A preclinical study of the safety and efficacy of Occlusin™ 500 artificial embolization device in sheep

CardioVascular and Interventional Radiology

Volumn 35, Issue 3, 2012, Pages 636-644

  Owen, Richard J ^a   Nation, Patrick N ^a   Polakowski, Robert ^b   Biliske, Jennifer A ^c   Tiege, Paul B ^c   Griffith, Irwin J ^d  

^a UNIVERSITY OF ALBERTA   (Canada)

^b BioLipids Inc   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

^d Advanced Technology Centre   (Canada)

Author keywords

Biodegradable; Embolic agent; PLGA; Recanalization; Uterine artery embolization

Indexed keywords

COLLAGEN; MICROSPHERE; POLYGLACTIN; ACRYLIC ACID RESIN; BIOMATERIAL; COLLAGEN TYPE 1; CONTRAST MEDIUM; GELATIN; GLYCOLIC ACID; GLYCOLIC ACID DERIVATIVE; IOHEXOL; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; POLYMER; TRISACRYL GELATIN MICROSPHERES;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CLINICAL EFFECTIVENESS; COHORT ANALYSIS; CONTROLLED STUDY; EWE; FEMALE; FLUOROSCOPY; MEDICAL DEVICE; NONHUMAN; OVARY; PRIORITY JOURNAL; RECANALIZATION; SAFETY; UTERINE ARTERY EMBOLIZATION; UTERUS; ANIMAL; CATTLE; INSTRUMENTATION; RANDOMIZATION; SHEEP;

ACRYLIC RESINS; ANIMALS; CATTLE; COATED MATERIALS, BIOCOMPATIBLE; COLLAGEN; COLLAGEN TYPE I; CONTRAST MEDIA; FEMALE; FLUOROSCOPY; GELATIN; GLYCOLATES; IOHEXOL; LACTIC ACID; MICROSPHERES; POLYGLYCOLIC ACID; POLYMERS; RANDOM ALLOCATION; SHEEP; UTERINE ARTERY EMBOLIZATION;

EID: 84864314023     PISSN: 01741551     EISSN: 1432086X     Source Type: Journal    
DOI: 10.1007/s00270-011-0218-7     Document Type: Article

References (15)

1. Pelage J-P, Laurent A, Bonneau M et al (2001) Arterial blood supply to the uterus in nonpregnant sheep: a pertinent model for clinical practice? Investig Radiol 36:721-725
2. Pelage J-P, Laurent A, Wassef M et al (2002) Uterine artery embolization in sheep: comparison of acute effects with polyvinyl alcohol particles and calibrated microspheres. Radiology 224:436-445
3. Laurent A, Wassef M, Namur J et al (2009) Recanalization and particle exclusion after embolization of uterine arteries in sheep: a long-term study. Fertil Steril 91:884-892
4. Brill A (2009) Treatment of fibroids via uterine artery occlusion uterine artery embolization and Doppler-guided uterine artery occlusion): potential role in today's armamentarium. Arch Gynecol Obstet 280:513-520
5. Laurent A, Pelage J-P, Wassef M et al (2008) Fertility after bilateral uterine artery embolization in a sheep model. Fertil Steril 89:1371-1383
6. Vlahos L, Benakis V, Dimakakos P et al (1980) A comparative study of the degree of arterial recanalization in kidneys of dogs following transcatheter embolization with eight different materials. Eur Urol 6:180-185
7. Geschwind J-F, Ramsey D, Cleffken B et al (2003) Transcatheter arterial chemoembolization of liver tumors: effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency. Cardiovasc Interv Radiol 26:111-117
8. Jander J, Russinovich N (1980) Transcatheter gelfoam embolization in abdominal, retroperitoneal, and pelvic hemorrhage. Radiology 136:337-344
9. Chrisman H, Saker M, Yu R et al (2000) The impact of uterine fibroid embolization on resumption of menses and ovarian function. J Vasc Interv Radiol 11:699-703
10. Goodwin SC, McLucas B, Lee M et al (1999) Uterine artery embolization for the treatment of uterine leiomyomata mid-term results. J Vasc Interv Radiol 10:1159-1165
11. Spies JB, Scialli A, Jha RC et al (1999) Initial results from uterine fibroid embolization for symptomatic leiomyomata. J Vasc Interv Radiol 10:1145-1157
12. Kim H, Tsai J, Lee J et al (2006) Effects of utero-ovarian anastomoses on basal follicle-stimulating hormone level change after uterine artery embolization with tris-acryl gelatin microspheres. J Vasc Interv Radiol 17:965-971
13. Marx M, Wack J, Baker E et al (2001) Ovarian protection by occlusion of uteroovarian collateral vessels before uterine fibroid embolization. J Vasc Interv Radiol 14:1329-1332
14. Bilbao J, de Luis E, García de Jalón J et al (2008) Comparative study of four different spherical embolic particles in an animal model: a morphologic and histologic evaluation. J Vasc Interv Radiol 19:1625-1638
15. Senturk C, Cakir V, Yorukoglu K et al (2010) Looking for the ideal particle: an experimental embolization study. Cardiovasc Intervent Radiol 33:336-345