Examining the relationship between diet-induced acidosis and cancer

Nutrition and Metabolism

Volumn 9, Issue , 2012, Pages

  Robey, Ian Forrest ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Acid base balance; Acidosis; Cancer; Diet

Indexed keywords

ADIPONECTIN; HYDROCORTISONE; LACTIC ACID; LEPTIN; SOMATOMEDIN C;

ACID BASE BALANCE; ACIDOSIS; CANCER GROWTH; CANCER RISK; CARCINOGENESIS; CELL ACTIVATION; DIET INDUCED ACIDOSIS; DISEASE ASSOCIATION; ENVIRONMENTAL FACTOR; HUMAN; INSULIN RESISTANCE; LIFESTYLE; NONHUMAN; OSTEOCLAST; REVIEW; TRYPTOPHAN METABOLISM;

ANIMALIA;

EID: 84864412729     PISSN: None     EISSN: 17437075     Source Type: Journal    
DOI: 10.1186/1743-7075-9-72     Document Type: Review

References (194)

1. Cancer Facts and Figures. American Cancer Society Atlanta, Society AC, 2004 http://www.cancer.org/acs/groups/content/@epidemiologysurveilance/ documents/document/acspc-028323.pdf
2. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Calle EE, Kaaks R, Nat Rev Cancer 2004 4 8 579 591 15286738 (Pubitemid 39025053)
3. Energy balance, host-related factors, and cancer progression. Hursting SD, Berger NA, J Clin Oncol 2010 28 26 4058 4065 10.1200/JCO.2010.27.9935 20697088
4. Research WCRFAIfC, Food, Nutrition, and Physical Activity, and the Prevention of Cancer: A Global Perspective In. Washington DC: AICR 2007
5. Acidic extracellular pH induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase D-mitogen-activated protein kinase signaling. Kato Y, Lambert CA, Colige AC, Mineur P, Noel A, Frankenne F, Foidart JM, Baba M, Hata R, Miyazaki K, et al. J Biol Chem 2005 280 12 10938 10944 10.1074/jbc.M411313200 15657063 (Pubitemid 40418395)
6. Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma. Kato Y, Ozawa S, Tsukuda M, Kubota E, Miyazaki K, St-Pierre Y, Hata R, FEBS J 2007 274 12 3171 3183 10.1111/j.1742-4658.2007.05848.x 17540003 (Pubitemid 46849097)
7. Acidic pH enhances the invasive behavior of human melanoma cells. Martinez-Zaguilan R, Seftor EA, Seftor RE, Chu YW, Gillies RJ, Hendrix MJ, Clin Exp Metastasis 1996 14 2 176 186 10.1007/BF00121214 8605731 (Pubitemid 26074280)
8. Acid treatment of melanoma cells selects for invasive phenotypes. Moellering RE, Black KC, Krishnamurty C, Baggett BK, Stafford P, Rain M, Gatenby RA, Gillies RJ, Clin Exp Metastasis 2008 25 4 411 425 10.1007/s10585-008-9145-7 18301995
9. Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Rofstad EK, Mathiesen B, Kindem K, Galappathi K, Cancer Res 2006 66 13 6699 6707 10.1158/0008-5472.CAN-06-0983 16818644 (Pubitemid 44085627)
10. Pericellular pH affects distribution and secretion of cathepsin B in malignant cells. Rozhin J, Sameni M, Ziegler G, Sloane BF, Cancer Res 1994 54 24 6517 6525 7987851
11. Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells. Shi Q, Le X, Wang B, Abbruzzese JL, Xiong Q, He Y, Xie K, Oncogene 2001 20 28 3751 3756 10.1038/sj.onc.1204500 11439338 (Pubitemid 32624967)
12. Influence of aldosterone on renal ammonia production. Welbourne TC, Francoeur D, Am J Physiol 1977 233 1 56 E60 18022
13. Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells. Xu L, Fidler IJ, Cancer Res 2000 60 16 4610 4616 10969814 (Pubitemid 32103647)
14. Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF. Xu L, Fukumura D, Jain RK, J Biol Chem 2002 277 13 11368 11374 10.1074/jbc.M108347200 11741977 (Pubitemid 34952903)
15. Contributions of cell metabolism and H + diffusion to the acidic pH of tumors. Schornack PA, Gillies RJ, Neoplasia 2003 5 2 135 145 12659686 (Pubitemid 36369009)
16. Origins and evolution of the Western diet: health implications for the 21st century. Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, O'Keefe JH, Brand-Miller J, Am J Clin Nutr 2005 81 2 341 354 15699220 (Pubitemid 43078368)
17. Metabolism and acid-base physiology. Halperin ML, Artif Organs 1982 6 4 357 362 10.1111/j.1525-1594.1982.tb04126.x 7165550 (Pubitemid 13110030)
18. Acid Production. Kleinman J, Lemann J, Clinical disorders of fluid and electrolyte metabolism New York: McGraw Hill, Maxwell M, Kleeman C, Narins R, 4 1987 159 173
19. Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet. Frassetto LA, Morris RC, Sebastian A, Am J Physiol Renal Physiol 2007 293 2 521 F525 10.1152/ajprenal.00048.2007 17522265 (Pubitemid 47358122)
20. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. Frings-Meuthen P, Baecker N, Heer M, J Bone Miner Res 2008 23 4 517 524 18052757 (Pubitemid 351501892)
21. Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein contents. Frassetto LA, Todd KM, Morris RC, Sebastian A, Am J Clin Nutr 1998 68 3 576 583 9734733 (Pubitemid 28402379)
22. Paleolithic diet, sweet potato eaters, and potential renal acid load. Remer T, Manz F, Am J Clin Nutr 2003 78 4 802 803 author reply 803-804 14522740
23. Estimation of the renal net acid excretion by adults consuming diets containing variable amounts of protein. Remer T, Manz F, Am J Clin Nutr 1994 59 6 1356 1361 8198060 (Pubitemid 24165890)
