Independent beneficial effects of aged garlic extract intake with regular exercise on cardiovascular risk in postmenopausal women

Nutrition Research and Practice

Volumn 6, Issue 3, 2012, Pages 226-231

  Seo, Dae Yun ^a   Lee, Sung Ryul ^a   Kim, Hyoung Kyu ^a   Baek, Yeong Ho ^b   Kwak, Yi Sub ^c   Ko, Tae Hee ^a   Kim, Nari ^a   Rhee, Byoung Doo ^a   Ko, Kyoung Soo ^a   Park, Byung Joo ^d   Han, Jin ^a  

^a Inje University College of Medicine   (South Korea)

^b Pusan National University   (South Korea)

^c Dong Eui University   (South Korea)

^d Dongseo University   (South Korea)

Author keywords

Aged garlic extract; Cardiovascular risk factor; Exercise; Homocysteine; Postmenopausal women

Indexed keywords

ALLIUM SATIVUM;

EID: 84864263739     PISSN: 19761457     EISSN: 20056168     Source Type: Journal    
DOI: 10.4162/nrp.2012.6.3.226     Document Type: Article

References (44)

1. Bittner V. Menopause, age, and cardiovascular risk: a complex relationship. J Am Coll Cardiol 2009;54:2374-2375.
2. Colditz GA, Willett WC, Stampfer MJ, Rosner B, Speizer FE, Hennekens CH. Menopause and the risk of coronary heart disease in women. N Engl J Med 1987;316:1105-1110.
3. Utian WH. Biosynthesis and physiologic effects of estrogen and pathophysiologic effects of estrogen deficiency: a review. Am J Obstet Gynecol 1989;161:1828-1831.
4. Mendelsohn ME, Karas RH. Molecular and cellular basis of cardiovascular gender differences. Science 2005;308:1583-1587.
5. Andreassi MG, Barale R, Iozzo P, Picano E. The association of micronucleus frequency with obesity, diabetes and cardiovascular disease. Mutagenesis 2011;26:77-83.
6. Gijón-Conde T, Banegas JR. Cardiovascular disease in hypertension: gender differences in 100,000 clinical records. Rev Clin Esp 2012;212:55-62.
7. Farhangkhoee H, Khan ZA, Kaur H, Xin X, Chen S, Chakrabarti S. Vascular endothelial dysfunction in diabetic cardiomyopathy: pathogenesis and potential treatment targets. Pharmacol Ther 2006;111:384-399.
8. Purushothaman KR, Meerarani P, Moreno PR. Inflammation and neovascularization in diabetic atherosclerosis. Indian J Exp Biol 2007;45:93-102.
9. Kruger HS, Venter CS, Vorster HH; THUSA Study. Physical inactivity as a risk factor for cardiovascular disease in communities undergoing rural to urban transition: the THUSA study. Cardiovasc J S Afr 2003;14:16-23.
10. Armstrong K, Rakhit D, Jeffriess L, Johnson D, Leano R, Prins J, Garske L, Marwick T, Isbel N. Cardiorespiratory fitness is related to physical inactivity, metabolic risk factors, and atherosclerotic burden in glucose-intolerant renal transplant recipients. Clin J Am Soc Nephrol 2006;1:1275-1283.
11. Laufs U, Wassmann S, Czech T, Münzel T, Eisenhauer M, Böhm M, Nickenig G. Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis. Arterioscler Thromb Vasc Biol 2005;25:809-814.
12. Haapanen-Niemi N, Miilunpalo S, Pasanen M, Vuori I, Oja P, Malmberg J. Body mass index, physical inactivity and low level of physical fitness as determinants of all-cause and cardiovascular disease mortality--16 y follow-up of middle-aged and elderly men and women. Int J Obes Relat Metab Disord 2000;24:1465-1474.
13. Riesco E, Aubertin-Leheudre M, Maltais ML, Audet M, Dionne IJ. Synergic effect of phytoestrogens and exercise training on cardiovascular risk profile in exercise-responder postmenopausal women: a pilot study. Menopause 2010;17:1035-1039.
14. Yoshizawa M, Maeda S, Miyaki A, Misono M, Choi Y, Shimojo N, Ajisaka R, Tanaka H. Additive beneficial effects of lactotri-peptides and aerobic exercise on arterial compliance in postmeno-pausal women. Am J Physiol Heart Circ Physiol 2009;297: H1899-903.
15. Duvernoy CS, Martin JW, Briesmiester K, Muzik O, Mosca L. Self-reported physical activity and myocardial flow reserve in postmenopausal women at risk for cardiovascular disease. J Womens Health (Larchmt) 2006;15:45-50.
16. Yoshizawa M, Maeda S, Miyaki A, Misono M, Choi Y, Shimojo N, Ajisaka R, Tanaka H. Additive beneficial effects of lactotripeptides intake with regular exercise on endothelium-dependent dilatation in postmenopausal women. Am J Hypertens 2010;23:368-372.
17. Brown DA, Chicco AJ, Jew KN, Johnson MS, Lynch JM, Watson PA, Moore RL. Cardioprotection afforded by chronic exercise is mediated by the sarcolemmal, and not the mitochondrial, isoform of the KATP channel in the rat. J Physiol 2005;569:913-924.
18. Okura T, Rankinen T, Gagnon J, Lussier-Cacan S, Davignon J, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study. Eur J Appl Physiol 2006;98:394-401.
