Reductive amination by continuous-flow hydrogenation: Direct and scalable synthesis of a benzylpiperazine

Synthesis (Germany)

Volumn 44, Issue 15, 2012, Pages 2469-2473

  Liu, Jing ^a   Fitzgerald, Anne E ^a   Mani, Neelakandha S ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

amination; benzylation; green chemistry; hydrogenation; palladium

Indexed keywords

BENZYLATION; CONTINUOUS-FLOW; ENVIRONMENTALLY-FRIENDLY; GREEN CHEMISTRY; LARGE SCALE SYNTHESIS; PROTECTING GROUP; REDUCTIVE AMINATION; SCALABLE SYNTHESIS;

ALDEHYDES; AMINATION; AMINES; PALLADIUM;

HYDROGENATION;

1 (2,2 DIFLUOROBENZO[1,3]DIOXOL 5 YLMETHYL)PIPERAZINE; BENZALDEHYDE; BENZYLPIPERAZINE; PIPERAZINE; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; CATALYST; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; FLOW RATE; HIGH TEMPERATURE; HYDROGENATION; PARTICLE SIZE; PROCESS OPTIMIZATION; SYNTHESIS;

EID: 84864286130     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0032-1316550     Document Type: Article

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