24. Dietary protein as a modulator of the renal net acid excretion capacity: Evidence that an increased protein intake improves the capability of the kidney to excrete ammonium. Remer T, Manz F, J Nutr Biochem 1995 6 431 437 10.1016/0955-2863(95)00064-7
25. Sellmeyer DE, Todd K, Sebastian A: Diet, evolution and aging-the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet. Frassetto L, Morris RC, Eur J Nutr 2001 40 5 200 213 10.1007/s394-001-8347-4 11842945 (Pubitemid 34093226)
26. Age and systemic acid-base equilibrium: analysis of published data. Frassetto L, Sebastian A, J Gerontol A Biol Sci Med Sci 1996 51 1 91 B99 8548506
27. Effect of age on blood acid-base composition in adult humans: role of age-related renal functional decline. Frassetto LA, Morris RC, Sebastian A, Am J Physiol 1996 271 6 Pt 2 1114 F1122 8997384
28. Diet-induced acidosis: is it real and clinically relevant? Pizzorno J, Frassetto LA, Katzinger J, Br J Nutr 2010 103 8 1185 1194 20003625
29. Effect of diet on plasma acid-base composition in normal humans. Kurtz I, Maher T, Hulter HN, Schambelan M, Sebastian A, Kidney Int 1983 24 5 670 680 10.1038/ki.1983.210 6663989 (Pubitemid 14208765)
30. Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors. Sebastian A, Frassetto LA, Sellmeyer DE, Merriam RL, Morris RC, Am J Clin Nutr 2002 76 6 1308 1316 12450898 (Pubitemid 35416567)
31. Latent acidosis: acidity as a cause for chronic diseases [Latente Azidose: Übersäuerung als Ursache chronischer Erkrankungen]. Vormann J, Goedeke T, Schewiz Zschr Ganszheits Medizin 2002 2 90 96
32. Acid-base. Gluck SL, Lancet 1998 352 9126 474 479 10.1016/S0140-6736(98) 03087-6 9708770 (Pubitemid 28364938)
33. Metabolic acidosis: pathophysiology, diagnosis and management. Kraut JA, Madias NE, Nat Rev Nephrol 2010 6 5 274 285 10.1038/nrneph.2010.33 20308999
34. Acid-base balance and weight gain: are there crucial links via protein and organic acids in understanding obesity? Berkemeyer S, Med Hypotheses 2009 73 3 347 356 10.1016/j.mehy.2008.09.059 19410381
35. Effect of acute alterations in acid-base balance on rat renal glutaminase and phosphoenolpyruvate carboxykinase gene expression. Hwang JJ, Curthoys NP, J Biol Chem 1991 266 15 9392 9396 1709637 (Pubitemid 21906668)
36. Renal handling of NH4+ in relation to the control of acid-base balance by the kidney. Karim Z, Attmane-Elakeb A, Bichara M, J Nephrol 2002 15 Suppl 5 128 S134 12027211
37. Acidosis activation of the pituitary-adrenal-renal glutaminase I axis. Welbourne TC, Endocrinology 1976 99 4 1071 1079 10.1210/endo-99-4-1071 185045
38. Effects of dietary cation-anion difference on blood cortisol and ACTH levels in reproducing ewes. Espino L, Suarez ML, Santamarina G, Goicoa A, Fidalgo LE, J Vet Med A Physiol Pathol Clin Med 2005 52 1 8 12 10.1111/j.1439-0442.2004.00677.x 15703004 (Pubitemid 41640963)
39. Increased salivary cortisol reliably induced by a protein-rich midday meal. Gibson EL, Checkley S, Papadopoulos A, Poon L, Daley S, Wardle J, Psychosom Med 1999 61 2 214 224 10204975 (Pubitemid 29168652)
40. Meal stimulation of cortisol secretion: a protein induced effect. Slag MF, Ahmad M, Gannon MC, Nuttall FQ, Metabolism 1981 30 11 1104 1108 10.1016/0026-0495(81)90055-X 6270500 (Pubitemid 11026217)
41. Neutralization of Western diet inhibits bone resorption independently of K intake and reduces cortisol secretion in humans. Maurer M, Riesen W, Muser J, Hulter HN, Krapf R, Am J Physiol Renal Physiol 2003 284 1 32 F40 12388390
42. Influence of consumption of a high-protein vs. high-carbohydrate meal on the physiological cortisol and psychological mood response in men and women. Lemmens SG, Born JM, Martens EA, Martens MJ, Westerterp-Plantenga MS, PLoS One 2011 6 2 16826 10.1371/journal.pone.0016826 21304815
43. Effects of single macronutrients on serum cortisol concentrations in normal weight men. Martens MJ, Rutters F, Lemmens SG, Born JM, Westerterp-Plantenga MS, Physiol Behav 2010 101 5 563 567 10.1016/j.physbeh. 2010.09.007 20849868
44. Comment: response of the hypothalamic-pituitary-adrenocortical axis to high-protein/fat and high-carbohydrate meals in women with different obesity phenotypes. Vicennati V, Ceroni L, Gagliardi L, Gambineri A, Pasquali R, J Clin Endocrinol Metab 2002 87 8 3984 3988 10.1210/jc.87.8.3984 12161547 (Pubitemid 34879558)
45. Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D, Nat Med 2000 6 6 703 706 10.1038/76287 10835690 (Pubitemid 30398797)
46. Glucocorticoids induce a G1/G0 cell cycle arrest of Con8 rat mammary tumor cells that is synchronously reversed by steroid withdrawal or addition of transforming growth factor-alpha. Goya L, Maiyar AC, Ge Y, Firestone GL, Mol Endocrinol 1993 7 9 1121 1132 10.1210/me.7.9.1121 8247014 (Pubitemid 23285271)
47. The effects of glucocorticoids and progesterone on hormone-responsive human breast cancer in long-term tissue culture. Lippman M, Bolan G, Huff K, Cancer Res 1976 36 12 4602 4609 1000505
