Small molecule and peptide-mediated inhibition of Epstein-Barr virus nuclear antigen 1 dimerization

Biochemical and Biophysical Research Communications

Volumn 424, Issue 2, 2012, Pages 251-256

  Kim, Sun Young ^a,b   Song, Kyung A ^a,b   Kieff, Elliott ^c   Kang, Myung Soo ^a,b,c  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Samsung Medical Center   (South Korea)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Dimerization; DNA binding; EBNA1; EBV; EBV encoded nuclear antigen 1; Epstein Barr virus; Inhibitor; OriP

Indexed keywords

ANTIVIRUS AGENT; EIK1 COMPOUND; EPSTEIN BARR VIRUS ANTIGEN 1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIMERIZATION; DRUG STRUCTURE; EPSTEIN BARR VIRUS; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN MULTIMERIZATION; SURFACE PLASMON RESONANCE; VIRUS INHIBITION;

ANTIVIRAL AGENTS; BENZOIC ACIDS; DNA; DNA-BINDING PROTEINS; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; HUMANS; PEPTIDES; PROTEIN MULTIMERIZATION; REPLICATION ORIGIN; THIOBARBITURATES;

HUMAN HERPESVIRUS 4;

EID: 84864294340     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.06.095     Document Type: Article

References (16)

1. Sugden B., Marsh K., Yates J. A vector that replicates as a plasmid and can be efficiently selected in B-lymphoblasts transformed by Epstein-Barr virus. Mol. Cell. Biol. 1985, 5:410-413.
2. Yates J.L., Warren N., Sugden B. Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells. Nature 1985, 313:812-815.
3. Bochkarev A., Barwell J.A., Pfuetzner R.A., Bochkareva E., Frappier L., Edwards A.M. Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein, EBNA1, bound to DNA. Cell 1996, 84:791-800.
4. Bochkarev A., Bochkareva E., Frappier L., Edwards A.M. The 2.2 A structure of a permanganate-sensitive DNA site bound by the Epstein-Barr virus origin binding protein, EBNA1. J. Mol. Biol. 1998, 284:1273-1278.
5. Aras S., Singh G., Johnston K., Foster T., Aiyar A. Zinc coordination is required for and regulates transcription activation by Epstein-Barr nuclear antigen 1. PLoS Pathog. 2009, 5:e1000469.
6. Kang M.S., Lee E.K., Soni V., Lewis T.A., Koehler A.N., Srinivasan V., Kieff E. Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenance. J. Virol. 2011, 85:2859-2868.
7. Bochkarev A., Barwell J.A., Pfuetzner R.A., Furey W., Edwards A.M., Frappier L. Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein EBNA 1. Cell 1995, 83:39-46.
8. Hung S.C., Kang M.S., Kieff E. Maintenance of Epstein-Barr virus (EBV) oriP-based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1. Proc. Natl. Acad. Sci. USA 2001, 98:1865-1870.
9. Calderwood M.A., Venkatesan K., Xing L., Chase M.R., Vazquez A., Holthaus A.M., Ewence A.E., Li N., Hirozane-Kishikawa T., Hill D.E., Vidal M., Kieff E., Johannsen E. Epstein-Barr virus and virus human protein interaction maps. Proc. Natl. Acad. Sci. USA 2007, 104:7606-7611.
10. Nasimuzzaman M., Kuroda M., Dohno S., Yamamoto T., Iwatsuki K., Matsuzaki S., Mohammad R., Kumita W., Mizuguchi H., Hayakawa T., Nakamura H., Taguchi T., Wakiguchi H., Imai S. Eradication of epstein-barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1. Mol. Ther. 2005, 11:578-590.
11. McGovern S.L., Caselli E., Grigorieff N., Shoichet B.K. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J. Med. Chem. 2002, 45:1712-1722.
12. Chen M.R., Middeldorp J.M., Hayward S.D. Separation of the complex DNA binding domain of EBNA-1 into DNA recognition and dimerization subdomains of novel structure. J. Virol. 1993, 67:4875-4885.
13. Farrell C.J., Lee J.M., Shin E.C., Cebrat M., Cole P.A., Hayward S.D. Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptide. Proc. Natl. Acad. Sci. USA 2004.
14. Kang M.S., Lu H., Yasui T., Sharpe A., Warren H., Cahir-McFarland E., Bronson R., Hung S.C., Kieff E. Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice. Proc. Natl. Acad. Sci. USA 2005, 102:820-825.
15. Barwell J.A., Bochkarev A., Pfuetzner R.A., Tong H., Yang D.S., Frappier L., Edwards A.M. Overexpression, purification, and crystallization of the DNA binding and dimerization domains of the Epstein-Barr virus nuclear antigen 1. J. Biol. Chem. 1995, 270:20556-20559.
16. Sixbey J.W., Vesterinen E.H., Nedrud J.G., Raab-Traub N., Walton L.A., Pagano J.S. Replication of Epstein-Barr virus in human epithelial cells infected in vitro. Nature 1983, 306:480-483.