Enhanced exercise performance and survival associated with evidence of autonomic reinnervation in pediatric heart transplant recipients

American Journal of Transplantation

Volumn 12, Issue 8, 2012, Pages 2157-2163

  Vanderlaan, R D ^a   Conway, J ^a   Manlhiot, C ^a   McCrindle, B W ^a   Dipchand, A I ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Autonomic reinnervation; heart rate variability; heart transplant; pediatric

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; AUTONOMIC REINNERVATION; CHILD; CONGENITAL HEART DISEASE; EXERCISE; FEMALE; HEART RATE VARIABILITY; HEART TRANSPLANTATION; HOLTER MONITORING; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PEDIATRICS; PRESCHOOL CHILD; PRIORITY JOURNAL; REINNERVATION; SCHOOL CHILD; SURVIVAL;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; EXERCISE TEST; FEMALE; HEART; HEART TRANSPLANTATION; HUMANS; INFANT; INFANT, NEWBORN; MALE; RETROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 84864471152     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2012.04046.x     Document Type: Article

References (34)

1. Kirk R, Edwards LB, Kucheryavaya AY, et al,. The Registry of the International Society for Heart and Lung Transplantation: Thirteenth official pediatric heart transplantation report-2010. J Heart Lung Transplant 2010; 29: 1119-1128.
2. Marconi C, Marzorati M, Fiocchi R, et al,. Age-related heart rate response to exercise in heart transplant recipients. Functional significance. Pflugers Arch 2002; 443: 698-706.
3. Hsu DT, Garofano RP, Douglas JM, et al,. Exercise performance after pediatric heart transplantation. Circulation 1993; 88 (5 Pt 2): II238-II242.
4. Givertz MM, Hartley LH, Colucci WS,. Long-term sequential changes in exercise capacity and chronotropic responsiveness after cardiac transplantation. Circulation 1997; 96: 232-237.
5. Wilson RF, Laxson DD, Christensen BV, McGinn AL, Kubo SH,. Regional differences in sympathetic reinnervation after human orthotopic cardiac transplantation. Circulation 1993; 88: 165-171.
6. Schwaiger M, Hutchins GD, Kalff V, et al,. Evidence for regional catecholamine uptake and storage sites in the transplanted human heart by positron emission tomography. J Clin Invest 1991; 87: 1681-1690.
7. De Marco T, Dae M, Yuen-Green MS, et al,. Iodine-123 metaiodobenzylguanidine scintigraphic assessment of the transplanted human heart: Evidence for late reinnervation. J Am Coll Cardiol 1995; 25: 927-931.
8. Huikuri HV, Exner DV, Kavanagh KM, et al,. Attenuated recovery of heart rate turbulence early after myocardial infarction identifies patients at high risk for fatal or near-fatal arrhythmic events. Heart Rhythm 2010; 7: 229-235.
9. Wilson RF, Christensen BV, Olivari MT, Simon A, White CW, Laxson DD,. Evidence for structural sympathetic reinnervation after orthotopic cardiac transplantation in humans. Circulation 1991; 83: 1210-1220.
10. Uberfuhr P, Ziegler S, Schwaiblmair M, Reichart B, Schwaiger M,. Incomplete sympathic reinnervation of the orthotopically transplanted human heart: Observation up to 13 years after heart transplantation. Eur J Cardiothorac Surg 2000; 17: 161-168.
11. Uberfuhr P, Frey AW, Ziegler S, Reichart B, Schwaiger M,. Sympathetic reinnervation of sinus node and left ventricle after heart transplantation in humans: Regional differences assessed by heart rate variability and positron emission tomography. J Heart Lung Transplant 2000; 19: 317-323.
12. Beckers F, Ramaekers D, Speijer G, et al,. Different evolutions in heart rate variability after heart transplantation: A 10-year follow-up. Transplantation 2004; 78: 1523-1531.
13. Wilson RF, Johnson TH, Haidet GC, Kubo SH, Mianuelli M,. Sympathetic reinnervation of the sinus node and exercise hemodynamics after cardiac transplantation. Circulation 2000; 101: 2727-2733.
