Detection of the neurotoxin psychosine in samples of peripheral blood: Application in diagnostics and followup of krabbe disease

Archives of Pathology and Laboratory Medicine

Volumn 136, Issue 7, 2012, Pages 709-710

  Zhu, Hongling ^a   Lopez Rosas, Aurora ^a   Bongarzone, Ernesto R ^a   Qiu, Xi ^b   Van Breemen, Richard B ^b  

^a Dick Holland Regenerative Medicine Program   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PSYCHOSINE;

ANIMAL; BLOOD; GLOBOID CELL LEUKODYSTROPHY; LETTER; MOUSE; MOUSE MUTANT;

ANIMALS; LEUKODYSTROPHY, GLOBOID CELL; MICE; MICE, NEUROLOGIC MUTANTS; PSYCHOSINE;

EID: 84864272463     PISSN: 00039985     EISSN: 15432165     Source Type: Journal    
DOI: 10.5858/arpa.2011-0667-LE     Document Type: Letter

References (5)

1. Wenger DA, Riccardi VM. Possible misdiagnosis of Krabbe disease. J Pediatr. 1976;88(1):76-79.
2. White AB, Givogri MI, Lopez-Rosas A, et al. Psychosine accumulates in membrane microdomains in the brain of Krabbe patients, disrupting the raft architecture. J Neurosci. 2009;29(19):6068-6077.
3. Castelvetri LC, Givogri MI, Zhu H, et al. Axonopathy is a compounding factor in the pathogenesis of Krabbe disease. Acta Neuropathol. 2011;122(1):35-48.
4. Galbiati F, Basso V, Cantuti L, et al. Autonomic denervation of lymphoid organs leads to epigenetic immune atrophy in a mouse model of Krabbe disease. J Neurosci. 2007;27(50):13730-13738. (Pubitemid 350278274)
5. Duffner PK, Caggana M, Orsini JJ, et al. Newborn screening for Krabbe disease: the New York State model. Pediatr Neurol. 2009;40(4):245-252.