메뉴 건너뛰기




Volumn 1, Issue 1, 2012, Pages 12-17

Adjuvant bisphosphonate treatment for breast cancer: Where are we heading and can the pre-clinical literature help us get there?

Author keywords

Adjuvant treatment; Bisphosphonate; Bone metastasis; Breast cancer; Preclinical models; Xenograft

Indexed keywords

ANTINEOPLASTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CLODRONIC ACID; DOXORUBICIN; ESTROGEN RECEPTOR; HORMONE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PAMIDRONIC ACID; PLACEBO; PROGESTERONE RECEPTOR; TAMOXIFEN; TOREMIFENE; ZOLEDRONIC ACID;

EID: 84864208279     PISSN: 22121374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbo.2012.04.003     Document Type: Review
Times cited : (11)

References (47)
  • 1
    • 33744828376 scopus 로고    scopus 로고
    • Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026]
    • Powles T, Paterson A, McCloskey E, Schein P, Scheffler B, Tidy A, et al. Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026]. Breast Cancer Research 2006;8:R13.
    • (2006) Breast Cancer Research , vol.8
    • Powles, T.1    Paterson, A.2    McCloskey, E.3    Schein, P.4    Scheffler, B.5    Tidy, A.6
  • 2
    • 56749165071 scopus 로고    scopus 로고
    • Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: A long-term follow-up
    • Diel IJ, Jaschke A, Solomayer EF, Gollan C, Bastert G, Sohn C, et al. Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: a long-term follow-up. Annals of Oncology 2008;19:2007-11.
    • (2008) Annals of Oncology , vol.19 , pp. 2007-2011
    • Diel, I.J.1    Jaschke, A.2    Solomayer, E.F.3    Gollan, C.4    Bastert, G.5    Sohn, C.6
  • 3
    • 79959565208 scopus 로고    scopus 로고
    • Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial
    • Gnant M, Mlineritsch B, Stoeger H, Luschin-Ebengreuth G, Heck D, Menzel C, et al. Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial. The Lancet Oncology 2011;12:631-41.
    • (2011) The Lancet Oncology , vol.12 , pp. 631-641
    • Gnant, M.1    Mlineritsch, B.2    Stoeger, H.3    Luschin-Ebengreuth, G.4    Heck, D.5    Menzel, C.6
  • 4
    • 84857099998 scopus 로고    scopus 로고
    • Long-term follow-up in ABCSG-12: Significantly improved overall survival with adjuvant zoledronic acid in premenopausal patients with endocrine-receptor-positive early breast cancer
    • December 6-10 2011, San Antonio, Texas;
    • Gnant M, Mlineritsch B, Luschin-Ebengreuth G, Stoeger H, Dubsky P, Jakesz R, et al. Long-term follow-up in ABCSG-12: Significantly improved overall survival with adjuvant zoledronic acid in premenopausal patients with endocrine-receptor-positive early breast cancer. In San Antonio Breast Cancer Symposium. December 6-10 2011, San Antonio, Texas; 2011.
    • (2011) San Antonio Breast Cancer Symposium
    • Gnant, M.1    Mlineritsch, B.2    Luschin-Ebengreuth, G.3    Stoeger, H.4    Dubsky, P.5    Jakesz, R.6
  • 7
    • 84863098442 scopus 로고    scopus 로고
    • NSABP protocol B-34: A clinical trial comparing adjuvant clodro-nate vs. placebo in early stage breast cancer patients receiving systemic chemotherapy and/or tamoxifen or no therapy-final analysis
    • December 6-10 2011, San Antonio, Texas. Edited by CTRC-AACR;
    • Paterson AHG, Anderson SJ, Lembersky BC, Fehrenbacher L, Falkson CI, King KM, et al. NSABP protocol B-34: A clinical trial comparing adjuvant clodro-nate vs. placebo in early stage breast cancer patients receiving systemic chemotherapy and/or tamoxifen or no therapy-final analysis. In San Antonio Breast Cancer Symposium. December 6-10 2011, San Antonio, Texas. Edited by CTRC-AACR; 2011.
