Efficacy of orally administered Lentinula edodes mycelia extract for advanced gastrointestinal cancer patients undergoing cancer chemotherapy: A pilot study

Asian Pacific Journal of Cancer Prevention

Volumn 12, Issue 7, 2011, Pages 1671-1674

  Okuno, Kiyotaka ^a   Uno, Kazuko ^b  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Louis Pasteur Center for Medical Research   (Japan)

Author keywords

Advanced cancer; Cancer chemotherapy; Lentinula edodes mycelia extract

Indexed keywords

ANTINEOPLASTIC AGENT; CD56 ANTIGEN; GAMMA INTERFERON;

AGED; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; FEMALE; GASTROINTESTINAL TUMOR; HUMAN; IMMUNOLOGY; LENTINULA EDODES; MALE; METABOLISM; MIDDLE AGED; MYCELIUM; NATURAL KILLER CELL; PILOT STUDY;

AGED; ANTIGENS, CD56; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; GASTROINTESTINAL NEOPLASMS; HUMANS; INTERFERON-GAMMA; KILLER CELLS, NATURAL; MALE; MIDDLE AGED; MYCELIUM; PILOT PROJECTS; SHIITAKE MUSHROOMS;

EID: 84864351869     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Casado E, Pfeiffer P, Feliu J, et al (2008). UFT (tegafur-uracil) in rectal cancer. Ann Oncol, 19, 1371-8.
2. Chihara G, Maeda Y, Hamuro J, et al (1969). Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes (Berk.) sing. Nature, 222, 687-8.
3. Conklin KA (2000). Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects. Nutr Cancer, 37, 1-18.
4. Glimelius B (2005). Benefit-risk assessment of irinotecan in advanced colorectal cancer. Drug Safety, 28, 417-33.
5. Gonzalez Baron M, Feliu J, Ordonez A, et al (1993). Phase I study of UFT plus leucovorin in advanced colorectal cancer: a double modulation proposal. Anticancer Res, 13, 759-62.
6. Itoh A, Isoda K, Kondoh M, et al (2009). Hepatoprotective effect of syringic acid and vanillic acid on concanavalin a-induced liver injury. Biol Pharm Bull, 32, 1215-9.
7. Kojima H, Akaki J, Nakajima S, et al (2010). Structural analysis of glycogen-like polysaccharides having macrophage-activating activity in extracts of Lentinula edodes mycelia. J Nat Med, 64, 16-23.
8. Liu M, Li J, Kong F, et al (1998). Induction of immunomodulating cytokines by a new polysaccharide-peptide complex from culture mycelia of Lentinus edodes. Immunopharmacology, 40, 187-98.
9. Malet-Martino M, Martino R (2002). Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): a review. Oncologist, 7, 288-323.
10. Nagashima Y, Sanpei N, Yamamoto S, et al (2005). Evaluation of host immunity and side effects in breast cancer patients treated with adjuvant chemotherapy (FEC therapy). Gan To Kagaku Ryoho, 32, 1550-2 (in Japanese).
11. Naitoh H, Okauchi H, Endo Y, et al (1997). A case of multiple liver metastasis and local recurrence from rectal cancer effectively treated by arterial infusion chemotherapy using low-dose 5-fluorouracil, cisplatin and LV. Gan To Kagaku Ryoho, 24, 1764-7 (in Japanese).
12. Sugano N, Hibino Y, Choji Y, et al (1982). Anticarcinogenic actions of water-soluble and alcohol-insoluble fractions from culture medium of Lentinus edodes mycelia. Cancer Lett, 17, 109-14.
13. Sugano N, Choji Y, Hibino Y, et al (1985). Anticarcinogenic action of an alcohol-insoluble fraction (LAP1) from culture medium of Lentinus edodes mycelia. Cancer Lett, 27, 1-6.
14. Takiuchi H, Ajani JA (1998). Uracil-tegafur in gastric carcinoma: a comprehensive review. J Clin Oncol, 16, 2877-885.
15. Tanaka K (2011). Oral ingestion of Lentinula edodes mycelia extract inhibits B16 melanoma growth via mitigation of regulatory T cell-mediated immunosuppression. Cancer Sci, 102, 516-21.
16. Uno K, Mitsuishi Y, Tanigawa M, et al (2003). A series of immune responses leading to the induction of T cell IL-12/IL-18 responsiveness in patients with relatively large tumor burdens. Cancer Immunol Immunother, 52, 33-40.
17. Viale PH, Yamamoto DS (2008). Cardiovascular toxicity associated with cancer treatment. Clin J Oncol Nurs, 12, 627-38.