D-Pinitol attenuates 7, 12 dimethylbenz [a] anthracene induced hazards through modulating protein bound carbohydrates, adenosine triphosphatases and lysosomal enzymes during experimental mammary carcinogenesis

Journal of Experimental Therapeutics and Oncology

Volumn 10, Issue 1, 2012, Pages 39-49

  Rengarajan, Thamaraiselvan ^a   Nandakumar, Natarajan ^a   Balasubramanian, Maruthaiveeran Periyasamy ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

D Pinitol; DMBA; Glycoproteins; Lysosomal enzymes; Membrane ATPase

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ADENOSINE TRIPHOSPHATASE; CARBOHYDRATE; CELL SURFACE PROTEIN; D PINITOL; INOSITOL; LYSOSOME ENZYME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST; BREAST CARCINOMA; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; LIVER; NONHUMAN; PRIORITY JOURNAL; RAT;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ADENOSINE TRIPHOSPHATASES; ANIMALS; BREAST; CARCINOGENS, ENVIRONMENTAL; FEMALE; INOSITOL; LIVER; LYSOSOMES; MAMMARY NEOPLASMS, EXPERIMENTAL; MEMBRANE GLYCOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84864414588     PISSN: 13594117     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Anbuselvam C, Vijayavel K, Balasubramanian MP. Protective effect of Operculina turpethum against 7,12-dimethyl benz(a)anthracene induced oxidative stress with reference to breast cancer in experimental rats. Chemico-Biological Interactions 68: 229-236, 2007. (Pubitemid 46976883)
2. Nagamine MK, Da Silva TC, Matsuzaki P, Pinello KC, Gokithi B, Akisue G, Haraguchi M, Górniak SL, Sinhorini IL, Rao KV, Barbuto AJM, Dagli MLZ. Cytotoxic effects of butanolic extract from Pfaffia paniculata (Brazilian Ginseng) on cultured human breast cancer cell line MCF-7. Exp Toxicol Pathol 61: 75-82, 2009.
3. Selvendiran K, Prince Vijeya Singh J, Sakthisekaran D. In vivo effect of piperine on serum and tissue glycoprotein levels in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Pulmonary Pharmacology & Therapeutics 19: 107-111, 2006. (Pubitemid 43052998)
4. Lee JS, Jung ID, Jeong YI. D-Pinitol inhibits Th1 polarization via the suppression of dendritic cells. Int Immunopharmacol 7: 791-804, 2007. (Pubitemid 46635278)
5. Zhan TR, Ma YD, Fan PH, Ji M, Lou HX. Synthesis of 4/5-deoxy-4/5- nucleobase derivatives of 3-O-methyl-D-chiroinositol as potential antiviral agents. Chem Biodivers 3: 1126-37, 2006. (Pubitemid 44688001)
6. Chaubal R, Pawar PV, Hebbalkar GD. Larvicidal activity of Acacia nilotica extracts and isolation of D-pinitol- a bioactive carbohydrate. Chem Biodivers 2: 684-88, 2005. (Pubitemid 40790445)
7. Singh RK, Pandey BL, Tripathi M, Pandey VB. Anti-inflammatory effect of (+)-pinitol, Fitoterapia 72: 168-170, 2001. (Pubitemid 32153818)
8. Geethan PK, Prince PS. Antihyperlipidemic effect of D-Pinitol on streptozotocin-induced diabetic Wistar rats, J. Biochem. Mol. Toxicol 22: 220-224, 2008.
9. Kim JI, Kim JC, Kang MJ, Lee MS, Kim JJ, Cha IJ. Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study. Eur. J. Clin. Nutr 59: 456-458, 2005. (Pubitemid 40403302)
10. Lee JS, Lee CM, Jeong YI, Jung ID, Kim BH, Seong EY, Kim JI, Choi IW, Chung V, Park YM. D-Pinitol regulates Th1/Th2 balance via suppressing Th2 immune response in ovalbumin-induced asthma, FEBS Lett 581: 57-64, 2007. (Pubitemid 44960280)
11. Sivakumar S, Palsamy P, Subramanian S. Impact of D-Pinitol on the attenuation of proinflammatory cytokines, hyperglycemia-mediated oxidative stress and protection of kidney tissue ultrastructure in streptozotocin-induced diabetic rats. Chemico-Biological Interactions 188: 237-245, 2010.
12. Gautam Sethi, Kwang Seok Ahn, Bokyung Sung, Aggarwal BB. Pinitol targets nuclear factor-KB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis. Mol Cancer Ther 7: 1604-1614, 2008.
13. Glick MC, Mumoi M, Santer UV. Cancer Campaign 1-19, 1980.
14. Selvam S, Nagini S. Administration of the plasticizer di (2-ethylhexyl) phthalate alters glycoconjugate profile. Indian J Physiol Pharmacol 39(3): 252-4, 1995.
15. Randak L, Auerswald EA, Machleidt A, Mechleidt W. Inhibition of ATPase and adenylate kinase activities of the second nucleotide binding of the cystic fibrosis conditions by genistein. J Biochem. 340: 227, 1999.
16. Rajendran P, Ekambaram G, Magesh V, Sakthisekaran D. Chemopreventive efficacy of mangiferin against benzo(a)pyrene induced lung carcinogenesis in experimental animals. Environmental Toxicology and Pharmacology 26: 278-282, 2008.
