Concise review: The role of clinical trials in deciphering mechanisms of action of cardiac cell-based therapy

Stem Cells Translational Medicine

Volumn 1, Issue 1, 2012, Pages 29-35

  Suncion, Viky Y ^a   Schulman, Ivonne H ^a,b   Hare, Joshua M ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b GRECC Miami Veterans Affairs Healthcare System   (United States)

Author keywords

Cell transplantation; Heart failure; Magnetic resonance imaging; Mesenchymal stem cells; Myocardial infarction; Ventricular remodeling

Indexed keywords

ADRENOMEDULLIN; COLONY STIMULATING FACTOR 1; FIBROBLAST GROWTH FACTOR 2; KERATINOCYTE GROWTH FACTOR; LEUKEMIA INHIBITORY FACTOR; MATRIX METALLOPROTEINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PLACENTAL GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; CELL TYPE; COMPUTER ASSISTED TOMOGRAPHY; CORONARY ARTERY BYPASS GRAFT; ECHOCARDIOGRAPHY; FIBROSING ALVEOLITIS; GENE THERAPY; HEART ARRHYTHMIA; HEART INFARCTION; HEART INJURY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE INJURY; HEART MUSCLE PERFUSION; HEART VENTRICLE REMODELING; HUMAN; MESENCHYMAL STEM CELL; META ANALYSIS (TOPIC); MULTIDETECTOR COMPUTED TOMOGRAPHY; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHASE 1 CLINICAL TRIAL (TOPIC); POSITRON EMISSION TOMOGRAPHY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STEM CELL RESEARCH; STEM CELL TRANSPLANTATION; TISSUE REGENERATION; TISSUE REPAIR; ANIMAL; BIOASSAY; CLINICAL TRIAL (TOPIC); CONVALESCENCE; DISEASE MODEL; EVIDENCE BASED MEDICINE; HEART DISEASE; HEART MUSCLE; HEART VENTRICLE FUNCTION; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; REGENERATION; TREATMENT OUTCOME;

ANIMALS; CLINICAL TRIALS AS TOPIC; DISEASE MODELS, ANIMAL; ENDPOINT DETERMINATION; EVIDENCE-BASED MEDICINE; HEART DISEASES; HUMANS; MYOCARDIUM; PHENOTYPE; RECOVERY OF FUNCTION; REGENERATION; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME; VENTRICULAR FUNCTION; VENTRICULAR REMODELING;

EID: 84864251872     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2011-0014     Document Type: Review

References (51)

