blohmer J.U. et al. (2005) Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: the Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double-blind randomized trial. J Clin Oncol 23: 5108–5116.
    • (2005) J Clin Oncol , vol.23 , pp. 5108-5116
    • Smith, I.E.1    Dowsett, M.2    Ebbs, S.R.3    Dixon, J.M.4    Skene, A.5    Blohmer, J.U.6
  • 27
    • 33845914783 scopus 로고    scopus 로고
    • 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial
    • Smith I. Procter M. Gelber R.D. Guillaume S. Feyereislova A. Dowsett M. et al. (2007) 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet 369: 29–36.
    • (2007) Lancet , vol.369 , pp. 29-36
    • Smith, I.1    Procter, M.2    Gelber, R.D.3    Guillaume, S.4    Feyereislova, A.5    Dowsett, M.6
  • 28
    • 84859434396 scopus 로고    scopus 로고
    • Lapatinib vs. trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy: primary efficacy endpoint analysis of the Gueparquinto study (GBG 44)
    • Dec San Antonio Breast Cancer Symposium Texas, USA abstract S3-1
    • Untch M. Loibl S. Bischoff J. Eidtmann H. Kaufmann M. Blohmer J.U. et al. (Dec 2010) Lapatinib vs. trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy: primary efficacy endpoint analysis of the Gueparquinto study (GBG 44). San Antonio Breast Cancer Symposium, Texas, USA, 2010, abstract S3-1.
    • (2010)
    • Untch, M.1    Loibl, S.2    Bischoff, J.3    Eidtmann, H.4    Kaufmann, M.5    Blohmer, J.U.6
  • 29
    • 0036467826 scopus 로고    scopus 로고
    • Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
    • Vogel C.L. Cobleigh M.A. Tripathy D. Gutheil J.C. Harris L.N. Fehrenbacher L. et al. (2002) Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 20: 719–726.
    • (2002) J Clin Oncol , vol.20 , pp. 719-726
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3    Gutheil, J.C.4    Harris, L.N.5    Fehrenbacher, L.6
  • 30
    • 70350623516 scopus 로고    scopus 로고
    • A phase II study of trastuzumab-DM1 (TDM1), a HER2 antibody-drug conjugate (ADC), in patients with HER2+ metastatic breast cancer: final results
    • Vogel C.L. Burris H.A. Limentani S. Borson R. O'Shaughnessy J. Vukelja S. et al. (2009) A phase II study of trastuzumab-DM1 (TDM1), a HER2 antibody-drug conjugate (ADC), in patients with HER2+ metastatic breast cancer: final results. J Clin Oncol 27(Suppl.): 15s.
    • (2009) J Clin Oncol , vol.27 , pp. 15s
    • Vogel, C.L.1    Burris, H.A.2    Limentani, S.3    Borson, R.4    O'Shaughnessy, J.5    Vukelja, S.6


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