17. Rauchova H, Ledvinkova J, Kalous M, Drahota Z. The effect of lipid peroxidation on the activity of various membrane-bound ATPases in rat kidney. Int. J. Biochem. Cell. Biol. 27: 251, 1995.
18. Stoka V, Turk V, Turk B. Lysosomal cysteine cathepsins: signaling pathways in apoptosis. Biol Chem 388: 555-60, 2007. (Pubitemid 46883446)
19. Halaby R. Lysosomal enzyme-induced cell -death in MCF-7 and mammary gland cells. Breast Cancer Res 4: E001, 2002.
20. Barros ACSD, Muranaka ENK, Mori LJ, Pelizon CHT, Iriya K, Giocondo K, Pinotti JA. Induction of experimental mammary carcinogenesis in rats with 7,12-dimethylbenz(a) anthracene. Reviews in Hospital Clinical Faculty of Medicine Sao Paulo 59(5): 257-261, 2004.
21. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin-phenol reagent. J Biol Chem 193: 265-75, 1951.
22. Niebes P. Determination of enzyme and degradation products of GAG metabolism in the serum of healthy and varicose subjects. Clin Chim Acta 42: 399-408, 1972.
23. Wagner WD. More sensitive assay discriminating glactosamine and glucosamine in mixtures. Anal Biochem 94: 394-7, 1979.
24. Warren L. The thiobarbituric acid assay of sialic acid. J Biol Chem 234: 1971-75, 1959.
25. Dodge JT, Mitchell C, Hanahan DJ. The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. Arch Biochem Biophys 100: 119-30, 1963.
26. Quist EE. Regulation of erythrocyte membrane shape by Ca2+. Biochemical and Biophysical Research 29: 631-637, 1980. (Pubitemid 10098604)
27. Bonting SL. Sodium-potassium activated adenosine triphosphatase and cation transport. In: Bittar EE, editor. Membranes and ion transport, 1. London: Wiley-Interscience; 257-363, 1970.
28. Hjerten S, Pan H. Purification and characterization of two forms of a low-affinity Ca2+ -ATPase from erythrocyte membranes. Biochim Biophys Acta 728: 281-8, 1983. (Pubitemid 13133546)
29. Ohnishi T, Suzuki T, Suzuki Y, Ozawa K. A comparative study of plasma membrane Mg2+ -ATPase activities in normal, regenerating and malignant cells. Biochim Biophys Acta 684: 67-74, 1962.
30. Kawai Y, Anno K. Mucopolysaccharide-degrading enzymes from the liver of the squid, Ommastrephes sloani pacificus I. Hyaluronidase Biochem Biophys 242: 428-436, 1971.
31. Delvin E, Gianetoo R. The purification of lysosomal rat-liver [beta]-glucuronidase. Biochem Biophys 220: 93-100, 1970.
32. Marhun D. Rapid colorimetric assay of beta-galactosidase and N-acetyl-beta-glucosaminidase in human urine. Clin Chim Acta 73(3): 453-61, 1976.
33. Limer JL, Speirs V. Phyto-oestrogens and breast cancer-chemoprevention. Breast Cancer Res 6: 119-127, 2004.
34. Pugalendhi P, Manoharan S, Sindhu G, Vinothkumar V, Baskaran N. Protective effect of genistein and daidzein, in combination, against 7,12-dimethylbenz[a]anthracene induced chromosomal aberrations and dna damage in bone marrow cells of female sprague-dawley rats. Journal of Cell and Tissue Research 10(3): 2305-2309, 2010.
35. Bolt HM, Filser JG. Irreversible binding of chlorinated ethylenes to macromolecules. Environ. Health Perspect 21: 107-112, 1977. (Pubitemid 8366470)
36. Ebrahim AS, Gobalakrishnan R, Murugesan A, Sakthisekaran D. In vivo effect of vitamin E on serum and tissue glycoprotein levels inperchloroethylene induced cytotoxicity. Mol Cell Biochem 144: 13-18, 1995.
37. Shetlar MR, Erwin CP and Everett MR. Serum Polysaccharide Levels in Rats Bearing the Walker 256 Tumor. Cancer Res 10: 445-447, 1950.
38. Oplatka A, Friedman JE, Kosenheck K. In: Galeotti T, Cittadini A, Novi G, Papa S, Smets LA, editors. Cell membranes and cancer. Amsterdam: Elsevier Science Publishers 117-124, 1985.
39. Stekhoren MA, Bonding SL. Transport ATPases: properties and functions. Physiol. Rev 61: 1-76, 1985.
40. Geetha A, Marar T, Devi CS. Effect of alpha-tocopherol on doxorubicin-induced changes in rat liver and heart microsomes. Indian J Exp Biol 29(8): 782-5, 1991.
41. Jain MP, Sharma VK. Phytochemical investigation of roots of Adhatoda vasica. Planta Med. 46(4): 250-253, 1982.
42. Chen JW, Murphy TL, Willingham MC, Pastan I, August JT. Identification of two lysosomal membrane glycoproteins. J Cell Biol 101: 85-95, 1985. (Pubitemid 15061257)
43. Ricciutti MA. Myocardial lysosome stability in the early stages of acute ischemic injury. Am. J. Cardiol 492-497, 1972.
44. Slawson C, Pidala J, Potter R. Increased N-acetyl-[beta]-glucosaminidase activity in primary breast carcinomas corresponds to a decrease in N-acetylglucosamine containing proteins. Biochem Biophys Act 1537: 147-157, 2001. (Pubitemid 32885616)