Cystatin C as risk factor for cardiovascular events and all-cause mortality in the general population. the Tromso Study

Nephrology Dialysis Transplantation

Volumn 27, Issue 7, 2012, Pages 2780-2787

  Toft, Ingrid ^a,b   Solbu, Marit ^a   Kronborg, Jens ^c   Mathisen, Ulla D ^a,b   Eriksen, Bjorn O ^a,b   Storhaug, Hilde ^b   Melsom, Toralf ^a,b   Lochen, Maja Lisa ^b   Mathiesen, Ellisiv B ^a,b   Njølstad, Inger ^b   Wilsgaard, Tom ^b   Brox, Jan ^a,b  

^a UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^b UNIVERSITY OF TROMSØ   (Norway)

^c INNLANDET HOSPITAL TRUST   (Norway)

Author keywords

all cause mortality; cardiovascular disease; kidney; morbidity; women

Indexed keywords

CYSTATIN C;

ADULT; AGE DISTRIBUTION; AGED; ANALYSIS OF COVARIANCE; ARTICLE; BRAIN ISCHEMIA; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; HEART INFARCTION; HUMAN; KIDNEY DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; POPULATION RESEARCH; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE; TURBIDIMETRY;

AGED; CARDIOVASCULAR DISEASES; CYSTATIN C; FEMALE; FOLLOW-UP STUDIES; GLOMERULAR FILTRATION RATE; HUMANS; MALE; MIDDLE AGED; NORWAY; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE;

EID: 84864400404     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr751     Document Type: Article

References (36)