48. Overlapping but distinct gene regulation profiles by glucocorticoids and progestins in human breast cancer cells. Wan Y, Nordeen SK, Mol Endocrinol 2002 16 6 1204 1214 10.1210/me.16.6.1204 12040008 (Pubitemid 34621070)
49. Glucocorticoid effects on the production and actions of immune cytokines. Guyre PM, Girard MT, Morganelli PM, Manganiello PD, J Steroid Biochem 1988 30 1-6 89 93 2968487
50. Genetic and hormonal regulation of tryptophan kynurenine metabolism: implications for vascular cognitive impairment, major depressive disorder, and aging. Oxenkrug GF, Ann N Y Acad Sci 2007 1122 35 49 10.1196/annals.1403.003 18077563 (Pubitemid 350249540)
51. Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape. Katz JB, Muller AJ, Prendergast GC, Immunol Rev 2008 222 206 221 10.1111/j.1600-065X.2008.00610.x 18364004 (Pubitemid 351430372)
52. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Opitz CA, Litzenburger UM, Sahm F, Ott M, Tritschler I, Trump S, Schumacher T, Jestaedt L, Schrenk D, Weller M, et al. Nature 2011 478 7368 197 203 10.1038/nature10491 21976023
53. Towards a genetic definition of cancer-associated inflammation: role of the IDO pathway. Prendergast GC, Metz R, Muller AJ, Am J Pathol 2011 176 5 2082 2087
54. Tryptophan catabolism in IDO + plasmacytoid dendritic cells. Fallarino F, Gizzi S, Mosci P, Grohmann U, Puccetti P, Curr Drug Metab 2007 8 3 209 216 10.2174/138920007780362581 17430109 (Pubitemid 46628286)
55. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Apetoh L, Quintana FJ, Pot C, Joller N, Xiao S, Kumar D, Burns EJ, Sherr DH, Weiner HL, Kuchroo VK, Nat Immunol 2010 11 9 854 861 10.1038/ni.1912 20676095
56. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelli E, Caccamo M, Oukka M, Weiner HL, Nature 2008 453 7191 65 71 10.1038/nature06880 18362915 (Pubitemid 351630328)
57. An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis. Quintana FJ, Murugaiyan G, Farez MF, Mitsdoerffer M, Tukpah AM, Burns EJ, Weiner HL, Proc Natl Acad Sci U S A 2010 107 48 20768 20773 10.1073/pnas.1009201107 21068375
58. Differential binding of dexamethasone to ammonium sulfate precipitates of human adipose tissue cytosols. Miller LK, Kral JG, Strain GW, Zumoff B, Steroids 1987 49 6 507 522 10.1016/0039-128X(87)90091-2 3453560
59. Steroid hormone receptors in human adipose tissues. Rebuffe-Scrive M, Bronnegard M, Nilsson A, Eldh J, Gustafsson JA, Bjorntorp P, J Clin Endocrinol Metab 1990 71 5 1215 1219 10.1210/jcem-71-5-1215 2229280
60. Does central obesity reflect "Cushing's disease of the omentum? Bujalska IJ, Kumar S, Stewart PM, Lancet 1997 349 9060 1210 1213 10.1016/S0140-6736(96)11222-8 9130942 (Pubitemid 27190044)
61. Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes. Buren J, Liu HX, Jensen J, Eriksson JW, Eur J Endocrinol 2002 146 3 419 429 10.1530/eje.0.1460419 11888850 (Pubitemid 34257654)
62. Effect of glucocorticoids on hexose transport in rat adipocytes. Evidence for decreased transporters in the plasma membrane. Carter-Su C, Okamoto K, J Biol Chem 1985 260 20 11091 11098 4040912 (Pubitemid 16253270)
63. Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men. Fried SK, Russell CD, Grauso NL, Brolin RE, J Clin Invest 1993 92 5 2191 2198 10.1172/JCI116821 8227334 (Pubitemid 23333523)
64. Effect of glucocorticoids on the glucose transport system of isolated fat cells. Livingston JN, Lockwood DH, J Biol Chem 1975 250 21 8353 8360 1194258
65. Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction. Sakoda H, Ogihara T, Anai M, Funaki M, Inukai K, Katagiri H, Fukushima Y, Onishi Y, Ono H, Fujishiro M, et al. Diabetes 2000 49 10 1700 1708 10.2337/diabetes.49.10. 1700 11016454
66. The oxazolidinedione CP-92,768-2 partially protects insulin receptor substrate-1 from dexamethasone down-regulation in 3T3-L1 adipocytes. Turnbow MA, Smith LK, Garner CW, Endocrinology 1995 136 4 1450 1458 10.1210/en.136.4.1450 7895655
67. Adipose tissue and the insulin resistance syndrome. Frayn KN, Proc Nutr Soc 2001 60 3 375 380 10.1079/PNS200195 11681812 (Pubitemid 32772453)
68. Glucocorticoids and insulin resistance: old hormones, new targets. Andrews RC, Walker BR, Clin Sci (Lond) 1999 96 5 513 523 10.1042/CS19980388 (Pubitemid 29237902)
69. Glucocorticoids produce whole body insulin resistance with changes in cardiac metabolism. Qi D, Rodrigues B, Am J Physiol Endocrinol Metab 2007 292 3 654 E667 17077342
70. Human insulin resistance: the role of glucocorticoids. Reynolds RM, Walker BR, Diabetes Obes Metab 2003 5 1 5 12 10.1046/j.1463-1326.2003.00221.x 12542720 (Pubitemid 36367473)
71. Diabetes mellitus as a risk factor for pancreatic cancer. Everhart J, Wright D, A meta-analysis. JAMA 1995 273 20 1605 1609
72. Energy balance, insulin resistance biomarkers, and breast cancer risk. Fair AM, Dai Q, Shu XO, Matthews CE, Yu H, Jin F, Gao YT, Zheng W, Cancer Detect Prev 2007 31 3 214 219 10.1016/j.cdp.2007.04.003 17646056 (Pubitemid 47248150)
73. Insulin and colon cancer. Giovannucci E, Cancer Causes Control 1995 6 2 164 179 10.1007/BF00052777 7749056
74. Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk? McKeown-Eyssen G, Cancer Epidemiol Biomarkers Prev 1994 3 8 687 695 7881343 (Pubitemid 24377963)
75. Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies. Pisani P, Arch Physiol Biochem 2008 114 1 63 70 10.1080/13813450801954451 18465360 (Pubitemid 351998745)
76. Occurrence, trends and environment etiology of pancreatic cancer. Weiderpass E, Partanen T, Kaaks R, Vainio H, Porta M, Kauppinen T, Ojajarvi A, Boffetta P, Malats N, Scand J Work Environ Health 1998 24 3 165 174 10.5271/sjweh.295 9710368 (Pubitemid 28369431)
77. Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Kaaks R, Lukanova A, Kurzer MS, Cancer Epidemiol Biomarkers Prev 2002 11 12 1531 1543 12496040 (Pubitemid 36020003)
78. Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. Wideroff L, Gridley G, Mellemkjaer L, Chow WH, Linet M, Keehn S, Borch-Johnsen K, Olsen JH, J Natl Cancer Inst 1997 89 18 1360 1365 10.1093/jnci/89.18.1360 9308706 (Pubitemid 27418027)
79. Nutrition, hormones, and breast cancer: is insulin the missing link? Kaaks R, Cancer Causes Control 1996 7 6 605 625 10.1007/BF00051703 8932921 (Pubitemid 26377730)
80. Western nutrition and the insulin resistance syndrome: a link to breast cancer. Stoll BA, Eur J Clin Nutr 1999 53 2 83 87 10.1038/sj.ejcn.1600700 10099938 (Pubitemid 29082524)
81. Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women. Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, Li J, Ho GY, Xue X, Anderson GL, et al. J Natl Cancer Inst 2009 101 1 48 60 19116382
82. Fasting C-peptide levels and death resulting from all causes and breast cancer: the health, eating, activity, and lifestyle study. Irwin ML, Duggan C, Wang CY, Smith AW, McTiernan A, Baumgartner RN, Baumgartner KB, Bernstein L, Ballard-Barbash R, J Clin Oncol 2011 29 1 47 53 10.1200/JCO.2010.28.4752 21115859
83. Repeated measures of serum glucose and insulin in relation to postmenopausal breast cancer. Kabat GC, Kim M, Caan BJ, Chlebowski RT, Gunter MJ, Ho GY, Rodriguez BL, Shikany JM, Strickler HD, Vitolins MZ, et al. Int J Cancer 2009 125 11 2704 2710 10.1002/ijc.24609 19588485
84. Insulin promotion of colon tumors in rats. Tran TT, Medline A, Bruce WR, Cancer Epidemiol Biomarkers Prev 1996 5 12 1013 1015 8959325 (Pubitemid 26415875)
85. Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression. Fierz Y, Novosyadlyy R, Vijayakumar A, Yakar S, LeRoith D, Diabetes 2010 59 3 686 693 10.2337/db09-1291 19959755
86. Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes. Novosyadlyy R, Lann DE, Vijayakumar A, Rowzee A, Lazzarino DA, Fierz Y, Carboni JM, Gottardis MM, Pennisi PA, Molinolo AA, et al. Cancer Res 2010 70 2 741 751 10.1158/0008-5472.CAN-09-2141 20068149
87. Influence of insulin deprivation on growth of the 7,12-dimethylbenz(a) anthracene-induced mammary carcinoma in rats subjected to alloxan diabetes and food restriction. Heuson JC, Legros N, Cancer Res 1972 32 2 226 232 5058183
88. Insulin receptor and cancer. Belfiore A, Malaguarnera R, Endocr Relat Cancer 2011 18 4 125 R147 10.1530/ERC-11-0074 21606157
89. Obesity and cancer. Vigneri P, Frasca F, Sciacca L, Frittitta L, Vigneri R, Nutr Metab Cardiovasc Dis 2006 16 1 1 7 10.1016/j.numecd.2005.10.013 16399485
90. Effect of chronic metabolic acidosis on thyroid hormone homeostasis in humans. Brungger M, Hulter HN, Krapf R, Am J Physiol 1997 272 5 Pt 2 648 F653 9176376
91. Effect of metabolic acidosis on the expression of insulin-like growth factor and growth hormone receptor. Challa A, Chan W, Krieg RJ, Thabet MA, Liu F, Hintz RL, Chan JC, Kidney Int 1993 44 6 1224 1227 10.1038/ki.1993.372 8301923 (Pubitemid 23353302)
92. Reduction of plasma immunoreactive somatomedin C during fasting in humans. Clemmons DR, Klibanski A, Underwood LE, McArthur JW, Ridgway EC, Beitins IZ, Van Wyk JJ, J Clin Endocrinol Metab 1981 53 6 1247 1250 10.1210/jcem-53-6-1247 7197688 (Pubitemid 13237563)
93. Dietary components that regulate serum somatomedin-C concentrations in humans. Isley WL, Underwood LE, Clemmons DR, J Clin Invest 1983 71 2 175 182 10.1172/JCI110757 6681614 (Pubitemid 13137481)
94. Changes in plasma somatomedin-C in response to ingestion of diets with variable protein and energy content. Isley WL, Underwood LE, Clemmons DR, JPEN J Parenter Enteral Nutr 1984 8 4 407 411 10.1177/0148607184008004407 6540317 (Pubitemid 14045901)
95. Effects of chronic metabolic acidosis (CMA) in 24-hour growth hormone secretion. Caldas A, Fontoura M, J Am Soc Nephrol 1993 4 828 828
96. Milk intake and bone mineral acquisition in adolescent girls: randomised, controlled intervention trial. Cadogan J, Eastell R, Jones N, Barker ME, BMJ 1997 315 7118 1255 1260 10.1136/bmj.315.7118.1255 9390050 (Pubitemid 27488731)
97. Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk. Fontana L, Klein S, Holloszy JO, Am J Clin Nutr 2006 84 6 1456 1462 17158430 (Pubitemid 44912831)
