Pelizaeus-Merzbacher disease-associated proteolipid protein 1 inhibits oligodendrocyte precursor cell differentiation via extracellular-signal regulated kinase signaling

Biochemical and Biophysical Research Communications

Volumn 424, Issue 2, 2012, Pages 262-268

  Miyamoto, Yuki ^a   Torii, Tomohiro ^a   Tanoue, Akito ^a   Yamauchi, Junji ^a,b  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b The Japan Human Health Sciences Foundation   (Japan)

Author keywords

Differentiation; ERK; Oligodendrocyte precursor cells; PLP1; Primary culture system

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEOLIPID PROTEIN; PROTEOLIPID PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; COCULTURE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME INHIBITION; GENE EXPRESSION; MOLECULAR MECHANICS; MYELIN DEFICIENCY; NONHUMAN; OLIGODENDROGLIA; PELIZAEUS MERZBACHER DISEASE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPINAL GANGLION; STEM CELL;

CELL DIFFERENTIATION; COCULTURE TECHNIQUES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GANGLIA, SPINAL; HUMANS; MYELIN PROTEOLIPID PROTEIN; MYELIN SHEATH; NEURONS; OLIGODENDROGLIA; PELIZAEUS-MERZBACHER DISEASE; SIGNAL TRANSDUCTION; STEM CELLS;

RODENTIA;

EID: 84864325132     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.06.101     Document Type: Article

References (28)

1. Nave K.A., Trapp B.D. Axon-glial signaling and the glial support of axon function. Annu. Rev. Neurosci. 2008, 31:535-561.
2. Garbern J., Cambi F., Shy M., Kamholz J. The molecular pathogenesis of Pelizaeus-Merzbacher disease. Arch. Neurol. 1999, 56:1210-1214.
3. Dhaunchak A.S., Colman D.R., Nave K.A. Misalignment of PLP/DM20 transmembrane domains determines protein misfolding in Pelizaeus-Merzbacher disease. J. Neurosci. 2011, 31:14961-14971.
4. Garbern J.Y. Pelizaeus-Merzbacher disease: genetic and cellular pathogenesis. Cell. Mol. Life Sci. 2007, 64:50-65.
5. Gow A., Southwood C.M., Lazzarini R.A. Disrupted proteolipid protein trafficking results in oligodendrocyte apoptosis in an animal model of Pelizaeus-Merzbacher disease. J. Cell Biol. 1998, 140:925-934.
6. Southwood C.M., Garbern J., Liang W., Gow A. The unfolded protein response modulates disease severity in Pelizaeus-Merzbacher disease. Neuron 2002, 36:585-596.
7. Miyamoto Y., Yamauchi J., Chan J.R., Okada A., Tomooka Y., Hisanaga S., Tanoue A. Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin. J. Cell Sci. 2007, 120:4355-4366.
8. Miyamoto Y., Yamauchi J., Tanoue A. Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration thorough nonreceptor tyrosine kinase Fyn. J. Neurosci. 2008, 28:8326-8337.
9. Chan J.R., Watkins T.A., Cosgaya J.M., Zhang C., Chen L., Reichardt L.F., Shooter E.M., Barres B.A. NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes. Neuron 2004, 43:183-191.
10. Yamauchi J., Miyamoto Y., Hamasaki H., Sanbe A., Kusakawa S., Nakamura A., Tsumura H., Maeda M., Nemoto N., Kawahara K., Torii T., Tanoue A. The atypical guanine-nucleotide exchange factor, Dock7, negatively regulates Schwann cell differentiation and myelination. J. Neurosci. 2011, 31:12579-12592.
11. Kagawa T., Ikenaka K., Inoue Y., Kuriyama S., Tsujii T., Nakao J., Nakajima K., Aruga J., Okano H., Mikoshiba K. Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene. Neuron 1994, 13:427-442.
12. Macdonald S.G., Crews C.M., Wu L., Driller J., Clark R., Erikson R.L., McCormick F. Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro. Mol. Cell. Biol. 1993, 13:6614-6620.
13. Koopman G., Reutelingsperger C.P., Kuijten G.A., Keehnen R.M., Pals S.T., van Oers M.H. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 1995, 84:1415-1420.
14. Fyffe-Maricich S.L., Karlo J.C., Landreth G.E., Miller R.H. The ERK2 mitogen-activated protein kinase regulates the timing of oligodendrocyte differentiation. J. Neurosci. 2011, 31:843-850.
15. Galabova-Kovacs G., Catalanotti F., Matzen D., Reyes G.X., Zezula J., Herbst R., Silva A., Walter I., Baccarini M. Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development. J. Cell Biol. 2008, 180:947-955.
16. Bar-Sagi D., Hall A. Ras and Rho GTPases: a family reunion. Cell 2000, 103:227-238.
17. Mason C.S., Springer C.J., Cooper R.G., Superti-Furga G., Marshall C.J., Marais R. Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation. EMBO J. 1999, 18:2137-2148.
18. Yamauchi J., Miyamoto Y., Tanoue A., Shooter E.M., Chan J.R. Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration. Proc. Natl. Acad. Sci. USA 2005, 102:14889-14894.
19. Harrisingh M.C., Perez-Nadales E., Parkinson D.B., Malcolm D.S., Mudge A.W., Lloyd A.C. The Ras/Raf/ERK signaling pathway drives Schwann cell dedifferentiation. EMBO J. 2004, 23:3061-3071.
20. Cunningham J.J., Roussel M.F. Cyclin-dependent kinase inhibitors in the development of the central nervous system. Cell Growth Differ. 2001, 12:387-396.
21. Zezula J., Casaccia-Bonnefil P., Ezhevsky S.A., Osterhout D.J., Levine J.M., Dowdy S.F., Chao M.V., Koff A. P21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal. EMBO Rep. 2001, 2:27-34.
22. Tang X.M., Beesley J.S., Grinspan J.B., Seth P., Kamholz J., Cambi F. Cell cycle arrest induced by ectopic expression of p27 is not sufficient to promote oligodendrocyte differentiation. J. Cell. Biochem. 1999, 76:270-279.
23. Dugas J.C., Ibrahim A., Barres B.A. A crucial role for p57(Kip2) in the intracellular timer that controls oligodendrocyte differentiation. J. Neurosci. 2007, 27:6185-6196.
24. Pereira J.A., Lebrun-Julien F., Suter U. Molecular mechanisms regulating myelination in the peripheral nervous system. Trends Neurosci. 2012, 35:123-134.
25. Ryan M.C., Shooter E.M., Notterpek L. Aggresome formation in neuropathy models based on peripheral myelin protein 22 mutations. Neurobiol. Dis. 2002, 10:109-118.
26. Tobler A.R., Liu N., Mueller L., Shooter E.M. Differential aggregation of the Trembler and Trembler J mutants of peripheral myelin protein 22. Proc. Natl. Acad. Sci. USA 2002, 99:483-488.
27. Newbern J.M., Snider W.D. Bers-ERK Schwann cells coordinate nerve regeneration. Neuron 2012, 73:623-626.
28. Napoli I., Noon L.A., Ribeiro S., Kerai A.P., Parrinello S., Rosenberg L.H., Collins M.J., Harrisingh M.C., White I.J., Woodhoo A., Lloyd A.C. A central role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration in vivo. Neuron 2012, 73:729-742.