Development and characterization of phyto-vesicles of wedelolactone for hepatoprotective activity

Drug Development and Industrial Pharmacy

Volumn 38, Issue 9, 2012, Pages 1152-1158

  Upadhyay, Kirti ^a   Gupta, Nishant Kumar ^a   Dixit, Vinod Kumar ^a  

^a DR H S GOUR UNIVERSITY   (India)

Author keywords

Absorption; Bioavailability; Complexation; Hepatoprotective activity; Pharmacokinetic; Phosphatidyl choline; Phyto vesicles; Wedelolactone

Indexed keywords

PHOSPHATIDYLCHOLINE; WEDELOLACTONE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG SOLUBILITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; LIVER PROTECTION; MELTING POINT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; ANTI-BACTERIAL AGENTS; CARBON TETRACHLORIDE; CELL SURVIVAL; CELLS, CULTURED; COUMARINS; DRUG DELIVERY SYSTEMS; ECLIPTA; HEMOSTATICS; HEPATOCYTES; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INDIA; MICELLES; PHOSPHATIDYLCHOLINES; PLANT EXTRACTS; PLANT LEAVES; PROTECTIVE AGENTS; RATS; SOLUBILITY; TRANSITION TEMPERATURE;

EID: 84864476380     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2011.643892     Document Type: Article

References (33)

1. Sharma PC, Yelne MB, Denn's TJ. Database on medicinal plants used in Ayurveda. New Delhi: Central council for research in Ayurveda and Siddha; 2001. p 114.
2. Bhargava KK, Krishnaswamy NR, Seshadri TR. Desmethylwedelolactone glucoside from Eclipta alba Leaves. Ind J Chem, 1972;10: 810-811.
3. Abdel-Kader MS, Bahler BD, Malone S, Werkhoven MC, van Troon F, David et al. (1998). DNA-damaging steroidal alkaloids from Eclipta alba from the suriname rainforest1. J Nat Prod, 61:1202-1208.
4. Das B, Chakravarty AK. Ecliptal: A new terthienyl aldehyde from Eclipta alba. Ind J Chem, 1991;30:1052-1053.
5. Upadhyay RK, Pandey MB, Jha RN, Pandey VB. (2001). Eclalbatin, a triterpene saponin from Eclipta alba. J Asian Nat Prod Res, 3:213-217.
6. Wagner H, Fessler B. Coumestans as the main active principles of the liver drugs Eclipta alba and Wedelia calendulaceae. Plant Med, 1986;52:374-377.
7. Ma-Ma K, Nyunt N, Tin KM. (1978). The protective effect of Eclipta alba on carbon tetrachloride-induced acute liver damage. Toxicol Appl Pharmacol, 45:723-728.
8. Dixit SP, Achar MP. Study of Bhringaraj [Eclipta alba] therapy in jaundice in children. Curr Med Pract, 1979;23:237-242.
9. Ananthi J, Prakasam A, Pugalendi KV. (2003). Antihyperglycemic activity of Eclipta alba leaf on alloxan-induced diabetic rats. Yale J Biol Med, 76:97-102.
10. Do Tat Loi. "The Vietnamese medicinal plants and ingredients". Hanoi: Publishing House Medicine; 2004. p 282.
11. Sagar BPS, Panwar R, Goswami A, Kadian K, Tyagi K, Chugh M, Dalal S, Zafar R. Pharmacokinetic interactions of antihepatotoxic Wedelolactone with paracetamol in Wistar albino rats. Pharmaceut Bio, 2006;44:554-561.
12. Nakaguchi O, Okamoto H, Matsuyama Y, Katsurada M, Sakano T. Hair Growth stimulants contain Wedelolactone from Eclipta alba, 2000:134.
13. Wu J, Danielsson A, Zern MA. (1999). Toxicity of hepatotoxins: New insights into mechanisms and therapy. Expert Opin Investig Drugs, 8:585-607.
14. Vitaglione P, Morisco F, Caporaso N, Fogliano V. (2004). Dietary antioxidant compounds and liver health. Crit Rev Food Sci Nutr, 44:575-586.
15. Recknagel RO. Carbon tetrachloride hepatotoxicity. Life Sciences, 1983;33:401-408.
16. Saxena AK, Singh B, Anand KK. (1993). Hepatoprotective effects of Eclipta alba on subcellular levels in rats. J Ethnopharmacol, 40:155-161.
17. Lieber CS, Robins SJ, Li J, DeCarli LM, Mak KM, Fasulo JM et al. (1994). Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon. Gastroenterology, 106:152-159.
18. Mascarella S, Giusti A, Marra F, Marena C, Lampertico M, Relli P, Gentilini P, Buzzelli G. Therapeutic and antilipoperoxidant effects of silybin phosphatidyl choline complex in chronic liver disease: Preliminary results. Curr Ther Res, 1993;53:98-102.
19. Gupta NK, Dixit VK. (2011). Bioavailability enhancement of curcumin by complexation with phosphatidyl choline. J Pharm Sci, 100:1987-1995.
20. Gupta NK, Dixit VK. (2011). Development and evaluation of vesicular system for curcumin delivery. Arch Dermatol Res, 303:89-101.
21. Gupta NK, Dixit VK. (2011). Absorption enhancement of grape seed polyphenols by complexation with phosphatidyl choline. Drug Deliv, 18:312-319.
22. Sharma A, Gupta NK, Dixit VK. (2010). Complexation with phosphatidyl choline as a strategy for absorption enhancement of boswellic acid. Drug Deliv, 17:587-595.
23. Rajpal Y. Standardization of botanicals. New Delhi: Eastern Publishers; 2002. pp 95-101.
24. Viet Thanh NT, Van Dau N. Bioactive principles of the Vietnamese Eclipta alba (l.) Hassk (Asteraceae). J Chem, 2006;44:777-781.
25. Bombardelli E, Curri SB, Loggia DR, Tubaro A, Gariboldi P. Complexes between phospholipids and vegetal derivatives of biological interest. Fitoterapia, 1989;60:1-9.
26. Handa SA, Sharma A, Chakraborti KK. Natural products and plants as liver protecting drugs. Fitoterapia, 1986;57:307-351.
27. Kiso Y, Tohkin M, Hikino H. (1983). Assay method for antihepatotoxic activity using carbon tetrachloride induced cytotoxicity in primary cultured hepatocytes.. Planta Med, 49:222-225.
28. Seglen PO. (1976). Preparation of isolated rat liver cells. Methods Cell Biol, 13:29-83.
29. Visen PKS, Shukla B, Patnaik GK, Chandra R, Singh V, Kapoor NK, Dhawan BN. Hepatoprotective activity of picroliv isolated from Picrorrhiza kurroa against thioacetamide toxicity on rat hepatocytes. Phytother Res, 1991;5:224-227.
30. Reitman S, Frankel S. (1957). A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol, 28:56-63.
31. Haslam G, Wyatt D, Kitos PA. (2000). Estimating the number of viable animal cells in multi-well cultures based on their lactate dehydrogenase activities. Cytotechnology, 32:63-75.
32. Das SK, Vasudevan DM. Effect of lecithin in the treatment of ethanol mediated free radical induced hepatotoxicity. Indian J Clin Biochem, 2006;21:62-69.
33. Raj PV, Nitesh K, Chandrashekhar HR, Rao CM, Rao JV, Udupa N. (2010). Effect of lecithin and silymarin on d-galactosamine induced toxicity in isolated hepatocytes and rats. Indian J Clin Biochem, 25:169-74.