Influence of drug distribution and solubility on release from geopolymer pellets-A finite element method study

Journal of Pharmaceutical Sciences

Volumn 101, Issue 5, 2012, Pages 1803-1810

  Jämstorp, Erik ^a   Strømme, Maria ^a   Bredenberg, Susanne ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b Orexo AB   (Sweden)

Author keywords

Controlled release; Diffusion; Dissolution; Materials science; Oral drug delivery; Solubility

Indexed keywords

FENTANYL; GEOPOLYMER; NITROGEN; POLYMER; SACCHARIN; SUMATRIPTAN; THEOPHYLLINE; UNCLASSIFIED DRUG; DRUG;

ABSORPTION; ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; MATHEMATICAL COMPUTING; SCANNING ELECTRON MICROSCOPY; CHEMISTRY; FINITE ELEMENT ANALYSIS; SOLUBILITY;

FINITE ELEMENT ANALYSIS; MICROSCOPY, ELECTRON, SCANNING; NITROGEN; PHARMACEUTICAL PREPARATIONS; POLYMERS; SOLUBILITY;

EID: 84864293001     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23071     Document Type: Article

References (18)

1. Jumbelic MI. 2010. Deaths with transdermal fentanyl patches. Am J Forensic Med Pathol 31(1):18-21.
2. Aulton ME. 2007. Aulton's pharmaceutics: The design and manufacture of medicines. London, UK: Churchill Livingstone.
3. Davidovits J. 2008. Geopolymer chemistry and applications. Geopolymer Institute. France: Saint-Quetin.
4. Jämstorp E, Forsgren J, Bredenberg S, Engqvist H, Strømme M. 2010. Mechanically strong geopolymers offer new possibilities in treatment of chronic pain. J Control Release 146(3):370-377.
5. Jämstorp E, Strømme M, Frenning G. 2011. Modeling structure-function relationships for diffusive drug transport in inert porous geopolymer matrices. J Pharm Sci 100(10):4338-4348.
6. Crank J. 1975. The mathematics of diffusion. 2nd ed. Oxford, UK: Clarendon Press.
7. Frenning G. 2011. Modelling drug release from inert matrix systems: From moving-boundary to continuous-field descriptions. Int J Pharm 418(1):88-99.
8. Siepmann J, Siepmann F. 2008. Mathematical modeling of drug delivery. Int J Pharm 364(2):328-343.
9. Wu XY, Zhou Y. 1999. Studies of diffusional release of a dispersed solute from polymeric matrixes by finite element method. J Pharm Sci 88(10):1050-1057.
10. Kriven WM, Bell JL, Gordon M. 2003. Microstructure and microchemistry of fully-reacted geopolymers and geopolymer matrix composites. Ceram Trans 153:227-250.
11. Murray KL, Seaton NA, Day MA. 1999. An adsorption-based method for the characterization of pore networks containing both mesopores and macropores. Langmuir 15(20):6728-6737.
12. Barrett EP, Joyner LG, Halenda PP. 1951. The determination of pore volume and area distributions in porous substances. I. Computations from nitrogen isotherms. J Am Chem Soc 73(1):373-380.
13. Frenning G, Brohede U, Strømme M. 2005. Finite element analysis of the release of slowly dissolving drugs from cylindrical matrix systems. J Control Release 107(2):320-329.
14. Brunauer S, Emmett PH, Teller E. 1938. Adsorption of gases in multimolecular layers. J Am Chem Soc 60(2):309-319.
15. Cussler EL. 2009. Diffusion: Mass transfer in fluid systems. 3rd ed. Cambridge, UK: Cambridge University Press, pp xxii, 631.
16. Roy SD, Flynn GL. 1989. Solubility behavior of narcotic analgesics in aqueous media: Solubilities and dissociation constants of morphine, fentanyl, and sufentanil. Pharm Res 6(2):147-151.
17. Kimberley AL, Sanna T, Paul JS, James EP. 2002. Solubility and permeability determination of anhydrous theophylline with application to the biopharmaceutics classification system. Midland: The Dow Chemical Company Literature.
18. Dixon CM, Saynor DA, Andrew PD, Oxford J, Bradbury A, Tarbit MH. 1993. Disposition of sumatriptan in laboratory animals and humans. Drug Metab Dispos 21(5):761-769.