Adenovirus receptors: Implications for targeting of viral vectors

Trends in Pharmacological Sciences

Volumn 33, Issue 8, 2012, Pages 442-448

  Arnberg, Niklas ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; IMMUNOGLOBULIN M; INTEGRIN; MEMBRANE COFACTOR PROTEIN; TRASTUZUMAB; VIRUS DNA;

ADENOVIRUS; BINDING AFFINITY; CARDIOVASCULAR DISEASE; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; EXTRACELLULAR MATRIX; GENE MUTATION; GENE TARGETING; HUMAN; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; KUPFFER CELL; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; SIMIAN VIRUS 40; T LYMPHOCYTE; TISSUE DISTRIBUTION; VIRAL GENE THERAPY; VIRAL TROPISM; VIRION; VIRUS ATTACHMENT; VIRUS CAPSID; VIRUS CELL INTERACTION;

ADENOVIRIDAE; ANIMALS; GENE THERAPY; GENETIC VECTORS; HUMANS; LIVER; RECEPTORS, VIRUS; VIRAL TROPISM;

EID: 84864284194     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2012.04.005     Document Type: Review

References (92)

1. B. Harrach Adenoviridae A.M.Q. King, Virus Taxonomy. Ninth Report of the International Committee on Taxonomy of Viruses 2011 Elsevier Academic Press 125 141
2. Reddy Crystal Structure of Human Adenovirus at 3.5 Å Resolution Science 329 2010 1071 1075
3. Edelstein, M. (2011) Gene Therapy Clinical Trials Worldwide (http://www.wiley.com/legacy/wileychi/genmed/clinical/)
4. J.M. Bergelson Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5 Science 275 1997 1320 1323 (Pubitemid 27114163)
5. I. Kirby Adenovirus type 9 fiber knob binds to the coxsackie B virus-adenovirus receptor (CAR) with lower affinity than fiber knobs of other CAR-binding adenovirus serotypes J. Virol. 75 2001 7210 7214 (Pubitemid 32641612)
6. P.W. Roelvink The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F J. Virol. 72 1998 7909 7915 (Pubitemid 28421782)
7. C.T. Garnett Latent species C adenoviruses in human tonsil tissues J. Virol. 83 2009 2417 2428
8. R.W. Walters Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape Cell 110 2002 789 799 (Pubitemid 35283966)
9. T.A. Smith Receptor interactions involved in adenoviral-mediated gene delivery after systemic administration in non-human primates Hum. Gene Ther. 14 2003 1595 1604 (Pubitemid 37452870)
10. E. Seiradake The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution PLoS Pathog. 5 2009 e1000277
11. D. Stone Adenovirus-platelet interaction in blood causes virus sequestration to the reticuloendothelial system of the liver J. Virol. 81 2007 4866 4871 (Pubitemid 46668683)
12. T. Sasaki A simple detection system for adenovirus receptor expression using a telomerase-specific replication-competent adenovirus Gene Ther. 2012 10.1038/gt.2011.213
13. R.P. Tomko HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses Proc. Natl. Acad. Sci. U.S.A. 94 1997 3352 3356 (Pubitemid 27157315)
14. R. Toivonen Dilated cardiomyopathy alters the expression patterns of CAR and other adenoviral receptors in human heart Histochem. Cell Biol. 133 2010 349 357
15. J.F. Beaulieu Integrins and human intestinal cell functions Front. Biosci. 4 1999 D310 D321
16. D. Sheppard Functions of pulmonary epithelial integrins: from development to disease Physiol. Rev. 83 2003 673 686 (Pubitemid 36828923)
17. F. Vigneault Control of integrin genes expression in the eye Prog. Retin. Eye Res. 26 2007 99 161 (Pubitemid 46217160)
18. N. Arnberg Adenovirus receptors, implications for tropism, treatment and targeting Rev. Med. Virol. 19 2009 165 178
19. S. Huang Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells J. Virol. 70 1996 4502 4508 (Pubitemid 26191142)
20. P.W. Roelvink Comparative analysis of adenovirus fiber-cell interaction: adenovirus type 2 (Ad2) and Ad9 utilize the same cellular fiber receptor but use different binding strategies for attachment J. Virol. 70 1996 7614 7621 (Pubitemid 26339066)
21. V. Lütschg Chemotactic antiviral cytokines promote infectious apical entry of human adenovirus into polarized epithelial cells Nat. Commun. 2 2011 391
22. S. Huang Upregulation of integrins alpha v beta 3 and alpha v beta 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery J. Virol. 69 1995 2257 2263
23. H. Dehari Enhanced antitumor effect of RGD fiber-modified adenovirus for gene therapy of oral cancer Cancer Gene Ther. 10 2003 75 85 (Pubitemid 36222079)
24. A.M. Witlox Conditionally replicative adenovirus with tropism expanded towards integrins inhibits osteosarcoma tumor growth in vitro and in vivo Clin. Cancer Res. 10 2004 61 67 (Pubitemid 38114162)
25. M.R. Kibbe Optimizing cardiovascular gene therapy: increased vascular gene transfer with modified adenoviral vectors Arch. Surg. 135 2000 191 197 (Pubitemid 30078474)