98. Dietary changes favorably affect bone remodeling in older adults. Heaney RP, McCarron DA, Dawson-Hughes B, Oparil S, Berga SL, Stern JS, Barr SI, Rosen CJ, J Am Diet Assoc 1999 99 10 1228 1233 10.1016/S0002-8223(99)00302-8 10524386 (Pubitemid 29480614)
99. Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial. Schurch MA, Rizzoli R, Slosman D, Vadas L, Vergnaud P, Bonjour JP, Ann Intern Med 1998 128 10 801 809 9599191 (Pubitemid 28267712)
100. Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men. Giovannucci E, Pollak M, Liu Y, Platz EA, Majeed N, Rimm EB, Willett WC, Cancer Epidemiol Biomarkers Prev 2003 12 2 84 89 12582016 (Pubitemid 36193996)
101. The IGF axis in the prostate. Cohen P, Peehl DM, Rosenfeld RG, Horm Metab Res 1994 26 2 81 84 10.1055/s-2007-1000777 8200618 (Pubitemid 24089214)
102. Insulin-like growth factors and cancer. LeRoith D, Baserga R, Helman L, Roberts CT, Ann Intern Med 1995 122 1 54 59 7619109
103. Endocrine effects of IGF-I on normal and transformed breast epithelial cells: potential relevance to strategies for breast cancer treatment and prevention. Pollak MN, Breast Cancer Res Treat 1998 47 3 209 217 10.1023/A:1005950916707 9516077 (Pubitemid 28059818)
104. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Chan JM, Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P, Hennekens CH, Pollak M, Science 1998 279 5350 563 566 10.1126/science.279. 5350.563 9438850 (Pubitemid 28067285)
105. Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia. Mantzoros CS, Tzonou A, Signorello LB, Stampfer M, Trichopoulos D, Adami HO, Br J Cancer 1997 76 9 1115 1118 10.1038/bjc.1997.520 9365156 (Pubitemid 27448004)
106. Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women. Kaaks R, Toniolo P, Akhmedkhanov A, Lukanova A, Biessy C, Dechaud H, Rinaldi S, Zeleniuch-Jacquotte A, Shore RE, Riboli E, J Natl Cancer Inst 2000 92 19 1592 1600 10.1093/jnci/92.19.1592 11018095
107. Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men. Ma J, Giovannucci E, Pollak M, Chan JM, Gaziano JM, Willett W, Stampfer MJ, J Natl Cancer Inst 2001 93 17 1330 1336 10.1093/jnci/93.17.1330 11535708 (Pubitemid 32910574)
108. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. Ma J, Pollak MN, Giovannucci E, Chan JM, Tao Y, Hennekens CH, Stampfer MJ, J Natl Cancer Inst 1999 91 7 620 625 10.1093/jnci/91.7.620 10203281 (Pubitemid 29194048)
109. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Hankinson SE, Willett WC, Colditz GA, Hunter DJ, Michaud DS, Deroo B, Rosner B, Speizer FE, Pollak M, Lancet 1998 351 9113 1393 1396 10.1016/S0140-6736(97)10384-1 9593409 (Pubitemid 28209997)
110. Positional cloning of the mouse obese gene and its human homologue. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM, Nature 1994 372 6505 425 432 10.1038/372425a0 7984236 (Pubitemid 24365442)
111. Metabolic acidosis lowers circulating adiponectin through inhibition of adiponectin gene transcription. Disthabanchong S, Niticharoenpong K, Radinahamed P, Stitchantrakul W, Ongphiphadhanakul B, Hongeng S, Nephrol Dial Transplant 2010 26 2 592 598 20627864
112. Acidosis downregulates leptin production from cultured adipocytes through a glucose transport-dependent post-transcriptional mechanism. Teta D, Bevington A, Brown J, Pawluczyk I, Harris K, Walls J, J Am Soc Nephrol 2003 14 9 2248 2254 10.1097/01.ASN.0000083903.18724.93 12937300 (Pubitemid 37052370)
113. Effects of acidosis on leptin secretion from 3T3-L1 adipocytes and on serum leptin in the uraemic rat. Teta D, Bevington A, Brown J, Throssell D, Harris KP, Walls J, Clin Sci (Lond) 1999 97 3 363 368 10.1042/CS19990137 (Pubitemid 29425333)
114. Changes in serum leptin levels in chronic renal failure patients with metabolic acidosis. Zheng F, Qiu X, Yin S, Li Y, J Ren Nutr 2001 11 4 207 211 10.1016/S1051-2276(01)70039-8 11680001 (Pubitemid 33601550)
115. Fish-rich diet, leptin, and body mass. Winnicki M, Somers VK, Accurso V, Phillips BG, Puato M, Palatini P, Pauletto P, Circulation 2002 106 3 289 291 10.1161/01.CIR.0000025241.01418.4D 12119240 (Pubitemid 34778948)
116. Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk. Fung TT, Rimm EB, Spiegelman D, Rifai N, Tofler GH, Willett WC, Hu FB, Am J Clin Nutr 2001 73 1 61 67 11124751 (Pubitemid 32016817)
117. Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men. Chu NF, Stampfer MJ, Spiegelman D, Rifai N, Hotamisligil GS, Rimm EB, Int J Obes Relat Metab Disord 2001 25 1 106 114 10.1038/sj.ijo.0801468 11244465 (Pubitemid 32142391)
118. Serum leptin concentrations are not related to dietary patterns but are related to sex, age, body mass index, serum triacylglycerol, serum insulin, and plasma glucose in the US population. Ganji V, Kafai MR, McCarthy E, Nutr Metab (Lond) 2009 6 3 10.1186/1743-7075-6-3
119. Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. Slieker LJ, Sloop KW, Surface PL, Kriauciunas A, LaQuier F, Manetta J, Bue-Valleskey J, Stephens TW, J Biol Chem 1996 271 10 5301 5304 10.1074/jbc.271.10.5301 8621378 (Pubitemid 26083858)