14. Bengel FM, Ueberfuhr P, Schiepel N, Nekolla SG, Reichart B, Schwaiger M,. Effect of sympathetic reinnervation on cardiac performance after heart transplantation. N Engl J Med 2001; 345: 731-738.
15. Pozza RD, Kleinmann A, Bechtold S, Fuchs A, Netz H,. Reinnervation after heart transplantation in children: Results of short-time heart rate variability testing. Pediatr Transplant 2006; 10: 429-433.
16. Constant I, Girard A, Le Bidois J, Villain E, Laude D, Elghozi JL,. Spectral analysis of systolic blood pressure and heart rate after heart transplantation in children. Clin Sci 1995; 88: 95-102.
17. Singh TP, Gauvreau K, Rhodes J, Blume ED,. Longitudinal changes in heart rate recovery after maximal exercise in pediatric heart transplant recipients: Evidence of autonomic re-innervation? J Heart Lung Transplant 2007 Dec; 26: 1306-1312.
18. Dipchand AI, Manlhiot C, Russell JL, Gurofsky R, Kantor PF, McCrindle BW,. Exercise capacity improves with time in pediatric heart transplant recipients. J Heart Lung Transplant 2009; 28: 585-590.
19. Akselrod S, Gordon D, Ubel FA, Shannon DC, Berger AC, Cohen RJ,. Power spectrum analysis of heart rate fluctuation: A quantitative probe of beat-to-beat cardiovascular control. Science 1981; 213: 220-222.
20. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 1996; 93: 1043-1065.
21. Longin E, Dimitriadis C, Shazi S, Gerstner T, Lenz T, Konig S,. Autonomic nervous system function in infants and adolescents: Impact of autonomic tests on heart rate variability. Pediatr Cardiol 2009; 30: 311-324.
22. Ramaekers D, Ector H, Aubert AE, Rubens A, Van de Werf F,. Heart rate variability and heart rate in healthy volunteers. Is the female autonomic nervous system cardioprotective? Eur Heart J 1998; 19: 1334-1341.
23. Burke MN, McGinn AL, Homans DC, Christensen BV, Kubo SH, Wilson RF,. Evidence for functional sympathetic reinnervation of left ventricle and coronary arteries after orthotopic cardiac transplantation in humans. Circulation 1995; 91: 72-78.
24. Keeley EC, Toth ZK, Goldberg AD,. Long-term assessment of heart rate variability in cardiac transplant recipients. J Heart Lung Transplant 2000; 19: 310-312.
25. Uberfuhr P, Frey AW, Reichart B,. Vagal reinnervation in the long term after orthotopic heart transplantation. J Heart Lung Transplant 2000; 19: 946-950.
26. Bernardi L, Valenti C, Wdowczyck-Szulc J, et al,. Influence of type of surgery on the occurrence of parasympathetic reinnervation after cardiac transplantation. Circulation 1998; 97: 1368-1374.
27. Estorch M, Camprecios M, Flotats A, et al,. Sympathetic reinnervation of cardiac allografts evaluated by 123I-MIBG imaging. J Nucl Med 1999; 40: 911-916.
28. Bengel FM, Ueberfuhr P, Hesse T, et al,. Clinical determinants of ventricular sympathetic reinnervation after orthotopic heart transplantation. Circulation 2002; 106: 831-835.
29. Ohuchi H, Suzuki H, Yasuda K, Arakaki Y, Echigo S, Kamiya T,. Heart rate recovery after exercise and cardiac autonomic nervous activity in children. Pediatr Res 2000; 47: 329-335.
30. Imai K, Sato H, Hori M, et al,. Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure. J Am Coll Cardiol 1994; 24: 1529-1535.
31. Savin WM, Davidson DM, Haskell WL,. Autonomic contribution to heart rate recovery from exercise in humans. J Appl Physiol 1982; 53: 1572-1575.
32. Bengel FM, Ueberfuhr P, Karja J, et al,. Sympathetic reinnervation, exercise performance and effects of beta-adrenergic blockade in cardiac transplant recipients. Eur Heart J 2004; 25: 1726-1733.
33. Di Carli MF, Tobes MC, Mangner T, et al,. Effects of cardiac sympathetic innervation on coronary blood flow. N Engl J Med 1997 Apr 24; 336: 1208-1215.
34. Ewing DJ, Campbell IW, Clarke BF,. Assessment of cardiovascular effects in diabetic autonomic neuropathy and prognostic implications. Ann Intern Med 1980 Feb; 92 (2 Pt 2): 308-311.