Original articles effect of vitamin A adjunct therapy for cerebral malaria in children admitted to Mulago hospital: A randomized controlled trial

African Health Sciences

Volumn 12, Issue 2, 2012, Pages 90-97

  Mwanga Amumpaire, J ^a   Ndeezi, G ^a   Tumwine, J K ^a  

^a MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES   (Uganda)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; FREE RADICAL; PLACEBO; QUININE; RETINOL PALMITATE; ANTIMALARIAL AGENT; RETINOL; VITAMIN;

ADJUVANT THERAPY; ARTICLE; BRAIN MALARIA; CHILD; CHILD DEATH; CHILDHOOD MORTALITY; COMA; CONTROLLED STUDY; CONVULSION; DISEASE DURATION; DOUBLE BLIND PROCEDURE; DRUG POTENTIATION; FEEDING; FEMALE; FEVER; HOSPITAL ADMISSION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PARASITE CLEARANCE; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TREATMENT OUTCOME; VITAMIN SUPPLEMENTATION; CONTROLLED CLINICAL TRIAL; INTRAVENOUS ADMINISTRATION; ISOLATION AND PURIFICATION; LENGTH OF STAY; MALARIA; MORTALITY; REGRESSION ANALYSIS; SEIZURE; TIME; UGANDA;

ADMINISTRATION, INTRAVENOUS; ANTIMALARIALS; CHILD; CHILD, PRESCHOOL; COMA; DOUBLE-BLIND METHOD; FEMALE; FEVER; HUMANS; INFANT; LENGTH OF STAY; MALARIA, CEREBRAL; MALE; PLASMODIUM FALCIPARUM; QUININE; REGRESSION ANALYSIS; SEIZURES; TIME FACTORS; TREATMENT OUTCOME; UGANDA; VITAMIN A; VITAMINS;

EID: 84864329186     PISSN: 16806905     EISSN: None     Source Type: Journal    
DOI: 10.4314/ahs.v12i2.3     Document Type: Article

References (32)

