Preparation of pancreatic β-cells from human iPS cells with small molecules

Islets

Volumn 4, Issue 3, 2012, Pages 249-252

  Hosoya, Masaki ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Diabetes cell therapy; Differentiation; Human ips cells; Pancreatic cells; Small molecules

Indexed keywords

2 (3 (6 METHYLPYRIDIN 2 YL) 1H PYRAZOL 4 YL) 1,5 NAPHTHYRIDINE; 3 KETO N (AMINOETHYLAMINOCAPROYLDIHYDROCINNAMOYL)CYCLOPAMINE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; CHIR 99021; CYCLOPAMINE; DEXAMETHASONE; DORSOMORPHIN; FORSKOLIN; INDOLACTAM V; N [(3,5 DIFLUOROPHENYL)ACETYL]L ALANYL 2 PHENYLGLYCINE 1,1 DIMETHYLETHYLESTER; NICOTINAMIDE; RETINOIC ACID; SMALL MOLECULE TRANSPORT AGENT; UNCLASSIFIED DRUG;

ARTICLE; CELL THERAPY; CELL TRANSPLANTATION; CELL TYPE; DIABETES MELLITUS; EMBRYONIC STEM CELL; HUMAN; HUMAN CELL; MOLECULAR LIBRARY; PANCREAS ISLET BETA CELL; PLURIPOTENT STEM CELL;

CELL DIFFERENTIATION; DIABETES MELLITUS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS TRANSPLANTATION;

EID: 84864412520     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/isl.20856     Document Type: Article

References (15)

1. D'Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, Smart NG, et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 2006; 24:1392-401; PMID:17053790; http://dx.doi.org/10.1038/nbt1259.
2. Jiang J, Au M, Lu K, Eshpeter A, Korbutt G, Fisk G, et al. Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells 2007; 25:1940-53; PMID:17510217; http://dx.doi.org/10.1634/stemcells.2006- 0761.
3. Kroon E, Martinson LA, Kadoya K, Bang AG, Kelly OG, Eliazer S, et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol 2008; 26:443-52; PMID:18288110; http://dx.doi.org/10.1038/nbt1393.
4. Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol 2009; 5:258-65; PMID:19287398; http://dx.doi.org/10.1038/ nchembio.154.
5. Thatava T, Nelson TJ, Edukulla R, Sakuma T, Ohmine S, Tonne JM, et al. Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny. Gene Ther 2011; 18:283-93; PMID:21048796; http://dx.doi.org/10.1038/gt.2010.145.
6. Kunisada Y, Tsubooka-Yamazoe N, Shoji M, Hosoya M. Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells. Stem Cell Res 2012; 8:274-84; PMID:22056147; http://dx.doi.org/10.1016/j.scr.2011.10.002.
7. Shim JH, Kim SE, Woo DH, Kim SK, Oh CH, McKay R, et al. Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia 2007; 50:1228-38; PMID:17457565; http://dx.doi.org/10.1007/s00125- 007-0634-z.
8. Nostro MC, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, et al. Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development 2011; 138:861-71; PMID:21270052; http://dx.doi.org/10.1242/dev. 055236.
9. Rezania A, Riedel MJ, Wideman RD, Karanu F, Ao Z, Warnock GL, et al. Production of functional glucagon-secreting α-cells from human embryonic stem cells. Diabetes 2011; 60:239-47; PMID:20971966; http://dx.doi.org/10.2337/ db10-0573.
10. Otonkoski T, Beattie GM, Mally MI, Ricordi C, Hayek A. Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells. J Clin Invest 1993; 92:1459-66; PMID:8104197; http://dx.doi.org/10.1172/ JCI116723.
11. Zhu FF, Zhang PB, Zhang DH, Sui X, Yin M, Xiang TT, et al. Generation of pancreatic insulin-producing cells from rhesus monkey induced pluripotent stem cells. Diabetologia 2011; 54:2325-36; PMID:21755313; http://dx.doi.org/10.1007/ s00125-011-2246-x.
12. Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, Sato Y, et al. Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol 2008; 26:313-5; PMID:18278034; http://dx.doi.org/10. 1038/nbt1383.
13. Okita K, Yamanaka S. Induced pluripotent stem cells: opportunities and challenges. Philos Trans R Soc Lond B Biol Sci 2011; 366:2198-207.
14. Basford CL, Prentice KJ, Hardy AB, Sarangi F, Micallef SJ, Li X, et al. The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells. Diabetologia 2012; 55:358-71; PMID:22075915; http://dx.doi.org/10.1007/s00125- 011-2335-x.
15. Eshpeter A, Jiang J, Au M, Rajotte RV, Lu K, Lebkowski JS, et al. In vivo characterization of transplanted human embryonic stem cell-derived pancreatic endocrine islet cells. Cell Prolif 2008; 41:843-58; PMID:19040565; http://dx.doi.org/10.1111/j.1365-2184.2008.00564.x.