26. A. Gaggar CD46 is a cellular receptor for group B adenoviruses Nat. Med. 9 2003 1408 1412 (Pubitemid 37466191)
27. M. Marttila CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7 J. Virol. 79 2005 14429 14436 (Pubitemid 41552740)
28. B.D. Persson An arginine switch in the species B adenovirus knob determines high-affinity engagement of the cellular receptor CD46 J. Virol. 83 2009 673 686
29. A. Segerman Adenovirus type 11 uses CD46 as a cellular receptor J. Virol. 77 2003 9183 9191 (Pubitemid 37011015)
30. H. Wang In vitro and in vivo properties of adenovirus vectors with increased affinity to CD46 J. Virol. 82 2008 10567 10579 (Pubitemid 352691205)
31. X. He 5/35 fiber-modified conditionally replicative adenovirus armed with p53 shows increased tumor-suppressing capacity to breast cancer cells Hum. Gene Ther. 22 2011 283 292
32. J. Yan The role of membrane complement regulatory proteins in cancer immunotherapy Adv. Exp. Med. Biol. 632 2008 159 174
33. D.J. Gustafsson Adenovirus 11p downregulates CD46 early in infection Virology 405 2010 474 482
34. H. Wang A recombinant adenovirus type 35 fiber knob protein sensitizes lymphoma cells to rituximab therapy Blood 115 2010 592 600
35. P.L. Sinn Measles virus preferentially transduces the basolateral surface of well-differentiated human airway epithelia J. Virol. 76 2002 2403 2409 (Pubitemid 34150708)
36. M.J. Ludford-Menting A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization J. Biol. Chem. 277 2002 4477 4484 (Pubitemid 34968715)
37. B.J. McLaughlin Novel role for a complement regulatory protein (CD46) in retinal pigment epithelial adhesion Invest. Ophthalmol. Vis. Sci. 44 2003 3669 3674 (Pubitemid 36909810)
38. R. Strauss Epithelial phenotype confers resistance of ovarian cancer cells to oncolytic adenoviruses Cancer Res. 69 2009 5115 5125
39. K. Cupelli Structure of adenovirus type 21 knob in complex with CD46 reveals key differences in receptor contacts among species B adenoviruses J. Virol. 84 2010 3189 3200
40. B.D. Persson Adenovirus type 11 binding alters the conformation of its receptor CD46 Nat. Struct. Mol. Biol. 14 2007 164 166
41. A. Segerman There are two different species B adenovirus receptors: sBAR, common to species B1 and B2 adenoviruses, and sB2AR, exclusively used by species B2 adenoviruses J. Virol. 77 2003 1157 1162 (Pubitemid 36055538)
42. S. Tuve A new group B adenovirus receptor is expressed at high levels on human stem and tumor cells J. Virol. 80 2006 12109 12120 (Pubitemid 44904362)
43. H. Wang Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14 Nat. Med. 17 2011 96 104
44. H.V. Trinh Avidity binding of human adenovirus serotypes 3 and 7 to the membrane cofactor CD46 triggers infection J. Virol. 86 2012 1623 1637
45. H. Wang Multimerization of adenovirus serotype 3 fiber knob domains is required for efficient binding of virus to desmoglein 2 and subsequent opening of epithelial junctions J. Virol. 85 2011 6390 6402
46. J. Rebetz Fiber mediated receptor masking in non-infected bystander cells restricts adenovirus cell killing effect but promotes adenovirus host co-existence PLoS ONE 4 2009 e8484
47. J.P. Thiery Epithelial-mesenchymal transitions in development and disease Cell 139 2009 871 890
48. P. Savagner The epithelial-mesenchymal transition (EMT) phenomenon Ann. Oncol. 21 Suppl. 7 2010 89 92
49. V. Tolmachev Imaging of HER-2 overexpression in tumors for guiding therapy Curr. Pharm. Des. 14 2008 2999 3019
50. N. Tao Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver Mol. Ther. 3 2001 28 35 (Pubitemid 32509802)
51. G. Wolff Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ J. Virol. 71 1997 624 629 (Pubitemid 26412334)
52. H.A. Jaffe Adenovirus-mediated in vivo gene transfer and expression in normal rat liver Nat. Genet. 1 1992 372 378
53. A.L. Parker Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes Blood 108 2006 2554 2561
54. L.P. Ganesan Rapid and efficient clearance of blood-borne virus by liver sinusoidal endothelium PLoS Pathog. 7 2011 e1002281
55. N.C. Di Paolo Redundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver Mol. Ther. 17 2009 675 684
56. H.J. Haisma, and A.R. Bellu Pharmacological interventions for improving adenovirus usage in gene therapy Mol. Pharm. 8 2011 50 55
57. E. Wisse The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer Gene Ther. 15 2008 1193 1199
58. J. Snoeys Lipid emulsions potently increase transgene expression in hepatocytes after adenoviral transfer Mol. Ther. 13 2006 98 107 (Pubitemid 41763487)
59. H.J. Haisma Scavenger receptor A: a new route for adenovirus 5 Mol. Pharm. 6 2009 366 374