1. World Health Organisation Malaria Report (2008) Geneva
2. WHO. Severe and complicated malaria. Trans R Soc Trop Med Hyg 1990; 84 (suppl 2): 1-65.
3. Uganda National Malaria Control Policy, Ministry of Health, Kampala, Uganda 2005-2010.
4. Dondorp AM, Fanello CI, Hendriksen IC, Gomes E, Seni A, Chhaganlal KD, et al. Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet. 2010 Nov 13;376(9753):1647-1657.
5. Dondorp A, Nosten F, Stepniewska K, Day N, White NJ, for the South East Asian Quinine Artesunate Malaria Trial (SEAQUAMAT) group. Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial. Lancet 2005; 366: 717-725.
6. Adjunctive therapy for cerebral malaria and other severe forms of Plasmodium falciparum malaria. Chandy C John1, Elizabeth Kutamba, Keith Mugarura, and Robert O Opoka. Expert Rev Anti Infect Ther. 2010 September; 8(9): 997-1008.
7. Davis T M; Skinner A T S, Beilby J. In vitro growth inhibition of Plasmodium falciparum by retinol at concentrations present in normal human serum. Acta Trop 1998; 69:111-119.
8. Shankar A H, Genton B. Effect of Vitamin A supplementation on morbidity due to plasmodium falciparum in young children in Papua New Guinea: a randomised trial. Lancet 1999; 354: 203-209.
9. Serghides L, Kain K C. Peroxisome Proliferator-Activated Receptor Ò-Retinoid X Receptor Agonists increase CD 36-Dependant Phagocytosis of plasmodium falciparum parasitized erythrocytes and decrease malaria-induced TNF-á Secretion by Monocytes/Macrophages. J. Immunol 2001; 166: 6742-6748.
10. Serghides L, Kain K.C. Mechanism of protection induced by vitamin A in falciparum malaria. Lancet 2002; 359:1404-406
11. Skinner A T, Barrett H. Heterogenous activity in vitro of Vitamin A (retinol) in combination with novel established antimalarial drugs. Trans R Soc Trop Med Hyg. 1999; 93 (5) 550-551.
12. Susan A. Keys and William F. Zimmerman. Antioxidant Activity of Retinol, Glutathione, and Taurine inBovine Photoreceptor Cell Membranes. Exp. Eye Res. (1999) 68, 693-702
13. Global prevalence of vitamin A deficiency. Micronutrient deficiency information system. WHO. MIDS working paper # 2; 1995.
14. Davis T M, Binh TQ, Thu LT, Rossi R, Danh PT, Barrett PH et al. Pharmacokinetics of Retinyl palmitate and retinol after intramuscular retinyl palmitate administration in severe malaria. Clin Sci 2000; 99:433-441.
15. Varandas L, Julien M, Gomes A, Rodrigues P, Van Lerberghe W, Malveiro F, et al. A Rrandomised, double blind, placebo controlled clinical trial of Vitamin A in severe malaria in hospitalised Mozambican children. Ann Trop Paed 2002;2201: 211-222.
16. Idro R, Karamagi C, Tumwine J. Immediate outcome and prognostic factors for cerebral malaria among children admitted to Mulago Hospital, Uganda Ann Trop Paediatr. 2004 Mar;24(1):17-24.
17. Newton C R, Krishna S. Severe falciparum malaria in children: Current understanding of pathophysiology and supportive treatment. Pharmacol-Therapeut. 1998; 79: 1-53.
18. WHO (2000) Severe falciparum malaria. Trans Roy Soc Trop Medicine and Hyg, 94, supplement 1.
19. Tabone M D, Mwanza K, Ja-del C. The role of interleukin-6 in Vitamin A deficiency during plasmodium falciparum malaria and possible consequences for Vitamin A supplementation. Immunology 1992; 75: 553-554.
20. Keusch G T. Micronutrients and susceptibility to infection. Ann NY Acad Sci. 1990; 587:181-188.
21. Hussey G D, Klein M. A randomised controlled trial of vitamin A in children with severe measles. New Eng J Med 1990;323:160-164
22. Idro R, Jenkins NE, Newton CR. Pathogenesis, clinical features, and neurological outcome of cerebral malaria. Lancet Neurol 2005; 4: 827-840
23. Molyneux M E, Taylor T E, Wirima J J, Harper G. Clinical features and prognostic indicators in peadiatric cerebral malaria: a study of 131 comatose Malawian children. Quart J Med 1989;71: 441-459.
24. Jaffer S, Van Hensbroek N B, Palmer A, Schneder G, Greenweel B. Predictors of fatal outcome following childhood cerebral malaria. Amer J Trop Med Hyg 1997; 57: 20-24.
25. Kwiatkowski D, Hill AV, Sambou I, Twumasi P, Castracane J, Manogue KR., et al. TNF concentration in fatal cerebral malaria, non-fatal cerebral malaria and uncomplicated Plasmodium falciparum malaria. Lancet 1990; 336:1201-1204.
26. Aceng JR, Byarugaba JS, Tumwine JK. Rectal arte mether versus intravenous quinine for the treatment of cerebral malaria in children in Uganda: randomised clinical trial. BMJ. 2005;330:334. doi: 10.1136/bmj.330.7487.334.
27. Brewster D R, Kwiatkowski D, White N J. Neurological sequalae of cerebral malaria in children. Lancet, 1990;336: 1039-1043.
28. Marsh K, Forster D, Waruiru C, Mwangi I, Winstanley M, Marsh V, et al. Indicators of life threatening malaria in African children. New Eng J Med 1995; 332: 1399-404.
29. Carme B, Bouquety J C, Plassart H. Mortality and se quelae due to cerebral malaria in African children in Brazzaville, Congo. Amer J Trop Med Hyg 1993; 48:216-221.
30. Genton B, al-Yaman F, Alpers M P, Mokela D. Indicators of fatal outcome in paeditric cerebral malaria: A study of 134 comatose Papua New Guinean children. Internat J Epidemiol 1997;26:670-676
31. Mayo-Wilson E, Imdad A, Herzer K, Yakoob MY, Bhutta ZA. Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis. BMJ. 2011 Aug 25; 343: d5094
32. Imdad A, Yakoob MY, Sudfeld C, Haider BA, Black RE, Bhutta Z. A Impact of vitamin A supplementation on infant and childhood mortality. BMC Public Health. 2011 Apr 13;11 Suppl:S20.