    • (2011) San Antonio Breast Cancer Symposium
    • Paterson, A.H.G.1    Anderson, S.J.2    Lembersky, B.C.3    Fehrenbacher, L.4    Falkson, C.I.5    King, K.M.6
  • 8
    • 85031183203 scopus 로고    scopus 로고
    • GAIN (German Adjuvant Intergroup Node Positive) study: A phase III-multi-center trial to compare dose dense, dose intense etc (iddETC) vs. EC-TX and K. Russell et al. / Journal of Bone Oncology 1 (2012) 12-17 17 ibandronate vs. observation in patients with node-positive primary breast cancer'1s tinterim efficacy analysis, December 6-10 2011, San Antonio, Texas. Edited by CTRC-AACR;
    • Thomssen Mobus V, Harbeck C, Untch N, Jackisch M, Diel C, Elling IJ, et al., GAIN (German Adjuvant Intergroup Node Positive) study: A phase III-multi-center trial to compare dose dense, dose intense etc (iddETC) vs. EC-TX and K. Russell et al. / Journal of Bone Oncology 1 (2012) 12-17 17 ibandronate vs. observation in patients with node-positive primary breast cancer'st interim efficacy analysis. In San Antonio Breast Cancer Symposium. December 6-10 2011, San Antonio, Texas. Edited by CTRC-AACR; 2011
    • (2011) San Antonio Breast Cancer Symposium
    • Thomssen Mobus, V.1    Harbeck, C.2    Untch, N.3    Jackisch, M.4    Diel, C.5    Elling, I.J.6
  • 9
    • 9444254706 scopus 로고    scopus 로고
    • Ten-year follow-up of a randomized controlled trial of adjuvant clodronate treatment in node-positive breast cancer patients
    • DOI 10.1080/02841860410032885
    • Saarto T, Vehmanen L, Virkkunen P, Blomqvist C. Ten-year follow-up of a randomized controlled trial of adjuvant clodronate treatment in nodepositive breast cancer patients. Acta Oncologica 2004;43:650-6. (Pubitemid 39563937)
    • (2004) Acta Oncologica , vol.43 , Issue.7 , pp. 650-656
    • Saarto, T.1    Vehmanen, L.2    Virkkunen, P.3    Blomqvist, C.4
  • 10
    • 0036148327 scopus 로고    scopus 로고
    • Actions of bisphosphonates in animal models of breast cancer
    • DOI 10.1186/bcr415
    • Padalecki SS, Guise TA. Actions of bisphosphonates in animal models of breast cancer. Breast Cancer Research 2002;4:35-41. (Pubitemid 34097555)
    • (2002) Breast Cancer Research , vol.4 , Issue.1 , pp. 35-41
    • Padelecki, S.S.1    Guise, T.A.2
  • 12
    • 0029101805 scopus 로고
    • Bispho- sphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice
    • Sasaki A, Boyce BF, Story B, Wright KR, Chapman M, Boyce R, et al. Bispho- sphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice. Cancer Research 1995;55:3551-7.
    • (1995) Cancer Research , vol.55 , pp. 3551-3557
    • Sasaki, A.1    Boyce, B.F.2    Story, B.3    Wright, K.R.4    Chapman, M.5    Boyce, R.6
  • 13
    • 0031806712 scopus 로고    scopus 로고
    • Effect of a newly developed bisphosphonate, YH529, on osteolytic bone metastases in nude mice
    • DOI 10.1002/(SICI)1097-0215(19980717)77:2<279::AID-IJC18>3.0.CO;2-6
    • Sasaki A, Kitamura K, Alcalde RE, Tanaka T, Suzuki A, Etoh Y, et al. Effect of a newly developed bisphosphonate, YH529, on osteolytic bone metastases in nude mice. International Journal of Cancer 1998;77:279-85. (Pubitemid 28287982)
    • (1998) International Journal of Cancer , vol.77 , Issue.2 , pp. 279-285
    • Sasaki, A.1    Kitamura, K.2    Alcalde, R.E.3    Tanaka, T.4    Suzuki, A.5    Etoh, Y.6    Matsumura, T.7
  • 14
    • 51649118688 scopus 로고    scopus 로고
    • Differential effect of doxorubicin and zoledronic acid on intraosseous versus extraosseous breast tumor growth in vivo
    • Ottewell PD, Deux B, Monkkonen H, Cross S, Coleman RE, Clezardin P, et al. Differential effect of doxorubicin and zoledronic acid on intraosseous versus extraosseous breast tumor growth in vivo. Clinical Cancer Research 2008;14: 4658-66.
