β-Cell dysfunction in chronic pancreatitis

Digestive Diseases and Sciences

Volumn 57, Issue 7, 2012, Pages 1764-1772

  Sasikala, M ^a   Talukdar, R ^a,b   Pavan Kumar, P ^a   Radhika, G ^a   Rao, G V ^b   Pradeep, R ^b   Subramanyam, C ^a   Nageshwar Reddy, D ^b  

^a Asian Healthcare Foundation   (India)

^b ASIAN INSTITUTE OF GASTROENTEROLOGY   (India)

Author keywords

cell dysfunction; Inflammation; Interferon gamma; Secondary diabetes; Transcription factors

Indexed keywords

GASTROINTESTINAL HORMONE; MICRORNA; NEUROGENIC DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR PDX 1;

CELL STRUCTURE; CHRONIC PANCREATITIS; CYSTIC FIBROSIS; DIABETES MELLITUS; GENETICS; HUMAN; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEOMICS; REVIEW;

ANIMALS; CYTOKINES; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; FIBROSIS; GASTROINTESTINAL HORMONES; HUMANS; INSULIN-SECRETING CELLS; MICRORNAS; PANCREATITIS, CHRONIC;

EID: 84864283157     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-012-2086-7     Document Type: Review

References (49)

1. Garg PK, Tandon RK. Survey on CP in the Asia-Pacific region. J Gastroenterol Hepatol. 2004;19:998-1004.
2. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1998; 21:5-19.
3. Lankisch PG. Natural course of CP. Pancreatology. 2001;1:3-14.
4. Mitchell RMS, Byrne MF, Baillie J. Pancreatitis. Lancet. 2003;361:1447-1455. (Pubitemid 36515050)
5. Blondet J, Carlson A, Kobayashi T, et al. The role of total pancreatectomy and islet autotransplantation for CP. Surg Clin N Am. 2007;87:1477-1501. (Pubitemid 350160791)
6. Kobayashi T, Manivel JC, Bellin MD, et al. Correlation of pancreatic histopathologic findings and islet yield in children with CP undergoing total pancreatectomy and islet autotransplantation. Pancreas. 2010;39:57-63.
7. Kobayashi T, Manivel JC, Carlson AM, et al. Correlation of histopathology, islet Yield, and islet graft function after islet autotransplantation in CP. Pancreas. 2011;40:193-199.
8. Bellin MD, Sutherland DE. Pediatric islet autotransplantation: indication, technique, and outcome. Curr Diab Rep. 2010;10:326-331.
9. Crawford JM, Cotran RS. The pancreas. In: Cotran et al., eds. Robbins Pathologic basis of Disease. 6th ed. Philadelphia: W.B. Saunders company; 1999:902-929.
10. Pipeleers D. The biosociology of pancreatic β-cells. Diabetologia. 1987;30:277-291.
11. Pipeleers D, Van De Winkel M. Cellular endogenous fluorescence: a basis for preparing subpopulations of functionally homogenous cells. In: Kohen E, ed. Cell Structure and Function by Microspectrofluorometry. USA: Academic Press; 1989: 391-404.
12. Kiekens R, In't Veld R, Mahler T, Schuit F, Van De Winkel M, Pipeleers D. Differences in glucose recognition by individual rat pancreatic B cells are associated with intercellular differences in glucose-induced biosynthetic activity. J Clin Invest. 1992;89: 117-125.
13. Stubbs M, Aiston S, Agius L. Subcellular localization, mobility, and kinetic activity of glucokinase in glucose-responsive insulinsecreting cells. Diabetes. 2000;49:2048-2055.
14. Poitout V, Rouault C, Guerre-Millo M, Briaud I, Reach G. Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans. Endocrinology. 1998;139:822-826. (Pubitemid 28510093)
15. Szecówka J, Sandberg E, Efendić S. The interaction of Vasoactive Intestinal Polypeptide (VIP), glucose and arginine on the secretion of insulin, glucagon and somatostatin in the perfused rat pancreas. Diabetologia. 1980;19:137-142. (Pubitemid 10085878)
16. Adrych K, Smoczynski M, Goyke E, Stelmanska E, Swierczynski J. Decreased serum leptin concentration in patients with CP. Pancreas. 2007;34:417-422. (Pubitemid 46725782)
17. Domschke S, Bloom SR, Adrian TE, Lux G, Domschke W. Chronic pancreatitis and diabetes mellitus: plasma and gastroduodenal mucosal profiles of regulatory peptides (gastrin, motilin, secretin, cholecystokinin, gastric inhibitory polypeptide, somatostatin, VIP, substance P, pancreatic polypeptide, glucagon, enteroglucagon, neurotensin). Hepatogastroenterology. 1988;35: 229-237.
18. Miyahara T, Kawabuchi M, Goto M, et al. Morphological study of pancreatic endocrine in an experimental CP with diabetes induced by stress and cerulein. Ultrastruct Pathol. 1999;23: 171-180. (Pubitemid 29300083)
19. Schrader H, Menge BA, Scneider S, et al. Reduced pancreatic volume and β-cell area in patients with CP. Gastroenterology. 2009;136:513-522.
20. Sasikala M, Pondugula PK, Guduru VR, et al. Reduced expression of Pdx-1 is associated with decreased beta cell function in CP. Pancreas. 2010;39:856-862.
21. Nyboe Andersen B, Krarup T, Thorsgaard Pedersen N, et al. B cell function in patients with CP and its relation to exocrine pancreatic function. Diabetolgia. 1982;23:86-89. (Pubitemid 12093492)