120. Is leptin the link between obesity and insulin resistance? Girard J, Diabetes Metab 1997 23 Suppl 3 16 24 9463021 (Pubitemid 27428609)
121. Obesity and insulin resistance. Kahn BB, Flier JS, J Clin Invest 2000 106 4 473 481 10.1172/JCI10842 10953022 (Pubitemid 30666380)
122. Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. Heiman ML, Ahima RS, Craft LS, Schoner B, Stephens TW, Flier JS, Endocrinology 1997 138 9 3859 3863 10.1210/en.138.9.3859 9275075 (Pubitemid 27351940)
123. Leptin levels do not change acutely with food administration in normal or obese subjects, but are negatively correlated with pituitary-adrenal activity. Korbonits M, Trainer PJ, Little JA, Edwards R, Kopelman PG, Besser GM, Svec F, Grossman AB, Clin Endocrinol (Oxf) 1997 46 6 751 757 10.1046/j.1365-2265.1997. 1820979.x (Pubitemid 27304461)
124. Renal net acid excretion and plasma leptin are associated with potentially bioactive free glucocorticoids in healthy lean women. Remer T, Dimitriou T, Maser-Gluth C, J Nutr 2008 138 2 426S 430S 18203916 (Pubitemid 351213664)
125. The role of neuropeptide Y in the antiobesity action of the obese gene product. Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L, Hale J, Hoffmann J, Hsiung HM, Kriauciunas A, et al. Nature 1995 377 6549 530 532 10.1038/377530a0 7566151
126. Leptin resistance and obesity. Enriori PJ, Evans AE, Sinnayah P, Cowley MA, Obesity (Silver Spring) 2006 14 Suppl 5 254S 258S
127. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, et al. N Engl J Med 1996 334 5 292 295 10.1056/NEJM199602013340503 8532024 (Pubitemid 26033933)
128. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ, Eur J Endocrinol 2003 149 4 331 335 10.1530/eje.0.1490331 14514348 (Pubitemid 37304704)
129. Leptin and cancer. Garofalo C, Surmacz E, J Cell Physiol 2006 207 1 12 22 10.1002/jcp.20472 16110483
130. Diet and cancer prevention studies in p53-deficient mice. Hursting SD, Perkins SN, Phang JM, Barrett JC, J Nutr 2001 131 11 Suppl 3092S 3094S 11694654 (Pubitemid 33070786)
131. Obesity, adipocytokines, and insulin resistance in breast cancer. Rose DP, Komninou D, Stephenson GD, Obes Rev 2004 5 3 153 165 10.1111/j.1467-789X. 2004.00142.x 15245384 (Pubitemid 38998240)
132. Prostate cancer cell proliferation is influenced by leptin. Somasundar P, Frankenberry KA, Skinner H, Vedula G, McFadden DW, Riggs D, Jackson B, Vangilder R, Hileman SM, Vona-Davis LC, J Surg Res 2004 118 1 71 82 10.1016/j.jss.2004.01.017 15093720 (Pubitemid 38490519)
133. Leptin is a growth factor in cancer. Somasundar P, McFadden DW, Hileman SM, Vona-Davis L, J Surg Res 2004 116 2 337 349 10.1016/j.jss.2003.09.004 15013374 (Pubitemid 38175325)
134. Leptin mediates a proliferative response in human MCF7 breast cancer cells. Dieudonne MN, Machinal-Quelin F, Serazin-Leroy V, Leneveu MC, Pecquery R, Giudicelli Y, Biochem Biophys Res Commun 2002 293 1 622 628 10.1016/S0006-291X(02)00205-X 12054648 (Pubitemid 34694255)
135. Leptin is a growth factor for colonic epithelial cells. Hardwick JC, Van Den Brink GR, Offerhaus GJ, Van Deventer SJ, Peppelenbosch MP, Gastroenterology 2001 121 1 79 90 10.1053/gast.2001.25490 11438496 (Pubitemid 32591517)
136. Leptin-a growth factor in normal and malignant breast cells and for normal mammary gland development. Hu X, Juneja SC, Maihle NJ, Cleary MP, J Natl Cancer Inst 2002 94 22 1704 1711 10.1093/jnci/94.22.1704 12441326 (Pubitemid 35446839)
137. Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line. Laud K, Gourdou I, Pessemesse L, Peyrat JP, Djiane J, Mol Cell Endocrinol 2002 188 1-2 219 226 11911959 (Pubitemid 34242679)
138. Leptin receptor action in hepatic cells. Wang Y, Kuropatwinski KK, White DW, Hawley TS, Hawley RG, Tartaglia LA, Baumann H, J Biol Chem 1997 272 26 16216 16223 10.1074/jbc.272.26.16216 9195922 (Pubitemid 27276440)
139. Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression. Okumura M, Yamamoto M, Sakuma H, Kojima T, Maruyama T, Jamali M, Cooper DR, Yasuda K, Biochim Biophys Acta 2002 1592 2 107 116 12379472
140. Leptin stimulates catecholamine synthesis in a PKC-dependent manner in cultured porcine adrenal medullary chromaffin cells. Takekoshi K, Ishii K, Nanmoku T, Shibuya S, Kawakami Y, Isobe K, Nakai T, Endocrinology 2001 142 11 4861 4871 10.1210/en.142.11.4861 11606454 (Pubitemid 33022362)
141. Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line. Catalano S, Marsico S, Giordano C, Mauro L, Rizza P, Panno ML, Ando S, J Biol Chem 2003 278 31 28668 28676 10.1074/jbc.M301695200 12734209 (Pubitemid 36935773)
142. Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells. Catalano S, Mauro L, Marsico S, Giordano C, Rizza P, Rago V, Montanaro D, Maggiolini M, Panno ML, Ando S, J Biol Chem 2004 279 19 19908 19915 10.1074/jbc.M313191200 14985328 (Pubitemid 38623433)
143. Leptin, the product of Ob gene, promotes angiogenesis. Bouloumie A, Drexler HC, Lafontan M, Busse R, Circ Res 1998 83 10 1059 1066 10.1161/01.RES.83.10.1059 9815153 (Pubitemid 28520935)
144. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Park HY, Kwon HM, Lim HJ, Hong BK, Lee JY, Park BE, Jang Y, Cho SY, Kim HS, Exp Mol Med 2001 33 2 95 102 10.1038/emm.2001.17 11460888 (Pubitemid 32655888)
145. Biological action of leptin as an angiogenic factor. Sierra-Honigmann MR, Nath AK, Murakami C, Garcia-Cardena G, Papapetropoulos A, Sessa WC, Madge LA,
146. Modulation by leptin of proliferation and apoptosis in vascular endothelial cells. Artwohl M, Roden M, Holzenbein T, Freudenthaler A, Waldhausl W, Baumgartner-Parzer SM, Int J Obes Relat Metab Disord 2002 26 4 577 580 10.1038/sj.ijo.0801947 12075587 (Pubitemid 34407273)
147. Potential role of leptin in endochondral ossification. Kume K, Satomura K, Nishisho S, Kitaoka E, Yamanouchi K, Tobiume S, Nagayama M, J Histochem Cytochem 2002 50 2 159 169 10.1177/002215540205000204 11799135 (Pubitemid 34106755)
148. The role of the novel adipocyte-derived hormone adiponectin in human disease. Diez JJ, Iglesias P, Eur J Endocrinol 2003 148 3 293 300 10.1530/eje.0.1480293 12611609 (Pubitemid 36410714)
149. Effect of the diet components on adiponectin levels. Reis CE, Bressan J, Alfenas RC, Nutr Hosp 2010 25 6 881 888 21519758
150. Adipocytokines: leptin-the classical, resistin-the controversical, adiponectin-the promising, and more to come. Koerner A, Kratzsch J, Kiess W, Best Pract Res Clin Endocrinol Metab 2005 19 4 525 546 10.1016/j.beem.2005.07. 008 16311215 (Pubitemid 41819217)
151. Plasma adiponectin and gastric cancer. Ishikawa M, Kitayama J, Kazama S, Hiramatsu T, Hatano K, Nagawa H, Clin Cancer Res 2005 11 2 Pt 1 466 472 15701829 (Pubitemid 40116868)
152. Association of serum adiponectin levels with breast cancer risk. Miyoshi Y, Funahashi T, Kihara S, Taguchi T, Tamaki Y, Matsuzawa Y, Noguchi S, Clin Cancer Res 2003 9 15 5699 5704 14654554 (Pubitemid 37499493)
153. Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. Wang Y, Lam KS, Xu JY, Lu G, Xu LY, Cooper GJ, Xu A, J Biol Chem 2005 280 18 18341 18347 15734737 (Pubitemid 41389081)
154. Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Brakenhielm E, Veitonmaki N, Cao R, Kihara S, Matsuzawa Y, Zhivotovsky B, Funahashi T, Cao Y, Proc Natl Acad Sci U S A 2004 101 8 2476 2481 10.1073/pnas.0308671100 14983034 (Pubitemid 38269336)
155. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, et al. Nature 2003 423 6941 762 769 10.1038/nature01705 12802337 (Pubitemid 36735700)
156. Adiponectin, the missing link in insulin resistance and obesity. Gil-Campos M, Canete RR, Gil A, Clin Nutr 2004 23 5 963 974 10.1016/j.clnu.2004. 04.010 15380884 (Pubitemid 39243008)
157. The straight line hypothesis elaborated: case reference obesity, an argument for acidosis, oxidative stress, and disease conglomeration? Berkemeyer S, Med Hypotheses 2010 75 1 59 64 10.1016/j.mehy.2009.12.034 20181434
158. Reactive oxygen species: role in the development of cancer and various chronic conditions. Waris G, Ahsan H, J Carcinog 2006 5 14 10.1186/1477-3163-5- 14 16689993
159. Major alterations in the nucleotide structure of DNA in cancer of the female breast. Malins DC, Haimanot R, Cancer Res 1991 51 19 5430 5432 1655250
160. Progression of human breast cancers to the metastatic state is linked to hydroxyl radical-induced DNA damage. Malins DC, Polissar NL, Gunselman SJ, Proc Natl Acad Sci U S A 1996 93 6 2557 2563 10.1073/pnas.93.6.2557 8637913 (Pubitemid 26104386)
161. Expression of 8-hydroxy-2'-deoxyguanosine in chronic liver disease and hepatocellular carcinoma. Ichiba M, Maeta Y, Mukoyama T, Saeki T, Yasui S, Kanbe T, Okano J, Tanabe Y, Hirooka Y, Yamada S, et al. Liver Int 2003 23 5 338 345 10.1034/j.1478-3231.2003.00868.x 14708894 (Pubitemid 37259203)
162. Increased hepatic oxidative DNA damage in patients with hepatocellular carcinoma. Schwarz KB, Kew M, Klein A, Abrams RA, Sitzmann J, Jones L, Sharma S, Britton RS, Di Bisceglie AM, Groopman J, Dig Dis Sci 2001 46 10 2173 2178 10.1023/A:1011958814371 11680593 (Pubitemid 32955228)
163. Reactive oxygen species in tumorigenesis. Feig DI, Reid TM, Loeb LA, Cancer Res 1994 54 7 Suppl 1890s 1894s 8137306 (Pubitemid 24132140)
164. Novel therapeutic strategies in prostate cancer. Retter AS, Gulley JL, Dahut WL, Cancer Biol Ther 2004 3 4 371 376 14726702 (Pubitemid 41357471)
165. Role of oxidative stress response elements and antioxidants in prostate cancer pathobiology and chemoprevention-a mechanistic approach. Sikka SC, Curr Med Chem 2003 10 24 2679 2692 10.2174/0929867033456341 14529458 (Pubitemid 37456038)
166. Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Vincent HK, Innes KE, Vincent KR, Diabetes Obes Metab 2007 9 6 813 839 10.1111/j.1463-1326.2007.00692.x 17924865 (Pubitemid 47555204)
167. Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status in epidemiologic research. Mayne ST, J Nutr 2003 133 Suppl 3 933S 940S 12612179 (Pubitemid 36262801)
168. Role of bone in regulation of systemic acid-base balance. Green J, Kleeman CR, Kidney Int 1991 39 1 9 26 10.1038/ki.1991.2 1706001