    • (2008) Clinical Cancer Research , vol.14 , pp. 4658-4666
    • Ottewell, P.D.1    Deux, B.2    Monkkonen, H.3    Cross, S.4    Coleman, R.E.5    Clezardin, P.6
  • 15
    • 0034660140 scopus 로고    scopus 로고
    • Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma
    • Yoneda T, Michigami T, Yi B, Williams PJ, Niewolna M, Hiraga T. Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma. Cancer 2000;88:2979-88. (Pubitemid 30413180)
    • (2000) Cancer , vol.88 , Issue.12 SUPPL. , pp. 2979-2988
    • Yoneda, T.1    Michigami, T.2    Yi, B.3    Williams, P.J.4    Niewolna, M.5    Hiraga, T.6
  • 16
    • 3042729728 scopus 로고    scopus 로고
    • Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model
    • DOI 10.1158/1078-0432.CCR-03-0325
    • Hiraga T, Williams PJ, Ueda A, Tamura D, Yoneda T. Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model. Clinical Cancer Research 2004;10:4559-67.G (Pubitemid 38878900)
    • (2004) Clinical Cancer Research , vol.10 , Issue.13 , pp. 4559-4567
    • Hiraga, T.1    Williams, P.J.2    Ueda, A.3    Tamura, D.4    Yoneda, T.5
  • 17
    • 3142685263 scopus 로고    scopus 로고
    • The follicle-deplete mouse ovary produces androgen
    • DOI 10.1095/biolreprod.103.016113
    • MayerLP, DevinePJ, DyerCA, HoyerPB. Thefollicle-depletemouseovary produces androgen. BiologyofReproduction2004;71:130-8. (Pubitemid 38915317)
    • (2004) Biology of Reproduction , vol.71 , Issue.1 , pp. 130-138
    • Mayer, L.P.1    Devine, P.J.2    Dyer, C.A.3    Hoyer, P.B.4
  • 18
    • 3142685263 scopus 로고    scopus 로고
    • The follicle-deplete mouse ovary produces androgen
    • DOI 10.1095/biolreprod.103.016113
    • Mayer LP, Devine PJ, Dyer CA, Hoyer PB. The follicle-deplete mouse ovary produces androgen. Biology of Reproduction 2004;71:130-8. (Pubitemid 38915317)
    • (2004) Biology of Reproduction , vol.71 , Issue.1 , pp. 130-138
    • Mayer, L.P.1    Devine, P.J.2    Dyer, C.A.3    Hoyer, P.B.4
  • 20
    • 77955870208 scopus 로고    scopus 로고
    • Use of bisphosphonates and risk of postmenopausal breast cancer
    • Rennert G, Pinchev M, Rennert HS. Use of bisphosphonates and risk of postmenopausal breast cancer. Journal of Clinical Oncology 2010;28: 3577-81.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 3577-3581
    • Rennert, G.1    Pinchev, M.2    Rennert, H.S.3
  • 21
    • 77649269901 scopus 로고    scopus 로고
    • Bisphosphonates for osteoporosis treatment are associated with reduced breast cancer risk
    • Newcomb PA, Trentham-Dietz A, Hampton JM. Bisphosphonates for osteoporosis treatment are associated with reduced breast cancer risk. British Journal of Cancer 2010;102:799-802.
