Synthesis and biological activity assays of some new N1-(flavon-7-yl) amidrazone derivatives and related congeners

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 65-74

  Abu Aisheh, Marwa N ^a   Mustafa, Mohammad S ^a   El Abadelah, Mustafa M ^a   Naffa, Randa G ^a   Ismail, Said I ^a   Zihlif, Malek A ^a   Taha, Mutasem O ^a   Mubarak, Mohammad S ^a  

^a UNIVERSITY OF JORDAN   (Jordan)

Author keywords

1 piperazinyl amidrazones; 4 oxo N (chromen 7 yl) hydrazonoyl chloride; 7 amino 2 methylchromen 4 one; 7 aminoflavone; Antitumor activity; Nitrile imine

Indexed keywords

2 METHYL 7 [2 (1 MORPHOLINO 2 OXOPROPYLIDENE)HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; 2 METHYL 7 [2 [1 [4 (2 FLUOROPHENYL)PYRIMIDIN 2 YL] 2 OXOPROPYLIDENE]HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; 2 METHYL 7 [2 [2 OXO 1 (4 PHENYLPIPERAZIN 1 YL)HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; 2 METHYL 7 [2 [2 OXO 1 (PIPERIDIN 1 YL)PROPYLIDENE]HYDRAZINYL] 4H CHROMEN 4 ONE; 2 METHYL 7 [2 [2 OXO 1 THIOMORPHOLINOPROPYLIDENE]HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; 2 OXO N (4 OXO 2 PHENYL 4H CHROMEN 7 YL)PROPANEHYDRAZONOYL; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 7 [2 (1 MORPHOLINO 2 OXOPROPYLIDENE)HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; 7 [2 (2 OXO 1 THIOMORPHOLINOPROPYLIDENE)HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; 7 [2 [1 (4 (2 HYDROXYETHYL)PIPERAZIN 1 YL) 2 OXOPROPYLIDENE]HYDRAZINYL] 2 METHYL 4H CHROMEN 4 ONE; 7 [2 [1 [4 (2 FLUOROPHENYL)PIPERAZIN 1 YL] 2 OXOPROPYLIDENE]HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; 7 [2 [1 [4 (2 FLUOROPHENYL)PYRIMIDIN 2 YL] 2 OXOPROPYLIDENE]HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; 7 [2 [1 [4 (2 METHOXYPHENYL)PYRIMIDIN 2 YL] 2 OXOPROPYLIDENE]HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; 7 [2 [1 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL] 2 OXOPROPYLIDENE] 2 PHENYL 4H CHROMEN 4 ONE; 7 [2 [1 [4 (4 METHOXYPHENYL)PYRIMIDIN 2 YL] 2 OXOPROPYLIDENE]HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; 7 [2 [2 OXO 1 (4 BENZYLPIPERAZIN 1 YL)OXOPROPYLIDENE]HYDRAZINYL] 2 METHYL 4H CHROMEN 4 ONE; 7 [2 [2 OXO 1 (4 BENZYLPIPERAZIN 1 YL)OXOPROPYLIDENE]HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; 7 [2 [2 OXO 1 (4 ETHYLPIPERAZIN 1 YL)OXOPROPYLIDENE]HYDRAZINYL] 2 METHYL 4H CHROMEN 4 ONE; 7 [2 [2 OXO 1 (4 ETHYLPIPERAZIN 1 YL)OXOPROPYLIDENE]HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; 7 [2 [2 OXO 1 (4 METHYLPIPERAZIN 1 YL)OXOPROPYLIDENE]HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; 7 [2 [2 OXO 1 (4 PHENYLPIPERAZIN 1 YL)PROPYLIDENE]HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; 7 [2 [2 OXO 1 (PIPERAZIN 1 YL)PROPYLIDENE]HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; 7 [2 [2 OXO 1 (PIPERIDIN 1 YL)PROPYLIDENE)HYDRAZINYL] 2 PHENYL 4H CHROMEN 4 ONE; ANTINEOPLASTIC AGENT; DOXORUBICIN; ETHYL 4 [1 [2 (2 METHYL 4 OXO 4H CHROMEN 7 YL)HYDRAZONO] 2 OXOPROPYL]PIPERAZINE 1 CARBOXYLATE; ETHYL 4 [2 OXO 1 [2 (4 OXO 2 PHENYL 4H CHROMEN 7 YL)HYDRAZONO]PROPYL]PIPERAZINE 1 CARBOXYLATE; FLAVONE DERIVATIVE; N (2 METHYL 4 OXO 4H CHROMEN 7 YL) 2 OXO PROPANEHYDRAZONOYL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; FLAVONES; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-ABL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864416960     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.04.028     Document Type: Article

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