169. Regulation of bone cell function by acid-base balance. Arnett T, Proc Nutr Soc 2003 62 2 511 520 10.1079/PNS2003268 14506899 (Pubitemid 36841626)
170. Acid-base imbalance and the skeleton. Bushinsky DA, Eur J Nutr 2001 40 5 238 244 10.1007/s394-001-8351-5 11842949 (Pubitemid 34093230)
171. Acidosis, hypoxia and bone. Arnett TR, Arch Biochem Biophys 2010 503 1 103 109 10.1016/j.abb.2010.07.021 20655868
172. Effect of pH on bone resorption by rat osteoclasts in vitro. Arnett TR, Dempster DW, Endocrinology 1986 119 1 119 124 10.1210/endo-119-1-119 3720660 (Pubitemid 16100716)
173. Modulation of the resorptive activity of rat osteoclasts by small changes in extracellular pH near the physiological range. Arnett TR, Spowage M, Bone 1996 18 3 277 279 10.1016/8756-3282(95)00486-6 8703584 (Pubitemid 26118125)
174. H + stimulation of cell-mediated bone resorption in tissue culture. Goldhaber P, Rabadjija L, Am J Physiol 1987 253 1 Pt 1 90 E98 3605336
175. Effect of colchicine and calcitonin on calcemic response to metabolic acidosis. Kraut JA, Mishler DR, Kurokawa K, Kidney Int 1984 25 4 608 612 10.1038/ki.1984.64 6090754 (Pubitemid 14079954)
176. Effects of pH on bone calcium and proton fluxes in vitro. Bushinsky DA, Krieger NS, Geisser DI, Grossman EB, Coe FL, Am J Physiol 1983 245 2 204 F209 6881337
177. Net calcium efflux from live bone during chronic metabolic, but not respiratory, acidosis. Bushinsky DA, Am J Physiol 1989 256 5 Pt 2 836 F842 2719118
178. Metabolic acidosis stimulates RANKL RNA expression in bone through a cyclo-oxygenase-dependent mechanism. Frick KK, Bushinsky DA, J Bone Miner Res 2003 18 7 1317 1325 10.1359/jbmr.2003.18.7.1317 12854843 (Pubitemid 37294925)
179. Osteoclast differentiation and activation. Boyle WJ, Simonet WS, Lacey DL, Nature 2003 423 6937 337 342 10.1038/nature01658 12748652 (Pubitemid 40852708)
180. Mammalian MAP kinase signalling cascades. Chang L, Karin M, Nature 2001 410 6824 37 40 10.1038/35065000 11242034 (Pubitemid 32225829)
181. Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines. Nakashima T, Kobayashi Y, Yamasaki S, Kawakami A, Eguchi K, Sasaki H, Sakai H, Biochem Biophys Res Commun 2000 275 3 768 775 10.1006/bbrc.2000.3379 10973797
182. Mitogen-activated protein kinases in apoptosis regulation. Wada T, Penninger JM, Oncogene 2004 23 16 2838 2849 10.1038/sj.onc.1207556 15077147 (Pubitemid 38638846)
183. RANK/RANKL: regulators of immune responses and bone physiology. Leibbrandt A, Penninger JM, Ann N Y Acad Sci 2008 1143 123 150 10.1196/annals.1443.016 19076348
184. RANKL inhibition: a promising novel strategy for breast cancer treatment. Gonzalez-Suarez E, Clin Transl Oncol 2011 13 4 222 228 10.1007/s12094-011-0646- 5 21493182
185. Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator. Ishida N, Hayashi K, Hoshijima M, Ogawa T, Koga S, Miyatake Y, Kumegawa M, Kimura T, Takeya T, J Biol Chem 2002 277 43 41147 41156 10.1074/jbc.M205063200 12171919 (Pubitemid 35215706)
186. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, et al. Dev Cell 2002 3 6 889 901 10.1016/S1534-5807(02)00369-6 12479813 (Pubitemid 35460788)
187. Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Komarova SV, Pereverzev A, Shum JW, Sims SM, Dixon SJ, Proc Natl Acad Sci U S A 2005 102 7 2643 2648 10.1073/pnas.0406874102 15695591 (Pubitemid 40279430)
188. NFAT proteins: emerging roles in cancer progression. Mancini M, Toker A, Nat Rev Cancer 2009 9 11 810 820 10.1038/nrc2735 19851316
189. Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway. Buchholz M, Schatz A, Wagner M, Michl P, Linhart T, Adler G, Gress TM, Ellenrieder V, EMBO J 2006 25 15 3714 3724 10.1038/sj.emboj.7601246 16874304 (Pubitemid 44264881)
190. Genomic DNA-chip hybridization reveals a higher incidence of genomic amplifications in pancreatic cancer than conventional comparative genomic hybridization and leads to the identification of novel candidate genes. Holzmann K, Kohlhammer H, Schwaenen C, Wessendorf S, Kestler HA, Schwoerer A, Rau B, Radlwimmer B, Dohner H, Lichter P, et al. Cancer Res 2004 64 13 4428 4433 10.1158/0008-5472.CAN-04-0431 15231651 (Pubitemid 38856913)
191. NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells. Koenig A, Linhart T, Schlengemann K, Reutlinger K, Wegele J, Adler G, Singh G, Hofmann L, Kunsch S, Buch T, et al. Gastroenterology 2010 138 3 1189-1199 e1181-1182
192. Cyclosporine A inhibits colorectal cancer proliferation probably by regulating expression levels of c-Myc, p21(WAF1/CIP1) and proliferating cell nuclear antigen. Masuo T, Okamura S, Zhang Y, Mori M, Cancer Lett 2009 285 1 66 72 10.1016/j.canlet.2009.05.001 19481339
193. Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation. Singh G, Singh SK, Konig A, Reutlinger K, Nye MD, Adhikary T, Eilers M, Gress TM, Fernandez-Zapico ME, Ellenrieder V, J Biol Chem 2010 285 35 27241 27250 10.1074/jbc.M110.100438 20516082
194. The alkaline diet: is there evidence that an alkaline pH diet benefits health? Schwalfenberg GK, J Environ Public Health 2012 2012 727630 22013455