Protective mechanism of nicorandil on rat myocardial ischemia-reperfusion

Journal of Cardiovascular Medicine

Volumn 13, Issue 8, 2012, Pages 511-515

  Wang, Ailing ^a   Chen, Feng ^a   Xie, Yangjing ^a   Guo, Zeng ^a   Yu, Yuanxun ^b  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b Center of Medical Genetics of Anhui Province   (China)

Author keywords

cardioprotective mechanism; mitochondrial KATP channel; myocardial ischemia reperfusion injury; nicorandil

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); LACTATE DEHYDROGENASE; MALONALDEHYDE; NICORANDIL; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPE; ENZYME ACTIVITY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; IMMUNOHISTOCHEMISTRY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SPECTROPHOTOMETRY; ULTRASTRUCTURE ANALYSIS AND ELECTRON MICROSCOPY;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; CARDIOTONIC AGENTS; DRUG EVALUATION, PRECLINICAL; HEART VENTRICLES; L-LACTATE DEHYDROGENASE; MALE; MALONDIALDEHYDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, ELECTRON; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NICORANDIL; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE;

EID: 84864282549     PISSN: 15582027     EISSN: 15582035     Source Type: Journal    
DOI: 10.2459/JCM.0b013e3283542031     Document Type: Article

References (36)