1. Laflamme MA, Murry CE. Heart regeneration. Nature 2011;473:326-335.
2. Selem S, Hatzistergos KE, Hare JM. Cardiac stem cells: Biology and therapeutic applications. In: Atala A, Lanza R, Thomson JA, eds. Principles of Regenerative Medicine. San Diego, CA: Elsevier Inc, 2011:327-346.
3. Williams AR, Trachtenberg B, Velazquez DL et al. Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: Functional recovery and reverse remodeling. Circ Res 2011;108:792-796.
4. Abdel-Latif A, Bolli R, Tleyjeh IM et al. Adult bone marrow-derived cells for cardiac repair: A systematic review and meta-analysis. Arch Intern Med 2007;167:989-997.
5. Martin-Rendon E, Brunskill SJ, Hyde CJ et al. Autologous bone marrow stem cells to treat acute myocardial infarction: A systematic review. Eur Heart J 2008;29:1807-1818.
6. Wen Y, Meng L, Ding Y et al. Autologous transplantation of blood-derived stem/progenitor cells for ischaemic heart disease. Int J Clin Pract 2011;65:858-865.
7. Strauer BE, Brehm M, Zeus T et al. [Intracoronary, human autologous stem cell trans-plantation for myocardial regeneration following myocardial infarction]. Dtsch Med Wochenschr 2001;126:932-938.
8. Strauer BE, Brehm M, Zeus T et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 2002; 106:1913-1918.
9. Orlic D, Kajstura J, Chimenti S et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001;410:701-705.
10. Schächinger V, Erbs S, Elsasser A et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 2006;355:1210-1221.
11. Meyer GP, Wollert KC, Lotz J et al. Intracoronary bone marrow cell transfer after myocardial infarction: Eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation 2006;113:1287-1294.
12. Janssens S, Dubois C, Bogaert J et al. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet 2006;367: 113-121.
13. Hare JM, Traverse JH, Henry TD et al. A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol 2009;54:2277-2286.
14. Hendrikx M, Hensen K, Clijsters C et al. Recovery of regional but not global contractile function by the direct intramyocardial autolo\gous bone marrow transplantation: Results from a randomized controlled clinical trial. Circulation 2006;114(1 suppl):I101-I107.
15. Schächinger V, Assmus B, Britten MB et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: Final one-year results of the TOP-CARE-AMI Trial. J Am Coll Cardiol 2004;44: 1690-1699.
16. Schächinger V, Erbs S, Elsasser A et al. Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: Final 1-year results of the REPAIR-AMI trial. Eur Heart J 2006;27:2775-2783.
17. Pfeffer MA, Braunwald E. Ventricular enlargement following infarction is a modifiable process. Am J Cardiol 1991;68:127D-131D.
18. Lindsey ML, Mann DL, Entman ML et al. Extracellular matrix remodeling following myocardial injury. Ann Med 2003;35:316-326.
19. Kocher AA, Schuster MD, Szabolcs MJ et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001;7:430-436.
20. Harrison RW, Thakkar RN, Senzaki H et al. Relative contribution of preload and afterload to the reduction in cardiac output caused by nitric oxide synthase inhibition with L-N(G)-methylarginine hydrochloride 546C88. Crit Care Med 2000;28:1263-1268.
21. Dill T, Schächinger V, Rolf A et al. Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: Results of the Reinfusion of Enriched Progenitor cells And Infarct Remodeling in Acute Myocrdial Infarction study (REPAIR-AMI) cardiac magnetic resonance imaging substudy. Am Heart J 2009;157: 541-547.
22. Erbs S, Linke A, Adams V et al. Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: First randomized and placebo-controlled study. Circ Res 2005;97:756-762.
23. van der Spoel TI, Jansen Lorkeers SJ, Agostoni P et al. Human relevance of pre-clinical studies in stem cell therapy: Systematic review and meta-analysis of large animal models of ischaemic heart disease. Cardiovasc Res 2011;91:649-658.
24. Schuleri KH, Feigenbaum GS, Centola M et al. Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathy. Eur Heart J 2009;30:2722-2732.
25. Foley PW, Chalil S, Khadjooi K et al. Left ventricular reverse remodelling, long-term clinical outcome, and mode of death after cardiac resynchronization therapy. Eur J Heart Fail 2011;13:43-51.
26. Paterson DI, OMeara E, Chow BJ et al. Recent advances in cardiac imaging for patients with heart failure. Curr Opin Cardiol 2011;26:132-143.
27. Schwitter J. Perfusion cardiovascular magnetic resonance: Will it replace SPECT? Dalogues Cardiovasc Med 2007;12:114-122.
28. Shehata ML, Cheng S, Osman NF et al. Myocardial tissue tagging with cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2009;11:55.
29. Nesser HJ, Mor-Avi V, Gorissen W et al. Quantification of left ventricular volumes using three-dimensional echocardiographic speckle tracking: Comparison with MRI. Eur Heart J 2009;30:1565-1573.
30. Danias PG. Cardiovascular magnetic resonance imaging: An opportunity for fruitful collaborations. Hellenic J Cardiol 2007;48:53-54.
31. Nieman K, Shapiro MD, Ferencik M et al. Reperfused myocardial infarction: Contrast-enhanced 64-Section CT in comparison to MR imaging. Radiology 2008;247:49-56.
32. Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284: 143-147.
33. Quevedo HC, Hatzistergos KE, Oskouei BN et al. Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity. Proc Natl Acad Sci U S A 2009;106: 14022-14027.
34. Hatzistergos KE, Quevedo H, Oskouei BN et al. Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res 2010;107:913-922.
35. Mirotsou M, Jayawardena TM, Schmeck-peper J et al. Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J Mol Cell Cardiol 2011;50:280-289.
36. Berry MF, Engler AJ, Woo YJ et al. Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol 2006;290: H2196-H2203.
37. Xu X, Xu Z, Xu Y et al. Effects of mesenchymal stem cell transplantation on extracellular matrix after myocardial infarction in rats. Coron Artery Dis 2005;16:245-255.
38. Ohnishi S, Sumiyoshi H, Kitamura S et al. Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions. FEBS Lett 2007;581: 3961-3966.
39. Schuleri KH, Amado LC, Boyle AJ et al. Early improvement in cardiac tissue perfusion due to mesenchymal stem cells. Am J Physiol Heart Circ Physiol 2008;294:H2002-H2011.
40. Tang YL, Zhao Q, Zhang YC et al. Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium. Regul Pept 2004;117:3-10.
41. Zhou Y, Wang S, Yu Z et al. Direct injection of autologous mesenchymal stromal cells improves myocardial function. Biochem Biophys Res Commun 2009;390:902-907.
42. Shabbir A, Zisa D, Suzuki G et al. Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: A noninvasive therapeutic regimen. Am J Physiol Heart Circ Physiol 2009;296:H1888-H1897.
43. Nakanishi C, Yamagishi M, Yamahara K et al. Activation of cardiac progenitor cells through paracrine effects of mesenchymal stem cells. Biochem Biophys Res Commun 2008;374:11-16.
44. Urbich C, Aicher A, Heeschen C et al. Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. J Mol Cell Cardiol 2005;39:733-742.
45. Tang JM, Wang JN, Zhang L et al. VEGF/ SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart. Cardiovasc Res 2011;91:402-411.
46. Kanashiro-Takeuchi RM, Schulman IH, Hare JM. Pharmacologic and genetic strategies to enhance cell therapy for cardiac regeneration. J Mol Cell Cardiol 2011;51:619-625.
47. Bearzi C, Rota M, Hosoda T et al. Human cardiac stem cells. Proc Natl Acad Sci U S A 2007;104:14068-14073.
48. D'Amario D, Fiorini C, Campbell PM et al. Functionally competent cardiac stem cells can be isolated from endomyocardial biopsies of patients with advanced cardiomyopathies. Circ Res 2011;108:857-861.
49. Urbanek K, Quaini F, Tasca G et al. Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci U S A 2003;100:10440-10445.
50. Messina E, De AL, Frati G et al. Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res 2004;95: 911-921.
51. Smith RR, Barile L, Cho HC et al. Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation 2007;115:896-908.