19. Brett SE, Jiang BY, Turner C, Ritter JM, Chowienczyk PJ. Elevation of plasma homocysteine by methionine loading increases the diastolic blood pressure response to exercise. J Hypertens 2006;24:1985-1989.
20. Squadrito F, Altavilla D, Morabito N, Crisafulli A, D'Anna R, Corrado F, Ruggeri P, Campo GM, Calapai G, Caputi AP, Squadrito G. The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women. Atherosclerosis 2002;163:339-347.
21. Liu ZM, Ho SC, Chen YM, Ho YP. The effects of isoflavones combined with soy protein on lipid profiles, C-reactive protein and cardiovascular risk among postmenopausal Chinese women. Nutr Metab Cardiovasc Dis 2011. [Epub ahead of print].
22. Kim SY, Seo SK, Choi YM, Jeon YE, Lim KJ, Cho S, Choi YS, Lee BS. Effects of red ginseng supplementation on menop-ausal symptoms and cardiovascular risk factors in postmeno-pausal women: a double-blind randomized controlled trial. Menopause 2012;19:461-466.
23. Sobenin IA, Andrianova IV, Fomchenkov IV, Gorchakova TV, Orekhov AN. Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension. Hypertens Res 2009;32:433-7.
24. Capraz M, Dilek M, Akpolat T. Garlic, hypertension and patient education. Int J Cardiol 2007;121:130-131.
25. Morihara N, Sumioka I, Ide N, Moriguchi T, Uda N, Kyo E. Aged garlic extract maintains cardiovascular homeostasis in mice and rats. J Nutr 2006;136:777S-7781S.
26. Morihara N, Hayama M, Fujii H. Aged garlic extract scavenges superoxide radicals. Plant Foods Hum Nutr 2011;66:17-21.
27. Ried K, Frank OR, Stocks NP. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial. Maturitas 2010;67:144-150.
28. Morihara N, Ide N, Weiss N. Aged garlic extract inhibits homocysteine-induced scavenger receptor CD36 expression and oxidized low-density lipoprotein cholesterol uptake in human macrophages in vitro. J Ethnopharmacol 2011;134:711-716.
29. Morihara N, Sumioka I, Moriguchi T, Uda N, Kyo E. Aged garlic extract enhances production of nitric oxide. Life Sci 2002;71: 509-517.
30. Lee YM, Gweon OC, Seo YJ, Im J, Kang MJ, Kim MJ, Kim JI. Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes mellitus. Nutr Res Pract 2009;3:156-161.
31. Figueroa A, Park SY, Seo DY, Sanchez-Gonzalez MA, Baek YH. Combined resistance and endurance exercise training improves arterial stiffness, blood pressure, and muscle strength in post-menopausal women. Menopause 2011;18:980-984.
32. Pereira IR, Faludi AA, Aldrighi JM, Bertolami MC, Saleh MH, Silva RA, Nakamura Y, Campos MF, Novaes N, Abdalla DS. Effects of soy germ isoflavones and hormone therapy on nitric oxide derivatives, low-density lipoprotein oxidation, and vascular reactivity in hypercholesterolemic postmenopausal women. Menopause 2006;13:942-950.
33. Harauma A, Moriguchi T. Aged garlic extract improves blood pressure in spontaneously hypertensive rats more safely than raw garlic. J Nutr 2006;136:769S-773S.
34. Hoshino T, Kashimoto N, Kasuga S. Effects of garlic preparations on the gastrointestinal mucosa. J Nutr 2001;131:1109S-1113S.
35. Lawson LD, Gardner CD. Composition, stability, and bioavaila-bility of garlic products used in a clinical trial. J Agric Food Chem 2005;53:6254-6261.
36. Imayama I, Alfano CM, Kong A, Foster-Schubert KE, Bain CE, Xiao L, Duggan C, Wang CY, Campbell KL, Blackburn GL, McTiernan A. Dietary weight loss and exercise interventions effects on quality of life in overweight/obese postmenopausal women: a randomized controlled trial. Int J Behav Nutr Phys Act 2011;8:118.
37. Lukaski HC, Nielsen FH. Dietary magnesium depletion affects metabolic responses during submaximal exercise in postmeno-pausal women. J Nutr 2002;132:930-5.
38. Ryan AS, Nicklas BJ, Berman DM, Elahi D. Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women. Int J Obes Relat Metab Disord 2003;27:1066-1071.
39. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39:44-84.
40. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991;324:1149-1155.
41. Moat SJ, Lang D, McDowell IF, Clarke ZL, Madhavan AK, Lewis MJ, Goodfellow J. Folate, homocysteine, endothelial function and cardiovascular disease. J Nutr Biochem 2004;15: 64-79.
42. Yeh YY, Yeh SM. Homocysteine-lowering action is another potential cardiovascular protective factor of aged garlic extract. J Nutr 2006;136:745S-749S.
43. Miyauchi A. Pathophysiology and treatment of malignancy-associated hypercalcemia. Nihon Rinsho 2006;Suppl 2:161-164.
44. Cagnacci A, Tarquini R, Perfetto F, Arangino S, Zanni AL, Cagnacci P, Facchinetti F, Volpe A. Endothelin-1 and nitric oxide levels are related to cardiovascular risk factors but are not modified by estradiol replacement in healthy postmenopausal women. A cross-sectional and a randomized cross-over study. Maturitas 2003;44:117-124.