Changes in Tumor Blood Flow as Measured by Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) May Predict Activity of Single Agent Bevacizumab in Recurrent Epithelial Ovarian (EOC) and Primary Peritoneal Cancer (PPC) Patients: An exploratory analysis of a Gynecologic Oncology Group Phase II study

Gynecologic Oncology

Volumn 126, Issue 3, 2012, Pages 375-380

  Chase, Dana M ^a   Sill, Michael W ^b,i   Monk, Bradley J ^a   Chambers, Mark D ^c   Darcy, Kathleen M ^b,i   Han, Ernest S ^d   Buening, Barbara J ^e   Sorosky, Joel I ^f   Fruehauf, John P ^g   Burger, Robert A ^h  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Buffalo Niagara Enterprise   (United States)

^c VA LONG BEACH HEALTHCARE SYSTEM   (United States)

^d City of Hope   (United States)

^e SEATTLE CANCER CARE ALLIANCE   (United States)

^f Cancer Clinical Research Office   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h FOX CHASE CANCER CENTER   (United States)

ⁱ UNIVERSITY AT BUFFALO   (United States)

Author keywords

Dynamic contrast enhanced magnetic resonance imaging; GOG; Primary peritoneal cancer

Indexed keywords

BEVACIZUMAB;

ADULT; AGED; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER SURVIVAL; CONTRAST ENHANCEMENT; DISEASE COURSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MICROVASCULATURE; MULTIPLE CYCLE TREATMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; OVARY CARCINOMA; OVERALL SURVIVAL; PERITONEUM CANCER; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; TREATMENT DURATION; TREATMENT RESPONSE; TUMOR BLOOD FLOW;

AGED; ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL, HUMANIZED; BLOOD VESSELS; CONTRAST MEDIA; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; NEOPLASMS, GLANDULAR AND EPITHELIAL; NEOVASCULARIZATION, PATHOLOGIC; OVARIAN NEOPLASMS; PERITONEAL NEOPLASMS; PREDICTIVE VALUE OF TESTS; REGIONAL BLOOD FLOW; SINGLE-BLIND METHOD;

EID: 84864415237     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2012.06.002     Document Type: Article

References (14)

1. American Cancer Society Cancer Facts & Figures 2012 2012 American Cancer Society Atlanta
2. R.A. Burger Overview of anti-angiogenic agents in development for ovarian cancer Gynecol Oncol 121 2011 230 238
3. R.A. Burger, M.W. Sill, B.J. Monk, B.E. Greer, and J.I. Sorosky Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study J Clin Oncol 25 2007 5165 5171 (Pubitemid 350237599)
4. S.A. Cannistra, U.A. Matulonis, R.T. Penson, J. Hambleton, J. Dupont, and H. Mackey Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer J Clin Oncol 25 2007 5180 5186 (Pubitemid 350232248)
5. R.A. Burger, M.F. Brady, M.A. Bookman, G.F. Fleming, B.J. Monk, and H. Huang Incorporation of bevacizumab in the primary treatment of ovarian cancer N Engl J Med 365 26 Dec 29 2011 2473 2483
6. E.S. Han, R.A. Burger, K.M. Darcy, M.W. Sill, L.M. Randall, and D. Chase Predictive and prognostic angiogenic markers in a gynecologic oncology group phase II trial of bevacizumab in recurrent and persistent ovarian or peritoneal cancer Gynecol Oncol 119 2010 484 490
7. J. Neter, W. Wasserman, and M.H. Kutner Applied Linear Statistical Models 3rd ed. 1990 Richard D. Irwin, Inc. Homewood, IL
8. M. Hollander, and D.A. Wolfe Nonparametric Statistical Methods 1973 John Wiley & Sons New York
9. J.L. Hodges, and E.L. Lehmann Hodges-Lehmann Estimators S. Kotz, N.L. Johnson, C.B. Read, Encyclopedia of Statistical Sciences 1983 John Wiley & Sons New York 463 465
10. C. Spearman The proof and measurement of association between two things Am J Psychol 15 1904 72 101
11. D. Collett Modelling Survival Data in Medical Research 2nd Edition 2003 Chapman & Hall/CRC Boca Raton
12. E. Sala, A. Rockall, D. Rangarajan, and R.A. Kubik-Huch The role of dynamic contrast-enhanced and diffusion weighted magnetic resonance imaging in the female pelvis Eur J Radiol 76 2010 367 385
13. S. Kyriazi, S.B. Kaye, and N.M. deSouza Imaging ovarian cancer and peritoneal metastases - current and emerging techniques Nat Rev Clin Oncol 7 2010 381 393
14. S. Goel, D.G. Duda, L. Xu, L.L. Munn, Y. Boucher, and D. Fukumura Normalization of the vasculature for treatment of cancer and other diseases Physiol Rev 91 3 Jul 2011 1071 1121