1. Fox K, Garcia MA, Ardissino D, et al. Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur Heart J 2006; 27:1341-1381. (Pubitemid 43998110)
2. Kitakaze M, Asakura M, Kim J, et al. Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND). Two randomized trials. Lancet 2007; 370:1483-1493. (Pubitemid 47625560)
3. The IONA Study Group. Trial to show the impact of nicorandil in angina (IONA): design, methodology, and management. Heart 2001; 85:E9.
4. The IONA Study Group. Effect of nicorandil on coronary events in patients with stable angina. The impact of Nicorandil in Angina (IONA) randomized trial. Lancet 2002; 359:1269-1275.
5. Gross GJ, Pieper GM, Farber NE. Effects of nicorandil on coronary circulation and myocardial ischemia. Am J Cardiol 1989; 63:11J-17J. (Pubitemid 19161044)
6. Pieper GM, Gross GJ. Anti-free radical and neutrophil-modulating properties of the nitrovasodilator, nicorandil. Cardiovasc Drugs Ther 1992; 2:225-232.
7. Kitakaze M, Minamino T, Node K, et al. Role of activation of 5-nucleotidase in the cardioprotection mediated by opening K+ channels. Am J Physiol 1996; 270:H1744-H1756.
8. Poon S, Goodman SG, Yan RT, et al. Bridging the gender gap: Insights from a contemporary analysis of sex-related differences in the treatment and outcomes of patients with acute coronary syndromes. Am Heart J 2012; 163:66-73.
9. Bugiardini R, Yan AT, Yan RT, et al., Canadian Acute Coronary Syndrome Registry I and II Investigators. Factors influencing underutilization of evidence-based therapies in women. Eur Heart J 2011; 32:1337-1344.
10. Xhyheri B, Bugiardini R. Diagnosis and treatment of heart disease: are women different from men? Prog Cardiovasc Dis 2010; 53:227-236.
11. Pizzi C, Bugiardini R. Further insights into syndrome X. Heart 2010; 96:1865-1867.
12. Tatu-Chitoiu G, Cinteza M, Dorobantu M, et al. In-hospital case fatality rates for acute myocardial infarction in Romania. CMAJ 2009; 180:1207-1213.
13. Bugiardini R, Estrada JL, Nikus K, Hall AS, Manfrini O. Gender bias in acute coronary syndromes. Curr Vasc Pharmacol 2010; 8:276-284.
14. Manfrini O, Bugiardini R. Barriers to clinical risk scores adoption. Eur Heart J 2007; 28:1045-1046. (Pubitemid 47343886)
15. Bugiardini R, Badimon L, Collins P, et al. Angina, ''normal'' coronary angiography, and vascular dysfunction: risk assessment strategies. PLoS Med 2007; 4:e12.
16. Bugiardini R. Women, 'non-specific' chest pain, and normal or near-normal coronary angiograms are not synonymous with favourable outcome. Eur Heart J 2006; 27:1387-1389. (Pubitemid 43998066)
17. Manfrini O, Bazzocchi G, Luati A, Borghi A, Monari P, Bugiardini R. Coronary spasm reflects inputs from adjacent esophageal system. Am J Physiol Heart Circ Physiol 2006; 290:H2085-H2091.
18. Bugiardini R. Normal coronary arteries: clinical implications and further classification. Herz 2005; 30:3-7. (Pubitemid 40521551)
19. Manfrini O, Morgagni G, Pizzi C, Fontana F, Bugiardini R. Changes in autonomic nervous system activity: spontaneous versus balloon-induced myocardial ischaemia. Eur Heart J 2004; 25:1502-1508. (Pubitemid 39165628)
20. Manfrini O, Pizzi C, Morgagni G, Fontana F, Bugiardini R. Effect of pravastatin on myocardial perfusion after percutaneous transluminal coronary angioplasty. Am J Cardiol 2004; 93:1391-1393. (Pubitemid 38692468)
21. Manfrini O, Pizzi C, Trerè D, Fontana F, Bugiardini R. Parasympathetic failure and risk of subsequent coronary events in unstable angina and non-STsegment elevation myocardial infarction. Eur Heart J 2003; 24:1560-1566. (Pubitemid 37012190)
22. Bedetti G, Pasanisi EM, Pizzi C, Turchetti G, LoréC. Economic analysis including long-term risks and costs of alternative diagnostic strategies to evaluate patients with chest pain. Cardiovasc Ultrasound 2008; 6:21.
23. Mariuaz MZ, Juian S, Cabriela N. The respiration and calcium content of heart mitochondria from rats with vitamin D induced cardionecrosis. Biochem J 1985; 266:155-161.
24. Baracca A, Sgarbi G, Solaini G. Rhodamine 123 as a probe of mitochondrial membrane potential. Evaluation of proton flux through FO during ATP synthesis. Biochim Biophya Acta 2003; 1606:137-146. (Pubitemid 37267877)
25. Liling Wu, Youyi Zhang. Pathophysiology of cardiovascular disease. Peking University Medical Press; 2009.
26. Nishikawa S, Tatsumi T, Shiraishi J, et al. Nicorandil regulates Bcl-2 family proteins and protects cardiac myocytes against hypoxia-induced apoptosis. J Mol Cell Cardiol 2006; 40:510-519.
27. Jia D. The protective effect of mitochondrial ATP-Sensitive K+ channel opener, nicorandil, combined with Na+/Ca2+ exchange blocker KBR7943 on myocardial ischemia-reperfusion injury in rat. Cell Biochem Biophys 2011; 60:219-224.
28. Neichi T, Tomisawa S, Kubodera N, Uchida Y. Enhancement of PGI2 formation by a new vasodilator, 2-nicotinamidoethyl nitrate in the coupled system of platelets and aortic microsomes. Prostaglandins 1980; 19:577-586. (Pubitemid 10070949)
29. Bugiardini R, Galvani M, Ferrini D, et al. Effects of iloprost, a stable prostacyclin analog, on exercise capacity and platelet aggregation in stable angina pectoris. Am J Cardiol 1986; 58:453-459. (Pubitemid 16052672)
30. Bugiardini R, Galvani M, Ferrini D, et al. Myocardial ischemia induced by prostacyclin and iloprost. Clin Pharmacol Ther 1985; 38:101-108. (Pubitemid 15242208)
31. Argaud L, Garrier O, Loufouat J. Second-generation sulfonylureas preserve inhibition of mitochondrial permeability transition by the mitochondrial K+ (ATP) opener nicorandil in experimental myocardial infarction. Shock 2009; 32:247-252.
32. Wijns W, Barbato E. Reperfusion strategies for acute coronary syndrome. J Cardiovasc Med (Hagerstown) 2011; 12:849.
33. Colombo A, Castellani M, Piccaluga E, et al. Myocardial blood flow and infarct size after CD133+ cell injection in large myocardial infarction with good recanalization and poor reperfusion: results from a randomized controlled trial. J Cardiovasc Med (Hagerstown) 2011; 12:239-248.
34. Picchi A, Limbruno U. Thrombus aspiration during primary percutaneous coronary intervention. J Cardiovasc Med (Hagerstown) 2012; 13:16-23.
35. Bilen E, Yasar AS, Bilge M, et al. Effect of primary percutaneous coronary intervention on myocardial repolarization. J Cardiovasc Med (Hagerstown) 2011; 12:795-799.
36. Escaned J, Gonzalo N. Lessons learned from advanced intracoronary imaging in patients with acute myocardial infarction. J Cardiovasc Med (Hagerstown) 2011; 12:868-877.