    • (2010) British Journal of Cancer , vol.102 , pp. 799-802
    • Newcomb, P.A.1    Trentham-Dietz, A.2    Hampton, J.M.3
  • 22
    • 3843067789 scopus 로고    scopus 로고
    • Proliferation rate, hormone receptor status and p53 expression in skeletal metastasis of breast carcinoma
    • DOI 10.1080/02841860410033721
    • Wedin R, Skoog L, Bauer HC. Proliferation rate, hormone receptor status and p53 expression in skeletal metastasis of breast carcinoma. Acta Oncologica 2004;43:460-6. (Pubitemid 39037094)
    • (2004) Acta Oncologica , vol.43 , Issue.5 , pp. 460-466
    • Wedin, R.1    Skoog, L.2    Bauer, H.C.F.3
  • 24
    • 79952697149 scopus 로고    scopus 로고
    • Breast carcinomas with isolated bone metastases have different hormone receptor expression profiles than those with metastases to other sites or multiple organs
    • Wei S, Li Y, Siegal GP, Hameed O. Breast carcinomas with isolated bone metastases have different hormone receptor expression profiles than those with metastases to other sites or multiple organs. Annals of Diagnostic Pathology 2011;15:79-83.
    • (2011) Annals of Diagnostic Pathology , vol.15 , pp. 79-83
    • Wei, S.1    Li, Y.2    Siegal, G.P.3    Hameed, O.4
  • 25
    • 9144258469 scopus 로고    scopus 로고
    • Steroid-free medium discloses oestrogenic effects of the bisphosphonate clodronate on breast cancer cells
    • DOI 10.1038/sj.bjc.6602181
    • Journe F, Chaboteaux C, Dumon JC, Leclercq G, Laurent G, Body JJ. Steroid-free medium discloses oestrogenic effects of the bisphosphonate clodronate on breast cancer cells. British Journal of Cancer 2004;91:1703-10. (Pubitemid 39546144)
    • (2004) British Journal of Cancer , vol.91 , Issue.9 , pp. 1703-1710
    • Journe, F.1    Chaboteaux, C.2    Dumon, J.-C.3    Leclercq, G.4    Laurent, G.5    Body, J.-J.6
  • 26
    • 80052734955 scopus 로고    scopus 로고
    • New perspectives on zoledronic acid in breast cancer: Potential augmentation of anticancer immune response
    • Hamilton E, Clay TM, Blackwell KL. New perspectives on zoledronic acid in breast cancer: potential augmentation of anticancer immune response. Cancer Investigation 2011;29:533-41.
    • (2011) Cancer Investigation , vol.29 , pp. 533-541
    • Hamilton, E.1    Clay, T.M.2    Blackwell, K.L.3
  • 27
    • 79959916377 scopus 로고    scopus 로고
    • High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity in vivo
    • Benzaid I, Monkkonen H, Stresing V, Bonnelye E, Green J, Monkkonen J, et al. High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity in vivo. Cancer Research 2011;71:4562-72.
    • (2011) Cancer Research , vol.71 , pp. 4562-4572
    • Benzaid, I.1    Monkkonen, H.2    Stresing, V.3    Bonnelye, E.4    Green, J.5    Monkkonen, J.6
  • 28
    • 78650456974 scopus 로고    scopus 로고
    • Lysis of aminobisphosphonate-sensitized MCF-7 breast tumor cells by Vgamma9Vdelta2 T cells
    • Dhar S, Chiplunkar SV. Lysis of aminobisphosphonate-sensitized MCF-7 breast tumor cells by Vgamma9Vdelta2 T cells. Cancer Immunity 2010;10:10.
    • (2010) Cancer Immunity , vol.10 , pp. 10
    • Dhar, S.1    Chiplunkar, S.V.2
  • 29
    • 77954652637 scopus 로고    scopus 로고
    • In vivo manipulation of Vgamma9 Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients
    • Meraviglia S, Eberl M, Vermijlen D, Todaro M, Buccheri S, Cicero G, et al. In vivo manipulation of Vgamma9 Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients. Clinical and Experimental Immunology 2010;161:290-7.
