Glucose metabolism and gray-matter concentration in apolipoprotein E ε4 positive normal subjects

Neurobiology of Aging

Volumn 33, Issue 10, 2012, Pages 2321-2323

  Samuraki, Miharu ^a   Matsunari, Ichiro ^b   Chen, Wei Ping ^b   Shima, Keisuke ^a   Yanase, Daisuke ^a   Takeda, Nozomi ^b   Matsuda, Hiroshi ^c   Yamada, Masahito ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b The Medical and Pharmacological Research Center Foundation   (Japan)

^c SAITAMA MEDICAL UNIVERSITY INTERNATIONAL MEDICAL CENTER   (Japan)

Author keywords

Alzheimer's disease; ApoE 4; FDG PET

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE;

ADULT; AGED; ALZHEIMER DISEASE; APOLIPOPROTEIN E EPSILON 4 GENE; ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; FEMALE; GENE; GENE FREQUENCY; GLUCOSE METABOLISM; GRAY MATTER; HUMAN; IMAGE ANALYSIS; IMAGE DISPLAY; IMAGE PROCESSING; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PREVALENCE; PRIORITY JOURNAL; SCORING SYSTEM; VOXEL BASED MORPHOMETRY;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; BRAIN; FEMALE; FLUORODEOXYGLUCOSE F18; GLUCOSE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; YOUNG ADULT;

EID: 84864383170     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2011.11.020     Document Type: Article

References (7)

1. Good C.D., Johnsrude I.S., Ashburner J., Henson R.N., Friston K.J., Frackowiak R.S. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 2001, 14:21-36.
2. Kim J., Basak J.M., Holtzman D.M. The role of apolipoprotein E in Alzheimer's disease. Neuron 2009, 63:287-303.
3. Langbaum J.B., Chen K., Caselli R.J., Lee W., Reschke C., Bandy D., Alexander G.E., Burns C.M., Kaszniak A.W., Reeder S.A., Corneveaux J.J., Allen A.N., Pruzin J., Huentelman M.J., Fleisher A.S., Reiman E.M. Hypometabolism in Alzheimer-affected brain regions in cognitively healthy Latino individuals carrying the apolipoprotein E epsilon4 allele. Arch. Neurol 2010, 67:462-468.
4. Lemaître H., Crivello F., Dufouil C., Grassiot B., Tzourio C., Alpérovitch A., Mazoyer B. No epsilon4 gene dose effect on hippocampal atrophy in a large MRI database of healthy elderly subjects. Neuroimage 2005, 24:1205-1213.
5. Matsunari I., Samuraki M., Chen W.P., Yanase D., Takeda N., Ono K., Yoshita M., Matsuda H., Yamada M., Kinuya S. Comparison of 18F-FDG PET and Optimized Voxel-Based Morphometry for Detection of Alzheimer's Disease: Aging Effect on Diagnostic Performance. J. Nucl. Med 2007, 48:1961-1970.
6. Reiman E.M., Caselli R.J., Yun L.S., Chen K., Bandy D., Minoshima S., Thibodeau S.N., Osborne D. Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J. Med 1996, 334:752-758.
7. Reiman E.M., Uecker A., Caselli R.J., Lewis S., Bandy D., de Leon M.J., De Santi S., Convit A., Osborne D., Weaver A., Thibodeau S.N. Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease. Ann. Neurol 1998, 44:288-291.