Dose-dependent mesothelioma induction by intraperitoneal administration of multi-wall carbon nanotubes in p53 heterozygous mice

Cancer Science

Volumn 103, Issue 8, 2012, Pages 1440-1444

  Takagi, Atsuya ^a   Hirose, Akihiko ^a   Futakuchi, Mitsuru ^b   Tsuda, Hiroyuki ^c   Kanno, Jun ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD45 ANTIGEN; MULTI WALLED NANOTUBE; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; CYTOPLASM; DOSE RESPONSE; EPITHELIOID CELL; FEMALE; FIBROSIS; GRANULOMA; HETEROZYGOSITY; LYMPHOCYTE; MACROPHAGE; MALE; MESOTHELIOMA; MICROSCOPY; MONONUCLEAR CELL; MOUSE; NONHUMAN; PERITONEUM; PHAGOCYTOSIS; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; SURVIVAL; TUMOR MICROENVIRONMENT;

ANIMALS; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, P53; HETEROZYGOTE; INJECTIONS, INTRAPERITONEAL; MALE; MESOTHELIOMA; MICE; MICE, INBRED STRAINS; NANOTUBES, CARBON; PERITONEUM; SURVIVAL ANALYSIS;

EID: 84864317151     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2012.02318.x     Document Type: Article

References (29)

1. Service RF. CHEMISTRY: nanotubes: the next asbestos? Science 1998; 281: 941.
2. Takagi A, Hirose A, Nishimura T et al. Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci 2008; 33: 105-16.
3. Stanton MF, Layard M, Tegeris A et al. Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals. J Natl Cancer Inst 1981; 67: 965-75.
4. Pott F, Roller M, Kamino K, Bellmann B. Significance of durability of mineral fibers for their toxicity and carcinogenic potency in the abdominal cavity of rats in comparison with the low sensitivity of inhalation studies. Environ Health Perspect 1994; 102(Suppl 5): 145-50.
5. Adachi S, Yoshida S, Kawamura K et al. Inductions of oxidative DNA damage and mesothelioma by crocidolite, with special reference to the presence of iron inside and outside of asbestos fiber. Carcinogenesis 1994; 15: 753-8.
6. Roller M, Pott F, Kamino K, Althoff GH, Bellmann B. Dose-response relationship of fibrous dusts in intraperitoneal studies. Environ Health Perspect 1997; 105(Suppl 5): 1253-6.
7. World Health Organization. WHO Workshop on Mechanisms of Fibre Carcinogenesis and Assessment of Chrysotile Asbestos Substitutes, 8-12 November 2005. Lyon, France: Summary Consensus Report World Health Organization, 2006.
8. European Chemicals Bureau. Carcinogenicity of synthetic mineral fibres after intraperitoneal injection in rats (ECB/TM/18(97) rev. 1). In: Bernstein DM, Riego Sintes JM, eds. Methods for the Determination of the Hazardous Properties for Human Health of Man Made Mineral Fibres (MMMF) (EUR 18748 EN [1999]). Ispra, Italy: Institute for Health and Consumer Protection, Unit Toxicology and Chemical Substances, 1999; 41-52. [Cited 26 May 2012.] Available from URL:.
9. Marsella JM, Liu BL, Vaslet CA, Kane AB. Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers. Environ Health Perspect 1997; 105(Suppl 5): 1069-72.
10. Mahler JF, Flagler ND, Malarkey DE, Mann PC, Haseman JK, Eastin W. Spontaneous and chemically induced proliferative lesions in Tg. AC transgenic and p53-heterozygous mice. Toxicol Pathol 1998; 26: 501-11.
11. Eastin WC, Haseman JK, Mahler JF, Bucher JR. The National Toxicology Program evaluation of genetically altered mice as predictive models for identifying carcinogens. Toxicol Pathol 1998; 26: 461-73.
12. Tsukada T, Tomooka Y, Takai S et al. Enhanced proliferative potential in culture of cells from p53-deficient mice. Oncogene 1993; 8: 3313-22.
13. Chung A, Cagle PT, Roggli VL, eds. Tumors of the Serosal Membranes. Washington, DC: American Registry of Pathology, 2006.
14. Chalabreysse L, Guillaud C, Tabib A, Loire R, Thivolet-Bejui F. Malignant mesothelioma with osteoblastic heterologous elements. Ann Pathol 2001; 21: 428-30.
15. Matsukuma S, Aida S, Hata Y, Sugiura Y, Tamai S. Localized malignant peritoneal mesothelioma containing rhabdoid cells. Pathol Int 1996; 46: 389-91.
16. Ordonez NG. Mesothelioma with rhabdoid features: an ultrastructural and immunohistochemical study of 10 cases. Mod Pathol 2006; 19: 373-83.
17. Courtice FC, Simmonds WJ. The removal of protein from the subarachnoid space. Aust J Exp Biol Med Sci 1951; 29: 255-63.
18. Weller RO, Djuanda E, Yow HY, Carare RO. Lymphatic drainage of the brain and the pathophysiology of neurological disease. Acta Neuropathol 2009; 117: 1-14.
19. National Toxicology Program. NTP technical report on the toxicology and carcinogenesis studies of dimethyl vinyl chloride (L-chloro-2-methylpropene) (Cas No. 513-37-1) in F344/N rats and B6C3F1 mice (Gavage Studies) (NTP TR 316). National Toxicology Program, Research Triangle Park, North Carolina, 1986. [Cited 26 May 2012.] Available from URL:.
20. National Toxicology Program. NTP technical report on the toxicology and carcinogenesis studies of glycidol (Cas No. 556-52-5) in F344/N rats and B6C3F1 mice (Gavage Studies) (NTP TR 374). National Toxicology Program, Research Triangle Park, North Carolina, 1990. [Cited 26 May 2012.] Available from URL:.
21. Boffetta P, Burdorf A, Goldberg M, Merler E, Siemiatycki J. Towards the coordination of European research on the carcinogenic effects of asbestos. Scand J Work Environ Health 1998; 24: 312-7.
22. Yano E, Wang ZM, Wang XR, Wang MZ, Lan YJ. Cancer mortality among workers exposed to amphibole-free chrysotile asbestos. Am J Epidemiol 2001; 154: 538-43.
23. Donaldson K, Murphy FA, Duffin R, Poland CA. Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part Fibre Toxicol 2010; 7: 5.
24. Poland CA, Duffin R, Kinloch I et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 2008; 3: 423-8.
25. Nagai H, Toyokuni S. Biopersistent fiber-induced inflammation and carcinogenesis: lessons learned from asbestos toward safety of fibrous nanomaterials. Arch Biochem Biophys 2010; 502: 1-7.
26. Tossavainen A, Karjalainen A, Karhunen PJ. Retention of asbestos fibers in the human body. Environ Health Perspect 1994; 102(Suppl 5): 253-5.
27. Miserocchi G, Sancini G, Mantegazza F, Chiappino G. Translocation pathways for inhaled asbestos fibers. Environ Health 2008; 7: 4.
28. Goldsmith JR. Asbestos as a systemic carcinogen: the evidence from eleven cohorts. Am J Ind Med 1982; 3: 341-8.
29. Noonan CW, Pfau JC, Larson TC, Spence MR. Nested case-control study of autoimmune disease in an asbestos-exposed population. Environ Health Perspect 2006; 114: 1243-7.