Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 113-122

  Breda, Ardala ^a   MacHado, Pablo ^a   Rosado, Leonardo Astolfi ^a   Souto, André Arigony ^a   Santos, Diógenes Santiago ^a   Basso, Luiz Augusto ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Inhibitors; Mycobacterium tuberculosis; Orotate phosphoribosyltransferase; Pyrimidin 2(1H) ones compounds; Pyrimidine; Tuberculosis

Indexed keywords

3 (2 HYDROXYBENZYLIDINE) 2,6 DIOXO 1,2,3,6 TETRAHYDROPYRIDINE 4 CARBOXYLIC ACID; 3 BENZYLIDINE 2,6 DIOXO 1,2,3,6 TETRAHYDROPYRIDINE 4 CARBOXYLIC ACID; 3,5 BIS((DIMETHYLAMINO)METHYL) 6 HYDROXY 2 OXO 1,2 DIHYDROPYRIDINE 4 CARBOXYLIC ACID; 4 HYDROXY 5 ((2 HYDROXYETHYLAMINO)METHYL) 6 METHYL 3 NITROPYRIDIN 2(1H) ONE; 5 ((1,3 DIHYDROXY 2 METHYLPROPAN 2 YLAMINO)METHYL) 4 HYDROXY 6 METHYL 3 NITROPYRIDIN 2(1H) ONE; 5 ((2,3 DIHYDROXYPROPYLAMINO)METHYL) 4 HYDROXY 6 METHYL 3 NITROPYRIDIN 2(1H) ONE; 5 ((DIMETHYLAMINO)METHYL) 4 HYDROXY 6 METHYL 3 NITROPYRIDIN 2(1H) ONE; 6 HYDROXY 2 OXO 1,2 DIHYDROPYRIDINE 4 CARBOXYLIC ACID; 6 HYDROXY 5 ((2 HYDROXYETHYLAMINO)METHYL) 2 OXO 1,2 DIHYDROPYRIDINE 4 CARBOXYLIC ACID; OROTATE PHOSPHORIBOSYLTRANSFERASE; OROTIC ACID; OROTIDINE 5' PHOSPHATE DECARBOXYLASE; PYRIMIDIN 2(1H) ONE; PYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG DESIGN; DRUG POTENCY; ENZYME BINDING; ENZYME INHIBITION; HYDROPHOBICITY; INHIBITION KINETICS; ISOTHERMAL TITRATION CALORIMETRY; MEASUREMENT; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STEADY STATE; SYNTHESIS; THERMODYNAMICS;

ANTI-BACTERIAL AGENTS; MYCOBACTERIUM TUBERCULOSIS; OROTATE PHOSPHORIBOSYLTRANSFERASE; PYRIMIDINONES; TIME FACTORS;

EID: 84864411484     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.04.031     Document Type: Article

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