    • (2010) Clinical and Experimental Immunology , vol.161 , pp. 290-297
    • Meraviglia, S.1    Eberl, M.2    Vermijlen, D.3    Todaro, M.4    Buccheri, S.5    Cicero, G.6
  • 30
    • 0035917560 scopus 로고    scopus 로고
    • The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: Evidence for synergy with paclitaxel
    • DOI 10.1054/bjoc.2001.1727
    • Jagdev SP, Coleman RE, Shipman CM, Rostami HA, Croucher PI. Thebispho- sphonate, zoledronic acid, induces apoptosis of breast cancer cells:evidence for synergy with paclitaxel. British Journal of Cancer 2001;84:1126-34 (Pubitemid 32448513)
    • (2001) British Journal of Cancer , vol.84 , Issue.8 , pp. 1126-1134
    • Jagdev, S.P.1    Coleman, R.E.2    Shipman, C.M.3    Rostami, H.A.4    Croucher, P.I.5
  • 33
    • 0035360867 scopus 로고    scopus 로고
    • The bisphosphonate ibandronate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases
    • Hiraga T, Williams PJ, Mundy GR, Yoneda T. The bisphosphonate ibandronate promotes apoptos is in MDA-MB-231 human breast cancer cells in bone metastases. Cancer Research 2001;61:4418-24. (Pubitemid 32685769)
    • (2001) Cancer Research , vol.61 , Issue.11 , pp. 4418-4424
    • Hiraga, T.1    Williams, P.J.2    Mundy, G.R.3    Yoneda, T.4
  • 34
    • 0042338751 scopus 로고    scopus 로고
    • Effects of oral UFT combined with or without zoledronic acid on bone metastasis in the 4T1/luc mouse breast cancer
    • DOI 10.1002/ijc.11330
    • Hiraga T, Ueda A, Tamura D, Hata K, Ikeda F, Williams PJ, et al. Effects of oral UFT combined with or without zoledronic acid on bone metastasis in the 4T1/luc mouse breast cancer. International Journal of Cancer 2003;106: 973-9. (Pubitemid 37071680)
    • (2003) International Journal of Cancer , vol.106 , Issue.6 , pp. 973-979
    • Hiraga, T.1    Ueda, A.2    Tamura, D.3    Hata, K.4    Ikeda, F.5    Williams, P.J.6    Yoneda, T.7
  • 35
    • 0037664952 scopus 로고    scopus 로고
    • Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells
    • DOI 10.1097/01.ju.0000070685.34760.5f
    • Oades GM, Senaratne SG, Clarke IA, Kirby RS, Colston KW. Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells. Journal of Urology 2003;170:246-52. (Pubitemid 36734471)
    • (2003) Journal of Urology , vol.170 , Issue.1 , pp. 246-252
    • Oades, G.M.1    Senaratne, S.G.2    Clarke, I.A.3    Kirby, R.S.4    Colston, K.W.5
  • 36
    • 3242771333 scopus 로고    scopus 로고
    • Zoledronic acid induces apoptosis and inhibits adhesion to mineralized matrix in prostate cancer cells via inhibition of protein prenylation
    • DOI 10.1111/j.1464-4096.2004.04831.x
    • Coxon JP, Oades GM, Kirby RS, Colston KW. Zoledronic acid induces apoptosis and inhibits adhesion to mineralized matrix in prostate cancer cells via inhibition of protein prenylation. British Journal of Urology International 2004;94:164-70. (Pubitemid 38980328)
    • (2004) BJU International , vol.94 , Issue.1 , pp. 164-170
    • Coxon, J.P.1    Oades, G.M.2    Kirby, R.S.3    Colston, K.W.4
  • 37
    • 78650972753 scopus 로고    scopus 로고
    • Breast cancer cells inhibit spontaneous and bisphosphonate-induced osteoclast apoptosis
    • Hussein O, Tiedemann K, Komarova SV. Breast cancer cells inhibit spontaneous and bisphosphonate-induced osteoclast apoptosis. Bone 2011; 48:202-11
    • (2011) Bone , vol.48 , pp. 202-211
    • Hussein, O.1    Tiedemann, K.2    Komarova, S.V.3
  • 39
    • 0038824960 scopus 로고    scopus 로고