1. Go AS, Chertow GM, Fan D et al. Chronic kidney disease and the risk of death, cardiovascular events, and hospitalization. N Engl J Med 2004; 351: 1296-1305.
2. Manjunath G, Tighiouart H, Ibrahim H et al. Level of kidney function as risk factor for atherosclerotic cardiovascular outcomes in the community. J Am Coll Cardiol 2003; 41: 47-55.
3. Sarnak MJ, Levey AS, Schoolwerth AC et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease. High Blood Pressure Research, Clinical Cardiology, and Epidemiology, and Prevention. Circulation 2003; 108: 2154-2169.
4. Kassirer JP. Clinical evaluation of kidney function-glomerular function. N Engl J Med 1971; 285: 385-389.
5. Levey AS. Measurement of renal function in chronic renal disease. Kidney Int 1990; 38: 167-184.
6. Coll E, Botey A, Alvarez L et al. Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as marker for early renal impairment. Am J Kidney Dis 2000; 36: 29-34.
7. Dharnidharka VR, Kvon C, Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis 2002; 40: 221-226.
8. Galteau MM, Guyon M, Gueguen R et al. Determination of serum cystatin C: biological variation and reference values. Clin Chem Lab Med 2001; 39: 850-857.
9. Kos J, Krasovec M, Cimerman N et al. Cysteine protease inhibitors stefin A, stefin B, and cystatin C in sera from patients with colorectal cancer: relation to prognosis. Clin Cancer Res 2000; 6: 505-511.
10. Wiesli P, Schwegler B, Spinas GA et al. Serum cystatin C is sensitive to small changes in thyroid function. Clin Chim Acta 2003; 338: 87-90.
11. Knight L, Verhave JC, Spiegelman D et al. Factors influencing cystatin C levels other than renal function, and the impact on renal function measurement. Kidney Int 2004; 65: 1416-1421.
12. Hojs R, Bevc S, Ekart R et al. Serum cystatin C as an endogenous marker of renal function in patients with mild to moderate impairment of kidney function. Nephrol Dial Transplant 2006; 21: 1855-1862.
13. Shlipak MG, Sarnak MJ, Katz R et al. Cystatin C and the risk of death and cardiovascular events among elderly persons. N Engl J Med 2005; 352: 2049-2060.
14. Shlipak MG, Katz R, Sarnac MJ et al. Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease. Ann Intern Med 2006; 145: 237-246.
15. Larsson A, Helmersson J, Hansson LO et al. Serum cystatin C is associated with cardiovascular risk markers and cardiovascular disease in elderly men. Int J Cardiol 2008; 125: 263-264.
16. Sarnak MJ, Katz R, Stehman-Breen CO et al. Cystatin C concentration as a risk factor for heart failure in failure adults. Ann Intern Med 2005; 142: 497-505.
17. Shlipak MG, Wassel Fyr CL, Chertow GM et al. Cystatin C and mortality risk in the elderly: the health, aging, and body composition study. J Am Soc Nephrol 2006; 17: 254-261.
18. Luc G, Bard JM, Lesueur C et al. Plasma cysteine C and development of coronary heart disease: the Prime Study. Atherosclerosis 2006; 185: 375-380.
19. Ix JH, Shlipak MG, Chertow GM et al. Association of cystatin C with mortality, cardiovascular events, and incident heart failure among persons with coronary heart disease. Data from the Heart and Soul study. Circulation 2007; 115: 173-179.
20. Koenig Heart W, Twardella D, Brenner H et al. Plasma concentration of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate. Clin Chem 2005; 51: 321-327.
21. Menon V, Shlipak MG, Wang X et al. Cystatin C as a risk factor for outcomes in chronic kidney disease. Ann Intern Med 2007; 147: 19-27.
22. Astor BC, Levey AS, Stevens LA et al. Method of glomerular filtration rate estimation affects prediction of mortality risk. J Am Soc Nephrol 2009; 20: 2214-2222.
23. Johnsen SH, Mathiesen EB, Fosse E et al. Elevated high-density lipoprotein cholesterol levels are protective against plaque progression: a follow-up study of 1952 persons with carotid atherosclerosis the Tromsø study. Circulation 2005; 112: 498-504.
24. Levey AS, Stevens LA, Schmid CH et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150: 604-612.
25. Stevens LA, Coresh J, Schmid CH et al. Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3.418 individuals with CKD. Am J Kidney Dis 2008; 51: 395-406.
26. Eriksen BO, Mathisen UD, Melsom T et al. Cystatin C is not a better estimator of GFR than plasma creatinine in the general population. Kidney Int 2010; 78: 1305-1311.
27. Dade BeringIncrease Sensitivity and Reliability in Renal Function Analysis 2005Marburg, GermanyDade Behring
28. Thomas L, Huber AR. Renal function-estimation of glomerular filtration rate. Clin Chem Lab Med 2006; 44: 1295-1302.
29. Luepker RV, Apple FS, Christenson RH et al. Case definition for acute coronary heart disease in epidemiology and clinical research studies: a statement from AHA Council on Epidemiology and Prevention; AHA Statistics Committee; World Heart Federation Council on Epidemiology and Prevention; the European Society of Cardiology Working Group on Epidemiology and Prevention; Centers for Disease Control and Prevention; and the national Heart, Lung and Blood Institute. Circulation 2003; 108: 2543-2549.
30. The World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): a major international collaboration. WHO MONICA Project Principal Investigators. J Clin Epidemiol 1988; 41: 105-114.
31. Köttgen A, Selvin E, Stevens LA et al. Serum cystatin C in the United States: the Third National Health and Nutrition Examination Survey (NHANES III). Am J Kidney Dis 2008; 51: 385-394.
32. Mathisen DU, Melsom T, Ingebretsen OC et al. Estimated GFR associates with cardiovascular risk factors independently of measured GFR. J Am Soc Nephrol 2011; 5: 927-937.
33. Wu CK, Chang MH, Lin JW et al. Renal-related biomarkers and long-term mortality in the US subjects with different coronary risks. Atherosclerosis 2011; 216: 226-236.
34. Hallan SI, Coresh J, Astor BC et al. International comparison of the relationship of chronic kidney disease prevalence and ESRD risk. J Am Soc Nephrol 2006; 17: 2275-2284.
35. Ni L, Lü J, Hou LB et al. Cystatin C, associated with hemorrhagic, ischemic stroke, is a strong predictor of the risk of cardiovascular events and death in Chinese. Stroke 2007; 38: 3287-3288.
36. Levey AS, Coresh J, Greene T et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med 2006; 145: 247-254.