22. Knop FK, Vilsboll T, Hojberg PV, et al. Reduced incretin effect in type 2 diabetes; cause or consequence of the diabetic state? Diabetes. 2007;56:1951-1959. (Pubitemid 47195814)
23. Larsen S, Hilsted J, Tronier B, et al. Pancreatic hormone secretion in CP without residual beta cell function. Acta Endocrinol (Copenh). 1988;118:357-364.
24. Linde J, Nilsson LHS, Barany FR. Diabetes and hypoglycemia in CP. Scand J Gastroenterol. 1977;12:369-373.
25. Kannan V, Nabarro JDN, Cotton PB. Glucagon secretion in CP. Horm Res. 1979;11:203-212.
26. Al-Eryani S, Duris I, Payer J, et al. Plasma cholecystokinin and somatostatin levels in CP patients. Hepatogastroenterology. 2000;47:869-874. (Pubitemid 30417313)
27. Mahurkar S, Bhaskar S, Reddy DN, et al. Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis. World J Gastroenterol. 2007;13:5938-5943. (Pubitemid 350148511)
28. Reddy DN, Prasad SS. Genetic basis of CP in Asia Pacific region. J Gastroenterol Hepatol. 2011;26:2-5.
29. Hawrami K, Mohan V, Bone A, Hitman GA. Analysis of islet regenerating (reg) gene polymorphisms in fibrocalculous pancreatic diabetes. Pancreas. 1997;14:122-125. (Pubitemid 27106098)
30. Mahurkar S, Bhaskar S, Reddy DN, et al. TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes. BMC Med Genet. 2008;9:80.
31. Chen R, Brentnall TA, Pan S, et al. Quantitative proteomics analysis reveals that proteins differentially expressed in CP are also frequently involved in pancreatic cancer. Mol Cell Proteomics. 2007;6:1331-1342. (Pubitemid 47365432)
32. Walker MD. Role of miRNA in pancreatic β Cells. Diabetes. 2008;57:2567.
33. Joglekar MV, Parekh VS, Hardikar AA. New pancreas from old: microregulators of pancreas regeneration. Trends Endocrinol Metab. 2007;18:393-400. (Pubitemid 350137766)
34. Poy MN, Eliasson L, Krutzfeldt J, et al. A pancreatic islet-specific microRNA regulates insulin secretion. Nature. 2004;432: 226-230. (Pubitemid 39545853)
35. Joglekar MV, Joglekar VM, Hardikar AA. Expression of isletspecific microRNAs during human pancreatic development. Gene Exp Patterns. 2009;9:109-113.
36. Modak MA, Parab PB, Ghaskadbi SS. Control of hyperglycemia significantly improves oxidative stress profile of pancreatic islets. Islets. 2011;3. Epub. 09/01/2011.
37. Mews P, Phillips P, Fahmy R, et al. Pancreatic stellate cells respond to inflammatory cytokines: potential role in CP. Gut. 2002;50:535-541. (Pubitemid 34638875)
38. Andersson AK, Flodström M, Sandler S. Cytokine induced inhibition of insulin release from mouse pancreatic b-cells deficient in inducible nitric oxide synthase. Biochem Biophys Res Commun. 2001;28:396-403. (Pubitemid 32928169)
39. Pavan kumar P, Sasikala M, Radhika G, Tandan M, Rao GV, Nageshwar Reddy D. Interferon gamma is a potent inhibitor of expression and nuclear translocation of homeodomain transcription factor Pdx-1 causing reduced β cell area in CP. Abstract presented at annual meeting of the Indian Society of Gastroenterology, 2010.
40. Hasel C, Durr S, Rau B, et al. In CP, widespread emergence of TRAIL receptors in epitheliacoincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas. Lab Invest. 2003;83:825-836. (Pubitemid 36723691)
41. Donath MY, Storling J, Berchtold LA, et al. Cytokines and β-cell biology: from concept to clinical translation. Endocr Rev. 2008;29:334-350. (Pubitemid 351679703)
42. Corbett JA, Sweetland MA, Wang JL, et al. Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc Natl Acad Sci U S A. 1993;90:1731-1735. (Pubitemid 23069930)
43. Eizirik D, Mandrup-Poulsen T. A choice of death-the signal transduction of immune-mediated β-cell apoptosis. Diabetologia. 2001;44:2115-2133. (Pubitemid 34015464)
44. Maedler K, Schumann DM, Sauter N, et al. Low concentrations of interleukin-1β induces FLICE-inhibitory protein-mediated β-cell proliferation in human pancreatic islets. Diabetes. 2006; 55:2713-2722. (Pubitemid 44923669)
45. Butler AE, Janson J, Bonner-Weir S, et al. β cell deficit and increased β cell apoptosis in humans with type 2 diabetes. Diabetes. 2003;52:102-110. (Pubitemid 36042113)
46. Korc M, Friess H, Yamanaka Y, et al. CP is associated with increased concentrations of epidermal growth factor receptor, transforming growth factor α and phospholipase C γ. Gut. 1994;35:1468-1473. (Pubitemid 24310914)
47. Soga Y, Konori H, Miyazaki T, et al. Toll-like receptor 3 signaling induces CP through the Fas/Fas ligand mediated cytotoxicity. Tohoku J Exptl Med. 2009;217:175-184.
48. Maedler K, Fontana A, Ris F, et al. FLIP switches Fas-mediated glucose signaling in human pancreatic β cells from apoptosis to cell replication. Proc Natl Acad Sci USA. 2002;99:8236-8241. (Pubitemid 34651036)
49. Jasmin J-F, Mercier I, Sotgia F, et al. SOCS proteins and caveolin-1 as negative regulators of endocrine signaling. Trends Endocrinol Metab. 2006;17:150-158.