60. Z. Xu Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors, natural antibodies and complement J. Virol. 82 2008 11705 11713
61. R. Khare Identification of adenovirus serotype 5 hexon regions that interact with scavenger receptors J. Virol. 86 2012 2293 2301
62. M.R. Duffy A cluster of basic amino acids in the factor X serine protease mediates surface attachment of adenovirus/FX complexes J. Virol. 85 2011 10914 10919
63. S.N. Waddington Adenovirus serotype 5 hexon mediates liver gene transfer Cell 132 2008 397 409 (Pubitemid 351200513)
64. R. Alba Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer Blood 114 2009 965 971
65. O. Kalyuzhniy Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo Proc. Natl. Acad. Sci. U.S.A. 105 2008 5483 5488 (Pubitemid 351753889)
66. R.C. Carlisle Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1 Blood 113 2009 1909 1918
67. M. Lyons Adenovirus type 5 interactions with human blood cells may compromise systemic delivery Mol. Ther. 14 2006 118 128 (Pubitemid 44191831)
68. R. Alba Coagulation factor X mediates adenovirus type 5 liver gene transfer in non-human primates (Microcebus murinus) Gene Ther. 19 2012 109 113
69. R. Khare Generation of a Kupffer cell-evading adenovirus for systemic and liver-directed gene transfer Mol. Ther. 19 2011 1254 1262
70. J.A. Greig Influence of coagulation factor X on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors Mol. Ther. 17 2009 1683 1691
71. A. Lenman Coagulation factor IX mediates serotype-specific binding of species A adenoviruses to host cells J. Virol. 85 2011 13420 13431
72. A.L. Parker Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D J. Virol. 81 2007 3627 3631 (Pubitemid 46456671)
73. L. Denby Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo Hum. Gene Ther. 15 2004 1054 1064 (Pubitemid 39552287)
74. E. Seiradake Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor J. Biol. Chem. 281 2006 33704 33716 (Pubitemid 46036749)
75. E. Wu Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitis J. Virol. 78 2004 3897 3905 (Pubitemid 38437196)
76. E.C. Nilsson The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis Nat. Med. 17 2011 105 109
77. S. Spjut A potent trivalent sialic acid inhibitor of adenovirus type 37 infection of human corneal cells Angew. Chem. Int. Ed. 50 2011 6519 6521
78. Y. Chu Vascular cell adhesion molecule-1 augments adenovirus-mediated gene transfer Arterioscler. Thromb. Vasc. Biol. 21 2001 238 242 (Pubitemid 32125372)
79. S.S. Hong Adenovirus type 5 fiber knob binds to MHC class I alpha2 domain at the surface of human epithelial and B lymphoblastoid cells EMBO J. 16 1997 2294 2306 (Pubitemid 27258631)
80. T.A. Smith Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice Hum. Gene Ther. 14 2003 777 787 (Pubitemid 36623514)
81. L. Balakireva Binding of adenovirus capsid to dipalmitoyl phosphatidylcholine provides a novel pathway for virus entry J. Virol. 77 2003 4858 4866 (Pubitemid 36402835)
82. J.J. Short Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors Virus Res. 122 2006 144 153 (Pubitemid 44740333)
83. A. Koski Systemic adenoviral gene delivery to orthotopic murine breast tumors with ablation of coagulation factors, thrombocytes and Kupffer cells J. Gene Med. 11 2009 966 977
84. R. Vogels Replication-deficient human adenovirus type 35 vectors for gene transfer and vaccination: efficient human cell infection and bypass of preexisting adenovirus immunity J. Virol. 77 2003 8263 8271 (Pubitemid 36871454)
85. A.H. Kidd Antibodies to fastidious faecal adenoviruses (species 40 and 41) in sera from children J. Med. Virol. 11 1983 333 341 (Pubitemid 13064530)
86. L. Gonzalez-Mariscal Virus interaction with the apical junctional complex Front. Biosci. 14 2009 731 768
87. P. Fender Impact of human adenovirus type 3 dodecahedron on host cells and its potential role in viral infection J. Virol. 86 2012 5380 5385
88. L. Franqueville Protein crystals in adenovirus type 5-infected cells: requirements for intranuclear crystallogenesis, structural and functional analysis PLoS ONE 3 2008 e2894
89. M.C. Bewley Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR Science 286 1999 1579 1583
90. H. Brandstetter X-Ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B Proc. Natl. Acad. Sci. U.S.A. 92 1995 9796 9800
91. B.D. Persson Structure of the extracellular portion of CD46 provides insights into its interactions with complement proteins and pathogens PLoS Pathog. 6 2010 e1001122
92. D. Venkateswarlu Structure and dynamics of zymogen human blood coagulation factor X Biophys. J. 82 2002 1190 1206 (Pubitemid 34204743)