    • How myeloma cells escape bisphosphonate-mediated killing: Development of specific resistance with preserved sensitivity to conventional chemotherapeutics
    • DOI 10.1046/j.1365-2141.2003.04437.x
    • Salomo M, Jurlander J, Nielsen LB, Gimsing P. How myeloma cells escape bisphosphonate-mediated killing: development of specific resistance with preserved sensitivity to conventional chemotherapeutics. British Journal of Haematology 2003;122:202-10. (Pubitemid 36859604)
    • (2003) British Journal of Haematology , vol.122 , Issue.2 , pp. 202-210
    • Salomo, M.1    Jurlander, J.2    Nielsen, L.B.3    Gimsing, P.4
  • 41
    • 34547849623 scopus 로고    scopus 로고
    • Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells
    • DOI 10.1016/j.ejphar.2007.05.075, PII S0014299907006504
    • Merrell MA, Wakchoure S, Lehenkari PP, Harris KW, Selander KS. Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells. European Journal of Pharmacology 2007;570:27-37. (Pubitemid 47247687)
    • (2007) European Journal of Pharmacology , vol.570 , Issue.1-3 , pp. 27-37
    • Merrell, M.A.1    Wakchoure, S.2    Lehenkari, P.P.3    Harris, K.W.4    Selander, K.S.5
  • 42
    • 42149090508 scopus 로고    scopus 로고
    • Efficacy of a nitrogen-containing bisphosphonate, minodronate, in conjunction with a p38 mitogen activated protein kinase inhibitor or doxorubicin against malignant bone tumor cells
    • DOI 10.1007/s00280-007-0580-y
    • Kubo T, Shimose S, Matsuo T, Sakai A, Ochi M. Efficacy of a nitrogen-containing bisphosphonate, minodronate, in conjunction with a p38 mitogen activated protein kinase inhibitor or doxorubicin against malignant bone tumor cells. Cancer Chemotherapy and Pharmacology 2008;62:111-6. (Pubitemid 351537851)
    • (2008) Cancer Chemotherapy and Pharmacology , vol.62 , Issue.1 , pp. 111-116
    • Kubo, T.1    Shimose, S.2    Matsuo, T.3    Sakai, A.4    Ochi, M.5
  • 43
    • 77958568496 scopus 로고    scopus 로고
    • Inhibition of heat-shock protein 27 expression eliminates drug resistance of osteosarcoma to zoledronic acid
    • Morii T, Ohtsuka K, Ohnishi H, Mochizuki K, Satomi K. Inhibition of heat-shock protein 27 expression eliminates drug resistance of osteosarcoma to zoledronic acid. Anticancer Research 2010;30:3565-71.
    • (2010) Anticancer Research , vol.30 , pp. 3565-3571
    • Morii, T.1    Ohtsuka, K.2    Ohnishi, H.3    Mochizuki, K.4    Satomi, K.5
  • 46
    • 0027366354 scopus 로고
    • The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines
    • Oesterreich S, Weng CN, Qiu M, Hilsenbeck SG, Osborne CK, Fuqua SA. The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines. Cancer Research 1993;53:4443-8. (Pubitemid 23304358)
    • (1993) Cancer Research , vol.53 , Issue.18 , pp. 4443-4448
    • Oesterreich, S.1    Weng, C.-N.2    Qiu, M.3    Hilsenbeck, S.G.4    Osborne, C.K.5    Fuqua, S.A.W.6
  • 47
    • 54049100335 scopus 로고    scopus 로고
    • Upregulated HSP27 in human breast cancer cells reduces herceptin susceptibility by increasing Her2 protein stability
    • Kang SH, Kang KW, Kim KH, Kwon B, Kim SK, Lee HY, et al. Upregulated HSP27 in human breast cancer cells reduces herceptin susceptibility by increasing Her2 protein stability. BMC Cancer 2008;8:286.
    • (2008) BMC Cancer , vol.8 , pp. 286
    • Kang, S.H.1    Kang, K.W.2    Kim, K.H.3    Kwon, B.4    Kim, S.K.5    Lee, H.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.