Evaluation of a multi-class, multi-residue liquid chromatography - tandem mass spectrometry method for analysis of 120 veterinary drugs in bovine kidney

Drug Testing and Analysis

Volumn 4, Issue SUPPL.1, 2012, Pages 91-102

  Schneider, Marilyn J ^a   Lehotay, Steven J ^a   Lightfield, Alan R ^a  

^a EASTERN REGIONAL RESEARCH CENTER   (United States)

Author keywords

Bovine kidney; LC MS MS; MS identification; Multi class veterinary drug residues analysis

Indexed keywords

DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETRY;

ANALYTES; BOVINE KIDNEY; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; MS IDENTIFICATION; MULTI-CLASS VETERINARY DRUG RESIDUE ANALYSE; PERFORMANCE; RESIDUE ANALYSIS; VETERINARY DRUG RESIDUE;

EXTRACTION;

7 (2 AMINOETHYLAMINO) 1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 4 OXO 3 QUINOLINECARBOXYLIC ACID; CIPROFLOXACIN; DANOFLOXACIN; DIFLOXACIN; DRUG RESIDUE; ENROFLOXACIN; FLUMEQUINE; LOMEFLOXACIN; NORDIFLOXACIN; NORFLOXACIN; OFLOXACIN; OXOLINIC ACID; SULFACETAMIDE; SULFACHLORPYRIDAZINE; SULFADIAZINE; SULFADIMETHOXINE; SULFADIMIDINE; SULFADOXINE; SULFAFURAZOLE; SULFAGUANIDINE; SULFAMERAZINE; SULFAMETHIZOLE; SULFAMETHOXAZOLE; SULFAMETHOXYPYRIDAZINE; SULFANILAMIDE; SULFAPYRIDINE; SULFAQUINOXALINE; SULFATHIAZOLE; UNINDEXED DRUG; VETERINARY DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COW; DIAGNOSTIC TEST ACCURACY STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG SCREENING; KIDNEY; LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

EID: 84864403133     PISSN: 19427603     EISSN: 19427611     Source Type: Journal    
DOI: 10.1002/dta.1359     Document Type: Article

References (15)

1. S.J. Lehotay, A.R. Lightfield, L. Geis-Asteggiante, M.J. Schneider, T. Dutko, C. Ng, et al. Development and validation of a streamlined method designed to detect residues of 62 veterinary drugs in bovine kidney using ultrahigh performance liquid chromatography - tandem mass spectrometry. Drug Test. Analysis 2012, 4(Suppl. 1), 75-90.
2. S.B. Clark, J.M. Storey, S.B. Turnipseed. Optimization and validation of a multiclass screening and confirmation method for drug residues in milk using high-performance liquid chromatography/tandem mass spectrometry. J. AOAC Int. 2011, 94, 383.
3. V. Jimenez, A. Rubies, F. Centrich, R. Companyo, J. Guiteras. Development and validation of a multiclass method for the analysis of antibiotic residues in eggs by liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2011, 1218, 1443.
4. D.A. Bohm, C.S. Stachel, P. Gowik. Validated determination of eight antibiotic substance groups in cattle and pig muscle by HPLC/MS/MS. J. AOAC Int. 2011, 94, 407.
5. P.A. Martos, F. Jayadundara, J. Dolbeer, W. Jin, L. Spilsbury, M. Mitchell, et al. Multiclass, Multiresidue drug analysis, including aminoglycosides, in animal tissue using liquid chromatography coupled to tandem mass spectrometry. J. Agr. Food Chem. 2010, 58, 5932.
6. C. Chiaochan, U. Koesukwiwat, S. Yudthavorasit, N. Leepipatpiboon. Efficient hydrophilic interaction liquid chromatography-tandem mass spectrometry for the multiclass analysis of veterinary drugs in chicken muscle. Anal. Chim. Acta 2010, 682, 117.
7. G. Stubbings, T. Bigwood. The development and validation of a multiclass liquid chromatography tandem mass spectrometry (LC-MS/MS) procedure for the determination of veterinary drug residues in animal tissue using a QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) approach. Anal. Chim. Acta 2009, 637, 68.
8. D. Ortelli, E. Cognard, P. Jan, P. Edder. Comprehensive fast multiresidue screening of 150 veterinary drugs in milk by ultra-performance liquid chromatography coupled to time of flight mass spectrometry. J. Chromatogr. B 2009, 877, 2363.
9. R.J.B. Peters, Y.J.C. Bolck, P. Rutgers, A.A.M. Stolker, M.W.F. Nielen. Multi-residue screening of veterinary drugs in egg, fish and meat using high-resolution liquid chromatography accurate mass time-of-flight mass spectrometry. J. Chromatogr. A 2009, 1216, 8206.
10. A. Kaufmann, P. Butcher, K. Maden, S. Walker, M. Widmer. Development of an improved high resolution mass spectrometry based multi-residue method for veterinary drugs in various food matrices. Anal. Chim. Acta 2011, 700, 86.
11. K. Mastovska, A.R. Lightfield. Streamlining methodology for the multiresidue analysis of beta-lactam antibiotics in bovine kidney using liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2008, 1202, 118.
12. M.J. Schneider, K. Mastovska, S.J. Lehotay, A.R. Lightfield, B. Kinsella, C.E. Schultz. Comparison of screening methods for antibiotics in beef kidney juice and serum. Anal. Chim. Acta 2009, 637, 290.
13. E.H. Steiner, in Statistical Manual of the Association of Official Analytical Chemists, (Eds: W.J. Youden, E.H. Steiner), AOAC International: Gaithersburg, MD, 1975, pp. 86.
14. C.R. Anderson, H.S. Rupp, W.H. Wu. Complexities in tetracycline analysis - chemistry, matrix extraction, cleanup, and liquid chromatography. J. Chromatogr. A 2005, 1075, 23.
15. US FDA, Center for Veterinary Medicine, Guidance for Industry Mass Spectrometry for Confirmation of the Identity of Animal Drug Residues Final Guidance. US Department of Health and Human Services. Available at: [18 October 2011].